Patents by Inventor Menachem Shoham

Menachem Shoham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-virulence compositions and methods
    Patent number: 11382882
    Abstract: A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) includes administering to the bacterium an amount of AgrA antagonist effective to inhibit the synthesis of one or more virulence factors by the bacterium.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: July 12, 2022
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventor: Menachem Shoham
  • ANTI-VIRULENCE COMPOSITIONS AND METHODS
    Publication number: 20210308082
    Abstract: A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) includes administering to the bacterium an amount of AgrA antagonist effective to inhibit the synthesis of one or more virulence factors by the bacterium.
    Type: Application
    Filed: January 29, 2019
    Publication date: October 7, 2021
    Inventor: Menachem Shoham
  • ANTI-VIRULENCE COMPOSITIONS AND METHODS
    Publication number: 20200237692
    Abstract: A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) includes administering to the bacterium an amount of AgrA antagonist effective to inhibit the synthesis of one or more virulence factors by the bacterium.
    Type: Application
    Filed: January 29, 2019
    Publication date: July 30, 2020
    Inventor: Menachem Shoham
  • Anti-virulence compositions and methods
    Patent number: 10227282
    Abstract: A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) includes administering to the bacterium an amount of AgrA antagonist effective to inhibit the synthesis of one or more virulence factors by the bacterium.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: March 12, 2019
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventor: Menachem Shoham
  • ANTI-VIRULENCE COMPOSITIONS AND METHODS
    Publication number: 20180021277
    Abstract: A method of treating a bacterial infection in a subject in need thereof includes administering to the subject an AgrA antagonist.
    Type: Application
    Filed: September 29, 2017
    Publication date: January 25, 2018
    Inventors: Menachem Shoham, Rajesh Viswanathan, Guanping Yu
  • Anti-virulance compositions and methods
    Patent number: 9782363
    Abstract: A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) or an ortholog of AgrA includes administering to the bacterium an amount of a pharmaceutical composition effective to inhibit the synthesis of one or more virulence factors by the bacterium, the pharmaceutical composition including an AgrA antagonist.
    Type: Grant
    Filed: October 14, 2013
    Date of Patent: October 10, 2017
    Assignee: Case Western Reserve University
    Inventors: Menachem Shoham, Rajesh Viswanathan, Guanping Yu
  • ANTI-VIRULANCE COMPOSITIONS AND METHODS
    Publication number: 20150265550
    Abstract: A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) or an ortholog of AgrA includes administering to the bacterium an amount of a pharmaceutical composition effective to inhibit the synthesis of one or more virulence factors by the bacterium, the pharmaceutical composition including an AgrA antagonist.
    Type: Application
    Filed: October 14, 2013
    Publication date: September 24, 2015
    Inventors: Menachem Shoham, Rajesh Viswanathan, Guanping Yu
  • ANTI-VIRULENCE COMPOSITIONS AND METHODS
    Publication number: 20140336258
    Abstract: A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) includes administering to the bacterium an amount of AgrA antagonist effective to inhibit the synthesis of one or more virulence factors by the bacterium.
    Type: Application
    Filed: July 29, 2014
    Publication date: November 13, 2014
    Inventor: Menachem Shoham
  • Anti-virulence compositions and methods
    Patent number: 8859626
    Abstract: A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) includes administering to the bacterium an amount of AgrA antagonist effective to inhibit the synthesis of one or more virulence factors by the bacterium.
    Type: Grant
    Filed: March 8, 2011
    Date of Patent: October 14, 2014
    Assignee: Case Western Reserve University
    Inventor: Menachem Shoham
  • Pomegranate seed separator
    Patent number: 8322535
    Abstract: An apparatus for separating the arils from a fruit such as a pomegranate. The apparatus comprising a perforated grid for fixing over a receptacle, and a dome for covering the fruit and a corresponding method for removing seeds from a fruit comprising: (a) opening the fruit into at least two pieces; (b) placing the opened fruit opening side down onto a perforated grid and placing a dome over the piece of fruit; (c) placing the grid over a receptacle; (d) tapping the dome to separate and dislodge the arils from the fruit so that they fall through the openings into the receptacle.
    Type: Grant
    Filed: October 22, 2010
    Date of Patent: December 4, 2012
    Assignee: Miriam Shoham, Ltd.
    Inventors: Menachem Shoham, Noa Ohad
  • ANTI-VIRULENCE COMPOSITIONS AND METHODS
    Publication number: 20110218226
    Abstract: A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) includes administering to the bacterium an amount of AgrA antagonist effective to inhibit the synthesis of one or more virulence factors by the bacterium.
    Type: Application
    Filed: March 8, 2011
    Publication date: September 8, 2011
    Inventor: MENACHEM SHOHAM
  • POMEGRANATE SEED SEPARATOR
    Publication number: 20110094947
    Abstract: An apparatus for separating the arils from a fruit such as a pomegranate. The apparatus comprising a perforated grid for fixing over a receptacle, and a dome for covering the fruit and a corresponding method for removing seeds from a fruit comprising: (a) opening the fruit into at least two pieces; (b) placing the opened fruit opening side down onto a perforated grid and placing a dome over the piece of fruit; (c) placing the grid over a receptacle; (d) tapping the dome to separate and dislodge the arils from the fruit so that they fall through the openings into the receptacle.
    Type: Application
    Filed: October 22, 2010
    Publication date: April 28, 2011
    Applicant: Miriam Shoham Ltd.
    Inventors: Menachem Shoham, Noa Ohad
  • Identification and Use of Non-Peptide Analogs of RNAIII-Inhibiting Peptide for the Treatment of Staphylococcal Infections
    Publication number: 20070293435
    Abstract: RNAIII inhibiting peptide (RIP) has been established as an effective inhibitor of staphylococcal infections. Non-peptide small molecule analogs based on a pharmacophore conforming to the putative atomic structure of RIP, can be identified by computer screening of that pharmacophore against established libraries of known small molecules other than peptides. One such identified structural analog is hamamelitannin. When tested for effective inhibition of staphylococcal infections, hamamelitannin demonstrated inhibition similar to that exhibited by RIP. Other analogs can be identified and similarly used.
    Type: Application
    Filed: June 15, 2007
    Publication date: December 20, 2007
    Inventors: Naomi Balaban, Menachem Shoham