Abstract: Disclosed is an inspection and system method and system for determining the orientation of a contact lens on a lens support, particularly in an automated contact lens manufacturing line.

Abstract: A contact lens inspection system, in particular for soft contact lenses, comprises a light source (40) for illuminating a contact lens to be inspected; a plenoptic camera (1) for producing an electronic plenoptic image; a processing unit (103) adapted for electronically processing the electronic plenoptic image of the contact lens and configured for refocusing the image.

Abstract: A method for determining the orientation of a contact lens (1) on a lens support (3) comprises the steps of: providing a contact lens (1) having a lens center (2) and a sagittal height (h), providing a lens support (3), arranging the contact lens (1) on the lens support (3), providing a camera system (40) having a depth of field (4) of less than the sagittal height (h), illuminating the contact lens (1) arranged on the lens support (3) with a light beam, focusing the camera system (40) to a set focus corresponding to the expected position of the lens center (2) of the properly oriented contact lens (1) arranged on the lens support (3) with the lens center (2) of the properly oriented contact lens (1) on the lens support (3) being within the depth of field (4) of the focused camera system (40), producing an image (10) of the contact lens (1), scanning the image (10) of the contact lens (1) in at least one image portion (S) of a predetermined size; determining the image defocus of the at least one image port

Abstract: A method for automated in-line determination of the center thickness of an ophthalmic lens including providing an inspection cuvette (2) having an optically transparent bottom (21) and a concave inner surface (210) and containing the lens immersed in a liquid, providing an interferometer having a light source and a focusing probe (30) focusing light coming from the light source to a set position (310) of the lens. Focusing probe (30) also directs light reflected at the boundary between the back surface of the lens and the liquid as well as light reflected at the boundary between the front surface of the lens and the liquid or at the boundary between the front surface of the lens and the concave inner surface (210) to a detector of the interferometer. The center thickness of the lens is determined using the light reflected at the respective boundary at the back surface and at the front surface of the lens.

Abstract: A method for determining the inversion state of a soft contact lens (1), comprising imaging a soft contact lens having a convex surface (2, 3) and a concave surface (3, 2), a lens center and a lens edge (5) surrounding said soft contact lens (1), the method comprising using an optical coherence tomography system to obtain at least one sectional image of at least a part of the contact lens (1) comprising the lens edge (5), determining a cross-sectional edge geometry of the contact lens (1) extending from the lens edge (5) towards the lens center of the contact lens in the sectional image, the cross-sectional edge geometry corresponding to the convex and concave surface boundaries of the contact lens (1) in the sectional image, selecting a parameter defining the cross-sectional edge geometry of the contact lens (1) imaged and comparing the parameter defining the cross-sectional edge geometry of the contact lens (1) with a predetermined parameter defining a cross-sectional edge geometry of a non-inverted contact

Abstract: A load transfer interface for a vehicle door that comprises an outer skin and at least one beam that is connected to the outer skin, wherein the outer skin and the at least one beam define a vehicle door plane, the load transfer interface comprising at least one door stop fitting that is provided to transfer pressure loads from the vehicle door to an associated vehicle structural frame, the at least one door stop fitting being provided for rotation in an associated rotation plane, wherein the associated rotation plane is at least approximately parallel to the vehicle door plane. The invention is further related to an aircraft cabin door having such a load transfer interface, as well as to an aircraft having such an aircraft cabin door.

Abstract: The present invention relates to a method for the in vitro selection of at least one therapeutic cell subpopulation from an original cell population of eukaryotic cells, as well as to the therapeutic cell subpopulation selected by the method, which can be used for the treatment of diseases of tissues or organs. The selected cells are highly migrative and the method according to the invention provides for the selection of these highly migrative subpopulations from a sample comprising a mixture of cells.

Abstract: The present invention relates to a method for the in vitro selection of at least one therapeutic cell subpopulation from an original cell population of eukaryotic cells, as well as to the therapeutic cell subpopulation selected by the method, which can be used for the treatment of diseases of tissues or organs. The selected cells are highly migrative and the method according to the invention provides for the selection of these highly migrative subpopulations from a sample comprising a mixture of cells.

Abstract: The present invention relates to a method for the in vitro selection of at least one therapeutic cell subpopulation from an original cell population of eukaryotic cells, as well as to the therapeutic cell subpopulation selected by the method, which can be used for the treatment of diseases of tissues or organs. The selected cells are highly migrative and the method according to the invention provides for the selection of these highly migrative subpopulations from a sample comprising a mixture of cells.

Abstract: The present invention relates to a contact lens inspection system, comprising: a light source (20) being adapted to illuminate the contact lens with collimated light from a front side or the rear side of the contact lens; a camera (40) having an objective lens (41) and an electronic sensor (42), said camera being arranged to produce an electronic orthographic image (10) of said contact lens on said electronic sensor (42), wherein said objective lens (41) has a diameter which is at least as large as a maximum diameter of said contact lens, said camera (40) being arranged on that side of the contact lens opposite to said side of said light source (20); an electronic scanning and evaluation unit (50) adapted for electronically scanning said electronic orthographic image (10) of said contact lens to determine whether or not said contact lens is inverted.

Abstract: Oligophenylene monomers for the synthesis of polymeric precursors for the preparation of graphene nanoribbons, the polymeric precursors, and methods for preparing them, as well as methods for preparing the graphene nauoribbons from the polymeric precursors and the monomers are provided.

Abstract: Disclosed is a diagnostic in vitro method for determining the activity of thiopurine S-methyltransferase (TPMT) in individuals to be examined, characterized in that the content of urothione and/or jukathione in body fluids is determined. Also disclosed is a diagnostic in vitro method for determining the TPMT activity in cellular extracts of test subjects of any origin, characterized in that molybdenum cofactor (Moco) and/or decomposition stages of Moco are used as substrates for the reaction and the formed quantity of jukathione and/or urothione is determined. Finally, a diagnostic in vitro method is disclosed, wherein urothione and/or jukathione serves as a biomarker for an increased susceptibility with regard to one or more particular diseases, which is determined in body fluids and/or cellular extracts.

Abstract: The present invention relates to a method for the in vitro selection of at least one therapeutic cell subpopulation from an original cell population of eukaryotic cells, as well as to the therapeutic cell subpopulation selected by the method, which can be used for the treatment of diseases of tissues or organs. The selected cells are highly migrative and the method according to the invention provides for the selection of these highly migrative subpopulations from a sample comprising a mixture of cells.

Abstract: A method for automated in-line determination of the center thickness of an ophthalmic lens including providing an inspection cuvette (2) having an optically transparent bottom (21) and a concave inner surface (210) and containing the lens immersed in a liquid, providing an interferometer having a light source and a focusing probe (30) focusing light coming from the light source to a set position (310) of the lens. Focusing probe (30) also directs light reflected at the boundary between the back surface of the lens and the liquid as well as light reflected at the boundary between the front surface of the lens and the liquid or at the boundary between the front surface of the lens and the concave inner surface (210) to a detector of the interferometer. The center thickness of the lens is determined using the light reflected at the respective boundary at the back surface and at the front surface of the lens.

Abstract: Disclosed is a process for manufacturing a nitrogen-containing porous carbonaceous material with an optional inorganic salt content of up to 50 ppm by weight. The process comprises the following steps: (A) conversion of (a) at least one heterocyclic hydrocarbon with at least two NH2-groups per molecular with (b) at least one aromatic compound with at least two aldehyde groups per molecular, (B) heating in the absence of oxygen to temperature in the range of from 700 to 1200° C.

Abstract: The invention relates to a porous polymeric monolith based on a polymerised high internal phase emulsion (polyHIPE) which is hypercrosslinked, and to the preparation and use thereof, preferably as gas storage material.

Abstract: The present invention provides diagnostic methods for predicting therapeutic efficacy in an individual being treated for an autoimmune or an inflammatory disease. In addition, the present invention also provides novel methods for monitoring azathioprine therapy or optimizing clinical responsiveness to azathioprine therapy in an individual by measuring 6-thioguanosine nucleotide levels in a sample from the individual.

Abstract: The present invention relates to a polymorphic TPMT polynucleotide. Moreover, the invention relates to genes or vectors comprising the polynucleotides of the invention and to a host cell genetically engineered with the polynucleotide or gene of the invention. Further, the invention relates to methods for producing molecular variant polypeptides or fragments thereof, methods for producing cells capable of expressing a molecular variant polypeptide and to a polypeptide or fragment thereof encoded by the polynucleotide or the gene of the invention or which is obtainable by the method or from the cells produced by the method of the invention. Furthermore, the invention relates to an antibody which binds specifically the polypeptide of the invention. Moreover, the invention relates to a transgenic non-human animal. The invention also relates to a solid support comprising one or a plurality of the above mentioned polynucleotides, genes, vectors, polypeptides, antibodies or host cells.

Abstract: The present invention provides diagnostic methods for predicting therapeutic efficacy in an individual being treated for an autoimmune or an inflammatory disease. In addition, the present invention also provides novel methods for monitoring azathioprine therapy or optimizing clinical responsiveness to azathioprine therapy in an individual by measuring 6-thioguanosine nucleotide levels in a sample from the individual.