Patents by Inventor Masaki Takiwaki

Masaki Takiwaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11927510
    Abstract: A standard calibration solution includes water, a non-alcoholic solvent that is mixed with water, and a steroid hormone, and a content of the non-alcoholic solvent is 10% by volume or more and 50% by volume or less. The standard calibration solution is used for quantitative measurement using a mass spectrometry device.
    Type: Grant
    Filed: November 20, 2020
    Date of Patent: March 12, 2024
    Assignee: JEOL Ltd.
    Inventors: Masaki Takiwaki, Seketsu Fukuzawa, Yoshikuni Kikutani, Kiyotaka Fujino, Kentaro Abe, Yoshiyuki Ito
  • Patent number: 11885819
    Abstract: Provided is a method for analyzing a diene compound including: a triazolinedione adduct heating step of heating a triazolinedione adduct to produce a triazolinedione compound; an ene compound formation step of reacting the triazolinedione compound with a diene compound to obtain an ene compound; and an ene compound analysis step of analyzing the ene compound to quantitative determine the diene compound. Also provided is a method for producing an ene compound, including: a triazolinedione adduct heating step of heating a triazolinedione adduct to produce a triazolinedione compound; and an ene compound formation step of reacting the triazolinedione compound with a diene compound to obtain an ene compound.
    Type: Grant
    Filed: October 7, 2020
    Date of Patent: January 30, 2024
    Assignees: JOEL LTD, TOKUYAMA CORPORATION
    Inventors: Masaki Takiwaki, Seketsu Fukuzawa, Misao Matsushige, Shin Watanabe
  • Patent number: 11718590
    Abstract: A compound represented by Chemical formula 1: wherein n is an integer of 2 or more, is provided. Also provided is a derivatization reagent for derivatizing a diene-containing compound, including a compound represented by Chemical formula 1. Further provided is a synthesis method for a compound, including a nucleophilic substitution reaction between an aryl halide and a heterocyclic amine compound being saturated, the compound being represented by Chemical formula 1.
    Type: Grant
    Filed: December 21, 2021
    Date of Patent: August 8, 2023
    Assignees: TOKYO UNIVERSITY OF SCIENCE FOUNDATION, JEOL Ltd.
    Inventors: Tatsuya Higashi, Shoujiro Ogawa, Masaki Takiwaki, Seketsu Fukuzawa
  • Publication number: 20230242480
    Abstract: The present invention is intended to provide a compound useful to analyze a vitamin D compound. The present invention provides an alkyne compound represented by Formula (I): where in Formula (I), A is a linear carbon chain having an alkynyl group at an end and having a vinyl group at another end; X1 is CH or 13CH; X2 is CHY, CDY, 13CHY, 13CDY, CO, 13CO, C18O, or 13C18O; m is an integer from 1 to 4; when m is 2 or more, X2s are identical or different; Y is H, D, NH2, 15NH2, OH, 18OH, SH, OR, O(CO)R, OSO3H, OSO3Na, or a sugar substituent; when Formula (I) contains two or more Ys, Ys are identical or different; R is an alcohol protective group, an alkyl group, an alkenyl group, or an aryl group; X3 is C or 13C; and at least one selected from the group consisting of X1, X2(s), and X3 is modified with a stable isotope D, 13C, 18O, or 15N.
    Type: Application
    Filed: December 23, 2022
    Publication date: August 3, 2023
    Inventors: Akiko Nagata, Yuka Mizumoto, Ryota Sakamoto, Kazuo Nagasawa, Masaki Takiwaki, Yoshikuni Kikutani, Koji Takahashi, Seketsu Fukuzawa
  • Publication number: 20230112623
    Abstract: Provided is a phosphonium compound represented by Formula (I): in Formula (I), R1, R2, and R3 are independently from each other, an alkyl group or an aryl group, the alkyl group is a substituted or unsubstituted, linear or branched alkyl group having 1 to 20 carbon atoms or a substituted or unsubstituted cyclic alkyl group having 5 to 20 carbon atoms, the aryl group is a substituted or unsubstituted aryl group having 6 to 20 carbon atoms; X is a reactive group having a hydrazide group, a halide group, a pseudohalide group, or a thioester group; and Y? is an anion having a total charge of ?1, or Y? is absence.
    Type: Application
    Filed: October 6, 2022
    Publication date: April 13, 2023
    Inventors: Seketsu Fukuzawa, Koji Takahashi, Yoshiyuki Itoh, Masaki Takiwaki, Shugo Tsuda, Masayoshi Mochizuki, Taku Yoshiya
  • Publication number: 20220204459
    Abstract: A compound represented by Chemical formula 1: wherein n is an integer of 2 or more, is provided. Also provided is a derivatization reagent for derivatizing a diene-containing compound, including a compound represented by Chemical formula 1. Further provided is a synthesis method for a compound, including a nucleophilic substitution reaction between an aryl halide and a heterocyclic amine compound being saturated, the compound being represented by Chemical formula 1.
    Type: Application
    Filed: December 21, 2021
    Publication date: June 30, 2022
    Inventors: Tatsuya Higashi, Shoujiro Ogawa, Masaki Takiwaki, Seketsu Fukuzawa
  • Patent number: 11339133
    Abstract: Provided is a method for industrially producing a triazolidinedione compound at a high purity and a high yield. A precipitation step for preparing a solution that contains a triazolidinedione compound represented by formula (1) and precipitating the triazolidinedione compound therefrom is performed. In this step, the pH of the solution is adjusted to 3.0 to 8.5 and the solution is prepared so as to contain 3-15 parts by volume of solvents for 1 part by mass of the triazolidinedione compound. (In the formula, R1 is a substituted or unsubstituted amino group-bearing organic group.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: May 24, 2022
    Assignees: TOKUYAMA CORPORATION, JOEL LTD.
    Inventors: Makoto Satou, Misao Matsushige, Seketsu Fukuzawa, Masaki Takiwaki
  • Patent number: 11193948
    Abstract: Provided is a method for quantifying vitamin D, with the vitamin D contained in a biological sample being derivatized with a derivatization reagent and being measured with a mass spectrometer, the method including, a derivatization step of derivatizing n number of samples by using n types of 4-(4?-dimethylaminophenyl)-1,2,4-triazoline-3,5-dione (DAPTAD) isotopologues respectively as derivatization reagents, a mixing step of mixing the n types of derivatization samples obtained in the derivatization step, and a quantitative analysis step of subjecting each of the n types of vitamin D derivatives contained in the mixed sample obtained in the mixing step to quantitative analysis using a mass spectrometer.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: December 7, 2021
    Assignees: Tokyo University of Science, National University Corporation Chiba University, JEOL Ltd.
    Inventors: Tatsuya Higashi, Shoujiro Ogawa, Fumio Nomura, Mamoru Satoh, Masaki Takiwaki
  • Patent number: 11192854
    Abstract: Provided is a method for producing a high-purity, high-quality semicarbazide compound at a high yield by a simple method. The semicarbazide compound is recrystallized by a solvent containing a halogenated hydrocarbon. Dichloromethane is preferred as the halogenated hydrocarbon.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: December 7, 2021
    Assignees: TOKUYAMA CORPORATION, JOEL LTD.
    Inventors: Makoto Satou, Misao Matsushige, Seketsu Fukuzawa, Masaki Takiwaki
  • Publication number: 20210253587
    Abstract: Provided are a stable triazolinedione adduct, a method for producing the same, a method for producing an ene compound, and a method for analyzing an ene compound. A triazolinedione adduct that is stable until the time of use and can be reacted while reverting to a triazolinedione compound at the time of use. Specifically, a triazolinedione adduct represented by formula (1). (In the formula, R1 is an organic group, and A is a fused ring of three or more rings including at least one aromatic ring.
    Type: Application
    Filed: June 11, 2019
    Publication date: August 19, 2021
    Applicants: TOKUYAMA CORPORATION, JEOL Ltd.
    Inventors: Masahiko SEKI, Seketsu FUKUZAWA, Masaki TAKIWAKI
  • Publication number: 20210253541
    Abstract: Provided is a method for industrially producing a triazolidinedione compound at a high purity and a high yield. A precipitation step for preparing a solution that contains a triazolidinedione compound represented by formula (1) and precipitating the triazolidinedione compound therefrom is performed. In this step, the pH of the solution is adjusted to 3.0 to 8.5 and the solution is prepared so as to contain 3-15 parts by volume of solvents for 1 part by mass of the triazolidinedione compound. (In the formula, R1 is a substituted or unsubstituted amino group-bearing organic group.
    Type: Application
    Filed: June 11, 2019
    Publication date: August 19, 2021
    Applicants: TOKUYAMA CORPORATION, JEOL Ltd.
    Inventors: Makoto SATOU, Misao MATSUSHIGE, Seketsu FUKUZAWA, Masaki TAKIWAKI
  • Publication number: 20210156770
    Abstract: A standard calibration solution includes water, a non-alcoholic solvent that is mixed with water, and a steroid hormone, and a content of the non-alcoholic solvent is 10% by volume or more and 50% by volume or less. The standard calibration solution is used for quantitative measurement using a mass spectrometry device.
    Type: Application
    Filed: November 20, 2020
    Publication date: May 27, 2021
    Inventors: Masaki Takiwaki, Seketsu Fukuzawa, Yoshikuni Kikutani, Kiyotaka Fujino, Kentaro Abe, Yoshiyuki Ito
  • Publication number: 20210109119
    Abstract: Provided is a method for analyzing a diene compound including: a triazolinedione adduct heating step of heating a triazolinedione adduct to produce a triazolinedione compound; an ene compound formation step of reacting the triazolinedione compound with a diene compound to obtain an ene compound; and an ene compound analysis step of analyzing the ene compound to quantitative determine the diene compound. Also provided is a method for producing an ene compound, including: a triazolinedione adduct heating step of heating a triazolinedione adduct to produce a triazolinedione compound; and an ene compound formation step of reacting the triazolinedione compound with a diene compound to obtain an ene compound.
    Type: Application
    Filed: October 7, 2020
    Publication date: April 15, 2021
    Applicants: JEOL Ltd., TOKUYAMA CORPORATION
    Inventors: Masaki TAKIWAKI, Seketsu FUKUZAWA, Misao MATSUSHIGE, Shin WATANABE
  • Publication number: 20210002212
    Abstract: Provided is a method for producing a high-purity, high-quality semicarbazide compound at a high yield by a simple method. The semicarbazide compound is recrystallized by a solvent containing a halogenated hydrocarbon. Dichloromethane is preferred as the halogenated hydrocarbon.
    Type: Application
    Filed: June 11, 2019
    Publication date: January 7, 2021
    Applicants: TOKUYAMA CORPORATION, JEOL Ltd.
    Inventors: Makoto SATOU, Misao MATSUSHIGE, Seketsu FUKUZAWA, Masaki TAKIWAKI
  • Publication number: 20200392090
    Abstract: Provided are a method for separating a DAPTAD-containing triazolinedione compound in solid form from a reaction solution, a separated solid triazolinedione compound, and a novel method for producing a triazolinedione compound. A triazolinedione solution in which a DAPTAD-containing triazolinedione compound is dissolved is brought into contact with a C5-15 hydrocarbon-based poor solvent to obtain a solid triazolinedione compound. Also, a triazolinedione compound is oxidized using an oxidizing agent that does not produce acid as a byproduct to obtain a triazolinedione compound.
    Type: Application
    Filed: June 11, 2019
    Publication date: December 17, 2020
    Applicants: TOKUYAMA CORPORATION, JEOL Ltd.
    Inventors: Masahiko SEKI, Seketsu FUKUZAWA, Masaki TAKIWAKI
  • Patent number: 10761102
    Abstract: Provided is a method for derivatizing an s-cis-diene compound with a Cookson-type derivatization reagent, the method including adding, in a reaction stopping step of stopping a derivatization reaction of the s-cis-diene compound, a decomposition inhibitor to inhibit decomposition of a derivative to be obtained.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: September 1, 2020
    Assignees: Tokyo University of Science, National University Corporation Chiba University, JEOL Ltd.
    Inventors: Tatsuya Higashi, Shoujiro Ogawa, Fumio Nomura, Mamoru Satoh, Masaki Takiwaki
  • Publication number: 20180136240
    Abstract: Provided is a method for quantifying vitamin D, with the vitamin D contained in a biological sample being derivatized with a derivatization reagent and being measured with a mass spectrometer, the method including, a derivatization step of derivatizing n number of samples by using n types of 4-(4?-dimethylaminophenyl)-1,2,4-triazoline-3,5-dione (DAPTAD) isotopologues respectively as derivatization reagents, a mixing step of mixing the n types of derivatization samples obtained in the derivatization step, and a quantitative analysis step of subjecting each of the n types of vitamin D derivatives contained in the mixed sample obtained in the mixing step to quantitative analysis using a mass spectrometer.
    Type: Application
    Filed: November 15, 2017
    Publication date: May 17, 2018
    Inventors: Tatsuya Higashi, Shoujiro Ogawa, Fumio Nomura, Mamoru Satoh, Masaki Takiwaki
  • Publication number: 20180088137
    Abstract: Provided is a method for derivatizing an s-cis-diene compound with a Cookson-type derivatization reagent, the method including adding, in a reaction stopping step of stopping a derivatization reaction of the s-cis-diene compound, a decomposition inhibitor to inhibit decomposition of a derivative to be obtained.
    Type: Application
    Filed: September 28, 2017
    Publication date: March 29, 2018
    Inventors: Tatsuya Higashi, Shoujiro Ogawa, Fumio Nomura, Mamoru Satoh, Masaki Takiwaki