Patents by Inventor Maurizio Rocchetti

Maurizio Rocchetti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20050143927
    Abstract: The present invention relates to a method for estimating or predicting anti-tumor activity of a compound and for estimating or predicting the tumor growth in mammals; the estimation comprises a) measuring the tumor weight in time; b) measuring the concentration of the compound in time; c) calculating kinetic parameters of the tumor growth: -a parameter (L0), representative of the portion of tumor cells present at the instant t0=0 that succeeds in taking root and in starting tumor cells proliferation in the mammals; -an index (?0) of the production rate of tumor cells during an exponential phase of tumor growth; -an index (?1) of tumor cells mass produced in the time unit during a linear phase of the tumor growth; and pharmacodynamic parameters: -an index (K1) of tumor cells death rate; -an index (K2) of the potency of the compound; and d) calculating tumor growth curves.
    Type: Application
    Filed: September 15, 2004
    Publication date: June 30, 2005
    Applicants: Pharmacia Italia S.p.A., Universita Degli Studi Di Pavia
    Inventors: Cristiano Cammia, Giuseppe DeNicolao, Italo Poggesi, Maurizio Rocchetti
  • Publication number: 20030153539
    Abstract: The use of estramustine phosphate and its metabolites estramusfine and estromustine allow to potentiate the therapeutic efficacy of taxanes by both improving their pharmacokinetic and pharmacodynamidc profile through the inhibition of (CYP)2C8 and (CYP)3A4 enzymes, both responsible for the metabolism of the taxanes; formulations of estramustine phosphate and metabolites, combinations of these latter with taxanes and therapeutic methods of treatment comprising them as a combined therapy are also disclosed.
    Type: Application
    Filed: December 12, 2002
    Publication date: August 14, 2003
    Inventors: Marius Monshouwer, Robert Ings, Maurizio Rocchetti
  • Publication number: 20030149248
    Abstract: A method of estimating the average exposure within a population of subjects to a pharmacological substance, administered according to a given protocol, by estimating the area under the concentration curve (AUC), characterised in that the area under the population concentration curve is estimated by the steps of obtaining measurements of the drug concentrations in each of the subjects at any time during the study, independently from the time when measurements of the drug concentration level in the other subjects are being taken; building a hierarchical stochastic model composed of the population and of the individual levels; determining the posterior probability distribution of the average AUC from the sample data and hence the average population AUC. The exposure of an individual and its precision within the sample of individuals can be determined by determining the posterior probability distribution of the individual AUC from the sample data.
    Type: Application
    Filed: December 12, 2002
    Publication date: August 7, 2003
    Inventors: Riccardo Bellazzi, Giuseppe De Nicolao, Paolo Magni, Italo Poggesi, Maurizio Rocchetti