Patents by Inventor Masaki Takiwaki
Masaki Takiwaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11927510Abstract: A standard calibration solution includes water, a non-alcoholic solvent that is mixed with water, and a steroid hormone, and a content of the non-alcoholic solvent is 10% by volume or more and 50% by volume or less. The standard calibration solution is used for quantitative measurement using a mass spectrometry device.Type: GrantFiled: November 20, 2020Date of Patent: March 12, 2024Assignee: JEOL Ltd.Inventors: Masaki Takiwaki, Seketsu Fukuzawa, Yoshikuni Kikutani, Kiyotaka Fujino, Kentaro Abe, Yoshiyuki Ito
-
Patent number: 11885819Abstract: Provided is a method for analyzing a diene compound including: a triazolinedione adduct heating step of heating a triazolinedione adduct to produce a triazolinedione compound; an ene compound formation step of reacting the triazolinedione compound with a diene compound to obtain an ene compound; and an ene compound analysis step of analyzing the ene compound to quantitative determine the diene compound. Also provided is a method for producing an ene compound, including: a triazolinedione adduct heating step of heating a triazolinedione adduct to produce a triazolinedione compound; and an ene compound formation step of reacting the triazolinedione compound with a diene compound to obtain an ene compound.Type: GrantFiled: October 7, 2020Date of Patent: January 30, 2024Assignees: JOEL LTD, TOKUYAMA CORPORATIONInventors: Masaki Takiwaki, Seketsu Fukuzawa, Misao Matsushige, Shin Watanabe
-
Patent number: 11718590Abstract: A compound represented by Chemical formula 1: wherein n is an integer of 2 or more, is provided. Also provided is a derivatization reagent for derivatizing a diene-containing compound, including a compound represented by Chemical formula 1. Further provided is a synthesis method for a compound, including a nucleophilic substitution reaction between an aryl halide and a heterocyclic amine compound being saturated, the compound being represented by Chemical formula 1.Type: GrantFiled: December 21, 2021Date of Patent: August 8, 2023Assignees: TOKYO UNIVERSITY OF SCIENCE FOUNDATION, JEOL Ltd.Inventors: Tatsuya Higashi, Shoujiro Ogawa, Masaki Takiwaki, Seketsu Fukuzawa
-
Publication number: 20230242480Abstract: The present invention is intended to provide a compound useful to analyze a vitamin D compound. The present invention provides an alkyne compound represented by Formula (I): where in Formula (I), A is a linear carbon chain having an alkynyl group at an end and having a vinyl group at another end; X1 is CH or 13CH; X2 is CHY, CDY, 13CHY, 13CDY, CO, 13CO, C18O, or 13C18O; m is an integer from 1 to 4; when m is 2 or more, X2s are identical or different; Y is H, D, NH2, 15NH2, OH, 18OH, SH, OR, O(CO)R, OSO3H, OSO3Na, or a sugar substituent; when Formula (I) contains two or more Ys, Ys are identical or different; R is an alcohol protective group, an alkyl group, an alkenyl group, or an aryl group; X3 is C or 13C; and at least one selected from the group consisting of X1, X2(s), and X3 is modified with a stable isotope D, 13C, 18O, or 15N.Type: ApplicationFiled: December 23, 2022Publication date: August 3, 2023Inventors: Akiko Nagata, Yuka Mizumoto, Ryota Sakamoto, Kazuo Nagasawa, Masaki Takiwaki, Yoshikuni Kikutani, Koji Takahashi, Seketsu Fukuzawa
-
Publication number: 20230112623Abstract: Provided is a phosphonium compound represented by Formula (I): in Formula (I), R1, R2, and R3 are independently from each other, an alkyl group or an aryl group, the alkyl group is a substituted or unsubstituted, linear or branched alkyl group having 1 to 20 carbon atoms or a substituted or unsubstituted cyclic alkyl group having 5 to 20 carbon atoms, the aryl group is a substituted or unsubstituted aryl group having 6 to 20 carbon atoms; X is a reactive group having a hydrazide group, a halide group, a pseudohalide group, or a thioester group; and Y? is an anion having a total charge of ?1, or Y? is absence.Type: ApplicationFiled: October 6, 2022Publication date: April 13, 2023Inventors: Seketsu Fukuzawa, Koji Takahashi, Yoshiyuki Itoh, Masaki Takiwaki, Shugo Tsuda, Masayoshi Mochizuki, Taku Yoshiya
-
Publication number: 20220204459Abstract: A compound represented by Chemical formula 1: wherein n is an integer of 2 or more, is provided. Also provided is a derivatization reagent for derivatizing a diene-containing compound, including a compound represented by Chemical formula 1. Further provided is a synthesis method for a compound, including a nucleophilic substitution reaction between an aryl halide and a heterocyclic amine compound being saturated, the compound being represented by Chemical formula 1.Type: ApplicationFiled: December 21, 2021Publication date: June 30, 2022Inventors: Tatsuya Higashi, Shoujiro Ogawa, Masaki Takiwaki, Seketsu Fukuzawa
-
Patent number: 11339133Abstract: Provided is a method for industrially producing a triazolidinedione compound at a high purity and a high yield. A precipitation step for preparing a solution that contains a triazolidinedione compound represented by formula (1) and precipitating the triazolidinedione compound therefrom is performed. In this step, the pH of the solution is adjusted to 3.0 to 8.5 and the solution is prepared so as to contain 3-15 parts by volume of solvents for 1 part by mass of the triazolidinedione compound. (In the formula, R1 is a substituted or unsubstituted amino group-bearing organic group.Type: GrantFiled: June 11, 2019Date of Patent: May 24, 2022Assignees: TOKUYAMA CORPORATION, JOEL LTD.Inventors: Makoto Satou, Misao Matsushige, Seketsu Fukuzawa, Masaki Takiwaki
-
Patent number: 11193948Abstract: Provided is a method for quantifying vitamin D, with the vitamin D contained in a biological sample being derivatized with a derivatization reagent and being measured with a mass spectrometer, the method including, a derivatization step of derivatizing n number of samples by using n types of 4-(4?-dimethylaminophenyl)-1,2,4-triazoline-3,5-dione (DAPTAD) isotopologues respectively as derivatization reagents, a mixing step of mixing the n types of derivatization samples obtained in the derivatization step, and a quantitative analysis step of subjecting each of the n types of vitamin D derivatives contained in the mixed sample obtained in the mixing step to quantitative analysis using a mass spectrometer.Type: GrantFiled: November 15, 2017Date of Patent: December 7, 2021Assignees: Tokyo University of Science, National University Corporation Chiba University, JEOL Ltd.Inventors: Tatsuya Higashi, Shoujiro Ogawa, Fumio Nomura, Mamoru Satoh, Masaki Takiwaki
-
Patent number: 11192854Abstract: Provided is a method for producing a high-purity, high-quality semicarbazide compound at a high yield by a simple method. The semicarbazide compound is recrystallized by a solvent containing a halogenated hydrocarbon. Dichloromethane is preferred as the halogenated hydrocarbon.Type: GrantFiled: June 11, 2019Date of Patent: December 7, 2021Assignees: TOKUYAMA CORPORATION, JOEL LTD.Inventors: Makoto Satou, Misao Matsushige, Seketsu Fukuzawa, Masaki Takiwaki
-
Publication number: 20210253587Abstract: Provided are a stable triazolinedione adduct, a method for producing the same, a method for producing an ene compound, and a method for analyzing an ene compound. A triazolinedione adduct that is stable until the time of use and can be reacted while reverting to a triazolinedione compound at the time of use. Specifically, a triazolinedione adduct represented by formula (1). (In the formula, R1 is an organic group, and A is a fused ring of three or more rings including at least one aromatic ring.Type: ApplicationFiled: June 11, 2019Publication date: August 19, 2021Applicants: TOKUYAMA CORPORATION, JEOL Ltd.Inventors: Masahiko SEKI, Seketsu FUKUZAWA, Masaki TAKIWAKI
-
Publication number: 20210253541Abstract: Provided is a method for industrially producing a triazolidinedione compound at a high purity and a high yield. A precipitation step for preparing a solution that contains a triazolidinedione compound represented by formula (1) and precipitating the triazolidinedione compound therefrom is performed. In this step, the pH of the solution is adjusted to 3.0 to 8.5 and the solution is prepared so as to contain 3-15 parts by volume of solvents for 1 part by mass of the triazolidinedione compound. (In the formula, R1 is a substituted or unsubstituted amino group-bearing organic group.Type: ApplicationFiled: June 11, 2019Publication date: August 19, 2021Applicants: TOKUYAMA CORPORATION, JEOL Ltd.Inventors: Makoto SATOU, Misao MATSUSHIGE, Seketsu FUKUZAWA, Masaki TAKIWAKI
-
Publication number: 20210156770Abstract: A standard calibration solution includes water, a non-alcoholic solvent that is mixed with water, and a steroid hormone, and a content of the non-alcoholic solvent is 10% by volume or more and 50% by volume or less. The standard calibration solution is used for quantitative measurement using a mass spectrometry device.Type: ApplicationFiled: November 20, 2020Publication date: May 27, 2021Inventors: Masaki Takiwaki, Seketsu Fukuzawa, Yoshikuni Kikutani, Kiyotaka Fujino, Kentaro Abe, Yoshiyuki Ito
-
Publication number: 20210109119Abstract: Provided is a method for analyzing a diene compound including: a triazolinedione adduct heating step of heating a triazolinedione adduct to produce a triazolinedione compound; an ene compound formation step of reacting the triazolinedione compound with a diene compound to obtain an ene compound; and an ene compound analysis step of analyzing the ene compound to quantitative determine the diene compound. Also provided is a method for producing an ene compound, including: a triazolinedione adduct heating step of heating a triazolinedione adduct to produce a triazolinedione compound; and an ene compound formation step of reacting the triazolinedione compound with a diene compound to obtain an ene compound.Type: ApplicationFiled: October 7, 2020Publication date: April 15, 2021Applicants: JEOL Ltd., TOKUYAMA CORPORATIONInventors: Masaki TAKIWAKI, Seketsu FUKUZAWA, Misao MATSUSHIGE, Shin WATANABE
-
Publication number: 20210002212Abstract: Provided is a method for producing a high-purity, high-quality semicarbazide compound at a high yield by a simple method. The semicarbazide compound is recrystallized by a solvent containing a halogenated hydrocarbon. Dichloromethane is preferred as the halogenated hydrocarbon.Type: ApplicationFiled: June 11, 2019Publication date: January 7, 2021Applicants: TOKUYAMA CORPORATION, JEOL Ltd.Inventors: Makoto SATOU, Misao MATSUSHIGE, Seketsu FUKUZAWA, Masaki TAKIWAKI
-
Publication number: 20200392090Abstract: Provided are a method for separating a DAPTAD-containing triazolinedione compound in solid form from a reaction solution, a separated solid triazolinedione compound, and a novel method for producing a triazolinedione compound. A triazolinedione solution in which a DAPTAD-containing triazolinedione compound is dissolved is brought into contact with a C5-15 hydrocarbon-based poor solvent to obtain a solid triazolinedione compound. Also, a triazolinedione compound is oxidized using an oxidizing agent that does not produce acid as a byproduct to obtain a triazolinedione compound.Type: ApplicationFiled: June 11, 2019Publication date: December 17, 2020Applicants: TOKUYAMA CORPORATION, JEOL Ltd.Inventors: Masahiko SEKI, Seketsu FUKUZAWA, Masaki TAKIWAKI
-
Patent number: 10761102Abstract: Provided is a method for derivatizing an s-cis-diene compound with a Cookson-type derivatization reagent, the method including adding, in a reaction stopping step of stopping a derivatization reaction of the s-cis-diene compound, a decomposition inhibitor to inhibit decomposition of a derivative to be obtained.Type: GrantFiled: September 28, 2017Date of Patent: September 1, 2020Assignees: Tokyo University of Science, National University Corporation Chiba University, JEOL Ltd.Inventors: Tatsuya Higashi, Shoujiro Ogawa, Fumio Nomura, Mamoru Satoh, Masaki Takiwaki
-
Publication number: 20180136240Abstract: Provided is a method for quantifying vitamin D, with the vitamin D contained in a biological sample being derivatized with a derivatization reagent and being measured with a mass spectrometer, the method including, a derivatization step of derivatizing n number of samples by using n types of 4-(4?-dimethylaminophenyl)-1,2,4-triazoline-3,5-dione (DAPTAD) isotopologues respectively as derivatization reagents, a mixing step of mixing the n types of derivatization samples obtained in the derivatization step, and a quantitative analysis step of subjecting each of the n types of vitamin D derivatives contained in the mixed sample obtained in the mixing step to quantitative analysis using a mass spectrometer.Type: ApplicationFiled: November 15, 2017Publication date: May 17, 2018Inventors: Tatsuya Higashi, Shoujiro Ogawa, Fumio Nomura, Mamoru Satoh, Masaki Takiwaki
-
Publication number: 20180088137Abstract: Provided is a method for derivatizing an s-cis-diene compound with a Cookson-type derivatization reagent, the method including adding, in a reaction stopping step of stopping a derivatization reaction of the s-cis-diene compound, a decomposition inhibitor to inhibit decomposition of a derivative to be obtained.Type: ApplicationFiled: September 28, 2017Publication date: March 29, 2018Inventors: Tatsuya Higashi, Shoujiro Ogawa, Fumio Nomura, Mamoru Satoh, Masaki Takiwaki