Abstract: A method of treatment of skin tissue with two laser devices of unequal wavelengths comprising the steps of: (1) activating the two laser devices simultaneously to produce two laser beams of unequal wavelength; (2) directing the two laser beams into a handpiece having a distal tip to direct the laser beams onto the skin tissue; (3) directing the two laser beams within the handpiece to an adjustable beam deflector; and, (4) the adjustable beam deflector directing the two laser beams onto the skin tissue to produce a pattern of laser spots simultaneously but separated from one another.

Abstract: The present disclosure relates generally to fluorinated glucosamine analogs and uses thereof, including analogs of N-acetyl glucosamine fluorinated at 4- and/or 6-position(s) and derivatives of xylose at anomeric position for the treatment of a neurological disease, such as multiple sclerosis; inflammation; cancer; central nervous system injury; or conditions associated with up-regulation of an extracellular matrix, such as chondroitin sulfate proteoglycans.

Abstract: Methods, systems and computer program products for organizing and displaying in real-time data related to a plurality of documents. A plurality of documents and a plurality of entity identifiers are stored in a relational database storage. Each entity identifier has an entity type selected from a plurality of entity types. A plurality of entity associations between the plurality of entity identifiers and the plurality of documents are stored in a non-relational database storage. Each entity association defines a relationship between one or more entity identifiers and a selected document in the plurality of documents. A plurality of file icons are displayed in a display interface. The plurality of file icons includes active icons corresponding to a selection of the plurality of documents where the selection is determined by querying the non-relational database storage using at least one currently-selected entity identifier.

Abstract: Event vectors can be determined for respective events based on respective command-line records and a trained representation mapping. Respective coordinate vectors can be determined, each having fewer elements than the respective event vector. Respective representations of at least some of the events can be presented via an electronic display at the respective coordinate vectors. A selection of a first representation can be received via a user interface. The events can be clustered based on the event vectors. A first cluster can be selected based on the selection. An indication of a tag can be received via the user interface. Each event of the first cluster can be associated with the tag. Some examples include transmitting a security command to cause a monitored computing device associated with an event in the first cluster to perform a mitigation action.

Abstract: The present disclosure relates to analogs of N-acetyl glucosamine fluorinated at 4- and/or 6-position(s) and derivatives of xylose at anomeric position for the treatment of a neurological disease, inflammation, cancer and a central nervous system injury.

Abstract: An automatic packaging machine is provided and comprises a plurality of in-feed conveyors for separately conveying contents. The conveyors are at different heights. The machine includes means for placing the contents into a packaging article, or placing the packaging article around the contents, with the contents in a vertically stacked configuration.

Abstract: A machine includes a motor; and a transmission to drive a knife plate. The knife plate includes a plurality of knife blades. The machine further includes a die plate. The knife plate and the die plate interface at a cutting edge of the knife plate. The machine cuts feed material from larger sized pieces to smaller pieces by forcing the material through the die plate and cutting it with the knife plate.

Abstract: A wraparound sleeving system is provided and comprises a sleeving machine having a conveyor for transporting packaging sleeves. The packaging sleeves comprise one or more apertures for receiving a portion of one or more respective products. The sleeving machine comprises a folder for folding the sleeve so as to wrap a portion of said sleeve over or around a portion of said product after said portion of said product is received in said aperture.

Abstract: Methods and systems for sharing electronic documents are described herein. The example method includes storing the electronic documents in a relational database storage; storing entity identifiers in the relational database storage, each entity identifier representing an entity type; recording in a non-relational database storage associations between the electronic documents and at least one entity identifier, each association comprising a relationship between a set of electronic documents and the at least one entity identifier; associating a delegate account with the at least one entity identifier; and based on an association recorded in the non-relational database storage for the at least one entity identifier, granting the delegate account a subset of document management functions available for the set of documents.

Abstract: An event can be associated with a monitored computing device and a command-line record. An event vector can be determined for each of a plurality of events based at least in part on at least a portion of the respective command-line record and on a trained representation mapping. A respective reduced event vector can be determined having fewer elements. The reduced event vectors can be clustered to determine cluster identifiers. A first event can be determined to be associated with a security violation based on a corresponding cluster identifier matching a cluster identifier of a second event that is associated with a security violation. In some examples, a cluster can include a relatively larger first group of events and a relatively smaller second group of events. That cluster can be determined to satisfy a criterion based on the numbers of events in at least one of the groups.

Abstract: The present invention provides, inter alia, compounds having the structures of formulas described herein; pharmaceutically acceptable salts, solvates, hydrates, tautomers, and isotopic forms thereof; and compositions (e.g., pharmaceutical compositions and kits) containing one or more of the foregoing. Also provided are methods of administering and uses involving the compounds and/or pharmaceutical compositions for treating or preventing disease. The disease can be a proliferative disease, such as a cancer (e.g., a blood cancer (e.g., a leukemia or lymphoma), a brain cancer, a breast cancer, melanoma, multiple myeloma, or an ovarian cancer) a benign neoplasm, pathologic angiogenesis, or a fibrotic disease.

Abstract: Systems and methods are disclosed that cause a transient exchange ratio between digital assets at a kiosk, together with a countdown timer or other indication of how much time remains within which the ratio applies. If a transaction proceeds a voucher may be dispensed to confirm it. If a transaction participant using the kiosk is not yet vetted, the transaction is nevertheless deemed inchoate, and a prolonged vetting begins.

Abstract: The present invention provides various compositions, including compounds of Formula (I) or (Ia), or a species thereof, and pharmaceutically acceptable salts, solvates (e.g., hydrates), stereoisomer, tautomers, isotopic and other specified forms thereof. Also provided are methods (or uses) and kits involving the compounds or pharmaceutically acceptable compositions containing them for treating or preventing a disease (e.g., a proliferative disease such as cancer) in a subject. Administration of a compound or pharmaceutical composition described herein is expected to inhibit cyclin-dependent kinase 7 (CDK7), and thereby, induce apoptosis in tumor cells in the subject.

Abstract: A method of treatment of skin tissue with two laser devices of unequal wavelengths comprising the steps of: (1) activating the two laser devices simultaneously to produce two laser beams of unequal wavelength; (2) directing the two laser beams into a handpiece having a distal tip to direct the laser beams onto the skin tissue; (3) directing the two laser beams within the handpiece to an adjustable beam deflector; and, (4) the adjustable beam deflector directing the two laser beams onto the skin tissue to produce a pattern of laser spots simultaneously but separated from one another.

Abstract: Methods and systems for sharing electronic documents are described herein. The example method includes storing the electronic documents in a relational database storage; storing entity identifiers in the relational database storage, each entity identifier representing an entity type; recording in a non-relational database storage associations between the electronic documents and at least one entity identifier, each association comprising a relationship between a set of electronic documents and the at least one entity identifier; associating a delegate account with the at least one entity identifier; and based on an association recorded in the non-relational database storage for the at least one entity identifier, granting the delegate account a subset of document management functions available for the set of documents.

Abstract: An apparatus for cutting a whole tire into strips may include a cutting device having a first rotary blade and a second rotary blade. The tire is positioned between the first rotary blade and the second rotary blade, which cut the tire into one or more strips. The apparatus may further include a positioning system operable to orient the tire between a plurality of vertical, horizontal, and intermediate positions, relative to the cutting device. The apparatus may include one or more support rollers. The apparatus may further include a control system that controls the operation of the cutting device and tire positioning system as the tire is cut into strips by the cutting device. The apparatus may include a chipper to cut the tire strips into chips. The apparatus may include a bead peeler to remove the exterior rubber sheath from the wire bead.

Abstract: The present disclosure relates to analogs of N-acetyl glucosamine fluorinated at 4- and/or 6-position(s) and derivatives of xylose at anomeric position for the treatment of a neurological disease, inflammation, cancer and a central nervous system injury.

Abstract: The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g., cyclin-dependent kinase 7 (CDK7)), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.

Abstract: The present invention is directed to a capo, or a fretpad for a capo, for use with a stringed musical instrument. The fretpad is manufactured from a pliable material that mimics the compression of a human finger, and which prevents the instrument from going out of tune prematurely. The fretpad insert is radiused and configured to be insertable into a frame, which may be detachably connected to a capo body.

Abstract: A marker band locator system locates a marker band, from a plurality of marker bands in a hopper, into a band receiver for further processing. A hopper is configured to loosely hold a plurality of marker bands and a band receiver, configured in an indexer, is configured under the hopper such that marker bands gravity feed down to the band receiver. A vacuum source produces a vacuum on the band receiver and if a marker band is properly located therein, the marker band forms a seal with the band receiver and the vacuum pressure exceeds a threshold vacuum pressure level. The indexer then actuates to a secondary position for further processing and removal of the marker band. If the vacuum pressure does not exceed the threshold, a burst of air jostles the marker bands in the hopper until a marker band is seated properly.