Patents by Inventor Masahiro Tanemura

Masahiro Tanemura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combined islet transplantation using pancreatic islets and adipose tissue derived stem cells
    Patent number: 9089550
    Abstract: An object of the present invention is to provide a pancreatic islet transplantation technique that enables increase of graft survival rate of pancreatic islets after pancreatic islet transplantation, to maintain survival of pancreatic islets, and to reduce the number of transplanted pancreatic islets required for normalizing blood glucose level. When performing pancreatic islet transplantation, by transplanting pancreatic islets and adipose tissue-derived stem cells together, it is possible to significantly improve graft survival rate of transplanted pancreatic islets, and reduce by half the number of transplanted pancreatic islets required for normalizing blood glucose level.
    Type: Grant
    Filed: August 5, 2011
    Date of Patent: July 28, 2015
    Assignee: OSAKA UNIVERSITY
    Inventors: Masahiro Tanemura, Yoshiaki Omura, Hiroaki Nagano, Masaki Mori, Yuichiro Doki, Toshinori Ito
  • Method for producing induced pluripotent stem cells
    Patent number: 8852941
    Abstract: A major object of the present invention is to provide a method for producing induced pluripotent stem cells with low tumorigenesis potential and high induction efficiency. The invention provides a method for producing induced pluripotent stem cells comprising the step of introducing one or more nucleic acids that facilitate expression of at least one gene selected from the group consisting of NANOG, SOX2, OCT3/4, KLF4, LIN28, and c-MYC into somatic cells.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: October 7, 2014
    Assignee: Osaka University
    Inventors: Masaki Mori, Hideshi Ishii, Norikatsu Miyoshi, Yuichiro Doki, Masahiro Tanemura, Kenichi Nagai, Hiromitsu Hoshino, Yoshiaki Omura, Naotsugu Haraguchi, Susumu Miyazaki
  • Pancreatic islet separation method, and protective solution for protecting pancreatic islet tissue
    Patent number: 8759099
    Abstract: The disclosed islet isolation method comprises: an injection step of injecting a preservation solution into the pancreatic duct of an excised pancreas; a preservation step of immersing the pancreas into an immersion fluid for preservation; a digestion step of breaking down the pancreas to provide pancreatic tissue; and a purification step of immersing the pancreatic tissue in a purification solution to provide islets. The digestion step consists of: an enzyme injection step of injecting an enzyme solution containing a digestion enzyme into the pancreas; a digestion initiation step of activating the digestion enzyme; a digestion termination step of inactivating the digestion enzyme; and a collection step of collecting the broken-down pancreatic tissue.
    Type: Grant
    Filed: July 13, 2011
    Date of Patent: June 24, 2014
    Assignee: Otsuka Pharmaceutical Factory, Inc.
    Inventors: Masahiro Tanemura, Yoshiki Sawa, Akira Myoui, Toshinori Ito, Masaki Mori, Yuichiro Doki
  • PANCREATIC ISLET SEPARATION METHOD, AND PROTECTIVE SOLUTION FOR PROTECTING PANCREATIC ISLET TISSUE
    Publication number: 20130177986
    Abstract: The disclosed islet isolation method comprises: an injection step of injecting a preservation solution into the pancreatic duct of an excised pancreas; a preservation step of immersing the pancreas into an immersion fluid for preservation; a digestion step of breaking down the pancreas to provide pancreatic tissue; and a purification step of immersing the pancreatic tissue in a purification solution to provide islets. The digestion step consists of: an enzyme injection step of injecting an enzyme solution containing a digestion enzyme into the pancreas; a digestion initiation step of activating the digestion enzyme; a digestion termination step of inactivating the digestion enzyme; and a collection step of collecting the broken-down pancreatic tissue.
    Type: Application
    Filed: July 13, 2011
    Publication date: July 11, 2013
    Inventors: Masahiro Tanemura, Yoshiki Sawa, Akira Myouri, Toshinori Ito, Masaki Mori, Yuichiro Doki
  • ISLETS OF LANGERHANS TRANSPLANT USING ISLETS OF LANGERHANS AND ADIPOSE TISSUE DERIVED STEM CELLS
    Publication number: 20130171114
    Abstract: An object of the present invention is to provide a pancreatic islet transplantation technique that enables increase of graft survival rate of pancreatic islets after pancreatic islet transplantation, to maintain survival of pancreatic islets, and to reduce the number of transplanted pancreatic islets required for normalizing blood glucose level. When performing pancreatic islet transplantation, by transplanting pancreatic islets and adipose tissue-derived stem cells together, it is possible to significantly improve graft survival rate of transplanted pancreatic islets, and reduce by half the number of transplanted pancreatic islets required for normalizing blood glucose level.
    Type: Application
    Filed: August 5, 2011
    Publication date: July 4, 2013
    Applicant: OSAKA UNIVERSITY
    Inventors: Masahiro Tanemura, Yoshiaki Omura, Hiroaki Nagano, Masaki Mori, Yuichiro Doki, Toshinori Ito
  • METHOD FOR PRODUCING INDUCED PLURIPOTENT STEM CELLS
    Publication number: 20130065243
    Abstract: A major object of the present invention is to provide a method for producing induced pluripotent stem cells with low tumorigenesis potential and high induction efficiency. The invention provides a method for producing induced pluripotent stem cells comprising the step of introducing one or more nucleic acids that facilitate expression of at least one gene selected from the group consisting of NANOG, SOX2, OCT3/4, KLF4, LIN28, and c-MYC into somatic cells.
    Type: Application
    Filed: February 18, 2011
    Publication date: March 14, 2013
    Inventors: Masaki Mori, Hideshi Ishii, Norikatsu Miyoshi, Yuichiro Doki, Masahiro Tanemura, Kenichi Nagai, Hiromitsu Hoshino, Yoshiaki Omura, Naotsugu Haraguchi, Susumu Miyazaki