Patents by Inventor Matthew Woodling

Matthew Woodling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SCALABLE CHROMATOGRAPHY PROCESS FOR PURIFICATION OF HUMAN CYTOMEGALOVIRUS
    Publication number: 20250011732
    Abstract: The present invention relates to a scalable process for the purification of human cytomegalovirus particles from cell culture medium. In particular, the process involves a two step chromatography process starting with an anion exchange chromatography step followed by a polishing chromatography step selected from mixed mode chromatography or cation exchange chromatography.
    Type: Application
    Filed: July 11, 2024
    Publication date: January 9, 2025
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Adam Kristopeit, Janelle Konietzko, Wanli MA, Katherine Phillips, Andrew Swartz, Sheng-Ching Wang, Marc D. Wenger, Matthew Woodling, Tiago Matos
  • Scalable chromatography process for purification of human cytomegalovirus
    Patent number: 12060583
    Abstract: The present invention relates to a scalable process for the purification of human cytomegalovirus particles from cell culture medium. In particular, the process involves a two step chromatography process starting with an anion exchange chromatography step followed by a polishing chromatography step selected from mixed mode chromatography or cation exchange chromatography.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: August 13, 2024
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Adam Kristopeit, Janelle Konietzko, Wanli Ma, Katherine Phillips, Andrew Swartz, Sheng-Ching Wang, Marc D. Wenger, Matthew Woodling, Tiago Matos
  • Addition of nucleases directly to cell culture to facilitate digestion and clearance of host cell nucleic acids
    Patent number: 11268071
    Abstract: The present invention provides an efficient process for culturing viruses in the presence of an endonuclease and for producing vaccines, typically from live attenuated viruses, under conditions to reduce the presence of host cell DNA and eliminate the need for a post-harvest DNA digestion step.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: March 8, 2022
    Assignee: Merck Sharp and Dohme Corp.
    Inventors: Yi Li, Matthew Woodling, Adam Kristopeit
  • SCALABLE CHROMATOGRAPHY PROCESS FOR PURIFICATION OF HUMAN CYTOMEGALOVIRUS
    Publication number: 20210047626
    Abstract: The present invention relates to a scalable process for the purification of human cytomegalovirus particles from cell culture medium. In particular, the process involves a two step chromatography process starting with an anion exchange chromatography step followed by a polishing chromatography step selected from mixed mode chromatography or cation exchange chromatography.
    Type: Application
    Filed: April 18, 2019
    Publication date: February 18, 2021
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Adam Kristopeit, Janelle Konieizko, Wanli Ma, Katie Phillips, Andrew Swartz, Sheng-Ching Wang, Marc D. Wenger, Matthew Woodling, Tiago Matos
  • ADDITION OF NUCLEASES DIRECTLY TO CELL CULTURE TO FACILITATE DIGESTION AND CLEARANCE OF HOST CELL NUCLEIC ACIDS
    Publication number: 20200392468
    Abstract: The present invention provides an efficient process for culturing viruses in the presence of an endonuclease and for producing vaccines, typically from live attenuated viruses, under conditions to reduce the presence of host cell DNA and eliminate the need for a post-harvest DNA digestion step.
    Type: Application
    Filed: March 28, 2018
    Publication date: December 17, 2020
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Yi Li, Matthew Woodling, Adam Kristopeit
  • ADDITION OF NUCLEASES DIRECTLY TO CELL CULTURE TO FACILITATE DIGESTION AND CLEARANCE OF HOST CELL NUCLEIC ACIDS
    Publication number: 20200040310
    Abstract: The present invention provides an efficient process for culturing viruses in the presence of an endonuclease and for producing vaccines, typically from live attenuated viruses, under conditions to reduce the presence of host cell DNA and eliminate the need for a post-harvest DNA digestion step.
    Type: Application
    Filed: March 28, 2018
    Publication date: February 6, 2020
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Yi Li, Matthew Woodling, Adam Kristopeit
  • USE OF MIXED MODE CHROMATOGRAPHY FOR THE CAPTURE AND PURIFICATION OF BASIC ANTIBODY PRODUCTS
    Publication number: 20120208986
    Abstract: Use of mixed mode chromatography for purification of an antibody from an antibody mixture, for example) a Pichia pastoris fermentation mixture containing impurities such as host cell proteins and DNA is described Mixed mode chromatography is used instead of protein A chromatography and presents certain advantages over protein A chromatography Furthermore, the integration of such a method into a multi-step procedure with other fractionation methods for purification of antibodies suitable for in vivo applications is provided.
    Type: Application
    Filed: October 13, 2010
    Publication date: August 16, 2012
    Inventors: Marc D. Wenger, Matthew Woodling