Patents by Inventor Michael Boyce-Jacino

Michael Boyce-Jacino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NANONOZZLE DEVICE ARRAYS: THEIR PREPARATION AND USE FOR MACROMOLECULAR ANALYSIS
    Publication number: 20230126737
    Abstract: Constricted nanochannel devices suitable for use in analysis of macromolecular structure, including DNA sequencing, are disclosed. Also disclosed are methods for fabricating such devices and for analyzing macromolecules using such devices.
    Type: Application
    Filed: November 16, 2022
    Publication date: April 27, 2023
    Inventors: Han Cao, Parikshit A. Deshpande, Michael David Austin, Michael Boyce-Jacino
  • Nanonozzle device arrays: their preparation and use for macromolecular analysis
    Patent number: 11529630
    Abstract: Constricted nanochannel devices suitable for use in analysis of macromolecular structure, including DNA sequencing, are disclosed. Also disclosed are methods for fabricating such devices and for analyzing macromolecules using such devices.
    Type: Grant
    Filed: June 1, 2020
    Date of Patent: December 20, 2022
    Assignee: Bionano Genomics, Inc.
    Inventors: Han Cao, Parikshit A. Deshpande, Michael David Austin, Michael Boyce-Jacino
  • NANONOZZLE DEVICE ARRAYS: THEIR PREPARATION AND USE FOR MACROMOLECULAR ANALYSIS
    Publication number: 20210053823
    Abstract: Constricted nanochannel devices suitable for use in analysis of macromolecular structure, including DNA sequencing, are disclosed. Also disclosed are methods for fabricating such devices and for analyzing macromolecules using such devices.
    Type: Application
    Filed: June 1, 2020
    Publication date: February 25, 2021
    Inventors: Han Cao, Parikshit A. Deshpande, Michael David Austin, Michael Boyce-Jacino
  • Nanonozzle device arrays: their preparation and use for macromolecular analysis
    Patent number: 10676352
    Abstract: Constricted nanochannel devices suitable for use in analysis of macromolecular structure, including DNA sequencing, are disclosed. Also disclosed are methods for fabricating such devices and for analyzing macromolecules using such devices.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: June 9, 2020
    Assignee: BIONANO GENOMICS, INC.
    Inventors: Han Cao, Parikshit A. Deshpande, Michael David Austin, Michael Boyce-Jacino
  • Microfluidic Chips and Cartridges and Systems Utilizing Microfluidic Chips and Cartridges
    Publication number: 20190168221
    Abstract: Microfluidic chips and cartridges and systems that include such chips are disclosed. In some embodiments, the chips include a microfluidic channel disposed in a substrate with the channel comprising at least one expansion region. The channel is configured to generate a vortex within the at least one expansion region in response to fluid through the microfluidic channel to trap cells or particles. The substrate in which the channel is formed may be relatively rigid to resist deformation.
    Type: Application
    Filed: April 17, 2017
    Publication date: June 6, 2019
    Inventors: Elodie Sollier, Michael Lee Kochersperger, Robert F. Englert, James Che, Kuo-Wei Huang, Michael Boyce-Jacino, Anatasia Neddersen, Anna Passernig, Bruce Richardson, Insang Choi
  • NANONOZZLE DEVICE ARRAYS: THEIR PREPARATION AND USE FOR MACROMOLECULAR ANALYSIS
    Publication number: 20180290885
    Abstract: Constricted nanochannel devices suitable for use in analysis of macromolecular structure, including DNA sequencing, are disclosed. Also disclosed are methods for fabricating such devices and for analyzing macromolecules using such devices.
    Type: Application
    Filed: November 1, 2017
    Publication date: October 11, 2018
    Inventors: Han Cao, Parikshit A. Deshpande, Michael David Austin, Michael Boyce-Jacino
  • Methods of macromolecular analysis using nanochannel arrays
    Patent number: 10000804
    Abstract: Methods of analyzing features such as the physical size of macromolecules or biomarkers along large genomic DNA molecules were disclosed as wen as the devices for carrying out such high throughput analysis in a massively parallel fashion. Methods of fabricating such devices are also disclosed.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: June 19, 2018
    Assignee: BioNano Genomics, Inc.
    Inventors: Han Cao, Parikshit A. Deshpande, Michael D. Austin, Michael Boyce-Jacino
  • Polynucleotide mapping and sequencing
    Patent number: 10000803
    Abstract: The present invention provides methods of obtaining structural information about a biopolymer sample. The methods include labeling portions of a biopolymer, such as DNA or RNA, linearizing the biopolymer in some cases, and determining the distance between the labels. The user can then compare different samples' between-label distances to qualitatively compare different samples and to assay a given sample for additions or deletions of nucleotides in the regions flanked by the labels. The methods also permit sequencing of biopolymers.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: June 19, 2018
    Assignee: BioNano Genomics, Inc.
    Inventors: Ming Xiao, Han Cao, Parikshit A. Deshpande, Michael Boyce-Jacino
  • Nanonozzle device arrays: their preparation and use for macromolecular analysis
    Patent number: 9845238
    Abstract: Constricted nanochannel devices suitable for use in analysis of macromolecular structure, including DNA sequencing, are disclosed. Also disclosed are methods for fabricating such devices and for analyzing macromolecules using such devices.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: December 19, 2017
    Assignee: BioNano Genomics, Inc.
    Inventors: Han Cao, Parikshit A. Deshpande, Michael David Austin, Michael Boyce-Jacino
  • METHODS OF MACROMOLECULAR ANALYSIS USING NANOCHANNEL ARRAYS
    Publication number: 20160289756
    Abstract: Methods of analyzing features such as the physical size of macromolecules or biomarkers along large genomic DNA molecules were disclosed as wen as the devices for carrying out such high throughput analysis in a massively parallel fashion. Methods of fabricating such devices are also disclosed.
    Type: Application
    Filed: March 7, 2016
    Publication date: October 6, 2016
    Inventors: Han Cao, Parikshit A. Deshpande, Michael D. Austin, Michael Boyce-Jacino
  • Methods of macromolecular analysis using nanochannel arrays
    Patent number: 9310376
    Abstract: Methods of analyzing features such as the physical size of macromolecules or biomarkers along large genomic DNA molecules were disclosed as wen as the devices for carrying out such high throughput analysis in a massively parallel fashion. Methods of fabricating such devices are also disclosed.
    Type: Grant
    Filed: March 3, 2014
    Date of Patent: April 12, 2016
    Assignee: BIONANO GENOMICS, INC.
    Inventors: Han Cao, Parikshit A Deshpande, Michael D Austin, Michael Boyce-Jacino
  • POLYNUCLEOTIDE MAPPING AND SEQUENCING
    Publication number: 20160097092
    Abstract: The present invention provides methods of obtaining structural information about a biopolymer sample. The methods include labeling portions of a biopolymer, such as DNA or RNA, linearizing the biopolymer in some cases, and determining the distance between the labels. The user can then compare different samples' between-label distances to qualitatively compare different samples and to assay a given sample for additions or deletions of nucleotides in the regions flanked by the labels. The methods also permit sequencing of biopolymers.
    Type: Application
    Filed: October 7, 2015
    Publication date: April 7, 2016
    Inventors: MING XIAO, HAN CAO, PARIKSHIT A. DESHPANDE, MICHAEL BOYCE-JACINO
  • NANONOZZLE DEVICE ARRAYS: THEIR PREPARATION AND USE FOR MACROMOLECULAR ANALYSIS
    Publication number: 20150323518
    Abstract: Constricted nanochannel devices suitable for use in analysis of macromolecular structure, including DNA sequencing, are disclosed. Also disclosed are methods for fabricating such devices and for analyzing macromolecules using such devices.
    Type: Application
    Filed: May 14, 2015
    Publication date: November 12, 2015
    Applicant: BIONANO GENOMICS, INC.
    Inventors: Han Cao, Parikshit A. Deshpande, Michael David Austin, Michael Boyce-Jacino
  • Polynucleotide mapping and sequencing
    Patent number: 9181578
    Abstract: The present invention provides methods of obtaining structural information about a biopolymer sample. The methods include labeling portions of a biopolymer, such as DNA or RNA, linearizing the biopolymer in some cases, and determining the distance between the labels. The user can then compare different samples' between-label distances to qualitatively compare different samples and to assay a given sample for additions or deletions of nucleotides in the regions flanked by the labels. The methods also permit sequencing of biopolymers.
    Type: Grant
    Filed: November 18, 2009
    Date of Patent: November 10, 2015
    Assignee: BIONANO GENOMICS, INC.
    Inventors: Ming Xiao, Han Cao, Parikshit A. Deshpande, Michael Boyce-Jacino
  • Nanonozzle device arrays: their preparation and use for macromolecular analysis
    Patent number: 9061901
    Abstract: Constricted nanochannel devices suitable for use in analysis of macromolecular structure, including DNA sequencing, are disclosed. Also disclosed are methods for fabricating such devices and for analyzing macromolecules using such devices.
    Type: Grant
    Filed: July 19, 2007
    Date of Patent: June 23, 2015
    Assignee: BioNano Genomics, Inc.
    Inventors: Han Cao, Parikshit A. Deshpande, Michael D. Austin, Michael Boyce-Jacino
  • METHODS OF MACROMOLECULAR ANALYSIS USING NANOCHANNEL ARRAYS
    Publication number: 20140249039
    Abstract: Methods of analyzing features such as the physical size of macromolecules or biomarkers along large genomic DNA molecules were disclosed as wen as the devices for carrying out such high throughput analysis in a massively parallel fashion. Methods of fabricating such devices are also disclosed.
    Type: Application
    Filed: March 3, 2014
    Publication date: September 4, 2014
    Applicant: BioNano Genomics, Inc.
    Inventors: Han Cao, Parikshit A. Deshpande, Michael D. Austin, Michael Boyce-Jacino
  • Methods of macromolecular analysis using nanochannel arrays
    Patent number: 8722327
    Abstract: Methods of analyzing features such as the physical size of macromolecules or biomarkers along large genomic DNA molecules were disclosed as well as the devices for carrying out such high throughput analysis in a massively parallel fashion. Methods of fabricating such devices are also disclosed.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: May 13, 2014
    Assignee: BioNano Genomics, Inc.
    Inventors: Han Cao, Parikshit A. Deshpande, Michael D. Austin, Michael Boyce-Jacino
  • Methods and devices for single-molecule whole genome analysis
    Patent number: 8628919
    Abstract: Provided are methods and devices for single-molecule genomic analysis. In one embodiment, the methods entail processing a double-stranded nucleic acid and characterizing said nucleic acid. These methods are useful in, e.g., determining structural variations and copy number variations between individuals.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: January 14, 2014
    Assignee: Bionano Genomics, Inc.
    Inventors: Ming Xiao, Parikshit A. Deshpande, Han Cao, Michael Austin, Kandaswamy Vijayan, Alexey Y. Sharonov, Michael Boyce-Jacino
  • POLYNUCLEOTIDE MAPPING AND SEQUENCING
    Publication number: 20110306504
    Abstract: The present invention provides methods of obtaining structural information about a biopolymer sample. The methods include labeling portions of a biopolymer, such as DNA or RNA, linearizing the biopolymer in some cases, and determining the distance between the labels. The user can then compare different samples' between-label distances to qualitatively compare different samples and to assay a given sample for additions or deletions of nucleotides in the regions flanked by the labels. The methods also permit sequencing of biopolymers.
    Type: Application
    Filed: November 18, 2009
    Publication date: December 15, 2011
    Applicant: Bionanomatrix, Inc.
    Inventors: Ming Xiao, Han Cao, Parikshit A. Deshpande, Michael Boyce-Jacino
  • METHODS AND DEVICES FOR SINGLE-MOLECULE WHOLE GENOME ANALYSIS
    Publication number: 20110171634
    Abstract: Provided are methods and devices for single-molecule genomic analysis. In one embodiment, the methods entail processing a double-stranded nucleic acid and characterizing said nucleic acid. These methods are useful in, e.g., determining structural variations and copy number variations between individuals.
    Type: Application
    Filed: June 30, 2009
    Publication date: July 14, 2011
    Applicant: Bionanomatrix, Inc.
    Inventors: Ming Xiao, Parikshit A. Deshpande, Han Cao, Michael Austin, Kandaswamy Vijayan, Alexey Y. Sharonov, Michael Boyce-Jacino