Abstract: The present invention is based on the idea of determining certain molecular lipids from a subject's blood sample, for example from serum or plasma sample, and based on the amounts of the determined lipids determining the amount of liver fat and/or diagnosing NAFLD in the subject. More specifically the subjects with elevated liver fat amount and NAFLD are characterized by elevated triglycerides with low carbon number and double bond content in the blood sample. Lysophosphatidylcholines, ether phospholipids, sphingomyelins and PUFA-containing phospholipids are diminished in the blood samples of subjects with an elevated liver fat amount and NAFLD. The method of the present invention can be further used for monitoring the subject's response to the treatment of NAFLD or to the treatment of lowering of the liver fat amount in the subject.

Abstract: This invention relates to a method for diagnosing a subject's increased risk of progressing to Alzheimer disease by measuring the concentration of a metabolite and comparing them to respective mean concentration of healthy subjects. According to the invention the increased risk of progressing to Alzheimer's disease by a subject with mild cognitive impairment can be diagnosed without invasive technology.

Abstract: Method/system for visualizing biological information. The system receives a user query relating to biological information and determines which database contains related biological information. A database query is sent to the database and the result indicates biological/chemical entities and relations. A network is created based on the result; biological/chemical entities are mapped to network nodes and relations to network connections. A distance matrix indicates a multi-dimensional distance for several pairs of network nodes. A dimensionality reduction function is adjusted based on a research context, to bias the search toward a relevant focus. The number of dimensions in the distance matrix is lowered by the dimensionality reduction function. Neighbors of a selected node are searched (2-18) based on the distance matrix to elucidate a biological role of the selected node. A re-created network is visualized (2-20) based on the adjusted dimensionality reduction function.

Abstract: The invention comprises methods for diagnosing the risk of onset of type 1 diabetes and for preventing the onset of type 1 diabetes. The genetic background, metabolomes, antibodies and diversity of gut microbiota of an individual can be used for diagnosis.

Abstract: The present invention provides methods and systems for developing profiles of a biological system based on the discernment of similarities, differences, and/or correlations between biomolecular components of a plurality of biological samples. Preferably, the method comprises utilizing hierarchical multivariate analysis of spectrometric data at one or more levels of correlation.

Abstract: The present teachings relate to gaining insight into biological states, e.g., disease states or drugged states, by gathering, integrating, and combining biomolecular data. More particularly, the present teachings relate to methods and systems for profiling a state of a biological system, finding accessible biomarkers representative of the state of a biological system, and deriving insights into the biochemistry of a biological system for therapeutic, diagnostic, prognostic and other purposes.

Abstract: The invention concerns a method for diagnosing a child's susceptibility for developing type 1 diabetes by using a serum metabolite as biomarker. The invention concerns also a method for prevention of the onset of type 1 diabetes in a child.

Abstract: This invention provides a diagnostic method for determining statin induced myopathy. The method is especially applicable for determining warnings, early signs and also symptomatic myopathy. The method includes collecting a lipidomic profile from a biological sample such as blood or serum and comparing the obtained lipidomic profile to reference lipidomic markers. The reference lipidomic markers have been established by combining a pro-inflammatory muscle tissue gene expression profile with a lipidomic profile associated with high dosage statin treatment. This invention also relates to a kit for performing a method for determining statin induced myopathy.

Abstract: The present invention relates to the field of plant secondary metabolites, particularly terpenoid indole alkaloids. More particularly the present invention relates to the production of the anti-cancer metabolites vincristine and vinblastine. The invention provides novel polynucleotide sequences derived from Catharanthus roseus and the use of said polynucleotide sequences to stimulate the production of vinblastine and/or vincristine in plants of Catharanthus roseus and plant cell lines derived thereof. The invention further relates to recombinant plants, plant cells, tissue and organ cultures obtainable by the process of the invention.

Abstract: A method for processing information on compounds of molecular classes sharing common building blocks. The method comprises maintaining pathway information on the compounds at individual compound level and/or generic class level (13-1); generating a diversity of the compounds based on a set of seed structures, each seed structure describing a lipid compound having a higher-than-average likelihood to occur in nature (13-2); using a formal description language to express the seed structures (13-3); using the structural elements to generate expected spectra for each compound, by using known experimental conditions for mass spectrometry (13-4); performing one or more spectroscopy experiments to obtain compound information (13-5); and linking the obtained compound information to existing information on the molecular classes (13-6).

Abstract: Method/system for visualizing biological information. The system receives a user query relating to biological information and determines which database contains related biological information. A database query is sent to the database and the result indicates biological/chemical entities and relations. A network is created based on the result; biological/chemical entities are mapped to network nodes and relations to network connections. A distance matrix indicates a multi-dimensional distance for several pairs of network nodes. A dimensionality reduction function is adjusted based on a research context, to bias the search toward a relevant focus. The number of dimensions in the distance matrix is lowered by the dimensionality reduction function. Neighbours of a selected node are searched (2-18) based on the distance matrix to elucidate a biological role of the selected node. A re-created network is visualised (2-20) based on the adjusted dimensionality reduction function.

Abstract: Normalization of spectra, including: preparing experiment runs; processing them in an LC/MS spectrometer to obtain a spectrum for each experiment run; internally representing each spectrum as mass/charge (m/z) versus retention time (rt); performing a peak detection of each spectrum; internally aligning the detected peaks; and normalizing the spectra, which includes modelling variation of Yij, denoted ?Yij, as a function of variability of ?, denoted f(??). ? denotes variability of a quantity, (the quantity's deviation from an average value of the quantity over the sample runs); X=Xij=intensity matrix for all peaks, mapped to Y via a first transformation function f such that Y=f?1(X); Z=Zij=intensity matrix for internal standard peaks (IS1-IS4), mapped to ? via a second transformation function t such that ?=t?1 (Z). i denotes peaks: i?{m/z, rt} and i=1 . . . N; and j denotes experiment runs.

Abstract: This invention provides a diagnostic method for determining statin induced myopathy. The method is especially applicable for determining warnings, early signs and also symptomatic myopathy. The method includes collecting a lipidomic profile from a biological sample such as blood or serum and comparing the obtained lipidomic profile to reference lipidomic markers. The reference lipidomic markers have been established by combining a pro-inflammatory muscle tissue gene expression profile with a lipidomic profile associated with high dosage statin treatment. This invention also relates to a kit for performing a method for determining statin induced myopathy.

Abstract: The present invention provides methods and systems for developing profiles of a biological system based on the discernment of similarities, differences, and/or correlations between biomolecular components, of a single biomolecular component type, of a plurality of biological samples. Preferably, the method comprises utilizing hierarchical multivariate analysis of spectrometric data at one or more levels of correlation.

Abstract: The present invention provides methods and systems for developing profiles of a biological system based on the discernment of similarities, differences, and/or correlations between biomolecular components, of a single biomolecular component type, of a plurality of biological samples. Preferably, the method comprises utilizing hierarchical multivariate analysis of spectrometric data at one or more levels of correlation.

Abstract: Methods and systems are disclosed for developing profiles of a state of a biological system based on the discernment of similarities, differences, and/or correlations between a plurality of data sets that are derived from one or more biomolecular component types, one or more biological sample types, and/or one or more types of measurements.