Patents by Inventor Meizhen Lou

Meizhen Lou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Structure of the insulin receptor ectodomain
    Patent number: 8301398
    Abstract: The present invention relates to the crystal structure of the insulin receptor ectodomain, to the nature of its N-linked glycans and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the insulin receptor and/or the closely-related insulin-like growth factor receptors or variants thereof.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: October 30, 2012
    Assignee: Walter and Eliza Hall Institute of Medical Research
    Inventors: Thomas P. J. Garrett, Timothy Edward Adams, George Lovrecz, Neil Moreton McKern, Michael Colin Lawrence, Lindsay Gale Sparrow, Colin Wesley Ward, Meizhen Lou, Victor Strelstov
  • Structure of the Insulin Receptor Ectodomain
    Publication number: 20100267927
    Abstract: The present invention relates to the crystal structure of the insulin receptor ectodomain, to the nature of its N-linked glycans and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the insulin receptor and/or the closely-related insulin-like growth factor receptors or variants thereof.
    Type: Application
    Filed: June 22, 2007
    Publication date: October 21, 2010
    Inventors: Thomas P.J. Garrett, Timothy Edward Admas, George Lovrecz, Neil Moreton McKern, Michael Colin Lawrence, Lindsay Gale Sparrow, Colin Wesley Ward, Meizhen Lou, Victor Strelstov
  • Methods of screening based on the EGF receptor crystal structure
    Publication number: 20080025983
    Abstract: This invention relates to the structure of members of the epidermal growth factor (EGF) receptor family and to receptor/ligand interactions. In particular, it relates to the field of using the EGF receptor family structure to select and screen for compounds that inhibit the formation of active receptor dimers.
    Type: Application
    Filed: August 3, 2007
    Publication date: January 31, 2008
    Inventors: Timothy Adams, Antony Burgess, Thomas Elleman, Thomas Garrett, Robert Jorissen, Meizhen Lou, George Lovrecz, Neil McKern, Edouard Nice, Colin Ward
  • Crystal Structure of Erbb2 and Uses Thereof
    Publication number: 20070281365
    Abstract: More particularly, the present invention relates to the crystal structure of the ErbB2, in particular the crystal structure of an extracellular portion of ErbB2 and to methods of using the crystal and related structural information to screen for and design compounds that interact with ErbB2, or variants of thereof.
    Type: Application
    Filed: October 6, 2003
    Publication date: December 6, 2007
    Inventors: Thomas Garrett, Thomas Elleman, Timothy Adams, Anthony Burgess, Robert Jorissen, Meizhen Lou, George Lovrecz, Neil McKern, Colin Ward
  • Cytokine receptor
    Publication number: 20070032640
    Abstract: A crystalline composition comprising a crystal of the IL-6 receptor I chain is provided. Also provided are methods of using the crystal and related structural information to screen for and design compounds that interact with IL-6R, or variants thereof. Also provided arc methods of modulating an IL-6 receptor comprising contacting the IL-6 receptor with a compound identified by the screening method of the invention.
    Type: Application
    Filed: September 16, 2002
    Publication date: February 8, 2007
    Inventors: Joseph Varghese, Richard Simpson, Robert Moritz, Meizhen Lou, Hong Ji, Kim Branson, Brian Smith
  • Method of designing agonists and antagonists to EGF receptor family
    Patent number: 6941229
    Abstract: The present invention relates to a method of designing compounds able to bind to a molecule of the EGF receptor family and to modulate the activity mediated by the receptor molecule based on the 3-D structure coordinates of the EGF receptor crystal of FIG. 6.
    Type: Grant
    Filed: May 31, 1999
    Date of Patent: September 6, 2005
    Assignees: Commonwealth Scientific and Industrial Research Organization, Ludwig Institute for Cancer Research
    Inventors: Thomas Charles Elleman, Vidanagamage Chandana Epa, Thomas Peter John Garrett, Robert Nicholas Jorissen, Meizhen Lou, Antony Wilks Burgess, Neil Moreton McKern, Herbert Rudolf Treutlein, Colin Lesley Ward
  • Methods of screening based on the egf receptor crystal structure
    Publication number: 20040248196
    Abstract: This invention relates to the structure of members of the epidermal growth factor (EGF) receptor family and to receptor/ligand interactions. In particular, it relates to the field of using the EGF receptor family structure to select and screen for compounds that inhibit the formation of active receptor dimers.
    Type: Application
    Filed: July 14, 2004
    Publication date: December 9, 2004
    Inventors: Timothy Edward Adams, Antony Wilks Burgess, Thomas Charles Elleman, Thomas Peter John Garrett, Robert Nicholas Jorissen, Meizhen Lou, George Oscar Lovrecz, Neil Moreton Mckern, Edouard Collins Nice, Colin Wesley Ward