Abstract: An 1-amido-3-(2-hydroxyphenoxy)-2-propanol derivative represented by the following formula (1), wherein cycle A may have further 1 to 4 substituents, and said substituent means a substituent selected from the group consisting of saturated or unsaturated C1-4 alkyl group, aralkyl group in which alkyl moiety has 1 to 4 carbon atoms, aryl group, halogen atom, halogenated C1-4 alkyl group, C2-5 alkanoyl group, mono or dialkylcarbamoyl group in which alkyl moiety has 1 to 4 carbon atoms, cyano group and nitro group, and the substituents at positions 3 and 6, or at positions 4 and 5 on the cycle A are different each other. Other ring may be fused at positions 3 and 4, or at positions 5 and 6 on the cycle A to form a condensed polycyclic hydrocarbon with the cycle A. R1 is alkanoyl group or aroyl group, and R2 is hydrogen atom, alkanoyl group or aroyl group, or R1 and R2 may be combined together with the N atom to form a cyclic imido group, which is useful as an intermediate of medicines, etc.

Abstract: A process for preparing 3-hydroxythiolane which is characterized in reacting a compound of the following formula, wherein X is halogen atom, and R2 is substituted or unsubstituted alkyl group, substituted or unsubstituted aralkyl group, or substituted or unsubstituted aryl group, with a metal sulfide.

Abstract: A process for preparing an amine which comprises in preparing an amine by decarboxylating an ?-amino acid under heating in a high boiling liquid polymer having average molecular weight 200 to 6000, and directly recovering this amine by distillation in the same reaction system, namely in one pot.

Abstract: A method for preparing an aldehyde or ketone by oxidizing a primary or secondary alcohol in the presence of a nitroxyl radical compound and a co-oxidant in an organic solvent, which process is characterized in using an organic N-bromoamide compound or a combination of N-chlorosuccinimide and a compound having bromide ion as the co-oxidant.

Abstract: A process for preparing a secondary alcohol which is characterized in adding a primary or a secondary amine in the reaction system in case that the secondary alcohol is prepared by hydrogenating in the presence of a noble metal, an epoxy derivative represented by the following formula, wherein R1 and R2 are the same or different, an organic group not containing aldehyde group or ketone group therein or hydrogen atom, provided that both R1 and R2 are not simultaneously hydrogen atom.

Abstract: A toe correction bushing (1) is composed of a main body (2) and a stopper member (3), wherein the main body (2) is integrally provided with an inner cylinder (4), an outer cylinder (5), and an elastic body (6). The outer cylinder (5) is provided at part of the axial end with an outwardly opening inclined section (7). A recessed space (8) is provided inside of the inclined section (7). The stopper member (3) is provided with a circular plate section (20) and a stopper projection (23) at the peripheral section thereof. A boss (21) provided at the central section of the stopper member (3) is press-fitted into one end of the inner cylinder (4) for integration and at the same time, the stopper projection (23) is caused to engage the recessed space (8). When a lateral force F to the right is applied to the outer cylinder (5), the axial movement of the outer cylinder (5) is controlled by the stopper projection (23) and displaced in the direction perpendicular to the axis by an inclined plane (24) for toe correction.

Abstract: A method for preparing an aldehyde or ketone by oxidizing a primary or secondary alcohol in the presence of a nitroxyl radical compound and a co-oxidant in an organic solvent, which process is characterized in using an organic N-bromoamide compound or a combination of N-chlorosuccinimide and a compound having bromide ion as the co-oxidant.

Abstract: A toe correction bushing (1) is composed of a main body (2) and a stopper member (3), wherein the main body (2) is integrally provided with an inner cylinder (4), an outer cylinder (5), and an elastic body (6). The outer cylinder (5) is provided at part of the axial end with an outwardly opening inclined section (7). A recessed space (8) is provided inside of the inclined section (7). The stopper member (3) is provided with a circular plate section (20) and a stopper projection (23) at the peripheral section thereof. A boss (21) provided at the central section of the stopper member (3) is press-fitted into one end of the inner cylinder (4) for integration and at the same time, the stopper projection (23) is caused to engage the recessed space (8). When a lateral force F to the right is applied to the outer cylinder (5), the axial movement of the outer cylinder (5) is controlled by the stopper projection (23) and displaced in the direction perpendicular to the axis by an inclined plane (24) for toe correction.

Abstract: An 1-amido-3-(2-hydroxyphenoxy)-2-propanol derivative represented by the following formula (1), wherein cycle A may have further 1 to 4 substituents, and said substituent means a substituent selected from the group consisting of saturated or unsaturated C1-4 alkyl group, aralkyl group in which alkyl moiety has 1 to 4 carbon atoms, aryl group, halogen atom, halogenated C1-4 alkyl group, C2-5 alkanoyl group, mono or dialkylcarbamoyl group in which alkyl moiety has 1 to 4 carbon atoms, cyano group and nitro group, and the substituents at positions 3 and 6, or at positions 4 and 5 on the cycle A are different each other. Other ring may be fused at positions 3 and 4, or at positions 5 and 6 on the cycle A to form a condensed polycyclic hydrocarbon with the cycle A. R1 is alkanoyl group or aroyl group, and R2 is hydrogen atom, alkanoyl group or aroyl group, or R1 and R2 may be combined together with the N atom to form a cyclic imido group, which is useful as an intermediate of medicines, etc.

Abstract: A process for preparing 3-hydroxythiolane which is characterized in reacting a compound of the following formula, wherein X is halogen atom, and R2 is substituted or unsubstituted alkyl group, substituted or unsubstituted aralkyl group, or substituted or unsubstituted aryl group, with a metal sulfide.

Abstract: A process for preparing an amine which comprises in preparing an amine by decarboxylating an ?-amino acid under heating in a high boiling liquid polymer having average molecular weight 200 to 6000, and directly recovering this amine by distillation in the same reaction system, namely in one pot.

Abstract: A process for preparing a secondary alcohol which is characterized in adding a primary or a secondary amine in the reaction system in case that the secondary alcohol is prepared by hydrogenating in the presence of a noble metal, an epoxy derivative represented by the following formula, wherein R1 and R2 are the same or different, an organic group not containing aldehyde group or ketone group therein or hydrogen atom, provided that both R1 and R2 are not simultaneously hydrogen atom.

Abstract: An object of the present invention is to provide a process wherein 1,2,4-butanetriol can be obtained safely, easily and inexpensively without causing problems concerning wastewater. A malic diester, 3-hydroxy-?-butyrolactone or 3,4-dihydroxybutanoate represented by the following formulae (I), or a mixture thereof is reduced with sodium borohydride in an organic solvent to give 1,2,4-butanetriol represented by the following formula (II). When an optically active substance is used as the above-mentioned starting compound, substantially no recemization occurs during the reduction, and optically active 1,2,4-butanetriol is obtained.

Abstract: The present invention relates to a compound of the formula (I) wherein R1 is optionally substituted aryl; R2 is optionally substituted aryl, optionally substituted heteroaryl, optionally substituted lower cycloalkyl, optionally substituted aryloxy, optionally substituted arylsulfonyl, vinyl, carbamoyl, protected carboxy or protected amino; ring A is bivalent residue derived from optionally substituted aryl or optionally substituted heteroaryl; X is bivalent residue derived from the group consisting of cycloalkene, naphthalene, unsaturated 5 or 6-membered heteromonocyclic group, each of which is optionally substituted, and substituted benzene; Y is -(A1)m1-(A2)m2-; and Z is direct bond or piperazine, or a salt thereof. The compound of the present invention and a salt thereof inhibit apolipoprotein B (Apo B) secretion and are useful as a medicament for prophylactic and treatment of diseases or conditions resulting from elevated circulating levels of Apo B.

Abstract: The present invention relates to compounds of the formula (I) wherein X1 is wherein R1, R2 and R10 are independently hydrogen or a suitable substituent; R11 and R12 are independently hydrogen or a suitable substituent; R is unsaturated 5 to 6-membered heteromonocyclic group; A is direct bond or —NH—; X2 is monocyclic arylene, unsaturated 5 to 6-membered heteromonocyclic group or cycloalkenylene; Y is bivalent group selected from ethylene, trimethylene and vinylene, wherein CH2 is optionally replaced by NH or O, and CH is optionally replaced by N; and Z is —(CH2)n—, —CO—(CH2)m—, —CH═CH— or —CO—NH—, wherein n is 1, 2 or 3 and m is 1 or 2, or a salt thereof. The compounds of the present invention inhibit apolipoprotein B (Apo B) secretion and are useful as a medicament for prophylactic and treatment of diseases or conditions resulting from elevated circulating levels of Apo B.

Abstract: A compound of the formula (I) 1

Abstract: A method for processing a solution of ethylene-vinyl alcohol copolymer in a solvent other than water, which involves continuously substituting a part of the solvent in the solution with water to produce a high-concentration ethylene vinyl alcohol copolymer solution without gelling, whereby an ethylene-vinyl alcohol copolymer solution is fed into a column vessel selected from a plate column and a packed column, and a part of the solvent in the solution is substituted with water in the column vessel.

Abstract: The present invention relates to compounds of the formula (I) wherein R1 and R2 are each independently lower alkyl lower alkenyl, acyl, amino, lower alkoxy, lower cycloalkyloxy, aryl, aryloxy, sulfooxy, mercapto, sulfo, hydrogen, halogen, nitro, cyano or hydroxy, or may form a ring structure; Q1 is N or CH; L is optionally substituted unsaturated 3 to 10-membered heterocyclic group; X is optionally substituted monocyclic arylene or monocyclic heteroarylene; Y is -(A1)m-(A2)n-(A4)k-; Z is directbond, —CH2-, —NH— or —O—; and R is hydrogen or lower alkyl, or a salt thereof The compounds of the present invention inhibit apolipoprotein B (Apo B) secretion and are useful as a medicament for prophylactic and treatment of diseases or conditions resulting from elevated circulating levels of Apo B.

Abstract: A process for preparing a butanetriol derivative of the formula (1) useful as intermediates of medicines 1

Abstract: A toe correction bushing (1) is composed of a main body (2) and a stopper member (3), wherein the main body (2) is integrally provided with an inner cylinder (4), an outer cylinder (5), and an elastic body (6). The outer cylinder (5) is provided at part of the axial end with an outwardly opening inclined section (7). A recessed space (8) is provided inside of the inclined section (7). The stopper member (3) is provided with a circular plate section (20) and a stopper projection (23) at the peripheral section thereof. A boss (21) provided at the central section of the stopper member (3) is press-fitted into one end of the inner cylinder (4) for integration and at the same time, the stopper projection (23) is caused to engage the recessed space (8). When a lateral force F to the right is applied to the outer cylinder (5), the axial movement of the outer cylinder (5) is controlled by the stopper projection (23) and displaced in the direction perpendicular to the axis by an inclined plane (24) for toe correction.