Patents by Inventor Masafumi Shiraiwa

Masafumi Shiraiwa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6020531
    Abstract: A benzothiophene compound represented by a formula: ##STR1## wherein R.sup.1 represents a lower alkyl group, and R.sup.2 represents a halogen atom; a lower alkyl group; or a cycloalkyl group or cycloalkenyl group which may optionally be substituted with a lower alkyl group, a hydroxy group, an acyloxy group or an oxo group,which is a useful intermediate for synthesizing a 2-sub-stituted-3-(4-substituted benzoyl)-6-hydroxybenzo[b]-thiophene derivative having an antiestrogenic activity can be produced in an industrially advantageous manner by subjecting a compound represented by a formula: ##STR2## to a ring-closing reaction. Further, the novel compound of the formula (II) described above is a useful intermediate in the process of the present invention.
    Type: Grant
    Filed: January 25, 1999
    Date of Patent: February 1, 2000
    Assignee: Teikoku Hormone Mfg. Co., Ltd.
    Inventors: Masafumi Shiraiwa, Shuichiro Sato, Koji Doguchi
  • Patent number: 5221674
    Abstract: A pyridazinone compound represented by the general formula ##STR1## wherein Ar is ##STR2## in which R.sup.1, R.sup.2 and R.sup.3 may be identical or different, and each represents a hydrogen atom, a lower alkyl group, a trifluoromethyl group, a halogen atom, a cyano group or a nitro group, and R.sup.4 represents a hydrogen atom, a lower alkoxy group, or a lower alkyl group substituted by a lower alkoxy group or a carbamoyl group, and C* is an assymmetric carbon atom,or a salt thereof. This compound is useful for the treatment of diseases of the circulatory system.
    Type: Grant
    Filed: September 27, 1991
    Date of Patent: June 22, 1993
    Assignee: Teikoku Hormone Mfg. Co., Ltd.
    Inventors: Kikuo Yasuda, Kenyu Shibata, Nobuyoshi Minami, Toshimi Seki, Masafumi Shiraiwa, Tomio Nakao, Katsuhiko Miyasaka, Tsutomu Ishimori, Kotaro Gotanda, Takako Sasaki
  • Patent number: 5130314
    Abstract: A pyridazinone compound represented by the general formula ##STR1## wherein Ar is ##STR2## in which R.sup.1, R.sup.2 and R.sup.3 may be identical or different, and each represents a hydrogen atom, a lower alkyl group, a trifluoromethyl group, a halogen atom, a cyano group or a nitro group, and R.sup.4 represents a hydrogen atom, a lower alkoxy group, or a lower alkyl group substituted by a lower alkoxy group or a carbamoyl group, and C* is an assymmetric carbon atom,or a salt thereof. This compound is useful for the treatment of diseases of the circulatory system.
    Type: Grant
    Filed: September 27, 1991
    Date of Patent: July 14, 1992
    Assignee: Teikoku Hormone Mfg. Co., Ltd.
    Inventors: Kikuo Yasuda, Kenyu Shibata, Nobuyoshi Minami, Toshimi Seki, Masafumi Shiraiwa, Tomio Nakao, Katsuhiko Miyasaka, Tsutomu Ishimori, Kotaro Gotanda, Takako Sasaki
  • Patent number: 5082844
    Abstract: A pyridazinone compound represented by the general formula ##STR1## wherein Ar is ##STR2## in which R.sup.1, R.sup.2 and R.sup.3 may be identical or different, and each represents a hydrogen atom, a lower alkyl group, a trifluoromethyl group, a halogen atom, a cyano group or a nitro group, and R.sup.4 represents a hydrogen atom, a lower alkoxy group, or a lower alkyl group substituted by a lower alkoxy group or a carbamoyl group, and C* is an asymmetric carbon atom, or a salt thereof. This compound is useful for the treatment of diseases of the circulatory system.
    Type: Grant
    Filed: June 18, 1990
    Date of Patent: January 21, 1992
    Assignee: Teikoku Hormone Mfg. Co., Ltd.
    Inventors: Kikuo Yasuda, Kenyu Shibata, Nobuyoshi Minami, Toshimi Seki, Masafumi Shiraiwa, Tomio Nakao, Katsuhiko Miyasaka, Tsutomu Ishimori, Kotaro Gotanda, Takako Sasaki