Abstract: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.

Abstract: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.

Abstract: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.

Abstract: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.

Abstract: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.

Abstract: In one embodiment of the present invention, a data-backup method includes partitioning a fingerprint namespace among a cluster of backup servers, the fingerprint namespace comprising fingerprints for representing units of data, each backup server of the cluster of backup servers managing units of data having fingerprints corresponding to an assigned partition of the fingerprint namespace. The method further includes receiving backup information from a client computing device for a block of data comprising units of data, the backup information including at least a fingerprint for each of the units of data and client-specific backup information. In addition, the method includes, utilizing the fingerprint for each of the units of data, deduplicating the units of data in parallel at the cluster of backup servers in accordance with the partitioning step, the deduplicating step comprising identifying ones of the units data already stored by the cluster of backup servers.

Abstract: Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an array of microholes in a substrate. Besides serving as an ordered array of sample chambers allowing the performance of multiple parallel reactions, the arrays can be used for reagent storage and transfer, library display, reagent synthesis, assembly of multiple identical reactions, dilution and desalting. Use of the arrays facilitates optical analysis of reactions, and allows optical analysis to be conducted in real time. Included within the invention are kits comprising a microhole apparatus and a reaction component of the method(s) to be carried out in the apparatus.

Abstract: In one embodiment of the present invention, a data-backup method includes partitioning a fingerprint namespace among a cluster of backup servers, the fingerprint namespace comprising fingerprints for representing units of data, each backup server of the cluster of backup servers managing units of data having fingerprints corresponding to an assigned partition of the fingerprint namespace. The method further includes receiving backup information from a client computing device for a block of data comprising units of data, the backup information including at least a fingerprint for each of the units of data and client-specific backup information. In addition, the method includes, utilizing the fingerprint for each of the units of data, deduplicating the units of data in parallel at the cluster of backup servers in accordance with the partitioning step, the deduplicating step comprising identifying ones of the units data already stored by the cluster of backup servers.

Abstract: In one embodiment of the present invention, a data-backup method includes partitioning a fingerprint namespace among a cluster of backup servers, the fingerprint namespace comprising fingerprints for representing units of data, each backup server of the cluster of backup servers managing units of data having fingerprints corresponding to an assigned partition of the fingerprint namespace. The method further includes receiving backup information from a client computing device for a block of data comprising units of data, the backup information including at least a fingerprint for each of the units of data and client-specific backup information. In addition, the method includes, utilizing the fingerprint for each of the units of data, deduplicating the units of data in parallel at the cluster of backup servers in accordance with the partitioning step, the deduplicating step comprising identifying ones of the units data already stored by the cluster of backup servers.

Abstract: A computer-based method includes determining, based at least in part on a quantity of first backup data on a source computer, a data-transfer mode for the first backup data, the data-transfer mode selected from the group consisting of network transfer of the first backup data and physical-media transfer of the first backup data and, responsive to the determining step, transferring the first backup data via the determined data-transfer mode to a server located at a remote destination from the source computer. The physical-media data-transfer mode of the first backup data includes physical transport of physical media to the server. The network-transfer data-transfer mode is accomplished via a network connection and does not include physical transport of physical media.

Abstract: In one embodiment of the present invention, a data-backup method includes partitioning a fingerprint namespace among a cluster of backup servers, the fingerprint namespace comprising fingerprints for representing units of data, each backup server of the cluster of backup servers managing units of data having fingerprints corresponding to an assigned partition of the fingerprint namespace. The method further includes receiving backup information from a client computing device for a block of data comprising units of data, the backup information including at least a fingerprint for each of the units of data and client-specific backup information. In addition, the method includes, utilizing the fingerprint for each of the units of data, deduplicating the units of data in parallel at the cluster of backup servers in accordance with the partitioning step, the deduplicating step comprising identifying ones of the units data already stored by the cluster of backup servers.

Abstract: A computer-based method includes determining, based at least in part on a quantity of first backup data on a source computer, a data-transfer mode for the first backup data, the data-transfer mode selected from the group consisting of network transfer of the first backup data and physical-media transfer of the first backup data and, responsive to the determining step, transferring the first backup data via the determined data-transfer mode to a server located at a remote destination from the source computer. The physical-media data-transfer mode of the first backup data includes physical transport of physical media to the server. The network-transfer data-transfer mode is accomplished via a network connection and does not include physical transport of physical media.

Abstract: A system includes shared Small Computer System Interface (SCSI) storage devices for processing clients coupled by a fiber channel interface. The storage devices include storage blocks, and locks controlling their use by clients. Clients issue actions to the storage devices for performing operations on the locks. A client may exclude other clients from using storage blocks using a state element to acquire the lock for shared or exclusive use. If the client modified the data, a version counter in the lock is updated when the lock is released. If an activity bit is set, the version counter is updated upon both reading and writing. Other clients can forcibly release a lock owned by a failed client by monitoring its version counter. Expiration timers associated with the locks allow acquired locks to be released by timing out. A serverless global file system (GFS) manages use of the shared storage resources, and allows remapping of the locks to the storage blocks, for example, based on activity of the locks.

Abstract: The present invention provides a microarray substrate comprising a plurality of photodetectors integrated therein. The invention further provides a detection device for use in conjunction with a microarray substrate of the invention, as well as methods of use of same.