Abstract: The invention relates to a method and a corresponding arrangement for sequencing at least two biopolymers (6), wherein for each biopolymer (6) a sequence signal is picked up by a respective measured variable pickup on the basis of the sequence of the biopolymer (6), the sequence signals are transferred to a shift register (16) and buffer-stored therein, the buffer-stored sequence signals are transferred from the shift register (16) sequentially to an evaluation device (26) and evaluated therein. Each sequence signal is preferably produced here by means of a nanopore arrangement (10). A corresponding sequencing arrangement (11) has the measured variable pickups and the shift register (16) integrated in it, preferably in an electrical circuit, that is to say on a sensor array, for example. Each sequence signal can be amplified here by a preamplifier (14) prior to transfer to the shift register (16).

Abstract: A device for detecting chemical or biochemical substances in fluids for use in an electrochemical camera. The device includes a first carrier having a sensor array with a plurality of electrochemical sensors. A second carrier includes a porous layer having at least one functional region, in which specifically binding capturing molecules are immobilized. The at least one functional region is arranged directly adjacent to at least one non-functionalized region. Assigned to the at least one functional region and the at least one non-functionalized region are several sensors of the sensor array, for use as the electrochemical camera.

Abstract: The invention relates to a method and a corresponding arrangement for sequencing at least two biopolymers (6), wherein for each biopolymer (6) a sequence signal is picked up by a respective measured variable pickup on the basis of the sequence of the biopolymer (6), the sequence signals are transferred to a shift register (16) and buffer-stored therein, the buffer-stored sequence signals are transferred from the shift register (16) sequentially to an evaluation device (26) and evaluated therein. Each sequence signal is preferably produced here by means of a nanopore arrangement (10). A corresponding sequencing arrangement (11) has the measured variable pickups and the shift register (16) integrated in it, preferably in an electrical circuit, that is to say on a sensor array, for example. Each sequence signal can be amplified here by a preamplifier (14) prior to transfer to the shift register (16).

Abstract: An identification circuit is provided for generating a unique identification pattern for an object to be identified. The circuit includes at least one bistable closed circuit ring that includes a plurality of switching stages, each switching stage having at least two parallel internal signal delay paths, which are connected directly to one another on the input side and are selectable on the output side by at least one challenge bit of a challenge word applied to the circuit ring. Each internal signal path has a production-determined individual signal transit time, wherein a reset element which shifts a downstream switching stage temporarily into an unstable state is provided for each switching stage. The switching stages transition out of the respective unstable states on the basis of signal transit times, which may be read out as a response word that forms the unique identification pattern for the object to be identified.

Abstract: The invention provides a Silicon Photomultiplier (SiPM). The SiPM includes a plurality of microcells, a nonlinear element integrated in each one of the plurality of microcells, and a trigger line for outputting a summated current of the plurality of microcells, wherein the nonlinear element provides for a separated timing and energy signal.

Abstract: Systems and methods of generating timing triggers to determine timing resolutions of gamma events for nuclear imaging includes receiving a pulse signature representing a succession of triggers associated with a photomultiplier. When a number of triggers occurring within a predetermined time interval matches a predetermined number, an event trigger can be initiated. A delayed version of the pulse signature can be generated and compared to a predetermined timing trigger level. When the delayed version matches the predetermined timing trigger level, a timing trigger can be generated. Based on the timing trigger level, the timing trigger can be generated at the pulse of the delayed version that corresponds to the first photoelectron of a gamma event. The timing trigger can correspond to a timestamp for the first photoelectron so that a data acquisition system can identify the pulse from which to acquire energy information to generate a nuclear image.

Abstract: An arrangement and a method measures cell vitalities with a sensor array. The sensor array is formed on a surface of a semiconductor chip. The semiconductor chip has integrated circuits and an integrated circuit is associated with each sensor of the sensor array, for processing the measurement signals of the respective sensor. The integrated circuits are formed in the semiconductor chip spatially in each case below the associated sensor and neighboring sensors of the sensor array have a center-to-center in the range of micrometers. The pH and/or pO2 can be measured in the environment of a living cell.

Abstract: A biosensor array having a substrate, a plurality of biosensor zones arranged on the substrate, each of which has a first terminal and a second terminal, at least one drive line and at least one detection line, the at least one drive line being electrically insulated from the at least one detection line. In each case the first terminal of each biosensor zone is coupled to precisely one of the at least one drive line and the second terminal of each biosensor zone is coupled to precisely one of the at least one detection line, and at least one of the at least one drive line and at least one of the at least one detection line is coupled to at least two of the biosensor zones.

Abstract: Systems and methods of generating timing triggers to determine timing resolutions of gamma events for nuclear imaging includes receiving a pulse signature representing a succession of triggers associated with a photomultiplier. When a number of triggers occurring within a predetermined time interval matches a predetermined number, an event trigger can be initiated. A delayed version of the pulse signature can be generated and compared to a predetermined timing trigger level. When the delayed version matches the predetermined timing trigger level, a timing trigger can be generated. Based on the timing trigger level, the timing trigger can be generated at the pulse of the delayed version that corresponds to the first photoelectron of a gamma event. The timing trigger can correspond to a timestamp for the first photoelectron so that a data acquisition system can identify the pulse from which to acquire energy information to generate a nuclear image.

Abstract: The invention provides a Silicon Photomultiplier (SiPM). The SiPM includes a plurality of microcells, a nonlinear element integrated in each one of the plurality of microcells, and a trigger line for outputting a summated current of the plurality of microcells, wherein the nonlinear element provides for a separated timing and energy signal.

Abstract: An arrangement and a method measures cell vitalities with a sensor array. The sensor array is formed on a surface of a semiconductor chip. The semiconductor chip has integrated circuits and an integrated circuit is associated with each sensor of the sensor array, for processing the measurement signals of the respective sensor. The integrated circuits are formed in the semiconductor chip spatially in each case below the associated sensor and neighboring sensors of the sensor array have a centre-to-centre in the range of micrometers. The pH and/or pO2 can be measured in the environment of a living cell.

Abstract: A sensor arrangement including a control circuit is disclosed. In at least one embodiment, at least one sensor electrode can be charged and/or discharged therewith and a comparator unit for the comparison of a provided voltage for the at least one electrode with a reference voltage. A duration necessary for the charging/discharging of the at least one sensor electrode is determined, whereby, from the determined duration, it is determined whether a sensor event, in the form of a hybridization between trap molecules and the particles for recording, has occurred.

Abstract: A device for detecting chemical or biochemical substances in fluids includes a first carrier having a sensor array with a plurality of electrochemical sensors. A second carrier includes a porous layer having at least one functional region, in which specifically binding capturing molecules are immobilized. The at least one functional region is arranged directly adjacent to at least one non-functionalized region. Assigned to the at least one functional region and the at least one non-functionalized region are several sensors of the sensor array, for use as an electrochemical camera.

Abstract: A circuit arrangement, an electrochemical sensor, a sensor arrangement, and a method for processing a current signal provided by a sensor electrode are disclosed. The circuit arrangement includes a sensor electrode, a first circuit unit, electrically coupled to the sensor electrode and a second circuit unit, including a first capacitor, whereby the first circuit arrangement is embodied to hold the electrical potential of the sensor electrode in a given first reference range about a set electrical potential and, when the sensor electrode potential falls outside the first reference range, the first capacitor and the sensor electrode are coupled such that a matching of the electrical potentials is possible. The second circuit unit is embodied such that, when the electrical potential of the first capacitor falls outside a second reference range, this event is detected and the first capacitor brought to a first electrical reference potential.

Abstract: Sensor arrangement having capture molecules immobilized on any of three sensor electrodes, wherein molecules to be detected can hybridize with the capture molecules; a control circuit for applying a first electrical signal to a selected sensor electrode and simultaneously applying a second electrical signal to at least two of the other sensor electrodes; a detection device, wherein in a first operating state a reference liquid is introduced into the sensor arrangement and a reference value of an electrical signal is detected at the selected sensor electrode, and in a second operating state an analyte possibly having molecules to be detected is introduced into the sensor arrangement and a sensor value of the electrical signal is detected at the selected sensor electrode; and an evaluation circuit, which, on the basis of the reference value and the sensor value, determines whether a hybridization event has taken place at the selected sensor electrode.

Abstract: A planar-sensor arrangement is disclosed, which is used to detect particles possibly contained in an analyte. The sensor element includes a substrate, a first planar-sensor electrode and a second planar-sensor electrode which are formed on and/or in the substrate and whereon catcher molecules can be immobilized. The first sensor-electrode and the second sensor-electrode are divided, respectively, into a plurality of planar sensor-electrode partial areas. The sensor electrode partial areas of the first sensor electrode and the sensor electrode partial areas of the second sensor electrode are arranged in an alternating manner in two dimensions on the surface plane of the substrate. The sensor element also includes a wiring structure by which at least one part of the sensor electrode partial areas of the first sensor electrode are electrically coupled together, and by which at least one part of the sensor-electrode partial areas of the second sensor electrode are electrically coupled together.

Abstract: A DNA chip includes a carrier and a microarray of spots containing immobilised catcher molecules which are arranged on the carrier. Each spot contains a microelectrode system for the impedance spectroscopic detection of binding events occurring between the catcher molecules and target molecules of an analyte solution applied to the spots. The microelectrode system has a pair of polarisation electrodes in order to produce an alternating electromagnetic field and a pair of sensor electrodes for measuring a voltage drop in the analyte.

Abstract: A switching circuit arrangement is disclosed. The arrangement includes a substrate, a plurality of functional units arranged on the substrate, a plurality of selection line groups including selection lines, a plurality of signal line groups including signal lines, a buffer unit for each signal line group, a selection unit which is coupled to the selection line groups, and a signal unit which is coupled to the signal lines.

Abstract: A sensor arrangement including a control circuit is disclosed. In at least one embodiment, at least one sensor electrode can be charged and/or discharged therewith and a comparator unit for the comparison of a provided voltage for the at least one electrode with a reference voltage. A duration necessary for the charging/discharging of the at least one sensor electrode is determined, whereby, from the determined duration, it is determined whether a sensor event, in the form of a hybridisation between trap molecules and the particles for recording, has occurred.

Abstract: A planar-sensor arrangement is disclosed, which is used to detect particles possibly contained in an analyte. The sensor element includes a substrate, a first planar-sensor electrode and a second planar-sensor electrode which are formed on and/or in the substrate and whereon catcher molecules can be immobilised. The first sensor-electrode and the second sensor-electrode are divided, respectively, into a plurality of planar sensor-electrode partial areas. The sensor electrode partial areas of the first sensor electrode and the sensor electrode partial areas of the second sensor electrode are arranged in an alternating manner in two dimensions on the surface plane of the substrate. The sensor element also includes a wiring structure by which at least one part of the sensor electrode partial areas of the first sensor electrode are electrically coupled together, and by which at least one part of the sensor-electrode partial areas of the second sensor electrode are electrically coupled together.