Patents by Inventor Masuo Koizumi

Masuo Koizumi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4507309
    Abstract: A treating agent whose effective ingredient is an anthranyl derivative of the formula: ##STR1## (wherein R.sub.1 and R.sub.2 may be the same or different and represent a hydrogen atom, a hydroxyl group, a lower alkoxy group, preferably C.sub.1 -C.sub.3 alkoxy group, a lower alkyl group, preferably C.sub.1 -C.sub.3 alkyl group, a nitro group or a halogen atom) is disclosed.
    Type: Grant
    Filed: April 12, 1982
    Date of Patent: March 26, 1985
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Shin-ichi Kaiho, Koji Mizuno, Shun-ichi Hata, Masuo Koizumi, Masamitsu Honda, Yasushi Murakami, Shigeru Takanashi, Minoru Shindo
  • Patent number: 4500714
    Abstract: Benzamide derivatives of the formula: ##STR1## wherein R.sub.1 is a hydrogen atom, a methyl group or a methoxy group; R.sub.2 is a straight-chain or branched-chain alkyl group having 2 to 8 carbon atoms, a substituted phenyl group, or group --NHR.sub.4, R.sub.4 being a hydrogen atom, a straight-chain or branched-chain or cyclic alkyl group having 1 to 6 carbon atoms, or a phenyl group that may have a substituent on the nucleus; R.sub.3 is a hydrogen atom or one or two alkyl groups having 1 to 4 carbon atoms and n is 0 or 1, a process for preparing these derivatives, and pharmaceutical compositions containing the same are provided.The compounds of the above formula have the action to reduce the blood glucose level and, therefore, are useful as medicines.
    Type: Grant
    Filed: October 7, 1982
    Date of Patent: February 19, 1985
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Masamitsu Honda, Hideaki Nagai, Shoko Takishima, Akinori Kawamura, Noriko Kawamura, Takashi Dan, Masuo Koizumi, Yasushi Murakami, Yoshikazu Hinohara, Hideki Nakano, Yoshio Takagaki
  • Patent number: 4435391
    Abstract: Dibenzoxazepine derivatives of the formula: ##STR1## wherein R.sub.1, n, R.sub.2 and R.sub.3 are as defined in the description, process for preparing the same, pharmaceutical composition containing the same and method of treating diseases in circulatory organs administering the composition to a patient are disclosed.The compounds of the formula have lipid lowering activity, lipid peroxide lowering activity, blood sugar lowering activity and activity to inhibit the aggregation of platelets, and hence are useful as a medicine.
    Type: Grant
    Filed: March 4, 1982
    Date of Patent: March 6, 1984
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Kazuo Sasahara, Masamitsu Honda, Masuo Koizumi, Yasushi Murakami, Tomohiro Neichi, Hiroshi Nakakimura, Yukifumi Noda, Hiroshi Matsushita, Shun-ichi Hata
  • Patent number: 4435202
    Abstract: A plant growth regulator containing as an active ingredient one or more compounds represented by the formula ##STR1## wherein R, X, Y and Z are defined in the specification is disclosed. The plant growth regulator is effective for a wide variety of plants, particularly for grassy plants. In addition to such activity, the regulator of this invention acts on plants to thicken the foliage and to aid health growth without causing substantial phytotoxicity.
    Type: Grant
    Filed: March 29, 1982
    Date of Patent: March 6, 1984
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Masuo Koizumi, Norio Shirakawa, Hiromi Tomioka, Masaki Takeuchi, Masanori Okada, Masahiro Yoshimoto, Yasushi Murakami, Yoshitaka Iwane
  • Patent number: 4379150
    Abstract: Dibenz[b,f][1,4]oxazepine derivatives of the formula ##STR1## (wherein R.sub.1 is a hydrogen atom or a lower alkyl group; R.sub.2 is a branched lower alkyl group; R.sub.3 is a hydrogen atom, a carboxyl group, a carbamoyl group, a lower alkoxycarbonyl group, or a lower alkoxy group; R.sub.4 and R.sub.5 are each a lower alkyl group or may, when taken together with a nitrogen atom, form a heterocyclic ring; and A is a lower alkylene group) or salts thereof, a process for preparing the same and pharmaceutical compositions comprising the same are disclosed. The derivatives of the formula above are effective to prevent and treat circulatory diseases, especially angina pectoris, and therefore, useful as medicines.
    Type: Grant
    Filed: December 17, 1981
    Date of Patent: April 5, 1983
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Kiyohiko Ito, Masuo Koizumi, Yasushi Murakami, Michitaka Akima, Jinichiro Aono, Yasuhiro Ohba, Tamotsu Yamazaki, Kazushige Sakai, Shun-ichi Hata, Shigeru Takanashi
  • Patent number: 4377407
    Abstract: Isonicotinanilide derivatives of the formula ##STR1## (wherein R.sub.1 is a hydrogen atom or a lower alkyl group; X is a halogen atom or methyl; n is an integer of from 0 to 2; R.sub.2 is phenyl, halo-substituted phenyl or a lower alkyl group; and Q is ##STR2## provided that Q is ##STR3## or --CH.sub.2 --when R.sub.2 is phenyl or halo-substituted phenyl, and Q is ##STR4## when R.sub.2 is a lower alkyl group) a process for preparing the same and a plant growth regulator containing the same are disclosed. The derivatives of the formula above have good activity for regulating the growth of various plants, especially of grassy plants.
    Type: Grant
    Filed: September 28, 1981
    Date of Patent: March 22, 1983
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Norio Shirakawa, Hiromi Tomioka, Masuo Koizumi, Masaki Takeuchi, Hiroshi Sugiyama, Masanori Okada, Masahiro Yoshimoto, Yoshitaka Iwane, Yasushi Murakami
  • Patent number: 4290953
    Abstract: Dibenz[b,f][1,4]oxazepine derivatives represented by the formula ##STR1## [wherein R.sub.1, n, R.sub.2 and R.sub.3 are as defined in the specification], and a process for preparing the same are disclosed. The object compounds have excellent serum cholesterol lowering activity, serum lipid lowering activity, blood lipid peroxide lowering activity and anti-aggregation of platelet activity, and therefore are useful as a drug.
    Type: Grant
    Filed: December 5, 1979
    Date of Patent: September 22, 1981
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Masuo Koizumi, Kazuo Sasahara, Yasushi Murakami, Sakae Wada, Hiroshi Nakakimura, Noboru Kubodera, Shun-Ichi Hata