Patents by Inventor Melvin L. Rueppel

Melvin L. Rueppel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • use of substituted N,N-disubstituted mercapto amino compounds for inhibiting cholesteryl ester transfer protein activity
    Patent number: 6458849
    Abstract: The invention relates to use of substituted polycyclic aryl and heteroaryl tertiary-heteroalkyamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Preferred tertiary-heteroalkylamine compounds are substituted N,N-disubstituted mercapto amines.
    Type: Grant
    Filed: November 14, 2001
    Date of Patent: October 1, 2002
    Assignee: G.D. Searle & Co.
    Inventors: James A. Sikorski, Richard C. Durley, Deborah A. Mischke, Emily J. Reinhard, Yvette M. Fobian, Michael B. Tollefson, Lijuan Wang, Margaret L. Grapperhaus, Brian S. Hickory, Mark A. Massa, Monica B. Norton, William F. Vernier, Barry L. Parnas, Michele A. Promo, Ashton T. Hamme, Dale P. Spangler, Melvin L. Rueppel
  • Substituted N-phenyl-N-heteroaralkyl aminoalcohol compounds for inhibiting cholesteryl ester transfer protein activity
    Patent number: 6458803
    Abstract: The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Preferred tertiary-heteroalkylamine compounds are substituted N-phenyl-N-heteroaralkyl aminoalcohols.
    Type: Grant
    Filed: November 23, 2001
    Date of Patent: October 1, 2002
    Assignee: G.D. Searle & Co.
    Inventors: James A. Sikorski, Richard C. Durley, Deborah A. Mischke, Emily J. Reinhard, Yvette M. Fobian, Michael B. Tollefson, Lijuan Wang, Margaret L. Grapperhaus, Brian S. Hickory, Mark A. Massa, Monica B. Norton, William F. Vernier, Barry L. Parnas, Michele A. Promo, Ashton T. Hamme, Dale P. Spangler, Melvin L. Rueppel
  • Use of substituted N, N-bis-phenyl aminoalcohol compounds for inhibiting cholesteryl ester transfer protein activity
    Patent number: 6458852
    Abstract: The invention relates to use of substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Preferred tertiary-heteroalkylamine compounds are substituted N,N- bis-phenyl aminoalcohols.
    Type: Grant
    Filed: November 14, 2001
    Date of Patent: October 1, 2002
    Assignee: G.D. Searle & Co.
    Inventors: James A. Sikorski, Richard C. Durley, Deborah A. Mischke, Emily J. Reinhard, Yvette M. Fobian, Michael B. Tollefson, Lijuan Wang, Margaret L. Grapperhaus, Brian S. Hickory, Mark A. Massa, Monica B. Norton, William F. Vernier, Barry L. Parnas, Michele A. Promo, Ashton T. Hamme, Dale P. Spangler, Melvin L. Rueppel
  • Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade
    Patent number: 6458952
    Abstract: The invention relates to substituted polycyclic aryl and heteroaryl uracil compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
    Type: Grant
    Filed: May 18, 2000
    Date of Patent: October 1, 2002
    Assignee: Pharmacia Corporation
    Inventors: Michael South, Darin E. Jones, Melvin L. Rueppel
  • Use of substituted N, N-disubstituted fused-heterocyclo amino compounds for inhibiting cholesteryl ester transfer protein activity
    Patent number: 6455519
    Abstract: The invention relates to use of substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Preferred tertiary-heteroalkylamine compounds are substituted N,N- disubstituted fused-heterocyclo amines.
    Type: Grant
    Filed: November 15, 2001
    Date of Patent: September 24, 2002
    Assignee: G.D. SEarle & Co.
    Inventors: James A. Sikorski, Richard C. Durley, Deborah A. Mischke, Emily J. Reinhard, Yvette M. Fobian, Michael B. Tollefson, Lijuan Wang, Margaret L. Grapperhaus, Brian S. Hickory, Mark A. Massa, Monica B. Norton, William F. Vernier, Barry L. Parnas, Michele A. Promo, Ashton T. Hamme, Dale P. Spangler, Melvin L. Rueppel
  • Use of substituted N,N-disubstituted non-fused heterocyclo amino compounds for inhibiting cholesteryl ester transfer protein activity
    Patent number: 6451830
    Abstract: The invention relates to use of substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Preferred tertiary-heteroalkylamine compounds are substituted N,N-disubstituted non-fused heterocyclo amines.
    Type: Grant
    Filed: November 14, 2001
    Date of Patent: September 17, 2002
    Assignee: G.D. Searle & Co.
    Inventors: James A. Sikorski, Richard C. Durley, Deborah A. Mischke, Emily J. Reinhard, Yvette M. Fobian, Michael B. Tollefson, Lijuan Wang, Margaret L. Grapperhaus, Brian S. Hickory, Mark A. Massa, Monica B. Norton, William F. Vernier, Barry L. Parnas, Michele A. Promo, Ashton T. Hamme, Dale P. Spangler, Melvin L. Rueppel
  • Use of substituted N-phenoxy-N-phenyl aminoalcohol compounds for inhibiting cholesteryl ester transfer protein activity
    Patent number: 6451823
    Abstract: The invention relates to use of substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Preferred tertiary-heteroalkylamine compounds are substituted N-phenoxy-N-phenyl aminoalcohols.
    Type: Grant
    Filed: November 14, 2001
    Date of Patent: September 17, 2002
    Assignee: G.D. Searle & Co.
    Inventors: James A. Sikorski, Richard C. Durley, Deborah A. Mischke, Emily J. Reinhard, Yvette M. Fobian, Michael B. Tollefson, Lijuan Wang, Margaret L. Grapperhaus, Brian S. Hickory, Mark A. Massa, Monica B. Norton, William F. Vernier, Barry L. Parnas, Michele A. Promo, Ashton T. Hamme, Dale P. Spangler, Melvin L. Rueppel
  • Use of substituted N-fused-phenyl-N-benzyl aminoalcohol compounds for inhibiting cholesteryl ester transfer protein activity
    Patent number: 6448295
    Abstract: The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Preferred tertiary-heteroalkylamine compounds are substituted N-fused-phenyl-N-benzyl aminoalcohols.
    Type: Grant
    Filed: November 14, 2001
    Date of Patent: September 10, 2002
    Assignee: G.D. Searle & Co.
    Inventors: James A. Sikorski, Richard C. Durley, Deborah A. Mischke, Emily J. Reinhard, Yvette M. Fobian, Michael B. Tollefson, Lijuan Wang, Margaret L. Grapperhaus, Brian S. Hickory, Mark A. Massa, Monica B. Norton, William F. Vernier, Barry L. Parnas, Michele A. Promo, Ashton T. Hamme, Dale P. Spangler, Melvin L. Rueppel
  • Substituted N, N-disubstituted diamino compounds useful for inhibiting cholesteryl ester transfer protein activity
    Publication number: 20020120011
    Abstract: The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Preferred tertiary-heteroalkylamine compounds are substituted N,N-disubstituted diamines.
    Type: Application
    Filed: November 14, 2001
    Publication date: August 29, 2002
    Inventors: James A. Sikorski, Richard C. Durley, Deborah A. Mischke, Emily J. Reinhard, Yvette M. Fobian, Michael B. Tollefson, Lijuan Wang, Margaret L. Grapperhaus, Brian S. Hickory, Mark A. Massa, Monica B. Norton, William F. Vernier, Barry L. Parnas, Michele A. Promo, Ashton T. Hamme, Dale P. Spangler, Melvin L. Rueppel
  • Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
    Publication number: 20010018446
    Abstract: The invention relates to substituted N-Aliphatic-N-Aromatic tertiary - Heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis, dyslipidemia, and other coronary artery disease.
    Type: Application
    Filed: January 16, 2001
    Publication date: August 30, 2001
    Applicant: G.D. Searle & Co.
    Inventors: James A. Sikorski, Richard C. Durley, Margaret L. Grapperhaus, Deborah A. Mischke, Emily J. Reinhard, Barry L. Parnas, Melvin L. Rueppel
  • Method for producing N-phosphonomethylglycine and its salts
    Patent number: 5948937
    Abstract: This invention relates to a process for the preparation of N-phosphonomethylglycine and its salts. More particularly, this invention is directed to a method for preparing N-phosphonomethylglycine involving the reaction of AMPA, an alkali metal cyanide or hydrogen cyanide, and formaldehyde and hydrolyzing the product of that reaction to form N-phosphonomethylglycine and its salts.
    Type: Grant
    Filed: September 5, 1997
    Date of Patent: September 7, 1999
    Assignee: Monsanto Company
    Inventors: Jimmy W. Worley, Melvin L. Rueppel, James C. Peterson, Sherrol L. Baysdon
  • Column switching procedure
    Patent number: 4454043
    Abstract: A method for increasing the capacity of a chromatographic system useful for the quantitative determination of at least one component of interest at a trace level concentration in a multi-component composition.
    Type: Grant
    Filed: November 17, 1980
    Date of Patent: June 12, 1984
    Assignee: Monsanto Company
    Inventors: Chihyuan C. Ting, David F. Tomkins, Melvin L. Rueppel
  • Method for the quantitative determination of cyanide
    Patent number: 4227888
    Abstract: A method for quantitatively determining the cyanide content of aqueous solution containing aldehydes and/or ketones as a measure of the sum of the free cyanide and cyanohydrin content. The method comprises converting cyanohydrin to free cyanide and then determining the free cyanide content of the solution.
    Type: Grant
    Filed: December 18, 1978
    Date of Patent: October 14, 1980
    Assignee: Monsanto Company
    Inventors: Melvin L. Rueppel, Chihyuan C. Ting
  • Treatment of sugarcane with N-(perfluoroacyl)-N-phosphonomethyl glycine
    Patent number: 4047926
    Abstract: N-(perfluoroacyl)-N-phosphonomethyl glycine compounds are prepared by the reaction of N-phosphonomethyl glycine with perfluoroacyl anhydrides employing an excess of the perfluoroalkanoic acid as the solvent. The N-(perfluoroacyl)-N-phosphonomethyl glycine compounds are useful as post-emergent herbicides and as sugar cane ripeners.
    Type: Grant
    Filed: May 3, 1976
    Date of Patent: September 13, 1977
    Assignee: Monsanto Company
    Inventor: Melvin L. Rueppel
  • N-(perfluoroacyl)-N-phosphonomethyl glycine compounds, method of preparing same
    Patent number: 4035176
    Abstract: N-(perfluoroacyl)-N-phosphonomethyl glycine compounds are prepared by the reaction of N-phosphonomethyl glycine with perfluoroacyl anhydrides employing an excess of the perfluoroalkanoic acid as the solvent. The N-(perfluoroacyl)-N-phosphonomethyl glycine compounds are useful as post-emergent herbicides and as sugar cane ripeners.
    Type: Grant
    Filed: May 3, 1976
    Date of Patent: July 12, 1977
    Assignee: Monsanto Company
    Inventor: Melvin L. Rueppel
  • N-(perfluoroacyl)-N-phosphonomethyl glycine compounds, method of preparing same
    Patent number: 3970695
    Abstract: N-(perfluoroacyl)-N-phosphonomethyl glycine compounds are prepared by the reaction of N-phosphonomethyl glycine with perfluoroacyl anhydrides employing an excess of the perfluoroalkanoic acid as the solvent. The N-(perfluoroacyl)-N-phosphonomethyl glycine compounds are useful as post-emergent herbicides.
    Type: Grant
    Filed: May 23, 1975
    Date of Patent: July 20, 1976
    Assignee: Monsanto Company
    Inventor: Melvin L. Rueppel