Abstract: Provided is a zinc oxide element which does not contain antimony oxide and has good nonlinear resistance characteristics (V10 kA/V1 mA nonlinearity) by controlling the particle size of zinc oxide particles in a sintered body. The zinc oxide element of the present invention includes a fired body containing zinc oxide, bismuth oxide, and zinc stannate (Zn2SO4). A method for producing a zinc oxide element of the present invention includes firing a raw material oxide that contains zinc oxide, bismuth oxide, and tin oxide and does not contain antimony oxide, and segregating zinc stannate (Zn2SO4) at grain boundaries of the fired zinc oxide.

Abstract: An object of the present invention is to provide an anti-CLDN4/anti-CD137 bispecific antibody usable in treatment of cancer. An anti-CLDN4/anti-CD137 bispecific antibody produced using an anti-CLDN4 antibody binding to CLDN4 and an anti-CD137 antibody binding to CD137 had agonistic activity for CD137, promoted production of interferon ? by a T cell, and exhibited cytotoxic activity against a cancer cell expressing CLDN4 on a cell surface thereof. Besides, it was shown that the anti-CLDN4/anti-CD137 bispecific antibody can be safely administered to monkeys. Therefore, the anti-CLDN4/anti-CD137 bispecific antibody is usable in treatment of human cancer.

Abstract: An object of the present invention is to provide an anti-CLDN4/anti-CD137 bispecific antibody usable in treatment of cancer. An anti-CLDN4/anti-CD137 bispecific antibody produced using an anti-CLDN4 antibody binding to CLDN4 and an anti-CD137 antibody binding to CD137 had agonistic activity for CD137, promoted production of interferon ? by a T cell, and exhibited cytotoxic activity against a cancer cell expressing CLDN4 on a cell surface thereof. Besides, it was shown that the anti-CLDN4/anti-CD137 bispecific antibody can be safely administered to monkeys. Therefore, the anti-CLDN4/anti-CD137 bispecific antibody is usable in treatment of human cancer.

Abstract: An objective of the present invention is to provide an anti-TSPAN8/anti-CD3 bispecific antibody and an anti-TSPAN8 antibody usable in treatment or prevention in human. A human monoclonal antibody producing mouse was immunized with a peritoneal disseminated cancer cell isolated from a patient, to obtain an antibody 16B11 and an antibody 16B12 that selectively bind to a peritoneal disseminated cancer cell. These antibodies were anti-TSPAN8 antibodies that bind to the region from amino acid positions 126 to 155 of TSPAN8 and exhibited strong binding activity to TSPAN8 expressed in the peritoneal disseminated cancer cell. Further, an anti-TSPAN8(16B11)-anti-CD3 bispecific antibody produced based on the sequence of 16B11 exhibited a cytotoxic activity against the TSPAN8-expressing cancer cell in vitro, exerted an anti-tumor action on TSPAN8-expressing cancer cell-bearing mice in vivo, and extended the lifetime of peritoneal dissemination model mice.

Abstract: An objective of the present invention is to provide an anti-TSPAN8/anti-CD3 bispecific antibody and an anti-TSPAN8 antibody usable in treatment or prevention in human. A human monoclonal antibody producing mouse was immunized with a peritoneal disseminated cancer cell isolated from a patient, to obtain an antibody 16B11 and an antibody 16B12 that selectively bind to a peritoneal disseminated cancer cell. These antibodies were anti-TSPAN8 antibodies that bind to the region from amino acid positions 126 to 155 of TSPAN8 and exhibited strong binding activity to TSPAN8 expressed in the peritoneal disseminated cancer cell. Further, an anti-TSPAN8(16B11)-anti-CD3 bispecific antibody produced based on the sequence of 16B11 exhibited a cytotoxic activity against the TSPAN8-expressing cancer cell in vitro, exerted an anti-tumor action on TSPAN8-expressing cancer cell-bearing mice in vivo, and extended the lifetime of peritoneal dissemination model mice.

Abstract: In a control device, an instruction acquirer acquires an instruction to suppress in a specified period supplying of generated power generated by power generator installed in a power-consuming area to a commercial electrical power system. Upon the instruction acquirer acquiring the instruction, a water heater controller commands a water heater installed in the power-consuming area to perform a water heat-up operation when a predetermined condition is satisfied in the specified period.

Abstract: An objective of the present invention is to provide an anti-TSPAN8/anti-CD3 bispecific antibody and an anti-TSPAN8 antibody usable in treatment or prevention in human. A human monoclonal antibody producing mouse was immunized with a peritoneal disseminated cancer cell isolated from a patient, to obtain an antibody 16B11 and an antibody 16B12 that selectively bind to a peritoneal disseminated cancer cell. These antibodies were anti-TSPAN8 antibodies that bind to the region from amino acid positions 126 to 155 of TSPAN8 and exhibited strong binding activity to TSPAN8 expressed in the peritoneal disseminated cancer cell. Further, an anti-TSPAN8(16B11)-anti-CD3 bispecific antibody produced based on the sequence of 16B11 exhibited a cytotoxic activity against the TSPAN8-expressing cancer cell in vitro, exerted an anti-tumor action on TSPAN8-expressing cancer cell-bearing mice in vivo, and extended the lifetime of peritoneal dissemination model mice.

Abstract: In a control device, an instruction acquirer acquires an instruction to suppress in a specified period supplying of generated power generated by power generator installed in a power-consuming area to a commercial electrical power system. Upon the instruction acquirer acquiring the instruction, a water heater controller commands a water heater installed in the power-consuming area to perform a water heat-up operation when a predetermined condition is satisfied in the specified period.

Abstract: A connection management device is communicatively connected to a plurality of server devices. A receiver receives from a terminal device a request for connection to one of the plurality of server devices. A location information extractor extracts, from the request for connection, location information indicating a location where the terminal device exists. A region determiner determines, based on the extracted location information, a region where the terminal device exists. A connection destination determiner determines, based on the determined region, which of the plurality of server devices is the server device to which the terminal device is to connect. A transmitter transmits to the determined server device the request for connection received from the terminal device.

Abstract: In a control device, an instruction acquirer acquires an instruction to suppress in a specified period supplying of generated power generated by power generator installed in a power-consuming area to a commercial electrical power system. Upon the instruction acquirer acquiring the instruction, a water heater controller commands a water heater installed in the power-consuming area to perform a water heat-up operation when a predetermined condition is satisfied in the specified period.

Abstract: A connection management device is included in a terminal device, which is communicatively connected to a plurality of server devices. A location information acquirer acquires location information indicating a location where the terminal device exists. A region determiner determines based on the acquired location information, a region where the terminal device exists. A connection destination determiner determines, based on the determined region, which of the plurality of server devices is the server device to which the terminal device is to connect. A transmitter transmits to the determined server device a request for connection to connect to the server device.

Abstract: A register includes an annular fin that can improve the directivity of air conditioning air while suppressing increase in the number of parts. A front fin includes an annular-shaped annular fin portion. A bezel has upstream side inclined surfaces formed on inner peripheral surfaces facing with each other in the shorter side direction (vertical direction) of an air blow outlet. The upstream side inclined surfaces incline toward a direction of approaching the annular fin portion from an upstream side toward a downstream side of an air blowing direction. An air conditioning air flowing in the air blowing direction is guided to the annular fin portion side by the upstream side inclined surfaces.

Abstract: A connection management device is communicatively connected to a plurality of server devices. A receiver receives from a terminal device a request for connection to one of the plurality of server devices. A location information extractor extracts, from the request for connection, location information indicating a location where the terminal device exists. A region determiner determines, based on the extracted location information, a region where the terminal device exists. A connection destination determiner determines, based on the determined region, which of the plurality of server devices is the server device to which the terminal device is to connect. A transmitter transmits to the determined server device the request for connection received from the terminal device.

Abstract: An information processing device (1) includes a signal receiver (12), an entry information inputter (16), a storage (11), and a document information generator (15). The signal receiver (12) receives a signal representing a transfer request to transfer data. The entry information inputter (16) inputs entry information that is information to be entered into a transfer procedure document that is a document for a transfer procedure with respect to the transfer request. The storage (11) stores the entry information inputted by the entry information inputter (16).

Abstract: A latch mechanism is configured to be shifted between a closed state in which a glove door is held on a compartment body at a closed position and an open state in which the glove door is not held on the compartment body. An operation lever is operated to shift the lock mechanism from the closed state to the open state. When the latch mechanism is shifted to the closed state, the first engaging member is engaged with the engagement hole. When the latch mechanism is shifted to the open state, the first engaging member is disengaged from the engagement hole. The compartment body includes an operation restriction wall that restricts operation of the first engaging member from the side surface of an instrument panel or the side surface of the compartment body so that the first engaging member is not disengaged from the engagement hole.

Abstract: A settings data storage stores unique serial numbers and information regarding a plurality of patterns for alternately switching between normal operation for operating at high capacity and suppressed operation for operating at low capacity each unit time. A pattern specifier determines information for a pattern set in accordance with even and odd serial numbers. A water-heating heat amount determiner determines a heat amount necessary for water heating. A water heating scheduler establishes a water heating plan based on information regarding the pattern determined by the pattern determiner and the water-heating heat amount as determined by the water-heating heat amount determiner. A water heating controller alternately switches between normal operating and suppressed operation to heat water in accordance with the water heating plan established by the water heating scheduler.

Abstract: In an appliance control system, a receiver receives, from a terminal device used by a first user, an instruction for remotely controlling an appliance installed in a home. A determiner determines whether a second user is present in a location in which an appliance-to-be-instructed is installed. When it is determined that the second user is not present in a location in which the appliance-to-be-instructed is installed, an appliance controller controls the appliance on the basis of the instruction. On the other hand, when it is determined that the second user is present in the location in which the appliance-to-be-instructed is installed, the appliance controller does not control the appliance.

Abstract: An apparatus control system includes smart glasses worn by a user, a home electrical apparatus that is a target of control, and a controller that controls the home electrical apparatus. In the smart glasses, a sensor detects information including at least one of image information, motion information, biological information, or environmental information. A communicator transmits to the controller the information detected by the sensor. The controller, based on the information detected by the sensor, determines a recommended operation indicating operational content recommended with respect to a recommended apparatus, and transmits the determined recommended operation to the smart glasses. The communicator receives the recommended operation transmitted from the controller. The display displays a candidate group for selection of the home electrical apparatus along with a recommended operation received from the communicator.

Abstract: A register faces a specific seat and feeds air to the specific seat. An hypothetical reference line is defined that extends in the front-back direction of the specific seat through the center in the width direction of the specific seat. In comparison between a first bezel side wall and a second bezel side wall, the second bezel side wall is positioned closer to the reference line than the first bezel side wall. A second duct side wall is bent such that a downstream side of the second duct side wall is positioned farther in the width direction from the reference line than an upstream side of the second duct side wall.

Abstract: An EV priority switch is configured to allow a user to request a change between an EV priority mode and an HV mode. If an SOC of a power storage device is less than a first threshold value when the change to the HV mode is requested from the EV priority switch during the EV priority mode, an ECU changes the running mode to attain the HV mode and controls the SOC to be close to the SOC at the moment of a request for the change to the HV mode. If the SOC is greater than or equal to the first threshold value, the ECU maintains the EV priority mode. If the SOC reaches a second threshold value less than the first threshold value, the ECU forcefully changes the running mode to attain the HV mode.