Patents by Inventor Melissa J. Stiglitz

Melissa J. Stiglitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preserved, non-infectious control cells prepared by the modulation or modification of normal leukocytes
    Patent number: 5861311
    Abstract: The invention describes the preparation of preserved, non-infectious control cells. The control cells are prepared by modification, activation or otherwise changing selected normal leukocyte cells, tissue culture cells or zenogenic transplants in immunosuppressed animals to have characteristics of abnormal cells or by the addition of cells from an established cell line, which has been similarly modified or activated, to a normal leukocyte population. The preferred method of preserving the control cells is by lyophilization using an isotonic 10% trehalose solution.
    Type: Grant
    Filed: July 29, 1996
    Date of Patent: January 19, 1999
    Assignee: Coulter Corporation
    Inventors: John A. Maples, Patricia A. Roth, Melissa J. Stiglitz
  • Preparation of preserved, non-infectious control cell for use in the identification of a disease through blood testing
    Patent number: 5763204
    Abstract: Preparation of non-infectious control cells from normal, non-infectious, non-disease altered blood by depletion or augmentation of one or more cell types found in normal blood to reflect a specific disease state. The control cells so produced are preserved and thereafter reconstituted for use in immunological assays.
    Type: Grant
    Filed: May 28, 1996
    Date of Patent: June 9, 1998
    Assignee: Coulter Corporation
    Inventors: John A. Maples, Robert H. Raynor, Olavi Siiman, Melissa J. Stiglitz, Stephen F. Healy, Jr.
  • Preserved, non-infectious control cells prepared by the modulation or modification of cultured cells
    Patent number: 5622855
    Abstract: The invention describes the preparation of preserved, non-infectious control cells. The control cells are prepared by modification, activation or otherwise changing selected normal leukocyte cells, tissue culture cells or zenogenic transplants in immunosuppressed animals to have characteristics of abnormal cells or by the addition of cells from an established cell line, which have been similarly modified or activated, to a normal leukocyte population. The preferred method of preserving the control cells is by lyophilization using an isotonic 10% trehalose solution.
    Type: Grant
    Filed: April 10, 1995
    Date of Patent: April 22, 1997
    Assignee: Coulter Corporation
    Inventors: John A. Maples, Patricia A. Roth, Melissa J. Stiglitz
  • Preserved, non-infectious control cells prepared by the modulation or modification of normal cells
    Patent number: 5409826
    Abstract: The invention describes the preparation of preserved, non-infectious control cells. The control cells are prepared by modification, activation or otherwise changing selected normal leukocyte cells, tissue culture cells or zenogenic transplants in immunosuppressed animals to have characteristics of abnormal cells or by the addition of cells from an established cell line, which has been similarly modified or activated, to a normal leukocyte population. The preferred method of preserving the control cells is by lyophilization using an isotonic 10% trehalose solution.
    Type: Grant
    Filed: June 8, 1993
    Date of Patent: April 25, 1995
    Assignee: Coulter Corporation
    Inventors: John A. Maples, Patricia A. Roth, Melissa J. Stiglitz
  • Preserved, non-infectious control cell for use in the identification of a disease through blood testing
    Patent number: 5342754
    Abstract: The invention describes the preparation of non-infectious control cells from normal, non-infectious, non-disease altered blood by depletion or augmentation of one or more cell types found in normal blood to reflect a specific disease state. The control cells so produced are preserved and thereafter reconstituted for use in immunological assays.
    Type: Grant
    Filed: September 14, 1992
    Date of Patent: August 30, 1994
    Assignee: Coulter Corporation
    Inventors: John A. Maples, Robert H. Raynor, Olavi Siiman, Melissa J. Stiglitz, Stephen F. Healy, Jr.