Abstract: A dry granulation process using a twin-screw extruder for granulating a powder mixture which includes at least one active ingredient and at least one carrier. The process includes steps of kneading the powder mixture in the screw barrel of the twin-screw extruder at a barrel temperature below a melting point of the at least one active ingredient and a melting point or a glass transition temperature of the at least one carrier to provide a kneaded powder mixture, and extruding the kneaded powder mixture to form granules. Granules and tablets produced using the dry granulation process in the twin-screw extruder are also provided.

Abstract: An enhanced security of multiple software processes executing on a computer system is provided by isolating those processes from each other and from access to system hardware resources. Embodiments provide such isolation by executing kernel software that manages hardware and controls physical address space on a separate hardware thread (e.g., in an isolation domain) from the process threads executing application programs (e.g., in execution domains). This renders the software executing in the isolation domain safe from privilege escalation attacks and permits implementation of enforceable isolation between execution systems. A multithreaded processor having switch-on-event multithreading is used to provide software isolation and hardware-controlled handling of a subset of system services by a different hardware thread than the one requesting the service.

Abstract: A processing system includes a system interconnect, a processor coupled to communicate with other components in the processing system through the system interconnect, distributed general purpose registers (GPRs) in the processing system wherein a first subset of the distributed GPRs is located in the processor and a second subset of the distributed GPRs is located in the processing system and external to the processor, and a first set of conductors directly connected between the processor and the second subsets of the distributed GPRs. An instruction execution pipeline in the processor accesses any register in the first and second subsets of the distributed GPRs as part of the processor's GPRs during instruction execution in the processor, in which the second subset of the distributed GPRs is accessed through the first conductor.

Abstract: Products containing a nicotine-polymer complex are provided herein, which can optionally further include one or more, different nicotine components. Certain such products are pouched products including an outer water-permeable pouch defining a cavity containing a composition comprising a water-soluble component capable of being released through the water-permeable pouch. The disclosure further provides methods of preparing such products.

Abstract: A bushing displacing system comprising an engaging member and a brace member. The engaging member is configured to engage the brace assembly to displace the engaging member in the displacement direction and at least a portion of the bushing assembly to displace at least a portion of the bushing assembly in the displacement direction. The brace member is adapted to engage the brace assembly and the structural member. Operation of the actuator displaces at least one of the brace assembly and the engaging member in the displacement direction relative to the structural member such that the engaging member displaces at least a portion of the bushing assembly towards a desired position relative to the housing opening in the structural member.

Abstract: The present invention is directed, in part, to methods of treating Epidermolysis Bullosa (EB) in a subject in need thereof, comprising topical administration of a pharmaceutical composition comprising a therapeutically effective amount of a of Coenzyme Q10 (CoQ10) to the subject.

Abstract: A bushing displacing system comprising an engaging member and a brace member. The engaging member is configured to engage the brace assembly to displace the engaging member in the displacement direction and at least a portion of the bushing assembly to displace at least a portion of the bushing assembly in the displacement direction. The brace member is adapted to engage the brace assembly and the structural member. Operation of the actuator displaces at least one of the brace assembly and the engaging member in the displacement direction relative to the structural member such that the engaging member displaces at least a portion of the bushing assembly towards a desired position relative to the housing opening in the structural member.

Abstract: The disclosed computer-implemented method may include (1) receiving an image of a section of a sectionable tissue sample block, the image including image data of, embedded into the section of the sectionable tissue sample block, (A) a section of a tissue sample, and (B) a section of a sectionable fiducial marker, (2) determining an attribute of the section of the sectionable fiducial marker from the received image of the section of the sectionable tissue sample block, and (3) executing a tissue sample management action based on the determined attribute of the section of the sectionable fiducial marker. Various other methods, systems, apparatuses, and computer-readable media are also disclosed.

Abstract: A system, method, and apparatus are provided for handling communications with external communication channel hardware devices by a processor executing event-based programming code to interface a plurality of virtual machines with the external communication channel hardware devices by providing the processor with an event latch for storing hardware events received from the external communication channel hardware devices, with a timer circuit that generates a sequence of timer interrupt signals, and with a masking circuit that masks the hardware events stored in the event latch with an event mask in response to each timer interrupt signal, where each event mask is associated with a different virtual machine running on the processor such that each virtual machine is allowed to communicate only on a masked subset of the hardware events specified by the event mask to ensure freedom from interference between the plurality of virtual machines when communicating with the external communication channel hardware device

Abstract: A processor including a pointer storage that stores pointer descriptors each including addressing information, an arithmetic logic unit (ALU) configured to execute an instruction which includes operand indexes each identifying a corresponding pointer descriptor, multiple address generation units (AGUs), each configured to translate addressing information from a corresponding pointer descriptors into memory addresses for accessing corresponding operands stored in a memory, and a smart cache. The smart cache includes a cache storage, and uses the memory addresses from the AGUs to retrieve and store operands from the memory into the cache storage, and to provide the stored operands to the ALU when executing the instruction. The smart cache replaces a register file used by a conventional processor for retrieving and storing operand information. The pointer operands include post-update capability that reduces instruction fetches. Wasted memory cycles associated with cache speculation are avoided.

Abstract: The present disclosure provides to transparent and controllable human-AI interaction via chaining of machine-learned language models. In particular, although existing language models (e.g., so-called “large language models” (LLMs)) have demonstrated impressive potential on simple tasks, their breadth of scope, lack of transparency, and insufficient controllability can make them less effective when assisting humans on more complex tasks. In response, the present disclosure introduces the concept of chaining instantiations of machine-learned language models (e.g., LLMs) together, where the output of one instantiation becomes the input for the next, and so on, thus aggregating the gains per step.

Abstract: Provided herein are methods, therapeutic agents and composition for treating a CNS-related disorder.

Abstract: A fusion cage has a first component that defines an outside surface that is configured to engage a vertebral endplate, and an interior surface. The fusion cage has a second component that defines first and second opposed surfaces. One of the first and second opposed surfaces can mate with the interior surface of the first component. The fusion cage can include vertical and lateral throughholes adapted to enhance fusion.

Abstract: Satellites may be integrated into a provider network for cloud-based services by utilizing a satellite-deployable computing device to execute one or more cloud services that are accessible by client devices of the provider network via respective associated Application Programming Interfaces (APIs). In some embodiments, the satellite-deployable computing device may process payload data of the satellite in accordance with one or more cloud-based services indicated in control instructions originating from a client device of the provider network. In some embodiments, the processed data may be transmitted to a ground station in accordance with one or more cloud-based services.

Abstract: A dual-layered midsole for footwear includes an internal midsole layer and an external midsole layer, which are coupled to and separated by a Strobel board. The internal midsole layer may compress and expand with the movement of a wearer of an article of footwear including the dual-layered midsole, while the external midsole may provide stability and cushion for the wearer. Materials selected for the internal and external midsole layers may provide tuned viscoelastic properties to different areas of the midsole as a function of midsole layer thickness at each sole area.

Abstract: A rocker recliner is disclosed that has a pair of stationary arms; a seat disposed between the arms; an ottoman; a back coupled to the seat. A full-recline linkage mechanism couples the ottoman, the seat and the back and is operable to move the ottoman, the seat and the back between a closed position, a TV position and a fully reclined position. A rocker assembly is coupled between the full-recline linkage mechanism and the stationary arms that allows the seat, back and ottoman to rock between the stationary arms in any of the closed position, the TV position or the fully reclined position.

Abstract: A method for increasing a detection distance of a surface of an object illuminated by near-IR electromagnetic radiation, including: (a) directing near-IR electromagnetic radiation from a near-IR electromagnetic radiation source towards an object at least partially coated with a near-IR reflective coating that increases a near-IR electromagnetic radiation detection distance by at least 15% as measured at a wavelength in a near-IR range as compared to the same object coated with a color matched coating which absorbs more of the same near-IR radiation, where the color matched coating has a ?E color matched value of 1.5 or less when compared to the near-IR reflective coating; and (b) detecting reflected near-IR electromagnetic radiation reflected from the near-IR reflective coating. A system for detecting proximity of vehicles is also disclosed.

Abstract: A retaining piece for an earpiece of an in-ear audio output device comprises a retainer portion and a cantilevered portion. The cantilevered portion comprises a coupling edge and a free edge which is substantially opposite the coupling edge. The cantilevered portion is coupled to the retainer portion at the coupling edge and is configured to engage with at least a part of an outer wall of a concha of a user's pinna. The cantilevered portion comprises a convexly curved section between the coupling edge and the free edge. When the cantilevered portion is in an engaged state, the coupling edge is more medial than the free edge.

Abstract: Embodiments of the present disclosure are drawn to systems and methods for adjusting a three-dimensional (3D) model used in metal additive manufacturing to maintain dimensional accuracy and repeatability of a fabricated 3D part. These embodiments may be used to reduce or remove geometric distortions in the fabricated 3D part. One exemplary method may include: receiving, via one or more processors, a selection made by a user; receiving a 3D model of a desired part; retrieving at least one model constant based on the user's selection; receiving an input of at least one process variable setting from a set of process variable settings; generating transformation factors based on the at least one process variable parameter and the at least one model constant; transforming the 3D model of the desired part based on the transformation factors; and generating processing instructions for fabricating the transformed 3D model of the desired part.

Abstract: Techniques are disclosed for fabricating multi-part assemblies. In particular, by forming release layers between features such as bearings or gear teeth, complex mechanical assemblies can be fabricated in a single additive manufacturing process.