Patents by Inventor Megan HARRISON

Megan HARRISON has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Abdominal hernia simulation model for surgical training
    Patent number: 11869379
    Abstract: A surgeon training apparatus includes a cassette, which includes biological tissue repurposed into a form consistent with the anatomical configuration of abdominal hernias, affixed into an anatomically correct silicon framework which replicates the abdominal anatomy. The framework positions the cassette in an anatomically correct position within the abdominal cavity, enabling surgeons to train using a properly positioned representation of the target anatomy, thus requiring the surgeon to properly use surgical tools to correct the pathologic condition caused by the hernia. The cassette is formed by applying biologic tissue to a specially designed “plate,” which affixes the tissue block into the anatomic framework, and is adapted for connection to a grounding device so the surgeon can use cautery during the simulated hernia repair.
    Type: Grant
    Filed: March 11, 2019
    Date of Patent: January 9, 2024
    Assignee: INTUITIVE SURGICAL OPERATIONS, INC.
    Inventors: John Alexander, W. Andrew Grubbs, Kaity Yu Emerson, Morgan Dominice Moore, Megan Harrison Dew, Samuel David Drew
  • Compositions and methods for generating hair cells by downregulating FOXO
    Patent number: 11617745
    Abstract: Provided are compositions and methods comprising a FOXO inhibitor for increasing proliferation of Lgr5+ cochlear cells, and related methods of treating hearing loss.
    Type: Grant
    Filed: August 19, 2019
    Date of Patent: April 4, 2023
    Assignee: Frequency Therapeutics, Inc.
    Inventors: Christopher Loose, Will McLean, Megan Harrison, Melissa Hill-Drzewi
  • COMPOSITIONS AND METHODS FOR GENERATING HAIR CELLS BY INHIBITING EPIGENETIC TARGETS
    Publication number: 20220127568
    Abstract: Provided are compositions and methods comprising an epigenetic agent and a Wnt agonist for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating inner ear hearing or balance disorders.
    Type: Application
    Filed: February 7, 2020
    Publication date: April 28, 2022
    Applicant: Frequency Therapeutics, Inc.
    Inventors: Will MCLEAN, Megan HARRISON, Melissa HILL-DRZEWI, Bradley TAIT
  • THERMOREVERSIBLE COMPOSITIONS FOR ADMINISTRATION OF THERAPEUTIC AGENTS
    Publication number: 20220096639
    Abstract: The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
    Type: Application
    Filed: October 1, 2021
    Publication date: March 31, 2022
    Inventors: Christopher LOOSE, Will MCLEAN, Megan HARRISON, Michael R. JIROUSEK
  • Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV
    Patent number: 11260130
    Abstract: The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: March 1, 2022
    Assignee: Frequency Therapeutics, Inc.
    Inventors: Christopher Loose, Will Mclean, Megan Harrison, Michael R. Jirousek
  • Thermoreversible compositions for administration of therapeutic agents
    Patent number: 11160868
    Abstract: The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: November 2, 2021
    Assignee: Frequency Therapeutics, Inc.
    Inventors: Christopher Loose, Will McLean, Megan Harrison, Michael R. Jirousek
  • Compositions and methods for generating hair cells by upregulating JAG-1
    Patent number: 11162071
    Abstract: Provided are compositions and methods comprising Jag-1 agonists for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating hearing or balance disorders.
    Type: Grant
    Filed: August 19, 2019
    Date of Patent: November 2, 2021
    Assignee: Frequency Therapeutics, Inc.
    Inventors: Christopher Loose, Will McLean, Megan Harrison
  • Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: I
    Patent number: 11033546
    Abstract: The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: June 15, 2021
    Assignee: Frequency Therapeutics, Inc.
    Inventors: Christopher Loose, Will McLean, Megan Harrison, Michael R. Jirousek
  • ABDOMINAL HERNIA SIMULATION MODEL FOR SURGICAL TRAINING
    Publication number: 20210043114
    Abstract: A surgeon training apparatus includes a cassette, which includes biological tissue repurposed into a form consistent with the anatomical configuration of abdominal hernias, affixed into an anatomically correct silicon framework which replicates the abdominal anatomy. The framework positions the cassette in an anatomically correct position within the abdominal cavity, enabling surgeons to train using a properly positioned representation of the target anatomy, thus requiring the surgeon to properly use surgical tools to correct the pathologic condition caused by the hernia. The cassette is formed by applying biologic tissue to a specially designed “plate,” which affixes the tissue block into the anatomic framework, and is adapted for connection to a grounding device so the surgeon can use cautery during the simulated hernia repair.
    Type: Application
    Filed: March 11, 2019
    Publication date: February 11, 2021
    Inventors: John Alexander, W. Andrew Grubbs, Kaity Yu Emerson, Morgan Dominice Moore, Megan Harrison Dew, Samuel David Drew
  • METHODS FOR HAIR FOLLICLE STEM CELL PROLIFERATION
    Publication number: 20200121681
    Abstract: The present invention relates to compositions of minoxidil and Sonic Hedgehog (Shh) pathway activators and optionally, Wnt agonists and methods of using them to induce self-renewal of hair follicle stem cells, including inducing the hair follicle stem cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair follicle epithelial cells.
    Type: Application
    Filed: October 17, 2019
    Publication date: April 23, 2020
    Inventors: Christopher LOOSE, Bradley TAIT, Rajesh MANCHANDA, Will MCLEAN, Megan HARRISON, Sara STRECKER
  • HUMAN PAPILLOMA VIRUS DETECTION
    Publication number: 20200088727
    Abstract: The invention is a self-administered urine based lateral flow immunoassay that detects the presence of an HPV oncogene and thus the presence in a test subject of HPV.
    Type: Application
    Filed: September 19, 2018
    Publication date: March 19, 2020
    Applicant: X Squared Health LLC
    Inventors: Megan Harrison Dew, Jewell Brey, Jazmin McCorkle, Andrea Morgan Rich, Melissa Serrano Burns
  • COMPOSITIONS AND METHODS FOR GENERATING HAIR CELLS BY DOWNREGULATING FOXO
    Publication number: 20200078350
    Abstract: Provided are compositions and methods comprising a FOXO inhibitor for increasing proliferation of Lgr5+ cochlear cells, and related methods of treating hearing loss.
    Type: Application
    Filed: August 19, 2019
    Publication date: March 12, 2020
    Inventors: Christopher LOOSE, Will MCLEAN, Megan HARRISON, Melissa HILL-DRZEWI
  • COMPOSITIONS AND METHODS FOR GENERATING HAIR CELLS BY UPREGULATING JAG-1
    Publication number: 20200080054
    Abstract: Provided are compositions and methods comprising Jag-1 agonists for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating hearing or balance disorders.
    Type: Application
    Filed: August 19, 2019
    Publication date: March 12, 2020
    Inventors: Christopher Loose, Will McLean, Megan Harrison
  • COMPOSITIONS AND METHODS FOR GENERATING HAIR CELLS BY UPREGULATING PI3K
    Publication number: 20200080055
    Abstract: Provided are compositions and methods comprising PI3K agonists for increasing proliferation of cochlear supporting cells or vestibular supporting cells, and related methods of treating hearing or balance disorders.
    Type: Application
    Filed: August 19, 2019
    Publication date: March 12, 2020
    Inventors: Christopher LOOSE, Will MCLEAN, Megan HARRISON
  • THERMOREVERSIBLE COMPOSITIONS FOR ADMINISTRATION OF THERAPEUTIC AGENTS
    Publication number: 20190231880
    Abstract: The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
    Type: Application
    Filed: January 4, 2019
    Publication date: August 1, 2019
    Inventors: Christopher LOOSE, Will MCLEAN, Megan HARRISON, Michael R. JIROUSEK
  • SOLUBILIZED COMPOSITIONS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING A GSK3 INHIBITOR: I
    Publication number: 20190201398
    Abstract: The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
    Type: Application
    Filed: December 20, 2018
    Publication date: July 4, 2019
    Inventors: Christopher LOOSE, Will MCLEAN, Megan HARRISON, Michael R. JIROUSEK
  • METHODS FOR CONTROLLED PROLIFERATION OF STEM CELLS / GENERATING INNER EAR HAIR CELLS USING GSK-3-ALPHA INHIBITORS
    Publication number: 20190093079
    Abstract: Provided are compositions and methods for inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells, and including compositions and methods of using GSK3-alpha inhibitors, and salts thereof, optionally in combination with a Differentiation Inhibitor such as a Notch agonist or an HDAC inhibitor (e.g., valproic acid).
    Type: Application
    Filed: March 2, 2017
    Publication date: March 28, 2019
    Inventors: Christopher LOOSE, Will MCLEAN, Megan HARRISON
  • Thermoreversible compositions for administration of therapeutic agents
    Patent number: 10213511
    Abstract: The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: February 26, 2019
    Assignee: Frequency Therapeutics, Inc.
    Inventors: Christopher Loose, Will McLean, Megan Harrison, Michael R. Jirousek
  • Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I
    Patent number: 10201540
    Abstract: The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: February 12, 2019
    Assignee: Frequency Therapeutics, Inc.
    Inventors: Christopher Loose, Will McLean, Megan Harrison, Michael R. Jirousek
  • Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: III
    Patent number: 10016507
    Abstract: The present invention relates to compositions and methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: July 10, 2018
    Assignee: Frequency Therapeutics, Inc.
    Inventors: Christopher Loose, Will McLean, Megan Harrison, Michael R. Jirousek