Patents by Inventor Michael Bagdasarian

Michael Bagdasarian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chimeric LTB vaccines
    Patent number: 5993820
    Abstract: A chimeric protein formed of a small peptide antigen inserted into an exposed surface region of the B subunit of heat-labile enterotoxin of E. coli useful as an immunogenic vaccine composition.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: November 30, 1999
    Assignee: Michigan State University
    Inventors: Michael Bagdasarian, James Ireland
  • Glucose isomerases with improved affinity for D-glucose
    Patent number: 5266475
    Abstract: A genetically engineered glucose isomerase with improved affinity for D-glucose and the method of preparation of such a glucose isomerase are disclosed. The glucose isomerase is obtained by mutagenizing the gene of a naturally occurring glucose isomerase such that a smaller amino acid replaces a larger amino acid in the catalytic site. In an especially advantageous embodiment of the present invention, the Clostridium glucose isomerase sequence is mutated and the residue replaced with a smaller amino acid is either Trp.sub.139 or Val.sub.186.
    Type: Grant
    Filed: September 19, 1991
    Date of Patent: November 30, 1993
    Assignee: Michigan Biotechnology Institute
    Inventors: Chanyong Lee, Michael Bagdasarian, J. Gregory Zeikus, Menghsiao Meng