Abstract: A method of delivering an agent to a mammal includes providing a device with an agent for delivery of the agent to anal and/or perianal tissues of the mammal. The device is inserted into an anus of the mammal and then an expandable portion of the device is expanded to anchor the device within the anus.

Abstract: An instrument guiding trajectory guide can include a ball-and-socket motion constrained by an arch. Z-height adjustment of a trajectory guide lumen can be provided, with or without a ball-and-socket, such as to permit target-centered alignment of the trajectory to a target. A polar-offset or x-y stage can be included. Contrast-enhanced imageable fiducial marker concentric rings can be used to help align the trajectory to the target. The concentric rings can be progressively smaller in a direction along the trajectory.

Abstract: A device or substance (e.g., a breast implant material) can be introduced through a port placed in a skin incision. A blunt blade can extend laterally with respect to a distal opening of the port. The blade can be rotated with respect to the port beneath a layer of skin, such as to separate the skin from underlying tissue. A device or substance can be introduced through a proximal port opening and then through a distal port opening and into the subject via a channel provided by the port. Rotating the blade can include rotating a first blade with respect to a second blade, such as can be performed by a user with one hand manipulating handles associated with the device.

Abstract: Reamer sleeves, reamer assemblies, and methods of assembling the reamer assemblies are disclosed. The reamer sleeves include a base portion with a top surface and a bottom surface and a securement mechanism extending away from the top surface of the base portion. The securement mechanism includes an opening, at least one engagement member adjacent the opening, and at least one engagement protrusion extending away from the engagement member into the opening. The opening extends through the securement mechanism to the bottom surface of the base portion. The bone reamer assembly including a reamer and a reamer sleeve removably coupled to the reamer. The reamer including a shaft with a first and second end, a cutting member coupled to the second end of the shaft, and a groove near the second end of the shaft. A method of assembling a hard tissue reamer assembly is also disclosed.

Abstract: Implant devices and cutting clamp apparatuses and methods for creating the implants for insertion into a patient's joint to restore anatomic length and assist in final positioning of the bones following removal of cartilage and/or bone in preparation for fusion. A first implant is a biplanar implant having a shape to mimic the normal anatomical shape of the bones the implant is configured to mate with. The first implant may be cut using a cutting clamp and jig having the anatomical shape of the bones the implant will be inserted within or between. A second implant is a cylindrical piece of bone having a convex end and a concave end for mating with bones reamed to have the opposite mating surfaces. The second implant is created using cup and cone reamers having dimensions corresponding to the size of the patient's bones. Surgical methods for inserting the implants within a patient.

Abstract: This document discusses, among other things, examples of a low profile instrument immobilizer and means for positioning the same. In one example, the low profile instrument immobilizer grasps, secures, and immobilizes an electrode or other instrument that extends through a burr hole in a skull to a target location in a patient's brain.

Abstract: Implant devices and cutting clamp apparatuses and methods for creating the implants for insertion into a patient's joint to restore anatomic length and assist in final positioning of the bones following removal of cartilage and/or bone in preparation for fusion. A first implant is a biplanar implant having a shape to mimic the normal anatomical shape of the bones the implant is configured to mate with. The first implant may be cut using a cutting clamp and jig having the anatomical shape of the bones the implant will be inserted within or between. A second implant is a cylindrical piece of bone having a convex end and a concave end for mating with bones reamed to have the opposite mating surfaces. The second implant is created using cup and cone reamers having dimensions corresponding to the size of the patient's bones. Surgical methods for inserting the implants within a patient.

Abstract: This document discusses, among other things, examples of a low profile instrument immobilizer and means for positioning the same. In one example, the low profile instrument immobilizer grasps, secures, and immobilizes an electrode or other instrument that extends through a burr hole in a skull to a target location in a patient's brain.

Abstract: Implant devices and cutting clamp apparatuses and methods for creating the implants for insertion into a patient's joint to restore anatomic length and assist in final positioning of the bones following removal of cartilage and/or bone in preparation for fusion. A first implant is a biplanar implant having a shape to mimic the normal anatomical shape of the bones the implant is configured to mate with. The first implant may be cut using a cutting clamp and jig having the anatomical shape of the bones the implant will be inserted within or between. A second implant is a cylindrical piece of bone having a convex end and a concave end for mating with bones reamed to have the opposite mating surfaces. The second implant is created using cup and cone reamers having dimensions corresponding to the size of the patient's bones. Surgical methods for inserting the implants within a patient.

Abstract: A trajectory guide for introducing an instrument into a human or animal subject is described. A guide stem can be removed in sections without disturbing the aligned instrument. An access port portion of the trajectory guide can be left in place, without disturbing trajectory alignment, and can allow overlying skin to be sutured closed. The access port can provide infusate delivery, such as using an injection port, catheter or the like. A fiducial marker arrangement can provide easy and accurate trajectory alignment, for use with the present trajectory guide, another trajectory guide, or without any trajectory guide.

Abstract: Implant devices and cutting clamp apparatuses and methods for creating the implants for insertion into a patient's joint to restore anatomic length and assist in final positioning of the bones following removal of cartilage and/or bone in preparation for fusion. A first implant is a biplanar implant having a shape to mimic the normal anatomical shape of the bones the implant is configured to mate with. The first implant may be cut using a cutting clamp and jig having the anatomical shape of the bones the implant will be inserted within or between. A second implant is a cylindrical piece of bone having a convex end and a concave end for mating with bones reamed to have the opposite mating surfaces. The second implant is created using cup and cone reamers having dimensions corresponding to the size of the patient's bones. Surgical methods for inserting the implants within a patient.

Abstract: Implant devices and cutting clamp apparatuses and methods for creating the implants for insertion into a patient's joint to restore anatomic length and assist in final positioning of the bones following removal of cartilage and/or bone in preparation for fusion. A first implant is a biplanar implant having a shape to mimic the normal anatomical shape of the bones the implant is configured to mate with. The first implant may be cut using a cutting clamp and jig having the anatomical shape of the bones the implant will be inserted within or between. A second implant is a cylindrical piece of bone having a convex end and a concave end for mating with bones reamed to have the opposite mating surfaces. The second implant is created using cup and cone reamers having dimensions corresponding to the size of the patient's bones. Surgical methods for inserting the implants within a patient.

Abstract: A trajectory guide for introducing an instrument into a human or animal subject is described. A guide stem can be removed in sections without disturbing the aligned instrument. An access port portion of the trajectory guide can be left in place, without disturbing trajectory alignment, and can allow overlying skin to be sutured closed. The access port can provide infusate delivery, such as using an injection port, catheter or the like. A fiducial marker arrangement can provide easy and accurate trajectory alignment, for use with the present trajectory guide, another trajectory guide, or without any trajectory guide.

Abstract: A system can be used to navigate or guide an instrument or device into an anatomy of a patient. The navigation can occur with the use of image data acquired of the patient. The image data can be registered to the patient space for navigation. One or more tracking devices can be the associated with the patient and with guiding instruments for tracking guiding devices relative to the patient.

Abstract: Orthopaedic plate and spreader apparatuses and methods for distracting and compressing bones and fractured bones in a patient. A first orthopaedic plate and tab assembly has ratcheting teeth on the plate and tab for distracting two bone surfaces to a desire wedge shape. The plate may have longitudinal and diametral curvatures. A second orthopaedic plate and tab assembly has a female plate with ratcheting teeth configured to mate with a male plate with ratcheting teeth for compression and distraction of two bone surfaces. The ratcheting teeth of the first and second orthopaedic plate and tab assemblies may be one way ratcheting teeth or two way ratcheting teeth. Surgical methods for inserting the implants within the patient.

Abstract: Devices and methods provide accurate targeting, placement, and/or stabilization of an electrode or other instrument(s) into the brain or other body organ, such as to treat severe tremor or other neurological disorders. Targeting is performed using any form of image-guidance, including real-time MRI, CT, or frameless surgical navigation systems.

Abstract: Devices and methods provide accurate targeting, placement, and/or stabilization of an electrode or other instrument(s) into the brain or other body organ, such as to treat severe tremor or other neurological disorders. Targeting is performed using any form of image-guidance, including real-time MRI, CT, or frameless surgical navigation systems.

Abstract: Reamer sleeves, reamer assemblies, and methods of assembling the reamer assemblies are disclosed. The reamer sleeves include a base portion with a top surface and a bottom surface and a securement mechanism extending away from the top surface of the base portion. The securement mechanism includes an opening, at least one engagement member adjacent the opening, and at least one engagement protrusion extending away from the engagement member into the opening. The opening extends through the securement mechanism to the bottom surface of the base portion. The bone reamer assembly including a reamer and a reamer sleeve removably coupled to the reamer. The reamer including a shaft with a first and second end, a cutting member coupled to the second end of the shaft, and a groove near the second end of the shaft. A method of assembling a hard tissue reamer assembly is also disclosed.

Abstract: Devices and methods provide accurate targeting, placement, and/or stabilization of an electrode or other instrument(s) into the brain or other body organ, such as to treat severe tremor or other neurological disorders. Targeting is performed using any form of image-guidance, including real-time MRI, CT, or frameless surgical navigation systems.

Abstract: A trajectory guide for introducing an instrument into a human or animal subject is described. A guide stem can be removed in sections without disturbing the aligned instrument. An access port portion of the trajectory guide can be left in place, without disturbing trajectory alignment, and can allow overlying skin to be sutured closed. The access port can provide infusate delivery, such as using an injection port, catheter or the like. A fiducial marker arrangement can provide easy and accurate trajectory alignment, for use with the present trajectory guide, another trajectory guide, or without any trajectory guide.