Abstract: The present invention aims to provide a medicament capable of treating and/or preventing diseases associated with oxidative stress by inhibiting the protein-protein interaction between Keap1 and Nrf2 and activating Nrf2. The present invention relates to a compound represented by the following formula (1): wherein each symbol is as described in the DESCRIPTION, or a pharmaceutically acceptable salt thereof. In addition, the present invention also relates to a medicament containing the aforementioned compound, for the prophylaxis and/or treatment of diseases involving oxidative stress selected from the group consisting of chronic kidney disease, non-alcoholic steatohepatitis, chronic obstructive pulmonary disease, radiation skin disorder, radiation mucosal disorder, cardiac failure, pulmonary arterial hypertension, Parkinson's disease, Friedreich's ataxia, multiple sclerosis, age-related macular degeneration, retinitis pigmentosa and glaucoma.

Abstract: A slab casting method using a twin-drum continuous casting device manufactures a slab by solidifying molten metal by a pair of rotating casting drums includes calculating estimated sheet thicknesses on both ends in a width direction of the slab from equation 1 ((estimated sheet thickness)=(cylinder screw down position)+(elastic deformation of casting drum)+(casting drum housing screw down system deformation)+(drum profile of casting drum)?(elastic deformation of casting drum at the time of screw down position zero adjustment)) by using a casting drum housing screw down system deformation characteristic indicating a deformation characteristic of housings that support the casting drums and a deformation characteristic of a screw down system that screws down the casting drums obtained before casting of the slab starts, and controlling screw down positions of cylinders provided on both ends in a width direction of the casting drums.

Abstract: A slab manufacturing method in which casting drum housing screw-down system deformation characteristics which have been acquired prior to the start of slab casting and which indicate deformation characteristics of a housing configured to support a casting drum and deformation characteristics of a screw-down system configured to screw down the casting drum is used to calculate an estimated plate thickness at both end portions of a slab in a width direction thereof from Expression 1 ((estimated plate thickness on entry side of rolling mill)=(screw-down position of casting cylinder)+(elastic deformation of casting drum)+(casting drum housing screw-down system deformation)+(drum profile of casting drum)?(elastic deformation of casting drum at time of screw-down position zero-point adjustment)), an entry-side wedge ratio and an exit-side wedge ratio are calculated on the basis of the estimated plate thickness calculated from Expression 1.

Abstract: In a display device including: a pixel array unit made up of pixels disposed on a substrate; a peripheral circuit unit that is disposed in a periphery of the pixel array unit and drives the pixels; and a temperature sensor circuit disposed on the same substrate as the pixels, the temperature sensor circuit is configured using an inverter circuit including a plurality of inverters made up of thin film transistors. Then, crystallinity of a channel portion of the thin film transistor of the temperature sensor circuit is different from crystallinity of a channel portion of a thin film transistor constituting the peripheral circuit unit.

Abstract: This thin strip manufacture method is a thin strip manufacture method for manufacturing a thin strip by supplying molten steel to a molten steel pool formed by a pair of rotating cooling drums and a pair of side weirs to form and grow a solidified shell on a peripheral surface of the cooling drums, wherein a pressing force P of the pair of the cooling drums is set so that the pressing force P (kgf/mm) of the pair of cooling drums, casting thickness D (mm), and radius R (m) of the cooling drums satisfy 0.90?P×(D×R)0.5?1.30.

Abstract: A non-oriented electrical steel sheet according to one embodiment of the invention has a chemical composition represented by C: 0.0030% or less, Si: 2.00% or less, Al: 1.00% or less, Mn: 0.10% to 2.00%, S: 0.0030% or less, one or more selected from the group consisting of Mg, Ca, Sr, Ba, Nd, Pr, La, Ce, Zn, and Cd: 0.0003% or greater and less than 0.0015% in total, a parameter Q represented by Q=[Si]+2×[Al]?[Mn]: 2.00 or less; Sn: 0.00% to 0.40%, Cu: 0.00% to 1.00%, and a remainder: Fe and impurities, and a parameter R represented by R?(I100+I310+I411+I521)/(I111+I211+I332+I221) is 0.80 or greater.

Abstract: A non-oriented electrical steel sheet according to one embodiment of the invention has a chemical composition represented by C: 0.0030% or less, Si: 2.00% or less, Al: 1.00% or less, Mn: 0.10% to 2.00%, S: 0.0030% or less, one or more selected from the group consisting of Mg, Ca, Sr, Ba, Nd, Pr, La, Ce, Zn, and Cd: greater than 0.0100% and not greater than 0.0250% in total, a parameter Q represented by Q=[Si]+2×[Al]?[Mn]: 2.00 or less; Sn: 0.00% to 0.40%, Cu: 0.00% to 1.00%, and a remainder: Fe and impurities, and a parameter R represented by R=(I100+I310+I411+I521)/(I111+I211+I332+I221) is 0.80 or greater.

Abstract: A non-oriented electrical steel sheet according to one embodiment of the invention has a chemical composition represented by C: 0.0030% or less, Si: 2.00% or less, Al: 1.00% or less, Mn: 0.10% to 2.00%, S: 0.0030% or less, one or more selected from the group consisting of Mg, Ca, Sr, Ba, Nd, Pr, La, Ce, Zn, and Cd: 0.0015% to 0.0100% in total, a parameter Q represented by Q=[Si]+2×[Al]?[Mn]: 2.00 or less; Sn: 0.00% to 0.40%, Cu: 0.00% to 1.00%, and a remainder: Fe and impurities, and a parameter R represented by R=(I100+I310+I411+I521)/(I111+I211+I332+I221) is 0.80 or greater.

Abstract: In this cast strip manufacturing method, in a first step, one end side and another end side in a rotation axis direction of a pair of cooling drums are pressed with a first pressure in a direction in which the cooling drums come close to each other, in a second step, the one end side and the another end side in the rotation axis direction of the cooling drums are pressed with a second pressure, which is higher than the first pressure, in the direction in which the cooling drums come close to each other, and in a third step, pressure control is performed so that a total value of reaction forces on the one end side and the another end side in the rotation axis direction of the cooling drums is set to a predetermined value, and rotation axes of the cooling drums are held in parallel.

Abstract: In this cast strip manufacturing method, in a first step, one end side and another end side in a rotation axis direction of a pair of cooling drums are pressed with a first pressure in a direction in which the cooling drums come close to each other, in a second step, the one end side and the another end side in the rotation axis direction of the cooling drums are pressed with a second pressure, which is higher than the first pressure, in the direction in which the cooling drums come close to each other, and in a third step, pressure control is performed so that a total value of reaction forces on the one end side and the another end side in the rotation axis direction of the cooling drums is set to a predetermined value, and rotation axes of the cooling drums are held in parallel.

Abstract: A slab casting method using a twin-drum continuous casting device manufactures a slab by solidifying molten metal by a pair of rotating casting drums includes calculating estimated sheet thicknesses on both ends in a width direction of the slab from equation 1 ((estimated sheet thickness)=(cylinder screw down position)+(elastic deformation of casting drum)+(casting drum housing screw down system deformation)+(drum profile of casting drum)?(elastic deformation of casting drum at the time of screw down position zero adjustment)) by using a casting drum housing screw down system deformation characteristic indicating a deformation characteristic of housings that support the casting drums and a deformation characteristic of a screw down system that screws down the casting drums obtained before casting of the slab starts, and controlling screw down positions of cylinders provided on both ends in a width direction of the casting drums.

Abstract: A side sealing device for a twin-roll continuous casting apparatus, which supplies molten metal to a molten metal pool portion formed by a pair of rotating mold rolls and a pair of side weirs through an immersion nozzle and causes solidified shells to be formed and to grow on peripheral surfaces of the mold rolls to manufacture a cast strip, seals end surface sides of the mold rolls by each side weir. The side sealing device includes a side weir pressing unit that presses the side weir against end surfaces of the mold rolls, and a side weir lifter that pulls the side weir at least upward in a vertical direction.

Abstract: A slab manufacturing method in which casting drum housing screw-down system deformation characteristics which have been acquired prior to the start of slab casting and which indicate deformation characteristics of a housing configured to support a casting drum and deformation characteristics of a screw-down system configured to screw down the casting drum is used to calculate an estimated plate thickness at both end portions of a slab in a width direction thereof from Expression 1 ((estimated plate thickness on entry side of rolling mill)=(screw-down position of casting cylinder)+(elastic deformation of casting drum)+(casting drum housing screw-down system deformation)+(drum profile of casting drum)?(elastic deformation of casting drum at time of screw-down position zero-point adjustment)), an entry-side wedge ratio and an exit-side wedge ratio are calculated on the basis of the estimated plate thickness calculated from Expression 1.

Abstract: This thin strip manufacture method is a thin strip manufacture method for manufacturing a thin strip by supplying molten steel to a molten steel pool formed by a pair of rotating cooling drums and a pair of side weirs to form and grow a solidified shell on a peripheral surface of the cooling drums, wherein a pressing force P of the pair of the cooling drums is set so that the pressing force P (kgf/mm) of the pair of cooling drums, casting thickness D (mm), and radius R (m) of the cooling drums satisfy 0.90?P×(D×R)0.5?1.30.

Abstract: A non-oriented electrical steel sheet according to an aspect of the present invention contains, as a chemical composition, by mass %, C: more than 0% and 0.0050% or less, Si: 3.0% to 4.0%, Mn: 1.2% to 3.3%, P: more than 0% and less than 0.030%, S: more than 0% and 0.0050% or less, sol. Al: more than 0% and 0.0040% or less, N: more than 0% and 0.0040% or less, one or more of La, Ce, Pr, and Nd: 0.0005% to 0.0200% in total, Ca: 0.0005% to 0.0100%, Ti: 0.0005% to 0.0100%, Sn: 0% to 0.10%, Sb: 0% to 0.10%, Mg: 0% to 0.0100%, and a remainder including Fe and impurities, in which Si?0.5×Mn: 2.0% or more, and Si+0.5×Mn: 3.8% or more.

Abstract: A non-oriented electrical steel sheet according to one embodiment of the invention has a chemical composition represented by C: 0.0030% or less, Si: 2.00% or less, Al: 1.00% or less, Mn: 0.10% to 2.00%, S: 0.0030% or less, one or more selected from the group consisting of Mg, Ca, Sr, Ba, Nd, Pr, La, Ce, Zn, and Cd: 0.0015% to 0.0100% in total, a parameter Q represented by Q=[Si]+2×[Al]?[Mn]: 2.00 or less; Sn: 0.00% to 0.40%, Cu: 0.00% to 1.00%, and a remainder: Fe and impurities, and a parameter R represented by R=(I100+I310+I411+I521)/(I111+I211+I332+I221) is 0.80 or greater.

Abstract: A non-oriented electrical steel sheet contains, as a chemical composition, by mass %, C: more than 0% and 0.0050% or less, Si: 3.0% to 4.0%, Mn: 1.0% to 3.3%, P: more than 0% and less than 0.030%, S: more than 0% and 0.0050% or less, sol. Al: more than 0% and 0.0040% or less, N: more than 0% and 0.0040% or less, O: 0.0110% to 0.0350%, Sn: 0% to 0.050%, Sb: 0% to 0.050%, Ti: more than 0% and 0.0050% or less, and a remainder including Fe and impurities, in which Sn+Sb: 0.050% or less, Si?0.5×Mn: 2.0% or more, and an O content in a sheet thickness central portion excluding a surface layer portion which is a range from a front surface and a rear surface to a position of 10 ?m in a depth direction is less than 0.0100%.

Abstract: When a Si content (mass %) is set to [Si], an Al content (mass %) is set to [Al], and a Mn content (mass %) is set to [Mn], a parameter Q represented by “Q=[Si]+2[Al]?[Mn]” is 2.00 or more, the total mass of S contained in sulfides or oxysulfides of Mg, Ca, Sr, Ba, Ce, La, Nd, Pr, Zn, or Cd is 40% or more of the total mass of S contained in a non-oriented electrical steel sheet, a {100} crystal orientation intensity is 3.0 or more, a thickness is 0.15 mm to 0.30 mm, and an average crystal grain diameter is 65 ?m to 100 ?m.

Abstract: When a Si content (mass %) is set to [Si], an Al content (mass %) is set to [Al], and a Mn content (mass %) is set to [Mn], a parameter Q represented by “Q=[Si]+2[Al]?[Mn]” is 2.00 or more, the total mass of S contained in sulfides or oxysulfides of Mg, Ca, Sr, Ba, Ce, La, Nd, Pr, Zn, or Cd is 40% or more of the total mass of S contained in a non-oriented electrical steel sheet, a {100} crystal orientation intensity is 3.0 or more, a thickness is 0.15 mm to 0.30 mm, and an average crystal grain diameter is 65 ?m to 100 ?m.

Abstract: When a Si content (mass %) is set to [Si], an Al content (mass %) is set to [Al], and a Mn content (mass %) is set to [Mn], a parameter Q represented by “Q=[Si]+2[Al]?[Mn]” is 2.00 or more, the total mass of S contained in sulfides or oxysulfides of Mg, Ca, Sr, Ba, Ce, La, Nd, Pr, Zn, or Cd is 10% or more of the total mass of S contained in a non-oriented electrical steel sheet, a {100} crystal orientation intensity is 3.0 or more, a thickness is 0.15 mm to 0.30 mm, and an average crystal grain diameter is 65 ?m to 100 ?m.