Abstract: Methods of preparing a composition comprising non-ionic, radioactive gold nanoparticles (R-GNPs) are disclosed. The method comprises: a) providing an aqueous composition comprising gold (Au-197) ions in the absence of a template; and b) exposing the aqueous composition in the absence of the template to neutron irradiation to generate the composition comprising the non-ionic R-GNPs. Alternatively, the method comprises: a) providing an aqueous composition comprising gold (Au-197) nanoparticles (GNPs) in the absence of a template; and b) exposing the aqueous composition comprising the GNPs in the absence of the template to neutron irradiation and thereby generating the composition comprising the non-ionic R-GNPs. Compositions that comprises mesoporous silica nanoparticles (MSNs) and non-ionic R-GNPs encapsulated within pores and/or channels and further anchored to the surfaces of the MSNs, and methods of making the same are also disclosed.

Abstract: Methods of preparing a composition comprising non-ionic, radioactive gold nanoparticles (R-GNPs) are disclosed. The method comprises: a) providing a solution comprising gold (Au-197) ions; and b) exposing the solution to neutron irradiation to generate a composition comprising non-ionic R-GNPs. Alternatively, the method comprises: a) providing a solution that comprises a composition comprising gold (Au-197) nanoparticles (GNPs); and b) exposing the GNP solution to neutron irradiation to generate a composition comprising non-ionic R-GNPs. Compositions that comprises non-ionic R-GNPs encapsulated within and/or anchored to MSNs, and methods of making the same are also disclosed.

Abstract: A microfluidics switch with moving planes has a first substrate with some holes and a second substrate with some micro-channels. Herein, the relative planes of both substrates are covered by a hydrophobic material. Therefore, while the substrates are neighboring and relatively moving, the overlap relation between the holes and the micro-channels are varied and a switch function is provided. Further, by using the hydrophobic material, while the distance between substrates is smaller than the height of drop of each liquid inputted into the holes, the fluids can not fluid between the planes and then different micro-channels are isolated from each other.

Abstract: The present invention provides a self-sealing high-temperature biochemical reaction apparatus and a method for the same. The present apparatus has a microfluidic channel including a main channel chamber, an inlet sub-channel and an outlet sub-channel. The main channel chamber has an inlet and an outlet respectively communicated with the inlet sub-channel and outlet sub-channel. The inner diameters of the inlet sub-channel and outlet sub-channel are smaller than that of the main channel chamber. The present invention controls the temperature gradient of the main channel chamber and sub-channels during the biochemical reaction such that the microfluid itself becomes self-sealing material to seal the openings of the sub-channels during the high-temperature reaction. The microfluid would not be vaporized to adversely influence the reaction result.

Abstract: An apparatus for controlling micro-fluid temperature is provided. The apparatus includes a chip, a fixed stand, a heat-absorption block, and an actuator. The chip has a reaction chamber for disposing a micro-fluid, and the temperature of the micro-fluid rises by heating the chip to reach the required reaction temperature. In the cooling-down operation, the heat-absorption block can contact the chip when pushed by the actuator, so as to dissipate the heat from the chip by way of heat conduction. Moreover, in the heating operation, the heat-conductive block is out of contact with the chip such that the micro-fluid in the chip is quickly heated, so as to reach the required reaction temperature of the micro-fluid rapidly.

Abstract: A method for manufacturing a micro nozzle is disclosed. The method includes the following steps: providing a substrate having a channel for fluids, wherein the thickness of the substrate is D1 and the depth of the bottom of the channel is D3; forming a protrusion having an acute angle ? on the edge of the substrate through the cutting operation; and further forming a nozzle with a thickness D2 of on the tip of the protrusion. The outlet of the channel is located on the tip of the protrusion. Moreover, the thickness of the nozzle on the tip of the protrusion is less than the depth of the channel or than the thickness of the substrate. The micro nozzle made by the method illustrated above can provide a reliable and stable interface for electro-spraying.

Abstract: A microfluidics switch with moving planes has a first substrate with some holes and a second substrate with some micro-channels. Herein, the relative planes of both substrates are covered by a hydrophobic material. Therefore, while the substrates are neighboring and relatively moving, the overlap relation between the holes and the micro-channels are varied and a switch function is provided. Further, by using the hydrophobic material, while the distance between substrates is smaller than the height of drop of each liquid inputted into the holes, the fluids can not fluid between the planes and then different micro-channels are isolated from each other.