Patents by Inventor Masayuki Heishi

Masayuki Heishi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20040234969
    Abstract: CYP1B1 was obtained as a gene whose expression levels in mononuclear cells greatly differs between a steroid responder group and a poorly steroid responder group of atopic dermatitis patients. CYP1B1 is a gene whose expression levels are reduced in mononuclear cells of the poorly steroid responder group. The present invention provides a method for testing steroid responsiveness and a method of screening for a compound that is useful in improving steroid responsiveness using the expression level of this gene in biological samples as an indicator.
    Type: Application
    Filed: May 19, 2004
    Publication date: November 25, 2004
    Inventors: Sugita Yuji, Masayuki Heishi, Shinji Kagaya, Shigemichi Gunji, Hiroshisa Saito
  • Publication number: 20040197786
    Abstract: RING6 and HLA-DMB are described herein as genes whose expression levels in mononuclear cells greatly differ between a steroid responder group and a poor steroid responder group in atopic dermatitis patients. Specifically, the expression levels of the RING6 and HLA-DMB genes were demonstrated to be reduced in steroid-responsive patients. Using the expression level of such genes in biological samples as markers of steroid responsiveness, the present invention provides a method of testing for steroid responsiveness and a method of screening for compounds that may be used to improve steroid responsiveness.
    Type: Application
    Filed: May 25, 2004
    Publication date: October 7, 2004
    Inventors: Yuji Sugita, Masayuki Heishi, Shinji Kagaya, Shigemichi Gunji, Gozoh Tsujimoto
  • Patent number: 6280951
    Abstract: A method for predicting reactivity to parathyroid hormone by determining the genotype with respect to polymorphism in the parathyroid hormone receptor gene. The results obtained by the analysis of genetic polymophism are useful for predicting the tendency for a hemodialyzed patient to develop severe secondary hyperparathyroidism, or for predicting the tendency for a human individual to develop severe primary hyperparathyroidism. Also, this method is useful for predicting the therapeutic effects by predicting reactivity to parathyroid hormone in a patient who is being treated for regressive osteoporosis by administration of parathyroid hormone.
    Type: Grant
    Filed: March 8, 2000
    Date of Patent: August 28, 2001
    Assignees: Sumikin Bio-Science, Inc.
    Inventors: Masayuki Heishi, Osamu Ishida, Hiromitsu Tazawa, Yusuke Tsukamoto