Patents by Inventor Masanori Asai

Masanori Asai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10370372
    Abstract: To provide a compound having an inhibitory activity for an androgen receptor. A fused pyrimidine compound represented by the following formula (I) or a pharmaceutically acceptable thereof (in the formula, X, Y, Z, R1, and R2 are as defined in the specification).
    Type: Grant
    Filed: November 25, 2016
    Date of Patent: August 6, 2019
    Assignee: TAIHO PHARMACEUTICAL CO., LTD.
    Inventors: Kazuhisa Minamiguchi, Shigeo Okajima, Takahiro Asai, Masanori Asai, Yoshio Ogino
  • Patent number: 10300067
    Abstract: A method for inhibiting androgen activity, including administering an effective amount of a tetrahydropyridopyrimidine compound of formula (I) or a pharmaceutically acceptable salt thereof to a subject in need thereof, and a method for treating tumor, including administering an effective amount of a tetrahydropyridopyrimidine compound of formula (I) or a pharmaceutically acceptable salt thereof to a subject in need thereof
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: May 28, 2019
    Assignee: TAIHO PHARMACEUTICAL CO., LTD.
    Inventors: Kazuhisa Minamiguchi, Shigeo Okajima, Shinichi Aoki, Masanori Asai, Takahiro Asai, Hiroyoshi Yamanaka, Suguru Dohi
  • Publication number: 20180312505
    Abstract: To provide a compound having an inhibitory activity for an androgen receptor. A fused pyrimidine compound represented by the following formula (I) or a pharmaceutically acceptable thereof (in the formula, X, Y, Z, R1, and R2 are as defined in the specification).
    Type: Application
    Filed: November 25, 2016
    Publication date: November 1, 2018
    Applicant: TAIHO PHARMACEUTICAL CO., LTD.
    Inventors: Kazuhisa MINAMIGUCHI, Shigeo OKAJIMA, Takahiro ASAI, Masanori ASAI, Yoshio OGINO
  • Publication number: 20180161331
    Abstract: A method for inhibiting androgen activity, including administering an effective amount of a tetrahydropyridopyrimidine compound of formula (I) or a pharmaceutically acceptable salt thereof to a subject in need thereof, and a method for treating tumor, including administering an effective amount of a tetrahydropyridopyrimidine compound of formula (I) or a pharmaceutically acceptable salt thereof to a subject in need thereof
    Type: Application
    Filed: February 12, 2018
    Publication date: June 14, 2018
    Applicant: TAIHO PHARMACEUTICAL CO., LTD.
    Inventors: Kazuhisa MINAMIGUCHI, Shigeo OKAJIMA, Shinichi AOKI, Masanori ASAI, Takahiro ASAI, Hiroyoshi YAMANAKA, Suguru DOHI
  • Patent number: 9889136
    Abstract: A method for inhibiting androgen activity, including administering an effective amount of a tetrahydropyridopyrimidine compound of formula (I) or a pharmaceutically acceptable salt thereof to a subject in need thereof, and a method for treating tumor, including administering an effective amount of a tetrahydropyridopyrimidine compound of formula (I) or a pharmaceutically acceptable salt thereof to a subject in need thereof
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: February 13, 2018
    Assignee: TAIHO PHARMACEUTICAL CO., LTD.
    Inventors: Kazuhisa Minamiguchi, Shigeo Okajima, Shinichi Aoki, Masanori Asai, Takahiro Asai, Hiroyoshi Yamanaka, Suguru Dohi
  • Patent number: 9665043
    Abstract: An image forming apparatus includes a controller for forming an adjustment toner image in a region corresponding to between a first region corresponding to a preceding sheet and a second region corresponding to a subsequent sheet, wherein the controller selectively executes a first mode for setting as a first length a gap between the adjustment image and a trailing edge of the first region and for setting as a second length a gap between the adjustment toner image and a leading end of the second region, or a second mode for setting as a third length a gap between the adjustment toner image and the trailing edge of the first region and for setting as a fourth length a gap between the adjustment image and the leading end of the second region. The third is shorter than the first, and the fourth length is longer than the first length.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: May 30, 2017
    Assignee: Canon Kabushiki Kaisha
    Inventors: Kazuhiro Funatani, Masanori Asai, Shuji Saito, Hiroyuki Seki, Yasutaka Yagi, Tetsuichiro Fujimoto
  • Patent number: 9662333
    Abstract: A tetrahydropyridopyrimidine compound represented by formula (I) or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition including the tetrahydropyridopyrimidine compound or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier:
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: May 30, 2017
    Assignee: TAIHO PHARMACEUTICAL CO., LTD.
    Inventors: Kazuhisa Minamiguchi, Shigeo Okajima, Shinichi Aoki, Masanori Asai, Takahiro Asai, Hiroyoshi Yamanaka, Suguru Dohi
  • Patent number: 9606477
    Abstract: An image forming apparatus including a cleaning member having a belt cleaning blade and a conductive brush. A value of a charging current that is generated when charging residual toner with the conductive brush is smaller when a color mode is executed compared to that when a monochrome mode is executed.
    Type: Grant
    Filed: March 22, 2016
    Date of Patent: March 28, 2017
    Assignee: Canon Kabushiki Kaisha
    Inventors: Yasutaka Yagi, Kazuhiro Funatani, Tetsuichiro Fujimoto, Hiroyuki Seki, Masanori Asai, Shuji Saito
  • Patent number: 9599935
    Abstract: In an adjustment step, an adjustment purpose toner image is formed on an intermediate transfer belt, and the adjustment purpose toner image is removed from the intermediate transfer belt by a cleaning member contacting the intermediate transfer belt and through an electrostatic cleaning step. This adjustment step is executed in a state where a toner attachment amount on a charging member is switched from a first limit value, which is allowed in the image forming step to a second limit value, which is allowed immediately before executing the adjustment step. This switching is performed by the execution of a toner discharging step, where a power supply changes the state of applying voltage to the charging member from that in the electrostatic cleaning step, so that toner attached to the charging member is transferred to the intermediate transfer belt.
    Type: Grant
    Filed: January 27, 2016
    Date of Patent: March 21, 2017
    Assignee: Canon Kabushiki Kaisha
    Inventors: Masanori Asai, Kazuhiro Funatani, Hiroyuki Seki, Shuji Saito, Yasutaka Yagi, Tetsuichiro Fujimoto
  • Publication number: 20160310496
    Abstract: A method for inhibiting androgen activity, including administering an effective amount of a tetrahydropyridopyrimidine compound of formula (I) or a pharmaceutically acceptable salt thereof to a subject in need thereof, and a method for treating tumor, including administering an effective amount of a tetrahydropyridopyrimidine compound of formula (I) or a pharmaceutically acceptable salt thereof to a subject in need thereof
    Type: Application
    Filed: July 6, 2016
    Publication date: October 27, 2016
    Applicant: TAIHO PHARMACEUTICAL CO., LTD.
    Inventors: Kazuhisa MINAMIGUCHI, Shigeo Okajima, Shinichi Aoki, Masanori Asai, Takahiro Asai, Hiroyoshi Yamanaka, Suguru Dohi
  • Publication number: 20160282767
    Abstract: An image forming apparatus including a cleaning member having a belt cleaning blade and a conductive brush. A value of a charging current that is generated when charging residual toner with the conductive brush is smaller when a color mode is executed compared to that when a monochrome mode is executed.
    Type: Application
    Filed: March 22, 2016
    Publication date: September 29, 2016
    Inventors: Yasutaka Yagi, Kazuhiro Funatani, Tetsuichiro Fujimoto, Hiroyuki Seki, Masanori Asai, Shuji Saito
  • Publication number: 20160244444
    Abstract: To provide a compound having an inhibitory activity for an androgen receptor. A tetrahydropyridopyrimidine compound represented by the following general formula (I) or a pharmaceutically acceptable thereof (in the formula, X and R are as defined in the specification).
    Type: Application
    Filed: May 28, 2015
    Publication date: August 25, 2016
    Applicant: TAIHO PHARMACEUTICAL CO., LTD.
    Inventors: Kazuhisa MINAMIGUCHI, Shigeo OKAJIMA, Shinichi AOKI, Masanori ASAI, Takahiro ASAI, Hiroyoshi YAMANAKA, Suguru DOHI
  • Publication number: 20160223932
    Abstract: In an adjustment step, an adjustment purpose toner image is formed on an intermediate transfer belt, and the adjustment purpose toner image is removed from the intermediate transfer belt by a cleaning member contacting the intermediate transfer belt and through an electrostatic cleaning step. This adjustment step is executed in a state where a toner attachment amount on a charging member is switched from a first limit value, which is allowed in the image forming step to a second limit value, which is allowed immediately before executing the adjustment step. This switching is performed by the execution of a toner discharging step, where a power supply changes the state of applying voltage to the charging member from that in the electrostatic cleaning step, so that toner attached to the charging member is transferred to the intermediate transfer belt.
    Type: Application
    Filed: January 27, 2016
    Publication date: August 4, 2016
    Inventors: Masanori Asai, Kazuhiro Funatani, Hiroyuki Seki, Shuji Saito, Yasutaka Yagi, Tetsuichiro Fujimoto
  • Publication number: 20160187815
    Abstract: An image forming apparatus includes a controller for forming an adjustment toner image in a region corresponding to between a first region corresponding to a preceding sheet and a second region corresponding to a subsequent sheet, wherein the controller selectively executes a first mode for setting as a first length a gap between the adjustment image and a trailing edge of the first region and for setting as a second length a gap between the adjustment toner image and a leading end of the second region, or a second mode for setting as a third length a gap between the adjustment toner image and the trailing edge of the first region and for setting as a fourth length a gap between the adjustment image and the leading end of the second region. The third is shorter than the first, and the fourth length is longer than the first length.
    Type: Application
    Filed: December 28, 2015
    Publication date: June 30, 2016
    Inventors: Kazuhiro Funatani, Masanori Asai, Shuji Saito, Hiroyuki Seki, Yasutaka Yagi, Tetsuichiro Fujimoto
  • Patent number: 8846700
    Abstract: Disclosed are compounds of the following formula and their pharmaceutically-acceptable salts, which have an effect of glucokinase activation and are useful in the field of medicines for treatment for diabetes, obesity, etc. (wherein ring A represents a pyrazolyl group optionally having a lower alkyl group, etc.; ring B represents a heteroaryl group; R represents a lower alkyl group, etc.; R1 represents a group of a formula: (wherein R11 and R12 each independently represent a hydrogen atom, etc.; m indicates an integer of from 2 to 6), etc.; R2 represents a lower alkyl group, etc.; r indicates an integer of from 0 to 3; k indicates an integer of from 0 to 4).
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: September 30, 2014
    Assignee: MSD K.K.
    Inventors: Tomoharu Iino, Akio Ohno, Norikazu Otake, Takuya Suga, Masanori Asai
  • Publication number: 20140011801
    Abstract: Disclosed are compounds of the following formula and their pharmaceutically-acceptable salts, which have an effect of glucokinase activation and are useful in the field of medicines for treatment for diabetes, obesity, etc. (wherein ring A represents a pyrazolyl group optionally having a lower alkyl group, etc.; ring B represents a heteroaryl group; R represents a lower alkyl group, etc.; R1 represents a group of a formula: (wherein R11 and R12 each independently represent a hydrogen atom, etc.; m indicates an integer of from 2 to 6), etc.; R2 represents a lower alkyl group, etc.; r indicates an integer of from 0 to 3; k indicates an integer of from 0 to 4).
    Type: Application
    Filed: September 9, 2013
    Publication date: January 9, 2014
    Applicant: MSD K.K.
    Inventors: Tomoharu Iino, Aklo Ohno, Norikazu Otake, Takuya Suga, Masanori Asai
  • Patent number: 8609699
    Abstract: The present invention relates to compounds, which are useful for treatment and/or prevention of diabetes mellitus, diabetes mellitus complications or obesity, since the compounds have glucokinase-activating effects, and are presented in Formula (I): wherein R1 represents a carbamoyl group; R2 represents a lower alkyl group; both of X1 and X2 represent CH, or any one of X1 and X2 represents a nitrogen atom and the other represents CH; a group of represents a group selected from the group consisting of a pyridinyl, a pyrazinyl, a pyrazolyl, a thiadiazolyl, a triazolyl, an isoxazolyl and a thiazolyl group; and k is zero or 1, or relates to pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: August 3, 2009
    Date of Patent: December 17, 2013
    Assignee: MSD K.K.
    Inventors: Tomoharu Iino, Masanori Asai, Akio Ohno, Seiichi Inamura, Makoto Ishikawa, Norikazu Ohtake
  • Patent number: 8338460
    Abstract: Compounds of a formula (I) and their pharmaceutically-acceptable salts are disclosed. The compounds have glucokinase-activating effect and are therefore useful for treatment of diabetes and obesity. R1 and R2 each independently represent a lower alkyl group; X1 represent a group of a formula (II-1): wherein: R11 and R12 each independently represent a hydrogen atom or a lower alkyl group, or taken together with the nitrogen atom to which they bond, R11 and R12 may form a 4- to 7-membered nitrogen-containing aliphatic ring (one carbon atom constituting the 4- to 7-membered nitrogen-containing aliphatic ring may be replaced by an oxygen atom), or taken together with a carbon atom in (CH2)m, R11 and R12 may form a 4- to 7-membered nitrogen-containing aliphatic ring; m indicates an integer of from 1 to 3.
    Type: Grant
    Filed: October 5, 2007
    Date of Patent: December 25, 2012
    Assignee: MSD K. K.
    Inventors: Noriaki Hashimoto, Yufu Sagara, Masanori Asai, Teruyuki Nishimura
  • Publication number: 20120270856
    Abstract: Disclosed are compounds of the following formula and their pharmaceutically-acceptable salts, which have an effect of glucokinase activation and are useful in the field of medicines for treatment for diabetes, obesity, etc. (wherein ring A represents a pyrazolyl group optionally having a lower alkyl group, etc.; ring B represents a heteroaryl group; R represents a lower alkyl group, etc.; R1 represents a group of a formula: (wherein R11 and R12 each independently represent a hydrogen atom, etc.; m indicates an integer of from 2 to 6), etc.; R2 represents a lower alkyl group, etc.; r indicates an integer of from 0 to 3; k indicates an integer of from 0 to 4).
    Type: Application
    Filed: July 2, 2012
    Publication date: October 25, 2012
    Inventors: Tomoharu IINO, Akio OHNO, Norikazu OTAKE, Takuya SUGA, Masanori ASAI
  • Patent number: 8232284
    Abstract: Disclosed are compounds of the following formula and their pharmaceutically-acceptable salts, which have an effect of glucokinase activation and are useful in the field of medicines for treatment for diabetes, obesity, etc. (wherein ring A represents a pyrazolyl group optionally having a lower alkyl group, etc.; ring B represents a heteroaryl group; R represents a lower alkyl group, etc.; R1 represents a group of a formula: (wherein R11 and R12 each independently represent a hydrogen atom, etc.; m indicates an integer of from 2 to 6), etc.; R2 represents a lower alkyl group, etc.; r indicates an integer of from 0 to 3; k indicates an integer of from 0 to 4).
    Type: Grant
    Filed: November 10, 2008
    Date of Patent: July 31, 2012
    Assignee: MSD K. K.
    Inventors: Tomoharu Iino, Akio Ohno, Norikazu Otake, Takuya Suga, Masanori Asai