Patents by Inventor Mengwei Huang

Mengwei Huang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MACROCYCLIC TLR7 AGONIST, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF
    Publication number: 20240124486
    Abstract: A macrocyclic TLR7 agonist, a preparation method therefor, a pharmaceutical composition and use thereof. The macrocyclic TLR7 agonist disclosed is as represented by formula I, has good TLR7 agonistic activity, and can be used for treating or preventing tumors or infections caused by viruses.
    Type: Application
    Filed: September 26, 2021
    Publication date: April 18, 2024
    Inventors: Guozhi TANG, Dawei MA, Mengwei HUANG, Yongfu LIU, Yingyi WANG
  • Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection
    Patent number: 10189838
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, W1, W2, W3, A and X are as described herein, compositions including the compounds and methods of using the compounds for the treatment and prophylaxis of respiratory syncytial virus infection.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: January 29, 2019
    Assignee: Hoffman-La Roche Inc.
    Inventors: Lisha Wang, Lu Gao, Mengwei Huang, Lei Guo, Chungen Liang, Wei Zhu, Song Feng, Xiufang Zheng, Weixing Zhang, Guolong Wu, Baoxia Wang, Hongying Yun
  • NOVEL AZA-OXO-INDOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION
    Publication number: 20180072726
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, W1, W2, W3, A and X are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: November 16, 2015
    Publication date: March 15, 2018
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Lisha WANG, Lu GAO, Mengwei HUANG, Lei GUO, Chungen LIANG, Wei ZHU, Song FENG, Xiufang ZHENG, Weixing ZHANG, Guolong WU, Baoxia WANG, Hongying YUN
  • NOVEL AZA-OXO-INDOLES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION
    Publication number: 20160068531
    Abstract: The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5, R6, W1, W2, W3, A and X are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: November 16, 2015
    Publication date: March 10, 2016
    Applicant: HOFFMANN-LA ROCHE INC.
    Inventors: Lisha WANG, Lu GAO, Mengwei HUANG, Lei GUO, Chungen LIANG, Wei ZHU, Song FENG, Xiufang ZHENG, Weixing ZHANG, Guolong WU, Baoxia WANG, Hongying YUN
  • Compounds for the treatment and prophylaxis of Respiratory Syncytial Virus disease
    Patent number: 8871756
    Abstract: A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R10, A, Q, X and Y are as defined in the specification and claims, and their use as a pharmaceutical for the treatment or prophylaxis of respiratory syncytial virus disease.
    Type: Grant
    Filed: July 30, 2012
    Date of Patent: October 28, 2014
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Li Chen, Lichun Feng, Song Feng, Lu Gao, Tao Guo, Mengwei Huang, Chungen Liang, Yongfu Liu, Lisha Wang, Jason Christopher Wong, Jim Zhen Wu, Xihan Wu, Hongying Yun, Xiufang Zheng
  • Novel Alkene Oxindole Derivatives
    Publication number: 20140288127
    Abstract: The present invention provides compounds of formula (I), as well as pharmaceutically acceptable salt thereof, wherein R1 to R7 have the significance given herein. The compounds are useful in the treatment of prophylaxis of diseases that are related to AMPK regulation.
    Type: Application
    Filed: June 3, 2014
    Publication date: September 25, 2014
    Inventors: Li Chen, Lichun Feng, Mengwei Huang, Jia Li, Fajun Nan, Tao Pang, Lifang Yu, Mei Zhang
  • Tetrahydroquinoline derivatives
    Patent number: 8809369
    Abstract: The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein R1 to R8, A1 to A3 have the are as described herein and compositions including the compounds.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: August 19, 2014
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Lichun Feng, Mengwei Huang, Yongfu Liu, Guolong Wu, Shixiang Yan, Hongying Yun, Mingwei Zhou
  • Alkene oxindole derivatives
    Patent number: 8778973
    Abstract: The present invention provides compounds of formula (I), as well as pharmaceutically acceptable salt thereof, wherein R1 to R7 have the significance given herein. The compounds are useful in the treatment of prophylaxis of diseases that are related to AMPK regulation.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: July 15, 2014
    Assignee: Hoffmann-LaRoche Inc.
    Inventors: Li Chen, Lichun Feng, Mengwei Huang, Jia Li, Fajun Nan, Tao Pang, Lifang Yu, Mei Zhang
  • Tetrahydro-quinoline derivatives
    Patent number: 8592594
    Abstract: A compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein A1 to A3 and R1 to R10 have the significance given in claim 1, can be used as a medicament. These compounds are useful in the treatment or prophylaxis of diseases that are related to AMPK regulation, such as obesity, dyslipidemia, hyperglycemia, type 1 or type 2 diabetes and cancers.
    Type: Grant
    Filed: June 27, 2011
    Date of Patent: November 26, 2013
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Li Chen, Lichun Feng, Yun He, Mengwei Huang, Yongfu Liu, Hongying Yun, Mingwei Zhou
  • 3,3-dimethyl tetrahydroquinoline derivatives
    Patent number: 8586747
    Abstract: A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R5 have the significance given in claim 1, can be used as a medicament.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: November 19, 2013
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Li Chen, Lichun Feng, Mengwei Huang, Yongfu Liu, Guolong Wu, Jim Zhen Wu, Mingwei Zhou
  • Tetrahydroquinoline derivatives
    Patent number: 8546427
    Abstract: The present invention relates to compounds according to formula (I) and pharmaceutically acceptable salts or esters thereof, wherein R1 to R7 have the significance given herein. The compounds are activators of AMP-activated protein kinase (AMPK) and are useful in the treatment or prophylaxis of diseases that are related to AMPK regulation, such as obesity, dyslipidemia, hyperglycemia, type 1 or type 2 diabetes and cancers.
    Type: Grant
    Filed: October 13, 2011
    Date of Patent: October 1, 2013
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Lichun Feng, Mengwei Huang, Yongfu Liu, Guolong Wu, Mingwei Zhou
  • COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS DISEASE
    Publication number: 20130196974
    Abstract: A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R10, A, Q, X and Y are as defined in the specification and claims, and their use as a pharmaceutical for the treatment or prophylaxis of respiratory syncytial virus disease.
    Type: Application
    Filed: July 30, 2012
    Publication date: August 1, 2013
    Inventors: Li Chen, Lichun Feng, Song Feng, Lu Gao, Tao Guo, Mengwei Huang, Chungen Liang, Yongfu Liu, Lisha Wang, Jason Christopher Wong, Jim Zhen Wu, Xihan Wu, Hongying Yun, Xiufang Zheng
  • Cyclopropane indolinone derivatives
    Patent number: 8354443
    Abstract: The present invention relates to a compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R4 have the significance given in claim 1. The compound may be used, for example, for the treatment or prophylaxis of obesity, hyperglycemia, dyslipidemia, and type 1 or type 2 diabetes.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: January 15, 2013
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Li Chen, Lichun Feng, Yun He, Mengwei Huang, Hongying Yun
  • 3,3-dimethyl tetrahydroquinoline derivatives
    Patent number: 8344137
    Abstract: A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R5 have the significance given in claim 1, can be used as a medicament.
    Type: Grant
    Filed: April 7, 2011
    Date of Patent: January 1, 2013
    Assignee: Hoffman-La Roche Inc.
    Inventors: Li Chen, Lichun Feng, Mengwei Huang, Yongfu Liu, Guolong Wu, Jim Zhen Wu, Mingwei Zhou
  • NOVEL TETRAHYDROQUINOLINE DERIVATIVES
    Publication number: 20120190677
    Abstract: The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein R1 to R8, A1 to A3 have the are as described herein and compositions including the compounds.
    Type: Application
    Filed: January 19, 2012
    Publication date: July 26, 2012
    Inventors: Lichun Feng, Mengwei Huang, Yongfu Liu, Guolong Wu, Shixiang Yan, Hongying Yun, Mingwei Zhou
  • NOVEL TETRAHYDROQUINOLINE DERIVATIVES
    Publication number: 20120101127
    Abstract: The present invention relates to compounds according to formula (I) and pharmaceutically acceptable salts or esters thereof, wherein R1 to R7 have the significance given herein. The compounds are activators of AMP-activated protein kinase (AMPK) and are useful in the treatment or prophylaxis of diseases that are related to AMPK regulation, such as obesity, dyslipidemia, hyperglycemia, type 1 or type 2 diabetes and cancers.
    Type: Application
    Filed: October 13, 2011
    Publication date: April 26, 2012
    Inventors: Lichun Feng, Mengwei Huang, Yongfu Liu, Guolong Wu, Mingwei Zhou
  • NOVEL TETRAHYDRO-QUINOLINE DERIVATIVES
    Publication number: 20120004218
    Abstract: A compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein A1 to A3 and R1 to R10 have the significance given in claim 1, can be used as a medicament. These compounds are useful in the treatment or prophylaxis of diseases that are related to AMPK regulation, such as obesity, dyslipidemia, hyperglycemia, type 1 or type 2 diabetes and cancers.
    Type: Application
    Filed: June 27, 2011
    Publication date: January 5, 2012
    Inventors: Li Chen, Lichun Feng, Yun He, Mengwei Huang, Yongfu Liu, Hongying Yun, Mingwei Zhou
  • NOVEL 3,3-DIMETHYL TETRAHYDROQUINOLINE DERIVATIVES
    Publication number: 20110257151
    Abstract: A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R5 have the significance given in claim 1, can be used as a medicament.
    Type: Application
    Filed: April 7, 2011
    Publication date: October 20, 2011
    Inventors: Li Chen, Lichun Feng, Mengwei Huang, Yongfu Liu, Guolong Wu, Jim Zhen Wu, Mingwei Zhou
  • NOVEL CYCLOPROPANE INDOLINONE DERIVATIVES
    Publication number: 20110144106
    Abstract: The present invention relates to a compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R4 have the significance given in claim 1.
    Type: Application
    Filed: December 3, 2010
    Publication date: June 16, 2011
    Inventors: Li Chen, Lichun Feng, Yun He, Mengwei Huang, Hongying Yun
  • Compounds for the treatment and prophylaxis of respiratory syncytial virus disease
    Patent number: RE49481
    Abstract: A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R10, A, Q, X and Y are as defined in the specification and claims, and their use as a pharmaceutical for the treatment or prophylaxis of respiratory syncytial virus disease.
    Type: Grant
    Filed: October 21, 2020
    Date of Patent: April 4, 2023
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Li Chen, Lichun Feng, Song Feng, Lu Gao, Tao Guo, Mengwei Huang, Chungen Liang, Yongfu Liu, Lisha Wang, Jason Christopher Wong, Jim Zhen Wu, Xihan Wu, Hongying Yun, Xiufang Zheng