Patents by Inventor Masao Koyama
Masao Koyama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 6498251Abstract: Compounds containing tetrahydrobenzindole which bind to serotonin receptor and are useful in treatment or prevention of disease induced by abnormality of central peripheral serotonin controlling functions.Type: GrantFiled: March 8, 2001Date of Patent: December 24, 2002Assignee: Meiji Seika Kaisha, Ltd.Inventors: Chika Kikuchi, Takashi Ando, Kazuyuki Fuji, Masayo Okuno, Eriko Morita, Masako Imai, Osamu Ushiroda, Masao Koyama, Toyokazu Hiranuma
-
Patent number: 6407112Abstract: Optically active tetrahydrobenzindole type compounds having affinity for a 5-HT receptor, useful for prevention and treatment of mental diseases. A species compound is (S)-2a-4-(4-(2-methoxyphenyl)piperazinyl)butyl)-2a,3,4,5,-tetrahydro 1 H-benz[cd]indol-2-one.Type: GrantFiled: October 23, 2000Date of Patent: June 18, 2002Assignee: Meiji Seika Kaisha, Ltd.Inventors: Masao Koyama, Osamu Ushiroda, Chika Kikuchi, Takashi Ando, Eriko Morita, Masayo Okuno, Toyokazu Hiranuma
-
Patent number: 6355642Abstract: A compound of formula (I) for use in the treatment or prevention of mental diseases A is N, CH, C having a double bond or CR5; each of B and Z is independently N, CH or CR1, with the proviso that A is N when B and/or Z is N; R1, R2, R3, R4 and R5 and n are as defined in the specification.Type: GrantFiled: December 28, 1998Date of Patent: March 12, 2002Assignee: Meiji Seika Kaisha, Ltd.Inventors: Masao Koyama, Chika Kikuchi, Osamu Ushiroda, Takashi Ando, Hiroshi Nagaso, Kazuyuki Fuji, Masayo Okuno, Toyokazu Hiranuma
-
Patent number: 6332909Abstract: A processing apparatus capable of separating and recovering resins and metals, respectively, from an object being processed, which has resins and metals as its constituent, comprises a first gastight area (102), in which temperature and pressure are regulated so as to permit selective thermal decomposition of resins from the object (150) being processed, a second gastight area (103), which is partitioned from the first gastight area by an openable and closeable partition (105C) and in which temperature and pressure are regulated so as to permit selective vaporization of metals from the object, first recovering chamber (111) connected to the first gastight area for recovering gases produced by thermal decomposition of resins, and second recovering chamber (115) connected to the second gastight area for recovering vaporized metals.Type: GrantFiled: February 23, 1999Date of Patent: December 25, 2001Assignee: Kabushiki Kaisha ToshibaInventors: Kouichi Teshima, Tomohiro Todoroki, Terunobu Hayata, Fuminobu Tezuka, Masao Koyama, Naohiko Oyasato, Tomiaki Furuya, Yoshiaki Yokoyama, Teruhisa Ogihara, Kaichiro Ogihara
-
Patent number: 6172275Abstract: Disclosed is a method and apparatus for pyrolytically decomposing waste plastic which may contain halogen-containing polymer such as PVC. The plastic is heated at 270° to 350° C., whereby a plasticizer contained in the plastic material is decomposed and vaporized, and a chlorine-containing polymer is dechlorinated to produce hydrogen chloride. The vaporized decomposition matter and the hydrogen chloride are removed from the plastic, and the vaporized decomposition matter is separated from the hydrogen chloride. Then isolated plastic is further heated to 450° C. or higher to produce a pyrolysis product. Alternatively, the former heating step is divided into two steps of: heating at a temperature lower than 270° C., whereby a plasticizer is decomposed; and heating to 270° to 350° C., whereby a chlorine-containing polymer contained in the plastic material is dechlorinated. Accordingly, the decomposition matter of plasticizer and hydrogen chloride are separately removed from the plastic.Type: GrantFiled: March 3, 1998Date of Patent: January 9, 2001Assignee: Kabushiki Kaisha ToshibaInventors: Masahiro Tadauchi, Yukishige Maezawa, Terunobu Hayata, Hideki Shimada, Isao Ito, Kazuo Suzuki, Fuminobu Tezuka, Jiro Kano, Takeshi Gotanda, Masao Koyama, Satoshi Kanazawa
-
Patent number: 5747448Abstract: Novel PF 1022 derivatives--cyclodepsipeptides represented by the below-described formula (I)--and acid addition salts thereof, which have been synthesized according to the present invention, have anthelmintic activities against various parasitic worms which are parasitic on human bodies, domestic animals and pet animals. They are therefore useful as anthelmintics for the prevention or treatment of parasitic infections. ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, Q, X, Y and Z have been defined herein.Type: GrantFiled: September 8, 1995Date of Patent: May 5, 1998Assignee: Meiji Seika Kaisha, Ltd.Inventors: Makoto Ohyama, Maki Ohishi, Yumiko Okada, Masao Koyama, Shinjiro Sumi, Yasushi Murai, Masayuki Takagi, Tadaaki Okada, Osamu Sakanaka, Toshio Yoneta, Katsuharu Iinuma, Seiji Shibahara
-
Patent number: 5312833Abstract: Tumor growth in a mammal is inhibited by the administration of an effective amount of xanthocillin X dimethylether. The xanthocillin X dimethylether is administered in a range of 10-3,000 milligrams per day for an average adult human patient. The xanthocillin X dimethylether can be administered orally, by direct application into a neoplastic lesion, or by other parenteral forms of administration including intravenous, subcutaneous, or intramuscular injections. Also, suppository forms can be used.Type: GrantFiled: November 15, 1991Date of Patent: May 17, 1994Assignee: Meiji Seika Kaisha, Ltd.Inventors: Tsutomu Tsuruoka, Harumi Fukuyasu, Katsumi Kawaharajo, Masao Koyama, Hiroshi Kurihara
-
Patent number: 5245937Abstract: A method of burning a combustible solid residue from a chemical plant, which comprises feeding a slurry of combustible solid residues in an oil, the amount of the oil being at least 0.5 part by weight per part by weight of the combustible solid residues, into a burner in a combustion furnace comprised of a main combustion chamber having the burner in its arch, a secondary combustion chamber formed in the lower portion of the main combustion chamber, and a flue gas duct provided beneath and following the secondary combustion chamber, burning the residue in the main combustion chamber, conducting the combustion gas into the secondary combustion chamber, and allowing it to reside at a temperature 800.degree. to 1000.degree. C. for at least 0.5 second.Type: GrantFiled: May 29, 1990Date of Patent: September 21, 1993Assignees: Mitsui Engineering & Shipbuilding Co., Ltd., Mitsui Petrochemical Industries, Ltd.Inventors: Noriaki Nakase, Masao Koyama, Masahiro Inada, Toshiaki Masaoka, Tohoru Abiko, Kenji Takahashi
-
Patent number: 5210097Abstract: A xanthocillin X monomethyl ether derivative represented by the formula (I) ##STR1## wherein R represents an alkyl group, an alkenyl group, an alkoxycarbonyl group, an aralkyl group, an alkyl group substituted with a pyridyl group or a halogen atom, an aralkyl group substituted with an alkyl group or a halogen atom, or an aroyl group, which exerts an intense effect of inhibiting the proliferation of a tumor, in particular, a solid tumor.Type: GrantFiled: May 18, 1990Date of Patent: May 11, 1993Assignee: Meiji Seika Kaisha Ltd.Inventors: Hiroshi Kurihara, Hiromi Watanabe, Masao Koyama, Masaji Sezaki, Tsutomu Tsuruoka, Harumi Fukuyasu, Haruo Yamamoto
-
Patent number: 5164507Abstract: A substance represented by formula: ##STR1## and a salt thereof, which has antifungal activity and a process for producing the same utilizing a microorganism capable of producing the substance and belonging to the genus Streptomyces.Type: GrantFiled: May 21, 1991Date of Patent: November 17, 1992Assignee: Meiji Seika Kaisha Ltd.Inventors: Toru Sasaki, Akira Shimizu, Junko Yoshida, Hiroomi Watabe, Masao Koyama
-
Patent number: 5053431Abstract: The present invention concerns compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen, a hydroxy group or a methoxy group;R.sup.2 is hydrogen or a methyl group;R.sup.3 is hydrogen or a methyl group;Y is a secondary amino group (NHalkyl) or a tertiary amino group (N(alkyl).sub.2); andZ is hydrogen or a halogen.The invention further provides a method of inhibiting topoisomerase II using a compound having the structure: ##STR2## wherein R.sup.1 is hydrogen, a hydroxy group or a methoxy group;R.sup.2 is hydrogen or a methyl group;R.sup.3 is hydrogen or a methyl group;Y is a halogen, secondary amino group (NHalkyl) or a tertiary amino group (N(alkyl).sub.2); andZ is hydrogen or a halogen.The invention further concerns pharmaceutical compositions which comprise the above-identified compound or the acid salts thereof, and the use of the compound or compositions for treating a malignancy in a subject.Type: GrantFiled: June 26, 1990Date of Patent: October 1, 1991Assignee: Sloan-Kettering Institute For Cancer ResearchInventors: Kyoichi A. Watanabe, Masao Koyama, Ting-Chao Chou
-
Patent number: 5037993Abstract: Novel substances exhibiting antimicrobial activity and antitumor activity, a process for producing them by cultivating a microorganism belonging to the genus Streptomyces and capable of producing them and derivatives of such substances.Type: GrantFiled: May 8, 1990Date of Patent: August 6, 1991Assignee: Meiji Seika Kaisha Ltd.Inventors: Kazunori Ohba, Masaji Sezaki, Shinichi Kondo, Masao Koyama, Tadashi Nakazawa, Haruo Yamamoto
-
Patent number: 4994578Abstract: Novel substances exhibiting antimicrobial activity and antitumor activity, a process for producing them by cultivating a microorganism belonging to the genus Streptomyces and capable of producing them and derivatives of such substances.Type: GrantFiled: April 28, 1989Date of Patent: February 19, 1991Assignee: Meiji Seika Kaisha, Ltd.Inventors: Kazunori Ohba, Hiroomi Watabe, Mieko Nagasawa, Shiro Sakakibara, Takashi Shomura, Masaji Sezaki, Shinichi Kondo, Masao Koyama, Tadashi Nakazawa, Haruo Yamamoto
-
Patent number: 4966918Abstract: The present invention concerns compounds of the formula: ##STR1## wherein R.sup.1 hydrogen, a hydroxyl group or a methoxy group;R.sup.2 is hydrogen or a methyl group;R.sup.3 is hydrogen or a methyl group;Y is a halogen, a secondary amino group or a tertiary amino group; andZ is hydrogen or a halogen.The invention further concerns pharmaceutical compositions which comprises the above-identified compound or the acid salts thereof, and the use of the compound or compositions for treating a malignancy in a subject.Type: GrantFiled: January 27, 1989Date of Patent: October 30, 1990Assignee: Sloan-Kettering Institute for Cancer ResearchInventors: Kyoichi A. Watanabe, Masao Koyama
-
Patent number: 4961833Abstract: A field-effect transistor-type semiconductor sensor is provided which comprises first and second semiconductor substrates bonded strongly to each other interposing a silicon oxide film therebetween by the use of a direct-bonding technique. The first semiconductor substrate is formed into an island-shape, and incorporates a source region, a drain region and a gate region. The island-shaped substrate constitutes an ion-sensitive portion, and is immersed in a solution when in use. The second semiconductor substrate has openings in which source and drain electrodes are formed.Type: GrantFiled: March 23, 1989Date of Patent: October 9, 1990Assignee: Kabushiki Kaisha ToshibaInventors: Tadashi Sakai, Shigeki Uno, Masao Koyama, Nanao Nakamura
-
Patent number: 4839378Abstract: Fluorophthalimide compounds represented by the following general formula (I): ##STR1## wherein R each stands for an ethyl group or an isopropyl group, are effective for controlling diseases of agricultural plants, especially diseases caused by microorganisms belonging to the genus Rhizoctonia, represented by sheath blight of rice plants, and diseases caused by Basidomycetes.Type: GrantFiled: April 28, 1987Date of Patent: June 13, 1989Assignee: Meiji Seika Kabushiki KaishaInventors: Masao Koyama, Michiaki Iwata, Kunihiko Kurihara, Masaji Sezaki
-
Patent number: 4758325Abstract: There are disclosed an ion selective electrode comprising a polyvinyl chloride series resin plate having a through hole; conductive member disposed along the through hole; ion sensitive membrane of a polyvinyl chloride series resin membrane; and a lead wire connected to the conductive member, and the flow type ion sensor comprises a plurality of the ion selective electrodes mutually integrally associated with each other with the interposition of electrical insulating members so that through holes of the respective ion selective electrodes may define a flow passage for a liquid to be measured, and a flow type ion sensor using the same.The ion selective electrode and flow type ion sensor using the same of this invention allow the measurement in a smaller amount of the sample to be measured and are excellect in the adhesion of the ion sensitive membranes, therefore they have effects of a stable potential supply and a prolonged life time, and these industrial merits are highly great.Type: GrantFiled: January 10, 1986Date of Patent: July 19, 1988Assignee: Kabushiki Kaisha ToshibaInventors: Ken-ichi Kanno, Tetsuya Gatayama, Masao Koyama
-
Patent number: 4651310Abstract: There is disclosed a polymeric piezoelectric ultrasonic probe using a polymeric piezoelectric member which comprises a polymeric piezoelectric member; a common electrode formed on one surface of the polymeric piezoelectric member; and electrodes for driving provided as opposed to the common electrode with the polymeric piezoelectric member being interposed therebetween, the electrodes for driving being formed on a polymeric thin film.The polymeric piezoelectric ultrasonic probe of the present invention has advantages that not only breaking or short circuit of electrodes shaped in rectangular strips can be prevented, but also it becomes possible to connect lead wires with good reliability. Besides, not only cumbersomeness is registration of electrodes shaped in rectangular strips during lamination of polymeric piezoelectric members can be cancelled, but also acoustic-electrical coupling or cross-talk can be reduced.Type: GrantFiled: December 16, 1985Date of Patent: March 17, 1987Assignee: Kabushiki Kaisha ToshibaInventors: Nagao Kaneko, Nanao Nakamura, Masao Koyama, Shiroh Saitoh, Hiroki Honda
-
Patent number: 4647572Abstract: Triiodoallyl- or iodopropargyl-substituted tetrazole compounds which are prepared by reacting substituted tetrazole compound with reactive derivatives of corresponding triiodoallyl alcohol or iodopropargyl alcohol or by iodinating propargyltetrazole compounds, as well as antibacterial and antifungal compositions for medicinal, agricultural and industrial fields which contain as active ingredient said tetrazole compounds.Type: GrantFiled: October 25, 1983Date of Patent: March 3, 1987Assignee: Meiji Seika Kaisha, Ltd.Inventors: Shigeharu Inouye, Masao Koyama, Keinosuke Miyauchi, Takashi Tsuruoka, Fumio Kai, Kuniomi Matsumoto, Taro Niida, Eiichi Akita
-
Patent number: 4624735Abstract: The constituent members of a semiconductor element-manufacturing apparatus which are formed by depositing a silicon carbide layer on a carbon substrate, and wherein a peak X-ray diffraction on the (200) plane of the silicon carbide layer has a half value width of 0.35.degree. or less as measured by the C.sub.u --K.sub..alpha. ray used in the X-ray diffraction analysis.Type: GrantFiled: February 11, 1985Date of Patent: November 25, 1986Assignee: Toshiba Ceramics Co., Ltd.Inventors: Masao Koyama, Syuitu Matuo, Chiaki Nakayama, Katsumi Hoshina