Patents by Inventor Masafumi Kinoshita

Masafumi Kinoshita has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11046751
    Abstract: Disclosed are a human serum albumin mutant that can be linked to a physiologically active protein to increase the stability of the protein in the blood, as well as a resulting protein produced by linking with the mutant. The protein produced by linking with the mutant consists of a human serum albumin mutant comprising the amino acid sequence set forth as SEQ ID NO:3 or an amino acid sequence that, in comparison with it, lacks not more than 10 amino acid residues and/or has not more than 10 amino acid residues replaced, with the proviso that the asparagine residue occurring at position 318 and the threonine at position 320 from the N-terminus of the amino acid sequence set forth as SEQ ID NO:3 are preserved and linked by peptide bonds via a single amino acid residue (X) except proline placed between those two amino acid residues, and a physiologically active protein linked to the mutant.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: June 29, 2021
    Assignee: JCR PHARMACEUTICALS CO., LTD.
    Inventors: Kenichi Takahashi, Aya Yoshioka, Hideto Morimoto, Masafumi Kinoshita
  • Patent number: 11010269
    Abstract: A distributed processing system includes a plurality of information processing apparatuses communicably coupled to one another and is capable of performing parallel processing in which the information processing apparatus performs predetermined processing in parallel with the other information processing apparatuses.
    Type: Grant
    Filed: May 29, 2018
    Date of Patent: May 18, 2021
    Assignee: HITACHI, LTD.
    Inventors: Hiroaki Konoura, Masafumi Kinoshita, Nobuyuki Chaki
  • Patent number: 10901699
    Abstract: The design and development of a data analysis process is assisted and the burden on the user such as a data analyst in data analysis process is reduced.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: January 26, 2021
    Assignee: Hitachi, Ltd.
    Inventors: Hiroaki Konoura, Ken Sugimoto, Yu Nakata, Masafumi Kinoshita
  • Publication number: 20200247872
    Abstract: Disclosed are a human serum albumin mutant that can be linked to a physiologically active protein to increase the stability of the protein in the blood, as well as a resulting protein produced by linking with the mutant. The protein produced by linking with the mutant consists of a human serum albumin mutant comprising the amino acid sequence set forth as SEQ ID NO:3 or an amino acid sequence that, in comparison with it, lacks not more than 10 amino acid residues and/or has not more than 10 amino acid residues replaced, with the proviso that the asparagine residue occurring at position 318 and the threonine at position 320 from the N-terminus of the amino acid sequence set forth as SEQ ID NO:3 are preserved and linked by peptide bonds via a single amino acid residue (X) except proline placed between those two amino acid residues, and a physiologically active protein linked to the mutant.
    Type: Application
    Filed: April 10, 2020
    Publication date: August 6, 2020
    Inventors: Kenichi TAKAHASHI, Aya YOSHIOKA, Hideto MORIMOTO, Masafumi KINOSHITA
  • Publication number: 20200242233
    Abstract: Provided is an information linkage system, comprising: a processor; and a storage device coupled to the processor, the storage device holds identification information of a user and information on the user, which are added by a first organization, in association with each other, the processor: transmits to a second organization an information linkage application regarding information on any one item included in the information on the user; acquires, when the information linkage application is received, identification information of the user and information on the user of the item specified by the information linkage application, which are added by the second organization; and stores the acquired information in the storage device in association with the identification information of the user and the information on the user regarding the same user as a user identified by the acquired identification information, which are added by the first organization.
    Type: Application
    Filed: September 18, 2019
    Publication date: July 30, 2020
    Applicant: Hitachi, Ltd.
    Inventors: Hiroaki Konoura, Masafumi Kinoshita, Hirofumi Inomata, Masaki Hirayama, Ryouichi Tanaka
  • Patent number: 10654912
    Abstract: Disclosed are a human serum albumin mutant that can be linked to a physiologically active protein to increase the stability of the protein in the blood, as well as a resulting protein produced by linking with the mutant. The protein produced by linking with the mutant consists of a human serum albumin mutant comprising the amino acid sequence set forth as SEQ ID NO:3 or an amino acid sequence that, in comparison with it, lacks not more than 10 amino acid residues and/or has not more than 10 amino acid residues replaced, with the proviso that the asparagine residue occurring at position 318 and the threonine at position 320 from the N-terminus of the amino acid sequence set forth as SEQ ID NO:3 are preserved and linked by peptide bonds via a single amino acid residue (X) except proline placed between those two amino acid residues, and a physiologically active protein linked to the mutant.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: May 19, 2020
    Assignee: JCR PHARMACEUTICALS CO., LTD.
    Inventors: Kenichi Takahashi, Aya Yoshioka, Hideto Morimoto, Masafumi Kinoshita
  • Publication number: 20200089585
    Abstract: A distributed processing system includes a plurality of information processing apparatuses communicably coupled to one another and is capable of performing parallel processing in which the information processing apparatus performs predetermined processing in parallel with the other information processing apparatuses.
    Type: Application
    Filed: May 29, 2018
    Publication date: March 19, 2020
    Applicant: HITACHI, LTD.
    Inventors: Hiroaki KONOURA, Masafumi KINOSHITA, Nobuyuki CHAKI
  • Publication number: 20200019383
    Abstract: The design and development of a data analysis process is assisted and the burden on the user such as a data analyst in data analysis process is reduced.
    Type: Application
    Filed: August 23, 2018
    Publication date: January 16, 2020
    Inventors: Hiroaki KONOURA, Ken SUGIMOTO, Yu NAKATA, Masafumi KINOSHITA
  • Patent number: 10425273
    Abstract: A data processing system comprises: at least one each of a plurality of types of data processing module conducting different types of the data processing; data flows through which a series of different types of data processing is conducted on a message and a message subjected to the series of different types of data processing is sent to the destination; and a dispatcher distributes the message and a message subjected to the data processing by the data processing module to a subsequent data processing module, wherein the dispatcher conducts: detecting a specific data processing module in a specific status of being a bottleneck; determining the number of the specific data processing module to resolve the specific status by increasing the number of the specific data processing module; and setting the number of the specific data processing module to the number to resolve the specific status.
    Type: Grant
    Filed: September 3, 2015
    Date of Patent: September 24, 2019
    Assignee: Hitachi, Ltd.
    Inventors: Masafumi Kinoshita, Tatsuhiko Miyata
  • Patent number: 10298715
    Abstract: The present invention relates to a distributed processing system having a master node and a plurality of worker nodes. Each worker node has an assigned identifier. A worker node caches in its own memory first output data, which is the result of the execution of a first task, and copies said first output data to another worker node. The master node selects, on the basis of the identifier information of the first worker node, a worker node to which to assign a second task, wherein the first output data is used as input data.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: May 21, 2019
    Assignee: Hitachi, Ltd.
    Inventors: Kazuhide Aikoh, Masafumi Kinoshita, Go Kojima
  • Publication number: 20190129763
    Abstract: A processing system includes an allotment server to receive and distribute events to a plurality of processing servers and an entry server to set pieces of information to the allotment server used upon the plurality of processing servers executing data processing; the entry server divides the pieces of data into groups based on the data items; allots a message to the groups; and transmits the pieces of information on the types of events, the message, the data items and the processing servers whose pieces of data processing are grouped and stored to the allotment server; upon receiving the events, specifies the message corresponding to the received events based on the data items included in the received events and the stored data items; selects the processing server to which the specified message is to be transferred; and transfers the specified message to the selected processing server.
    Type: Application
    Filed: February 28, 2017
    Publication date: May 2, 2019
    Applicant: HITACHI, LTD.
    Inventors: Yoshiki MATSUURA, Masafumi KINOSHITA, Tatsuhiko MIYATA, Hideya YOSHIUCHI
  • Publication number: 20180244754
    Abstract: Disclosed are a human serum albumin mutant that can be linked to a physiologically active protein to increase the stability of the protein in the blood, as well as a resulting protein produced by linking with the mutant. The protein produced by linking with the mutant consists of a human serum albumin mutant comprising the amino acid sequence set forth as SEQ ID NO:3 or an amino acid sequence that, in comparison with it, lacks not more than 10 amino acid residues and/or has not more than 10 amino acid residues replaced, with the proviso that the asparagine residue occurring at position 318 and the threonine at position 320 from the N-terminus of the amino acid sequence set forth as SEQ ID NO:3 are preserved and linked by peptide bonds via a single amino acid residue (X) except proline placed between those two amino acid residues, and a physiologically active protein linked to the mutant.
    Type: Application
    Filed: September 8, 2016
    Publication date: August 30, 2018
    Inventors: Kenichi TAKAHASHI, Aya YOSHIOKA, Hideto MORIMOTO, Masafumi KINOSHITA
  • Patent number: 9994641
    Abstract: Disclosed are a novel anti-human transferrin receptor antibody comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 4, 5, 6 and 7 that can pass through the blood-brain barrier, a fusion protein comprising a protein necessary to be brought into function in the central nervous system and the antibody, and method of their production. The fusion protein comprises amino acid sequences of an anti-human transferrin receptor antibody that recognizes an amino acid sequence selected from the group consisting of SEQ ID NOs:1, 2, and 3, and of other protein that is bound thereto on the C-terminal side.
    Type: Grant
    Filed: December 24, 2014
    Date of Patent: June 12, 2018
    Assignee: JCR PHARMACEUTICALS CO., LTD.
    Inventors: Hiroyuki Sonoda, Hideto Morimoto, Yuri Koshimura, Masafumi Kinoshita, Haruna Takagi, Yoshiko Yoshii
  • Patent number: 9967163
    Abstract: This server for distributing messages quickly detects a performance decline in a downstream server by using a method for keeping, for each distribution-destination server, a threshold such as a connection number and a time interval separate from a response timeout, and determining that performance has declined when the threshold is exceeded. In addition, the present invention improves system availability by identifying a server group in which performance has declined on the basis of a correlation pertaining to inter-server cooperative processing, when a distribution server exhibits a decline in performance, and by the distribution server distributing a message to a server not exhibiting a decline in performance.
    Type: Grant
    Filed: April 14, 2014
    Date of Patent: May 8, 2018
    Assignee: Hitachi, Ltd.
    Inventors: Masafumi Kinoshita, Takafumi Koike, Izumi Mizutani, Naoki Haraguchi
  • Publication number: 20180041600
    Abstract: The present invention relates to a distributed processing system having a master node and a plurality of worker nodes. Each worker node has an assigned identifier. A worker node caches in its own memory first output data, which is the result of the execution of a first task, and copies said first output data to another worker node. The master node selects, on the basis of the identifier information of the first worker node, a worker node to which to assign a second task, wherein the first output data is used as input data.
    Type: Application
    Filed: April 15, 2015
    Publication date: February 8, 2018
    Applicant: HITACHI, LTD.
    Inventors: Kazuhide AIKOH, Masafumi KINOSHITA, Go KOJIMA
  • Patent number: 9852031
    Abstract: A computer system for realizing increased speed of identifying extent of a failure in a messaging system, provided with: a first computer including a message receiving part, a first log output part, and a first memory part configured to store receiving log data; a second computer including a data store management part configured to manage a data store, a first search part configured to search a message that meets a given condition from among messages stored in the data store, a second log output part, and a second memory part configured to store data store log data; a third computer including a message sending part, a third log output part, and a third memory part configured to store sending log data; and a fourth computer including a monitoring part, a log collecting part, and a second search part configured to search for lost message.
    Type: Grant
    Filed: May 23, 2014
    Date of Patent: December 26, 2017
    Assignee: HITACHI, LTD.
    Inventors: Izumi Mizutani, Masafumi Kinoshita, Naoki Haraguchi
  • Publication number: 20170279654
    Abstract: A data processing system comprises: at least one each of a plurality of types of data processing module conducting different types of the data processing; data flows through which a series of different types of data processing is conducted on a message and a message subjected to the series of different types of data processing is sent to the destination; and a dispatcher distributes the message and a message subjected to the data processing by the data processing module to a subsequent data processing module, wherein the dispatcher conducts: detecting a specific data processing module in a specific status of being a bottleneck; determining the number of the specific data processing module to resolve the specific status by increasing the number of the specific data processing module; and setting the number of the specific data processing module to the number to resolve the specific status.
    Type: Application
    Filed: September 3, 2015
    Publication date: September 28, 2017
    Inventors: Masafumi KINOSHITA, Tatsuhiko MIYATA
  • Patent number: 9699026
    Abstract: There is provided a distributed processing system including: a data store server for storing data; a data store part for storing data in the data store server; a data acquisition part for obtaining data from the data store server; and an operation manager part for performing configuration change on the whole system. The distributed processing system has a function of managing the configuration content and the configuration order for each device according to the change content, to determine the target and order to be configured based on the managed information by the operation manager part. Further, the distributed processing system has a function of performing a configuration change process on the data store part, the data acquisition part, and the data store server by the operation manager part.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: July 4, 2017
    Assignee: Hitachi, Ltd.
    Inventors: Izumi Mizutani, Masafumi Kinoshita, Naoki Haraguchi
  • Publication number: 20160369001
    Abstract: Disclosed are novel anti transferrin receptor antibody that can pass through the blood-brain barrier, a fusion protein comprising a protein necessary to be brought into function in the central nervous system and the antibody, and method of their production. The fusion protein comprises amino acid sequences of an anti-human transferrin receptor antibody that recognizes an amino acid sequence selected from the group consisting of SEQ ID NOs: 1, 2, and 3, and of other protein that is bound thereto on the C- terminal side.
    Type: Application
    Filed: December 24, 2014
    Publication date: December 22, 2016
    Inventors: Hiroyuki SONODA, Hideto MORIMOTO, Yuri KOSHIMURA, Masafumi KINOSHITA, Haruna TAKAGI, Yoshiko YOSHII
  • Publication number: 20160261476
    Abstract: This server for distributing messages quickly detects a performance decline in a downstream server by using a method for keeping, for each distribution-destination server, a threshold such as a connection number and a time interval separate from a response timeout, and determining that performance has declined when the threshold is exceeded. In addition, the present invention improves system availability by identifying a server group in which performance has declined on the basis of a correlation pertaining to inter-server cooperative processing, when a distribution server exhibits a decline in performance, and by the distribution server distributing a message to a server not exhibiting a decline in performance.
    Type: Application
    Filed: April 14, 2014
    Publication date: September 8, 2016
    Applicant: HITACHI, LTD.
    Inventors: Masafumi KINOSHITA, Takafumi KOIKE, Izumi MIZUTANI, Naoki HARAGUCHI