Abstract: A refrigerator having an ice and water dispenser has a seal to sealingly engage the ice compartment when the refrigerator door is closed. The seal is flexible to accommodate manufacturing tolerance. The seal may be impregnated with a friction reducing agent to increase life of the seal.

Abstract: A stand alone ice making appliance or an ice maker within an appliance is provided where the ice maker includes a fluid inlet, a filtration element in fluid communication with the fluid inlet, a control housing configured to engage the filtration element, and a filter cover disposed adjacent the control housing and configured to support the filtration element, wherein the filter cover comprises a plurality of fluid draining slots.

Abstract: A stand alone ice making appliance or an ice maker within an appliance is provided where the ice maker includes a fluid inlet, a filtration element in fluid communication with the fluid inlet, a control housing configured to engage the filtration element, and a filter cover disposed adjacent the control housing and configured to support the filtration element, wherein the filter cover comprises a plurality of fluid draining slots.

Abstract: A stand alone ice making appliance or an ice maker within an appliance is provided including a fluid supply inlet, a fluid reservoir that is configured to receive a fluid from the fluid supply inlet, a cooling plate that is in fluid communication with the fluid reservoir, a refrigeration device in thermal contact with the cooling plate that is configured to freeze a predetermined amount of fluid to form a section of ice, a cutter grid configured adjacent the cooling plate to divide the section of ice, wherein at least a portion of the ice produces an excess fluid, an ice storage area in communication with the cutter grid where the storage area has at least one vertical wall, and a fluid diverter configured adjacent the cutter grid that is configured to direct the excess fluid toward the at least one vertical wall.

Abstract: Disclosed herein is a method for producing a recombinant polypeptide in a mammalian cell culture in which the mammalian cells have a modified microRNA activity level. In one embodiment, a microRNA activity level is increased. In another embodiment, a microRNA activity level is decreased. In a more particular embodiment, the mammalian cells have a reduced miRNA-let-7a activity level.

Abstract: A pump moves fluid by means of a piston reciprocating inside a cylinder. Fluid enters the cylinder through an inlet valve that passes through the cylinder head, and has an enlarged surface inside the cylinder, which seals against the cylinder head. This valve is normally held closed by a spring. As the piston advances, fluid is forced out of the cylinder through a passage in the cylinder head and a check valve. A rod is affixed to the piston and passes through the inlet valve. As the piston retracts, the rod slides through the inlet valve, until a stop, affixed to the rod, encounters the stem of the inlet valve. The spring holding the valve closed is overcome and the valve opens as the piston and rod move farther, until the piston is in its fully retracted position. Fluid enters the cylinder until the piston again begins to advance. The stop ceases to push the inlet valve open, and the spring again holds it closed.

Abstract: The present invention provides anti-human ICOS antibodies with increased effector function. The invention further relates to pharmaceutical compositions, immunotherapeutic compositions, and methods using therapeutic antibodies that bind to the human ICOS antigen and that may mediate ADCC, CDC, and/or antibody-dependent phagocytosis (opsonization) for the treatment and prevention of T cell-mediated diseases and disorders, such as, but not limited to, chronic infection, autoimmune disease or disorder, inflammatory disease or disorder, graft-versus-host disease (GVHD), transplant rejection, and T cell proliferative disorder.

Abstract: Variants of cytotoxic T-lymphocyte antigen 4 (CTLA-4) with high affinity, potency and stability. Formulations of CTLA-4 variants at high concentration for subcutaneous or intravenous administration, e.g. at monthly or less frequent dosage intervals. Use of CTLA-4 variants for treating rheumatoid arthritis and other inflammatory disorders. Fusion of CTLA-4 with IgG Fc having improved stability and longer in vivo half-life.

Abstract: The present disclosure pertains to a pressure support system configured to provide pressure support therapy to a subject, wherein the pressure support system comprises a subject interface heater configured to controllably heat a pressurized flow of breathable gas to a target temperature that is offset from a baseline temperature. The breathable gas baseline temperature target offset ensures the gas delivered to the subject is delivered at a comfortable temperature and/or humidity level that does not cause airway dryness or result in condensed water in the subject interface. In one embodiment, the pressure support system comprises one or more of a pressure generator, a subject interface, a subject interface heater, one or more subject interface temperature sensors, one or more baseline temperature sensors, one or more general sensors, a humidifier, a user interface, a processor, electronic storage, and/or other components.

Abstract: A refrigerator having an ice and water dispenser has a seal to sealingly engage the ice compartment when the refrigerator door is closed. The seal is flexible to accommodate manufacturing tolerance. The seal may be impregnated with a friction reducing agent to increase life of the seal.

Abstract: The present invention provides human anti-IL-6 antibodies with extended in vivo half-life. The invention further relates to pharmaceutical compositions, therapeutic compositions, and methods using therapeutic antibodies that bind to IL-6 and that has an extended in vivo half-life for the treatment and prevention of IL-6 mediated diseases and disorders, such as, but not limited to, inflammatory diseases and disorders, autoimmune diseases and disorders and tumors.

Abstract: A refrigerator having an ice and water dispenser has a seal to sealingly engage the ice compartment when the refrigerator door is closed. The seal is flexible to accommodate manufacturing tolerance. The seal may be impregnated with a friction reducing agent to increase life of the seal.

Abstract: A stand alone ice making appliance or an ice maker within an appliance is provided including a fluid supply inlet, a fluid reservoir that is configured to receive a fluid from the fluid supply inlet, a cooling plate that is in fluid communication with the fluid reservoir, a refrigeration device in thermal contact with the cooling plate that is configured to freeze a predetermined amount of fluid to form a section of ice, a cutter grid configured adjacent the cooling plate to divide the section of ice, wherein at least a portion of the ice produces an excess fluid, an ice storage area in communication with the cutter grid where the storage area has at least one vertical wall, and a fluid diverter configured adjacent the cutter grid that is configured to direct the excess fluid toward the at least one vertical wall.

Abstract: A stand alone ice making appliance or an ice maker within an appliance is provided where the ice maker includes a fluid inlet, a filtration element in fluid communication with the fluid inlet, a control housing configured to engage the filtration element, and a filter cover disposed adjacent the control housing and configured to support the filtration element, wherein the filter cover comprises a plurality of fluid draining slots.

Abstract: An apparatus and method for a metal clad facade includes a thin metal cladding having at least one edge. The facade or the object with which it is associated has at least one edge around which the metal cladding edge can be wrapped. The wrapped edge could optionally be crimped. Optionally, exposed edges of the cladding could be covered by raised bosses or ribs on the facade. Optionally, a projection or extension of the cladding, oblique to other parts of the cladding, could extend into an opening in or near a surface of the facade or its underlying object. Wrapping of at least one edge with the metal cladding provides the appearance of a more substantial metal part than if the edge were not wrapped and provides for a more securement and durable attachment between the cladding and the underlying object.

Abstract: Stabilized antibodies directed to Angiopoeitin-2 and uses of such antibodies are described. Nucleic acid and amino acid sequences, hybridomas or other cell lines for expressing such antibodies are also provided.

Abstract: Stabilized antibodies directed to Angiopoeitin-2 and uses of such antibodies are described. Nucleic acid and amino acid sequences, hybridomas or other cell lines for expressing such antibodies are also provided.

Abstract: The present invention provides anti-human ICOS antibodies with increased effector function. The invention further relates to pharmaceutical compositions, immunotherapeutic compositions, and methods using therapeutic antibodies that bind to the human ICOS antigen and that may mediate ADCC, CDC, and/or antibody-dependent phagocytosis (opsonisation) for the treatment and prevention of T cell-mediated diseases and disorders, such as, but not limited to, chronic infection, autoimmune disease or disorder, inflammatory disease or disorder, graft-versus-host disease (GVHD), transplant rejection, and T cell proliferative disorder.

Abstract: The present invention provides human anti-IL-6 antibodies with extended in vivo half-life. The invention further relates to pharmaceutical compositions, therapeutic compositions, and methods using therapeutic antibodies that bind to IL-6 and that has an extended in vivo half-life for the treatment and prevention of IL-6 mediated diseases and disorders, such as, but not limited to, inflammatory diseases and disorders, autoimmune diseases and disorders and tumors.