Abstract: The present invention relates to a family of peptides encoding antagonists of the vasoactive intestinal peptide (VIP) designed to distinguish multiple receptors that mediate VIP neurotransmission, neurotrophism and cell division. The invention also relates to methods of using these peptides to antagonize VIP-associated activity and function. The invention further relates to pharmaceutical compositions dsigned to inhibit VIP-associated activity.

Abstract: There are provided pharmaceutical compositions for topical transdermal application for the treatment of male impotence. The active ingredients of such compositions are selected from vasoactive intestinal peptide (VIP), effective derivatives thereof and effective fragments thereof. In the compositions for the treatment of male impotence a transdermally effective conjugate of VIP, its derivatives or fragments coupled to a hydrophogic moiety, is used.

Abstract: A process for producing reagents useful in organic synthesis, for removing metal values from solutions thereof, for the capture of aldehydes, of the general formula ##STR1## wherein Z designates a recurring part (CH.sub.2 --CH--CH.sub.2) of a polymeric backbone of a polymer like polystyrene, of a copolymer comprising polystyrene and divinylbenzene, and butadiene, or other copolymers comprising styrene moieties; or wherein Z is the aliphatic moiety of a long-chain aralkyl compound having a terminal aryl group; or wherein Z designates alkyl; corresponding compounds wherein instead of the optionally substituted phenyl group there is present an optionally substituted naphthyl group; wherein n is an integer of from 1 to 15, and wherein Q designates a group selected from: ##STR2## wherein R designates --H, lower alkyl, aryl, which may be substituted and wherein R" designates --H, alkyl, aryl, halogen, nitro or carboxy, or ##STR3## wherein R is --H, lower alkyl, aryl (which may be substituted), R.sub.

Abstract: A process for producing reagents useful in organic synthesis, for removing metal values from solutions thereof, for the capture of aldehydes, of the general formula ##STR1## wherein Z designates a recurring part (CH.sub.2 --CH--CH.sub.2 -- of a polymeric backbone of a polymer like polystyrene, of a copolymer comprising polystyrene and divinylbenzene, and butadiene, or other copolymers comprising styrene moieties; or wherein Z is the aliphatic moiety of a long-chain aralkyl compound having a terminal aryl group; or wherein Z designates alkyl; corresponding compounds wherein instead of the optionally substituted phenyl group there is present an optionally substituted naphthyl group; wherein n is an integer of from 1 to 15, and wherein Q designates a group selected from: ##STR2## wherein R designates --H, lower alkyl, aryl, which may be substituted and wherein R" designates --H, alkyl, aryl, halogen, nitro or carboxy, or ##STR3## wherein R is --H, lower alkyl, aryl (which may be substituted), R.sub.

Abstract: A process for producing reagents useful in organic synthesis, of the general formula ##SPC1##WhereinZ designates the ##EQU1## part of a polymeric backbone of a polymer like polystyrene, a copolymer comprising polystyrene and a comonomer like divinylbenzene, butadiene, and other copolymers comprising styrene, or wherein Z designates the aliphatic moiety of a long-chain aralkyl compound having a terminal phenyl moiety;n is an integer from 1 to 8, inclusive;R designates oxygen or sulfur;X designates nitro, carbonyl, carboxyl, cyano-carbalkoxy or a carboxamido group which may be substituted on the nitrogen atom, or a halogen atom, or alkyl, unsaturated alkyl, aralkyl;RH and X together designate hydroxytriazole; which comprises reacting a compound of the general formula ##SPC2##Wherein Y designates --Cl, --Br, or --OH and X and R are as defined above, with a polystyrene polymer or with a copolymer as defined above, or with a long-chain araliphatic compound as defined above, in a Friedel-Crafts reaction.