Patents by Inventor Masatomo Iwao

Masatomo Iwao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fourth-generation EGFR tyrosine kinase inhibitor
    Patent number: 11286261
    Abstract: Provided is a compound having a tyrosine kinase inhibitory activity specific to C797S resistant mutant EGFR (particularly C797S tertiary-resistant mutant EGFR) and is useful as a C797S resistant mutant EGFR (particularly C797S mutant tertiary-resistant EGFR) specific tyrosine kinase inhibitor, an agent for preventing and/or treating non-small cell lung cancer with resistance mutant EGFR and the like, and the like.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: March 29, 2022
    Assignees: NAGASAKI UNIVERSITY, IWATE MEDICAL UNIVERSITY, JAPANESE FOUNDATION FOR CANCER RESEARCH
    Inventors: Masatomo Iwao, Tsutomu Fukuda, Fumito Ishibashi, Yoshimasa Uehara, Naoyuki Nishiya, Yusuke Oku, Shingo Dan, Takao Yamori
  • FOURTH-GENERATION EGFR TYROSINE KINASE INHIBITOR
    Publication number: 20210122759
    Abstract: Provided is a compound having a tyrosine kinase inhibitory activity specific to C797S resistant mutant EGFR (particularly C797S tertiary-resistant mutant EGFR) and is useful as a C797S resistant mutant EGFR (particularly C797S mutant tertiary-resistant EGFR) specific tyrosine kinase inhibitor, an agent for preventing and/or treating non-small cell lung cancer with resistance mutant EGFR and the like, and the like. A compound represented by the formula (I): wherein X is O or NH, R1 and R2 are each independently a hydrogen atom or an optionally substituted hydrocarbon group; R3 and R4 are each independently a hydrogen atom, a halogen atom or an optionally substituted hydrocarbon group, and R5 and R6 are each independently an optionally substituted hydrocarbon group, excluding the following compounds: or a salt thereof.
    Type: Application
    Filed: March 29, 2018
    Publication date: April 29, 2021
    Inventors: Masatomo Iwao, Tsutomu Fukuda, Fumito Ishibashi, Yoshimasa Uehara, Naoyuki Nishiya, Yusukef Oku, Shingo Dan, Takao Yamori