Patents by Inventor Masaaki Tokuda

Masaaki Tokuda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11653685
    Abstract: A D-psicose-containing sweetener with the modification of the taste of D-psicose includes D-psicose, a sugar alcohol and/or a high intensity sweetener, preferably containing D-psicose as the main component, particularly a low-calorie sweetener and/or a sweetener giving refreshing feel in the oral cavity, as well as foods and drinks obtained by using the D-psicose-containing sweetener with the modification of the taste of D-psicose, and other products given with sweetness. The sugar alcohol is one or more sugar alcohols selected from the group consisting of sorbitol, mannitol, lactitol, maltitol, xylitol and erythritol, while the high intensity sweetener is one or more high intensity sweeteners as selected from aspartame, acesulfame K, sodium cyclamate, sodium saccharin, Sucralose (under trade name), stevia sweetener, dulcin, taumatin, neotame and monellin.
    Type: Grant
    Filed: October 16, 2020
    Date of Patent: May 23, 2023
    Assignees: MATSUTANI CHEMICAL INDUSTRY CO., LTD., NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
    Inventors: Hideki Fujihara, Kazuhiro Okuma, Tetsuo Iida, Ken Izumori, Masaaki Tokuda, Kazuhiro Fukada
  • Patent number: 11324763
    Abstract: Problem: A malaria transmission blocker or a malaria parasite growth inhibitor is provided as a result of finding a druq which inhibits malaria parasite growth in the body of a vector mosquito. Solution: A malaria parasite growth inhibitor or transmission blocker containing a rare sugar such as D-allose or D-psicose as an active ingredient.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: May 10, 2022
    Assignees: National University Corporation Kagawa University, MATSUTANI CHEMICAL INDUSTRY CO., LTD.
    Inventors: Masaaki Tokuda, Meiji Arai, Kazuhiro Okuma
  • Publication number: 20210030037
    Abstract: A D-psicose-containing sweetener with the modification of the taste of D-psicose includes D-psicose, a sugar alcohol and/or a high intensity sweetener, preferably containing D-psicose as the main component, particularly a low-calorie sweetener and/or a sweetener giving refreshing feel in the oral cavity, as well as foods and drinks obtained by using the D-psicose-containing sweetener with the modification of the taste of D-psicose, and other products given with sweetness. The sugar alcohol is one or more sugar alcohols selected from the group consisting of sorbitol, mannitol, lactitol, maltitol, xylitol and erythritol, while the high intensity sweetener is one or more high intensity sweeteners as selected from aspartame, acesulfame K, sodium cyclamate, sodium saccharin, Sucralose (under trade name), stevia sweetener, dulcin, taumatin, neotame and monellin.
    Type: Application
    Filed: October 16, 2020
    Publication date: February 4, 2021
    Applicants: MATSUTANI CHEMICAL INDUSTRY CO., LTD., NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
    Inventors: Hideki Fujihara, Kazuhiro Okuma, Tetsuo Iida, Ken Izumori, Masaaki Tokuda, Kazuhiro Fukada
  • Patent number: 10869494
    Abstract: Providing a D-psicose-containing sweetener with the modification of the taste of D-psicose, comprising D-psicose, a sugar alcohol and/or a high intensity sweetener, preferably containing D-psicose as the main component, particularly a low-calorie sweetener and/or a sweetener giving refreshing feel in the oral cavity, as well as foods and drinks obtained by using the D-psicose-containing sweetener with the modification of the taste of D-psicose, and other products given with sweetness. The sugar alcohol is one or more sugar alcohols selected from the group consisting of sorbitol, mannitol, lactitol, maltitol, xylitol and erythritol, while the high intensity sweetener is one or more high intensity sweeteners as selected from aspartame, acesulfame K, sodium cyclamate, sodium saccharin, Sucralose (under trade name), stevia sweetener, dulcin, taumatin, neotame and monellin.
    Type: Grant
    Filed: March 26, 2007
    Date of Patent: December 22, 2020
    Assignee: MATSUTANI CHEMICAL INDUSTRY CO., LTD.
    Inventors: Hideki Fujihara, Kazuhiro Okuma, Tetsuo Iida, Ken Izumori, Masaaki Tokuda, Kazuhiro Fukada
  • Patent number: 9668958
    Abstract: To provide a composition for preventing periodontal diseases (prophylactic agent of periodontal diseases), the composition having an excellent cariostatic property, being safe and stable for prolonged use and having less effects on flavor. A non-cariogenic material prepared by blending a rare sugar in the D form as selected from the group consisting of D-psicose, D-sorbose and D-tagatose, a rare sugar in the L form as selected from L-fructose, L-psicose and L-tagatose, or allitol as a rare sugar derivative, singly or in combination. A cariostatic agent comprising D-psicose, D-sorbose, D-tagatose, L-fructose, L-psicose and/or L-tagatose. A cariostatic agent in combination with catechins.
    Type: Grant
    Filed: February 9, 2012
    Date of Patent: June 6, 2017
    Assignees: MATSUTANI CHEMICAL INDUSTRY CO., LTD., NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY
    Inventors: Tetsuo Iida, Takashi Ichihara, Ken Izumori, Masaaki Tokuda, Takaaki Ogawa
  • Publication number: 20170100418
    Abstract: Problem: A malaria transmission blocker or a malaria parasite growth inhibitor is provided as a result of finding a druq which inhibits malaria parasite growth in the body of a vector mosquito. Solution: A malaria parasite growth inhibitor or transmission blocker containinq a rare sugar such as D-allose or D-psicose as an active ingredient.
    Type: Application
    Filed: March 20, 2015
    Publication date: April 13, 2017
    Applicants: NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY, MATSUTANI CHEMICAL INDUSTRY CO., LTD.
    Inventors: Masaaki Tokuda, Meiji Arai, Kazuhiro Okuma
  • Patent number: 9517677
    Abstract: A vehicle air conditioning system includes a duct, a refrigerant evaporator, an air conditioning cooling flow passage, a heater core, a heater hot fluid flow passage, a heat exchanger, an electric heater, an electrical component cooling flow passage, a communication flow passage, a fluid temperature sensor and a flow passage selector valve. The duct provides air to a vehicle cabin interior. The cooling flow passage provides cooled refrigerant to the evaporator. The hot fluid flow passage provides hot fluid to the heater core. The heat exchanger exchanges heat between the refrigerant and the hot fluid. The heater warms the hot fluid having undergone heat exchange. The cooling flow passage cools an electrical component. The communication flow passage parallelly connects the hot fluid and electrical component flow passages. The valve allows hot fluid to flow into the cooling flow passage when the hot fluid has a high temperature.
    Type: Grant
    Filed: May 19, 2011
    Date of Patent: December 13, 2016
    Assignee: Nissan Motor Co., Ltd.
    Inventors: Masaaki Tokuda, Shinichirou Mizoguchi, Satoshi Ogihara
  • Patent number: 9273050
    Abstract: Provided is a compound having at least one selected from the group consisting of cell growth promoting activity, angiogenesis promoting activity, lumen formation promoting activity, cell migration promoting activity, and neurocyte growth promoting activity, which is a chemically stable low-molecular-weight substance that has high absorbability and can be supplied stably at a low cost because of its low molecular weight. A cyclobutyl purine derivative, a tautomer or stereoisomer thereof, or a salt, solvate, or hydrate thereof according to the present invention is a cyclobutyl purine derivative represented by the following general formula (1), a tautomer or stereoisomer thereof, or a salt, solvate, or hydrate thereof.
    Type: Grant
    Filed: November 27, 2009
    Date of Patent: March 1, 2016
    Assignee: National University Corporation Kagawa University
    Inventors: Ikuko Tsukamoto, Ryoji Konishi, Masaaki Tokuda, Yasuo Kubota, Tokumi Maruyama, Hiroaki Kosaka, Junsuke Igarashi
  • Patent number: 9237744
    Abstract: A preservative solution for low temperature preservation of animal or human organs and animal or plant tissues or cells contains D-allose. For the human kidney, cells derived from animals or humans, or human or animal sperm and/or ovum and/or fermented ovum, the preservation is conducted at from ?5 to 20° C. For cells derived from animals or humans, or human or animal sperm and/or ovum and/or fermented ovum, the preservation is conducted at a temperature at which to start freezing to ?196° C. A method for the low temperature preservation of an animal or human organ and an animal or plant tissue or cell at a low temperature comprises (a) refluxing or immersing a preservative solution containing D-allose and the organ or the tissue or mixing the cell therewith, and (b) cooling the organ, the tissue or the cell to a low temperature of from ?5 to 20° C.
    Type: Grant
    Filed: May 26, 2005
    Date of Patent: January 19, 2016
    Assignees: NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY, MATSUTANI CHEMICAL INDUSTRY CO., LTD.
    Inventors: Masaaki Tokuda, Masaaki Ueki, Rikiya Taoka, Yoshiyuki Kakehi, Ken Izumori
  • Publication number: 20150320093
    Abstract: A processed konjac food having blood glucose increase suppressing effect is provided. The processed konjac food having blood glucose increase suppressing effect contains a konjac having a pH in a range of 2.5 to 7.4 and a rare sugar as active ingredients, is intended for ingestion of the rare sugar at a daily dose of 0.3 to 50 g/day for suppressing blood glucose increase, and is shaped into a rectangular, thread, round, grain, or plate form. The blood glucose increase effect can last for at least one day after one-time ingestion. For example, by making a konjac containing a rare sugar into a processed food, the product can be adapted to any consumer preferences without impediment upon eating or drinking, and therefore, a long-term ingestion is facilitated and the blood glucose increase suppressing effect can be sustained for a long period.
    Type: Application
    Filed: January 31, 2014
    Publication date: November 12, 2015
    Applicants: NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY, HAISKY FOODS CORPORATION, NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY, HAISKY FOODS CORPORATION
    Inventors: Masaaki Tokuda, Koji Murao, Noritsugu Hishitani
  • Publication number: 20140336267
    Abstract: A composition for treating disordered conditions in association with glucokinase activity contains a glucokinase-activating substance as the active ingredient. A promoting agent of glucokinase transfer from nucleus to cytoplasm contains D-psicose and/or D-tagatose as the active ingredient or a composition for preventing the onset of disordered conditions in association with glucokinase activity or for therapeutically treating the disordered conditions is in a form selected from a group consisting of food additives, food materials, drinks and foods, health drinks and foods, pharmaceutical product and feeds in blend with D-psicose and/or D-tagatose as the active ingredient for use in preventing the onset of disordered conditions in association with glucokinase activity or for therapeutically treating the disordered conditions, which are selected from impaired glucose tolerance, type 2 diabetes mellitus, insulin resistance, abnormal lipidemia, the metabolic syndrome and obesity.
    Type: Application
    Filed: July 24, 2014
    Publication date: November 13, 2014
    Applicants: NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY, MATSUTANI CHEMICAL INDUSTRY CO., LTD.
    Inventors: Masaaki Tokuda, Ken Izumori, Yukiyasu Toyoda, Ichitomo Miwa
  • Patent number: 8881523
    Abstract: A Rankine cycle (6) of a waste heat utilization device includes a circulation path (7) for circulating a working fluid therethrough, an evaporator (12) for causing heat to transfer from cooling water delivered from an internal combustion engine (2) to the working fluid to evaporate the working fluid, a superheater (10) for causing heat to transfer from the cooling water delivered from an exhaust gas heat exchanger (8) to the working fluid delivered from the evaporator to superheat the working fluid, an expander (22) for expanding the working fluid delivered from the superheater to produce driving force, a condenser (24) for condensing the working fluid delivered from the expander, and a pump (28) for feeding the working fluid delivered from the condenser to the evaporator. The evaporator, the superheater, the expander, the condenser and the pump are successively inserted in the working fluid circulation path.
    Type: Grant
    Filed: August 25, 2009
    Date of Patent: November 11, 2014
    Assignee: Sanden Corporation
    Inventors: Junichiro Kasuya, Tetsuya Nakano, Tomohiko Saito, Masaaki Tokuda, Satoshi Ogiwara
  • Patent number: 8748589
    Abstract: A complex crystalline sugar comprising D-psicose and D-allose and a method for producing the same are disclosed. The compositional ratio between D-psicose and D-allose in the sugar is about 1:1 to 1:4. A process for producing a complex crystalline sugar comprising D-psicose and D-allose, the process comprising producing a complex crystalline sugar comprising D-psicose and D-allose from a sugar solution containing D-psicose and p-allose and collecting the complex crystalline sugar. The solvent of the sugar solution used in the production of the complex crystalline sugar is water or a mixture of water and ethanol. The sugar solution containing D-psicose and D-allose is produced by a process comprising reacting D-psicose with L-rhamnose isomerase to convert D-psicose into D-allose. The L-rhamnose isomerase is derived from a strain (IPOD FERM BP-08593) belonging to Pseudomonas stutzeri.
    Type: Grant
    Filed: March 3, 2006
    Date of Patent: June 10, 2014
    Assignees: National University Corporation Kagawa University, Matsutani Chemical Industry Co., Ltd.
    Inventors: Ken Izumori, Masaaki Tokuda, Goro Takata, Kenji Morimoto
  • Publication number: 20130344008
    Abstract: To provide a composition for preventing periodontal diseases (prophylactic agent of periodontal diseases), the composition having an excellent cariostatic property, being safe and stable for prolonged use and having less effects on flavor. A non-cariogenic material prepared by blending a rare sugar in the D form as selected from the group consisting of D-psicose, D-sorbose and D-tagatose, a rare sugar in the L form as selected from L-fructose, L-psicose and L-tagatose, or allitol as a rare sugar derivative, singly or in combination. A cariostatic agent comprising D-psicose, D-sorbose, D-tagatose, L-fructose, L-psicose and/or L-tagatose. A cariostatic agent in combination with catechins.
    Type: Application
    Filed: February 9, 2012
    Publication date: December 26, 2013
    Applicants: NATIONAL UNIVERSITY CORPORATION KAGAWA UNIVERSITY, MATSUTANI CHEMICAL INDUSTRY CO., LTD.
    Inventors: Tetsuo Iida, Takashi Ichihara, Ken Izumori, Masaaki Tokuda, Takaaki Ogawa
  • Patent number: 8530222
    Abstract: Problem: To provide a microorganism with an ability to produce deoxy polyol dehydrogenase. Means for Resolution: A microorganism belonging to genus Enterobacter with an ability to produce a dehydrogenase for deoxy polyol of the same structure at the positions C2 and C3 as that of ribitol or L-iditol. The bacterial cell IK7 of the genus Enterobacter (accession No. NITE P-271). A method for producing deoxy ketose comprising allowing a culture containing the deoxy polyol dehydrogenase obtained by the culturing of the microorganism of the invention or allowing the deoxy polyol dehydrogenase to react with a solution containing deoxy polyol of the same structure at the positions C2 and C3 as that of ribitol or L-iditol to oxidize deoxy polyol to produce the corresponding deoxy ketose and then collecting the deoxy ketose. The deoxy polyol is 1-deoxy-D-allitol, while the corresponding deoxy ketose is 1-deoxy-L-psicose.
    Type: Grant
    Filed: March 27, 2007
    Date of Patent: September 10, 2013
    Assignees: National University Corporation Kagawa University, Rare Sugar Production Technical Research Laboratories, LLC., Matsutani Chemical Industry Co., Ltd.
    Inventors: Ken Izumori, Kenji Morimoto, Goro Takata, Masaaki Tokuda, Yoshio Tsujisaka, Kei Takeshita, Keiji Tsusaki, Kazuhiro Okuma
  • Patent number: 8496915
    Abstract: Object: To provide a composition for preventing periodontal diseases (prophylactic agent of periodontal diseases), the composition having an excellent cariostatic property, being safe and stable for prolonged use and having less effects on flavor. Means for Resolution: A non-cariogenic material prepared by blending a rare sugar in the D form as selected from the group consisting of D-psicose, D-sorbose and D-tagatose, a rare sugar in the L form as selected from L-fructose, L-psicose and L-tagatose, or allitol as a rare sugar derivative, singly or in combination. A cariostatic agent comprising D-psicose, D-sorbose, D-tagatose, L-fructose, L-psicose and/or L-tagatose. A cariostatic agent in combination with catechins.
    Type: Grant
    Filed: March 27, 2007
    Date of Patent: July 30, 2013
    Assignees: Matsutani Chemical Industry Co., Ltd., National University Corporation Kagawa University
    Inventors: Tetsuo Iida, Takashi Ichihara, Ken Izumori, Masaaki Tokuda, Takaaki Ogawa
  • Patent number: 8440619
    Abstract: The object is to provide a novel application of D-allose (e.g., use for prevention of hypertension or hypercardia). Thus, disclosed is a composition for preventing the increase in blood pressure which comprises D-allose as an active ingredient; or a composition containing D-allose and/or a derivative thereof, preferably in an amount of 0.1 to 50% by weight. Preferably, the composition is in a form selected from the group consisting of a food additive, a food material, a beverage/food, a health beverage/food, a pharmaceutical and a feeding stuff which can be used for the prevention and treatment of a cardiovascular system disorder (e.g., hypertension, hypercardia). The increase in blood pressure may be caused by salt-sensitive hypertension. Also disclosed is use of D-allose for preventing the increase in blood pressure (excluding medical practices).
    Type: Grant
    Filed: August 31, 2006
    Date of Patent: May 14, 2013
    Assignees: National University Corporation Kagawa University, Matsutani Chemical Industry Co., Ltd.
    Inventors: Masaaki Tokuda, Shoji Kimura, Ken Izumori
  • Patent number: 8420606
    Abstract: A method of utilizing the physiological activity of a rare saccharide, wherein physiological-activity sensitive cells are treated with the rare saccharide to modify the function of the cells. A composition containing, as an active ingredient, a rare saccharide which is introduced into physiological-activity sensitive cells and has an effect of modifying the function of the cells. The cells are human cells. The composition is a functional food, a drug, or a cosmetic. The rare saccharide is a rare saccharide belonging to aldose and/or ketose. The aldose is D-allose, and the cells are selected from the group consisting of cancer-cell proliferation inhibitory activity sensitive cells and active-oxygen production inhibitory activity sensitive cells. The ketose is D-psicose, and the cells are selected from the group consisting of chemokine secretion inhibitory activity sensitive cells, microglia migration inhibitory activity sensitive cells, and hypoglycemic activity sensitive cells.
    Type: Grant
    Filed: January 14, 2011
    Date of Patent: April 16, 2013
    Assignees: Fushimi Pharmaceutical Co., Ltd., Teikoku Seiyaku Co., Ltd., National University Corporation Kagawa University, Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Ken Izumori, Masaaki Tokuda, Toshifumi Itano, Osamu Miyamoto, Toshihiko Ishida, Koji Murao, Taizo Tasaka, Gan Muneuchi, Fuminori Yamaguchi, Terukazu Tanaka, Masaaki Ueki, Kazuyuki Hirooka, Tomohiko Taminato, Mohammad A. Hossain, Keiji Tsusaki, Takeo Takahashi, Mitsuhiro Nagata, Yutaka Ishida
  • Publication number: 20130075075
    Abstract: A vehicle air conditioning system includes a duct, a refrigerant evaporator, an air conditioning cooling flow passage, a heater core, a heater hot fluid flow passage, a heat exchanger, an electric heater, an electrical component cooling flow passage, a communication flow passage, a fluid temperature sensor and a flow passage selector valve. The duct provides air to a vehicle cabin interior. The cooling flow passage provides cooled refrigerant to the evaporator. The hot fluid flow passage provides hot fluid to the heater core. The heat exchanger exchanges heat between the refrigerant and the hot fluid. The heater warms the hot fluid having undergone heat exchange. The cooling flow passage cools an electrical component. The communication flow passage parallely connects the hot fluid and electrical component flow passages. The valve allows hot fluid to flow into the cooling flow passage when the hot fluid has a high temperature.
    Type: Application
    Filed: May 19, 2011
    Publication date: March 28, 2013
    Applicant: NISSAN MOTOR CO., LTD.
    Inventors: Masaaki Tokuda, Shinichirou Mizoguchi, Satoshi Ogihara
  • Patent number: 8389248
    Abstract: Providing 1- or 6-deoxy products corresponding to all of aldohexoses, ketohexoses and sugar alcohols, as based on Deoxy-Izumoring, as well as a method for systematically producing those products. A method for producing deoxyketohexose and a derivative thereof using a deoxyketohexose isomerase derived from Pseudomonas cichorii ST-24 (FERM BP-2736), comprising epimerizing 1-deoxy D-ketohexose or 6-deoxy D-ketohexose or 1-deoxy L-ketohexose or 6-deoxy L-ketohexose at position 3 to produce the individually corresponding 1-deoxy D-ketohexose or 6-deoxy D-ketohexose or 1-deoxy L-ketohexose or 6-deoxy L-ketohexose as an intended product.
    Type: Grant
    Filed: November 20, 2007
    Date of Patent: March 5, 2013
    Assignees: National University Corporation Kagawa University, Rare Sugar Production Technical Research Laboratories, LLC., Hayashibara Co., Ltd., Matsutani Chemical Industry Co., Ltd.
    Inventors: Ken Izumori, Masaaki Tokuda, George Fleet, Yoshio Tsujisaka, Kei Takeshita, Keiji Tsusaki, Kazuhiro Okuma