Patents by Inventor Mei He

Mei He has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11921612
    Abstract: In exemplary embodiments, a computer system detects performance anomalies for user computer services. Physical databases convert physical database KPIs into logical database KPI vectors for individual user services and individual time intervals. Physical application servers convert physical application server KPIs into logical application server KPI vectors for the individual user services and time intervals. Physical web servers convert physical web server KPIs into logical web server KPI vectors for the individual user services and time intervals. A KPI server combines the logical database KPI vectors, the logical application server KPI vectors, and the logical web server KPI vectors for individual time intervals into user service KPI vectors for the individual user services during the time intervals. The KPI server detects outlier user service KPI vectors as compared to normal user service KPI vectors and indicates corresponding computer performance anomalies for the user services.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: March 5, 2024
    Assignee: Oracle International Corporation
    Inventors: Octavian Gheorghe Morariu, Fa Wang, Raymond Michael Ofiaza Ordona, Xintao He, Mei Yuan, Victor Campbell Webb
  • Publication number: 20240070352
    Abstract: Methods, systems, and apparatus, including medium-encoded computer program products, for selecting, from a unified electrical power grid model, a first proper subset of elements of the model. A first electrical grid simulation model is selected. A second, differing proper subset of elements of the model are selected. A second electrical grid simulation model that differs from the first electrical grid simulation model is selected. A set of boundary conditions common to the first electrical grid simulation model and the second electrical grid simulation model are determined. Operation of the electrical power grid is simulated, and can include (i) simulating, using the first electrical grid simulation model, the first proper subset of elements of the unified model, and the set of boundary conditions; and (ii) simulating, using the second electrical grid simulation model and the second proper subset of elements of the unified model, and the set of boundary conditions.
    Type: Application
    Filed: August 30, 2022
    Publication date: February 29, 2024
    Inventors: Mike Miao He, Hamed Khalilinia, Sze Mei Cat Wong, Laura Elizabeth Fedoruk, Leo Francis Casey, Xinyue Li
  • Patent number: 11891668
    Abstract: Methods for producing engineered exosomes and other vesicle-like biological targets, including allowing a target vesicle-like structure to react and bind with immunomagnetic particles; capturing the immunomagnetic particle/vesicle complex by applying a magnetic field; further engineering the captured vesicles by surface modifying with additional active moieties or internally loading with active agents; and releasing the engineered vesicle-like structures, such as by photolytically cleaving a linkage between the particle and engineered vesicle-like structures, thereby releasing intact vesicle-like structures which can act as delivery vehicles for therapeutic treatments.
    Type: Grant
    Filed: October 29, 2021
    Date of Patent: February 6, 2024
    Assignees: The University of Kansas, Kansas State University Research Foundation
    Inventor: Mei He
  • Publication number: 20230390773
    Abstract: A system for releasing analytes contained within a sample. The system comprises a housing enclosing an interior space. The system additionally comprises a sample holder having at least one receptacle configured to receive a sample containing analytes bound within the sample. The system further includes at least one light emitting diode configured to generate light sufficient to separate photo-cleavable bonds binding the analytes within the sample.
    Type: Application
    Filed: October 5, 2021
    Publication date: December 7, 2023
    Inventors: Navdeep Singh, James West, Mei He
  • Publication number: 20230272120
    Abstract: The present disclosure provides immunomagnetic compositions and their methods of use, in particular magnetic particles conjugated to peptides that bind and capture extracellular vesicles.
    Type: Application
    Filed: May 10, 2021
    Publication date: August 31, 2023
    Inventor: Mei He
  • Patent number: 11726086
    Abstract: A graphene-based sandwich immunoassay for detecting whether a target biological substance is present in a sample, generally comprising contacting said sample with a plurality of particles coated with graphene nanosheets, each particle having at least one targeting receptor, such that the target biological substance, if present, associates with the targeting receptor, and detecting the presence of the target biological substance in the sample by subsequently contacting the sample with a detection antibody, wherein the detection antibody is capable of targeting and binding with the target biological substance if bound to the targeting receptor to yield a detectable complex. The targeting receptor can be an antibody or fragment thereof. The target biological substance can be an exosome.
    Type: Grant
    Filed: September 25, 2020
    Date of Patent: August 15, 2023
    Assignees: The University of Kansas, Kansas State University Research Foundation
    Inventors: Peng Zhang, Yong Zeng, Mei He
  • Publication number: 20230086091
    Abstract: Various embodiments generally relate to intelligently designing aptameric peptides for binding with a specific receptor and forming aptameric peptide libraries with the designed peptides. The aptameric peptides libraries can be tissue-specific and be used in drug delivery and therapeutic applications, in which designed peptides can be implanted on exosome surfaces for exosomal cargo delivery to a specific tissue. Various embodiments of the present disclosure involve the use of a generative adversarial network (GAN) machine learning model configured (e.g., trained) and used to output designed peptides that are similar to pre-existing peptides of a peptide dataset but that specifically bind to a selected receptor and have various selected physiochemical properties.
    Type: Application
    Filed: September 6, 2022
    Publication date: March 23, 2023
    Inventors: Zachary F. Greenberg, Mei He, Kiley S. Graim
  • Publication number: 20220405341
    Abstract: Embodiments of this application provide an article display processing method and apparatus and an electronic device. An exemplary method includes: displaying a plurality of articles on a webpage, each of the plurality of articles being associated with an user interface; receiving a user selection of the user interface associated with a selected article from a first user; obtaining an environment template corresponding to the selected article, wherein the environment template is a digitally-generated simulated environment and stored in a database; generating a display image comprising the environment template fused with the selected article as a main view angle according to feature data of the selected article; and sending the display image to a client device of the first user for display.
    Type: Application
    Filed: August 19, 2022
    Publication date: December 22, 2022
    Inventors: Chenzhe XIAO, Jiajia DENG, Xing TANG, Mei HE, Mengwei WANG, Xi GUO, Chengyue JIA, Jingjing ZHU, Lincheng ZENG
  • Publication number: 20220310278
    Abstract: A nuclear reactor includes a heat exchanger that transfers thermal energy from a primary reactor coolant to a secondary coolant. The heat exchanger is formed with a hot flow channel, a cold flow channel, and a porous layer between the hot flow channel and the cold flow channel. The porous layer may be thermally insulative to reduce the efficiency of thermal energy transfer from the hot flow channel to the cold flow channel. The porous layer may have a control gas passed therethrough that can be tailored to control the thermal energy transfer through the porous layer. The control gas can be tested for leakage within the heat exchanger. The control gas may also be used to sequester fission or activation products.
    Type: Application
    Filed: March 23, 2021
    Publication date: September 29, 2022
    Inventors: Joon Hyung Choi, Daniel Eichel, Mei He, Pavel Hejzlar, Mathieu G. Martin, Samuel J. Miller, James M. Vollmer
  • Publication number: 20220204911
    Abstract: Described herein is a system to remote-control magnetic actuation of dynamic cell culture. The systems described herein can include a porous, magnetic, elastomeric construct. The porous, magnetic, elastomeric construct can be formed from a composite including a biocompatible elastomer and a population of magnetic particles dispersed within the biocompatible elastomer.
    Type: Application
    Filed: December 23, 2021
    Publication date: June 30, 2022
    Inventors: Bryce Stottlemire, Mei He, Cory Berkland
  • Patent number: 11311533
    Abstract: The present invention relates to an opioid receptor antagonist conjugate and a use thereof. In particular, the present invention relates to a covalent coupling conjugate of a hydrophilic polymer and an opioid receptor antagonist and the use thereof.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: April 26, 2022
    Assignee: SHANGHAI HANMAI BIO-PHARMA CO., LTD.
    Inventor: Mei He
  • Publication number: 20220073999
    Abstract: Methods for producing engineered exosomes and other vesicle-like biological targets, including allowing a target vesicle-like structure to react and bind with immunomagnetic particles; capturing the immunomagnetic particle/vesicle complex by applying a magnetic field; further engineering the captured vesicles by surface modifying with additional active moieties or internally loading with active agents; and releasing the engineered vesicle-like structures, such as by photolytically cleaving a linkage between the particle and engineered vesicle-like structures, thereby releasing intact vesicle-like structures which can act as delivery vehicles for therapeutic treatments.
    Type: Application
    Filed: October 29, 2021
    Publication date: March 10, 2022
    Inventor: Mei He
  • Patent number: 11162143
    Abstract: Methods for producing engineered exosomes and other vesicle-like biological targets, including allowing a target vesicle-like structure to react and bind with immunomagnetic particles; capturing the immunomagnetic particle/vesicle complex by applying a magnetic field; further engineering the captured vesicles by surface modifying with additional active moieties or internally loading with active agents; and releasing the engineered vesicle-like structures, such as by photolytically cleaving a linkage between the particle and engineered vesicle-like structures, thereby releasing intact vesicle-like structures which can act as delivery vehicles for therapeutic treatments.
    Type: Grant
    Filed: April 21, 2021
    Date of Patent: November 2, 2021
    Assignees: The University of Kansas, Kansas State University Research Foundation
    Inventor: Mei He
  • Publication number: 20210268121
    Abstract: Methods for producing engineered exosomes and other vesicle-like biological targets, including allowing a target vesicle-like structure to react and bind with immunomagnetic particles; capturing the immunomagnetic particle/vesicle complex by applying a magnetic field; further engineering the captured vesicles by surface modifying with additional active moieties or internally loading with active agents; and releasing the engineered vesicle-like structures, such as by photolytically cleaving a linkage between the particle and engineered vesicle-like structures, thereby releasing intact vesicle-like structures which can act as delivery vehicles for therapeutic treatments.
    Type: Application
    Filed: April 21, 2021
    Publication date: September 2, 2021
    Inventor: Mei He
  • Publication number: 20210121455
    Abstract: The present invention relates to an opioid receptor antagonist conjugate and a use thereof. In particular, the present invention relates to a covalent coupling conjugate of a hydrophilic polymer and an opioid receptor antagonist and the use thereof.
    Type: Application
    Filed: January 26, 2017
    Publication date: April 29, 2021
    Applicant: SHANGHAI HANMAI BIO-PHARMA CO., LTD.
    Inventor: Mei HE
  • Publication number: 20210018501
    Abstract: A graphene-based sandwich immunoassay for detecting whether a target biological substance is present in a sample, generally comprising contacting said sample with a plurality of particles coated with graphene nanosheets, each particle having at least one targeting receptor, such that the target biological substance, if present, associates with the targeting receptor, and detecting the presence of the target biological substance in the sample by subsequently contacting the sample with a detection antibody, wherein the detection antibody is capable of targeting and binding with the target biological substance if bound to the targeting receptor to yield a detectable complex. The targeting receptor can be an antibody or fragment thereof. The target biological substance can be an exosome.
    Type: Application
    Filed: September 25, 2020
    Publication date: January 21, 2021
    Inventors: Peng Zhang, Yong Zeng, Mei He
  • Patent number: 10788486
    Abstract: A capture device for capturing a biological substance can include: a substrate; a graphene-oxide layer on the substrate; at least one polydopamine polymer coupled with the graphene-oxide; and at least one targeting receptor coupled to the polydopamine(s), wherein the targeting receptor is capable of targeting/binding with a target biological substance. The graphene-oxide may be covalently coupled with the substrate and polydopamine, and the polydopamine may be covalently coupled with the targeting receptor. The targeting receptor can be an antibody or fragment thereof. The target biological substance can be an exosome. The substrate can be a particle (e.g., magnetic, such as magnetically responsive) or a surface in a microfluidic channel. The surface can be a top surface of a post, the post having a Y-shaped cross-sectional profile. In one aspect, the substrate is a particle. The capture device can include the target biological substance bound to the targeting receptor.
    Type: Grant
    Filed: October 9, 2017
    Date of Patent: September 29, 2020
    Assignees: The University of Kansas, Kansas State University Research Foundation
    Inventors: Peng Zhang, Yong Zeng, Mei He
  • Patent number: 10764649
    Abstract: Disclosed are techniques for allowing a fallback from downloading and presenting a three-dimensional (3D) media content item to a 2D version of the same content item. During the download, a triggering condition is noted, such as network congestion or resource starvation on the receiving device. The receiving device requests a fallback and then begins to receive the 2D version of the media content item. (Generally, the 2D content item is downloaded beginning at a point specified by the recipient device rather than from the beginning.) The 2D version is presented to the user of the recipient device in place of the 3D version. If the triggering condition is resolved, then the download and presentation can resume in 3D, either on the request of the recipient device or by the download server noting the resolution of the triggering condition.
    Type: Grant
    Filed: August 17, 2012
    Date of Patent: September 1, 2020
    Assignee: Google Technology Holdings LLC
    Inventors: Jin-Yue Chen, Xiao-Mei He
  • Patent number: 10434511
    Abstract: A microfluidic exosome profiling platform integrating exosome isolation and targeted proteomic analysis is disclosed. This platform is capable of quantitative exosomal biomarker profiling directly from 30 ?L plasma samples within approximately 100 minutes with markedly enhanced sensitivity and specificity. Identification of distinct subpopulation of patient-derived exosomes is demonstrated by probing surface proteins and multiparameter analyses of intravesicular biomarkers in the selected subpopulation. The expression of IGF-1R and its phosphorylation level in non-small cell lung cancer (NSCLC) patient plasma is assessed, as a non-invasive alternative to the conventional biopsy and immunohistochemistry.
    Type: Grant
    Filed: March 16, 2015
    Date of Patent: October 8, 2019
    Assignee: University of Kansas
    Inventors: Mei He, Yong Zeng, Andrew Godwin
  • Patent number: 10424997
    Abstract: A motor and a rotary assembly of the motor are provided. The motor includes a rotary assembly and a stationary assembly supporting the rotary assembly. The rotary assembly includes a rotary shaft, a retainer rotating along with the rotary shaft, and a rotor magnet retained by the retainer. A portion of the rotor magnet engages with a portion of the retainer via interference fit, and a gap is defined between another portion of the rotor magnet and another portion of the retainer.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: September 24, 2019
    Assignee: JOHNSON ELECTRIC INTERNATIONAL AG
    Inventors: Wan Mei He, Jing Chen, Jun Jie Chu