Patents by Inventor Masao Koyama

Masao Koyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6498251
    Abstract: Compounds containing tetrahydrobenzindole which bind to serotonin receptor and are useful in treatment or prevention of disease induced by abnormality of central peripheral serotonin controlling functions.
    Type: Grant
    Filed: March 8, 2001
    Date of Patent: December 24, 2002
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Chika Kikuchi, Takashi Ando, Kazuyuki Fuji, Masayo Okuno, Eriko Morita, Masako Imai, Osamu Ushiroda, Masao Koyama, Toyokazu Hiranuma
  • Patent number: 6407112
    Abstract: Optically active tetrahydrobenzindole type compounds having affinity for a 5-HT receptor, useful for prevention and treatment of mental diseases. A species compound is (S)-2a-4-(4-(2-methoxyphenyl)piperazinyl)butyl)-2a,3,4,5,-tetrahydro 1 H-benz[cd]indol-2-one.
    Type: Grant
    Filed: October 23, 2000
    Date of Patent: June 18, 2002
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Masao Koyama, Osamu Ushiroda, Chika Kikuchi, Takashi Ando, Eriko Morita, Masayo Okuno, Toyokazu Hiranuma
  • Patent number: 6355642
    Abstract: A compound of formula (I) for use in the treatment or prevention of mental diseases A is N, CH, C having a double bond or CR5; each of B and Z is independently N, CH or CR1, with the proviso that A is N when B and/or Z is N; R1, R2, R3, R4 and R5 and n are as defined in the specification.
    Type: Grant
    Filed: December 28, 1998
    Date of Patent: March 12, 2002
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Masao Koyama, Chika Kikuchi, Osamu Ushiroda, Takashi Ando, Hiroshi Nagaso, Kazuyuki Fuji, Masayo Okuno, Toyokazu Hiranuma
  • Patent number: 6332909
    Abstract: A processing apparatus capable of separating and recovering resins and metals, respectively, from an object being processed, which has resins and metals as its constituent, comprises a first gastight area (102), in which temperature and pressure are regulated so as to permit selective thermal decomposition of resins from the object (150) being processed, a second gastight area (103), which is partitioned from the first gastight area by an openable and closeable partition (105C) and in which temperature and pressure are regulated so as to permit selective vaporization of metals from the object, first recovering chamber (111) connected to the first gastight area for recovering gases produced by thermal decomposition of resins, and second recovering chamber (115) connected to the second gastight area for recovering vaporized metals.
    Type: Grant
    Filed: February 23, 1999
    Date of Patent: December 25, 2001
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Kouichi Teshima, Tomohiro Todoroki, Terunobu Hayata, Fuminobu Tezuka, Masao Koyama, Naohiko Oyasato, Tomiaki Furuya, Yoshiaki Yokoyama, Teruhisa Ogihara, Kaichiro Ogihara
  • Patent number: 6172275
    Abstract: Disclosed is a method and apparatus for pyrolytically decomposing waste plastic which may contain halogen-containing polymer such as PVC. The plastic is heated at 270° to 350° C., whereby a plasticizer contained in the plastic material is decomposed and vaporized, and a chlorine-containing polymer is dechlorinated to produce hydrogen chloride. The vaporized decomposition matter and the hydrogen chloride are removed from the plastic, and the vaporized decomposition matter is separated from the hydrogen chloride. Then isolated plastic is further heated to 450° C. or higher to produce a pyrolysis product. Alternatively, the former heating step is divided into two steps of: heating at a temperature lower than 270° C., whereby a plasticizer is decomposed; and heating to 270° to 350° C., whereby a chlorine-containing polymer contained in the plastic material is dechlorinated. Accordingly, the decomposition matter of plasticizer and hydrogen chloride are separately removed from the plastic.
    Type: Grant
    Filed: March 3, 1998
    Date of Patent: January 9, 2001
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Masahiro Tadauchi, Yukishige Maezawa, Terunobu Hayata, Hideki Shimada, Isao Ito, Kazuo Suzuki, Fuminobu Tezuka, Jiro Kano, Takeshi Gotanda, Masao Koyama, Satoshi Kanazawa
  • Patent number: 5747448
    Abstract: Novel PF 1022 derivatives--cyclodepsipeptides represented by the below-described formula (I)--and acid addition salts thereof, which have been synthesized according to the present invention, have anthelmintic activities against various parasitic worms which are parasitic on human bodies, domestic animals and pet animals. They are therefore useful as anthelmintics for the prevention or treatment of parasitic infections. ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, Q, X, Y and Z have been defined herein.
    Type: Grant
    Filed: September 8, 1995
    Date of Patent: May 5, 1998
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Makoto Ohyama, Maki Ohishi, Yumiko Okada, Masao Koyama, Shinjiro Sumi, Yasushi Murai, Masayuki Takagi, Tadaaki Okada, Osamu Sakanaka, Toshio Yoneta, Katsuharu Iinuma, Seiji Shibahara
  • Patent number: 5312833
    Abstract: Tumor growth in a mammal is inhibited by the administration of an effective amount of xanthocillin X dimethylether. The xanthocillin X dimethylether is administered in a range of 10-3,000 milligrams per day for an average adult human patient. The xanthocillin X dimethylether can be administered orally, by direct application into a neoplastic lesion, or by other parenteral forms of administration including intravenous, subcutaneous, or intramuscular injections. Also, suppository forms can be used.
    Type: Grant
    Filed: November 15, 1991
    Date of Patent: May 17, 1994
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Tsutomu Tsuruoka, Harumi Fukuyasu, Katsumi Kawaharajo, Masao Koyama, Hiroshi Kurihara
  • Patent number: 5245937
    Abstract: A method of burning a combustible solid residue from a chemical plant, which comprises feeding a slurry of combustible solid residues in an oil, the amount of the oil being at least 0.5 part by weight per part by weight of the combustible solid residues, into a burner in a combustion furnace comprised of a main combustion chamber having the burner in its arch, a secondary combustion chamber formed in the lower portion of the main combustion chamber, and a flue gas duct provided beneath and following the secondary combustion chamber, burning the residue in the main combustion chamber, conducting the combustion gas into the secondary combustion chamber, and allowing it to reside at a temperature 800.degree. to 1000.degree. C. for at least 0.5 second.
    Type: Grant
    Filed: May 29, 1990
    Date of Patent: September 21, 1993
    Assignees: Mitsui Engineering & Shipbuilding Co., Ltd., Mitsui Petrochemical Industries, Ltd.
    Inventors: Noriaki Nakase, Masao Koyama, Masahiro Inada, Toshiaki Masaoka, Tohoru Abiko, Kenji Takahashi
  • Patent number: 5210097
    Abstract: A xanthocillin X monomethyl ether derivative represented by the formula (I) ##STR1## wherein R represents an alkyl group, an alkenyl group, an alkoxycarbonyl group, an aralkyl group, an alkyl group substituted with a pyridyl group or a halogen atom, an aralkyl group substituted with an alkyl group or a halogen atom, or an aroyl group, which exerts an intense effect of inhibiting the proliferation of a tumor, in particular, a solid tumor.
    Type: Grant
    Filed: May 18, 1990
    Date of Patent: May 11, 1993
    Assignee: Meiji Seika Kaisha Ltd.
    Inventors: Hiroshi Kurihara, Hiromi Watanabe, Masao Koyama, Masaji Sezaki, Tsutomu Tsuruoka, Harumi Fukuyasu, Haruo Yamamoto
  • Patent number: 5164507
    Abstract: A substance represented by formula: ##STR1## and a salt thereof, which has antifungal activity and a process for producing the same utilizing a microorganism capable of producing the substance and belonging to the genus Streptomyces.
    Type: Grant
    Filed: May 21, 1991
    Date of Patent: November 17, 1992
    Assignee: Meiji Seika Kaisha Ltd.
    Inventors: Toru Sasaki, Akira Shimizu, Junko Yoshida, Hiroomi Watabe, Masao Koyama
  • Patent number: 5053431
    Abstract: The present invention concerns compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen, a hydroxy group or a methoxy group;R.sup.2 is hydrogen or a methyl group;R.sup.3 is hydrogen or a methyl group;Y is a secondary amino group (NHalkyl) or a tertiary amino group (N(alkyl).sub.2); andZ is hydrogen or a halogen.The invention further provides a method of inhibiting topoisomerase II using a compound having the structure: ##STR2## wherein R.sup.1 is hydrogen, a hydroxy group or a methoxy group;R.sup.2 is hydrogen or a methyl group;R.sup.3 is hydrogen or a methyl group;Y is a halogen, secondary amino group (NHalkyl) or a tertiary amino group (N(alkyl).sub.2); andZ is hydrogen or a halogen.The invention further concerns pharmaceutical compositions which comprise the above-identified compound or the acid salts thereof, and the use of the compound or compositions for treating a malignancy in a subject.
    Type: Grant
    Filed: June 26, 1990
    Date of Patent: October 1, 1991
    Assignee: Sloan-Kettering Institute For Cancer Research
    Inventors: Kyoichi A. Watanabe, Masao Koyama, Ting-Chao Chou
  • Patent number: 5037993
    Abstract: Novel substances exhibiting antimicrobial activity and antitumor activity, a process for producing them by cultivating a microorganism belonging to the genus Streptomyces and capable of producing them and derivatives of such substances.
    Type: Grant
    Filed: May 8, 1990
    Date of Patent: August 6, 1991
    Assignee: Meiji Seika Kaisha Ltd.
    Inventors: Kazunori Ohba, Masaji Sezaki, Shinichi Kondo, Masao Koyama, Tadashi Nakazawa, Haruo Yamamoto
  • Patent number: 4994578
    Abstract: Novel substances exhibiting antimicrobial activity and antitumor activity, a process for producing them by cultivating a microorganism belonging to the genus Streptomyces and capable of producing them and derivatives of such substances.
    Type: Grant
    Filed: April 28, 1989
    Date of Patent: February 19, 1991
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Kazunori Ohba, Hiroomi Watabe, Mieko Nagasawa, Shiro Sakakibara, Takashi Shomura, Masaji Sezaki, Shinichi Kondo, Masao Koyama, Tadashi Nakazawa, Haruo Yamamoto
  • Patent number: 4966918
    Abstract: The present invention concerns compounds of the formula: ##STR1## wherein R.sup.1 hydrogen, a hydroxyl group or a methoxy group;R.sup.2 is hydrogen or a methyl group;R.sup.3 is hydrogen or a methyl group;Y is a halogen, a secondary amino group or a tertiary amino group; andZ is hydrogen or a halogen.The invention further concerns pharmaceutical compositions which comprises the above-identified compound or the acid salts thereof, and the use of the compound or compositions for treating a malignancy in a subject.
    Type: Grant
    Filed: January 27, 1989
    Date of Patent: October 30, 1990
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Kyoichi A. Watanabe, Masao Koyama
  • Patent number: 4961833
    Abstract: A field-effect transistor-type semiconductor sensor is provided which comprises first and second semiconductor substrates bonded strongly to each other interposing a silicon oxide film therebetween by the use of a direct-bonding technique. The first semiconductor substrate is formed into an island-shape, and incorporates a source region, a drain region and a gate region. The island-shaped substrate constitutes an ion-sensitive portion, and is immersed in a solution when in use. The second semiconductor substrate has openings in which source and drain electrodes are formed.
    Type: Grant
    Filed: March 23, 1989
    Date of Patent: October 9, 1990
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Tadashi Sakai, Shigeki Uno, Masao Koyama, Nanao Nakamura
  • Patent number: 4839378
    Abstract: Fluorophthalimide compounds represented by the following general formula (I): ##STR1## wherein R each stands for an ethyl group or an isopropyl group, are effective for controlling diseases of agricultural plants, especially diseases caused by microorganisms belonging to the genus Rhizoctonia, represented by sheath blight of rice plants, and diseases caused by Basidomycetes.
    Type: Grant
    Filed: April 28, 1987
    Date of Patent: June 13, 1989
    Assignee: Meiji Seika Kabushiki Kaisha
    Inventors: Masao Koyama, Michiaki Iwata, Kunihiko Kurihara, Masaji Sezaki
  • Patent number: 4758325
    Abstract: There are disclosed an ion selective electrode comprising a polyvinyl chloride series resin plate having a through hole; conductive member disposed along the through hole; ion sensitive membrane of a polyvinyl chloride series resin membrane; and a lead wire connected to the conductive member, and the flow type ion sensor comprises a plurality of the ion selective electrodes mutually integrally associated with each other with the interposition of electrical insulating members so that through holes of the respective ion selective electrodes may define a flow passage for a liquid to be measured, and a flow type ion sensor using the same.The ion selective electrode and flow type ion sensor using the same of this invention allow the measurement in a smaller amount of the sample to be measured and are excellect in the adhesion of the ion sensitive membranes, therefore they have effects of a stable potential supply and a prolonged life time, and these industrial merits are highly great.
    Type: Grant
    Filed: January 10, 1986
    Date of Patent: July 19, 1988
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Ken-ichi Kanno, Tetsuya Gatayama, Masao Koyama
  • Patent number: 4651310
    Abstract: There is disclosed a polymeric piezoelectric ultrasonic probe using a polymeric piezoelectric member which comprises a polymeric piezoelectric member; a common electrode formed on one surface of the polymeric piezoelectric member; and electrodes for driving provided as opposed to the common electrode with the polymeric piezoelectric member being interposed therebetween, the electrodes for driving being formed on a polymeric thin film.The polymeric piezoelectric ultrasonic probe of the present invention has advantages that not only breaking or short circuit of electrodes shaped in rectangular strips can be prevented, but also it becomes possible to connect lead wires with good reliability. Besides, not only cumbersomeness is registration of electrodes shaped in rectangular strips during lamination of polymeric piezoelectric members can be cancelled, but also acoustic-electrical coupling or cross-talk can be reduced.
    Type: Grant
    Filed: December 16, 1985
    Date of Patent: March 17, 1987
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Nagao Kaneko, Nanao Nakamura, Masao Koyama, Shiroh Saitoh, Hiroki Honda
  • Patent number: 4647572
    Abstract: Triiodoallyl- or iodopropargyl-substituted tetrazole compounds which are prepared by reacting substituted tetrazole compound with reactive derivatives of corresponding triiodoallyl alcohol or iodopropargyl alcohol or by iodinating propargyltetrazole compounds, as well as antibacterial and antifungal compositions for medicinal, agricultural and industrial fields which contain as active ingredient said tetrazole compounds.
    Type: Grant
    Filed: October 25, 1983
    Date of Patent: March 3, 1987
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Shigeharu Inouye, Masao Koyama, Keinosuke Miyauchi, Takashi Tsuruoka, Fumio Kai, Kuniomi Matsumoto, Taro Niida, Eiichi Akita
  • Patent number: 4624735
    Abstract: The constituent members of a semiconductor element-manufacturing apparatus which are formed by depositing a silicon carbide layer on a carbon substrate, and wherein a peak X-ray diffraction on the (200) plane of the silicon carbide layer has a half value width of 0.35.degree. or less as measured by the C.sub.u --K.sub..alpha. ray used in the X-ray diffraction analysis.
    Type: Grant
    Filed: February 11, 1985
    Date of Patent: November 25, 1986
    Assignee: Toshiba Ceramics Co., Ltd.
    Inventors: Masao Koyama, Syuitu Matuo, Chiaki Nakayama, Katsumi Hoshina