Abstract: A tubing is anchored in a boiler casing positioned in a borehole that extends into a magma reservoir. The tubing may include a notch that is secured to a tubing anchor receptacle of the boiler casing. The boiler casing may include a float shoe that helps to prevent or restrict the flow of magma from the magma reservoir into the boiler casing and tubing.

Abstract: Systems and methods for operating a fluid supply system. The methods comprise: using a micro-turbine and an Energy Harvesting Circuit (“EHC”) to harvest energy from a fluid flowing through a pipeline; operating a switch to disconnect the EHC from the micro-turbine when an amount of energy harvested reaches a threshold value; detecting by a sensor device an amount of natural fluid flow through the pipeline while the EHC is disconnected from the micro-turbine; and operating the switch to reconnect the EHC to the micro-turbine after the amount of natural fluid flow has been detected.

Abstract: This invention relates to compounds useful as lysyl oxidase (LOX) and lysyl oxidase-like (LOXL) family member (LOXL1, LOXL2, LOXL3, LOXL4) inhibitors. In addition there are contemplated pharmaceutical compositions comprising the compounds and the use of the compounds in the treatment of conditions mediated by LOX and LOXL, for example cancer. In particular a LOX inhibitor such as the present compounds may be for use in the treatment of a cancer associated with EGFR. The present invention also contemplates the identification of biomarkers that predict responsiveness to a LOX inhibitor.

Abstract: A non-crosslinked polymeric heat shrink tubing including poly(ether-block-amide) (PEBA) and methods for making such non-crosslinked polymeric heat shrink tubing is provided. The non-crosslinked PEBA heat shrink tubing disclosed herein finds application, e.g., as a processing aid and final component in the manufacture of catheters and other medical devices.

Abstract: A surgical access system includes a connector including an arm, a coupling element, a rod, and a ridged slider. The arm includes first and second notched sections disposed in opposed lateral sides thereof. The coupling element includes a body section defining an opening therethrough, and opposed tabs protruding therefrom that are configured to receive the second notched section therebetween such that the arm is pivotably coupled to the coupling element. The rod includes a shaft having a plurality of angled grooves defined partially along a length thereof. The rod extends through the opening of the coupling element and the first notched section of the arm. The ridged slider includes a first surface having a plurality of ridges extending along a partial length thereof. The ridged slider extends through the coupling element with the plurality of ridges operably engaged with the plurality of angled grooves of the rod.

Abstract: Modular synthetic receptors are provided. The synthetic receptors may include an extracellular domain capable of binding to one or more ligand molecules and may be released from the synthetic receptor after binding, a transmembrane domain derived from the Notch receptor, and an intracellular domain which may have one or more functional activities when released from the synthetic receptor. A method of use for the synthetic receptors is also provided, wherein upon binding of the extracellular domain to a specific ligand, the synthetic receptor undergoes proteolytic cleavage to release either or both the extracellular and intracellular domains. The extracellular binding domain, if released, may continue to bind to its cognate ligand and may carry one or more additional functional activities and the intracellular domain, if released, may stimulate or inhibit one or more intracellular activities.

Abstract: Methods of enhancing efficiency of downstream chromatography steps for purification of proteins comprising: (a) passing a composition comprising a polypeptide of interest and various contaminants through an ion exchange membrane, wherein the polypeptide and the membrane have opposite charge, at operating conditions comprised of a buffer having a pH sufficiently distinct from the pi of the polypeptide to enhance the charge of the polypeptide and a low ionic strength effective to prevent the shielding of charges by buffer ions, which cause the membrane to bind the polypeptide and at least one contaminant, (b) overloading the ion exchange membrane such that at least one contaminant remains bound to the membrane while the polypeptide of interest is primarily in the effluent; (c) collecting the effluent from the ion exchange membrane comprising the polypeptide of interest; (d) subjecting the membrane effluent comprising the polypeptide of interest to a purification step of similar charge as the previous membrane,

Abstract: A method of identifying a vehicle total loss claim includes retrieving a plurality of historical vehicle records, labeling the records as repaired or total loss, calculating mean cost values, training a regression model, optimizing a probability threshold, analyzing a plurality of inputs to generate a prediction, and transmitting the prediction. A computing system includes a transceiver; a processor; and a memory storing instructions that, when executed by the processor, cause the computing system to receive answers, transmit the answers, receive a prediction, when the prediction is repairable, generate a repair suggestion, and when the prediction is total loss, generate a settlement offer. A non-transitory computer readable medium containing program instructions that when executed, cause a computer to receive answers, transmit the answers, receive a prediction, when the prediction is repairable, generate a repair suggestion, and when prediction is total loss, generate a settlement offer.

Abstract: The disclosure relates to compounds of Formula (I), or pharmaceutically acceptable salts thereof, wherein X1 and X5 is each selected from CR1 or N; X2, X3 and X4 is each selected from CR1, CR2 or N, provided at least one of X2, X3 and X4 is CR2 and provided only one of X1, X2, X3, X4 and X5 can be N. R1, R2, R3, R4, R5, L1, L2 and L3 are as defined herein. Compounds according to Formula (I) are pharmacologically effective as lysyl oxidase (LOX) inhibitors and are believed to be useful in the treatment of, for instance, cancer.

Abstract: The attachment of a pluggable hardware module to a server via a slot on an enclosure of the server is detected. In response to determining, using metadata stored at the server, that the module is in a group of approved modules, a first security artifact is obtained from the module. In response to validating the first security artifact using a second security artifact which is part of the metadata, a program running within a virtual machine launched at the server is enabled to access application data of an application from the module.

Abstract: The present disclosure provides a method of measuring the production of a cytokine in a sample in response to an agonist to determine responsiveness of a patient to immunotherapy. The present disclosure also provides a method of treating a cancer patient with an oncolytic viral therapy when a sample from the patient has a certain level of anti-viral antibodies. Further, the present disclosure describes, in part, an immune competence blood test that allows for one skilled in the art to determine if a tumor is immunoproficient to respond to an immunotherapy.

Abstract: Embodiments include a battery pack having a balanced current collector plate configured to connect a plurality of battery cells to one another and an electric vehicle including the same. The balanced current collector plate includes a terminal and a plurality of cell connection regions, each corresponding to one of the plurality of battery cells. Each of the plurality of cell connection regions includes one or more sidewalls, a cell connection tab that is configured to contact a terminal of a battery cell, and a cell fuse that is configured to electrically connect the cell connection tab to the balanced current collector plate. The geometry of each of the plurality of cell connection regions is configured to minimize a difference among the current draw between each of the plurality of battery cells and the terminal.

Abstract: In one embodiment, a method includes generating, from an accessed image, one or more image patches, and for each image patch: (1) accessing a set of point-spread functions (PSFs), wherein each PSF in the set of PSFs corresponds to one of a plurality of points in the image patch; (2) generating a set of deconvolved image patches by deconvolving the image patch with each PSF from the set of PSFs for that patch; (3) determining, for each of one or more portions of the image patch, a set of weights, wherein each weight in the set of weights is associated with one of the deconvolved image patches; and (4) generating a restored image patch by interpolating the set of deconvolved image patches based on the set of weights.

Abstract: An information handling system may include at least one processor and a memory. The information handling system may be configured to: host a container; execute a containerized application within the container, wherein the containerized application executes with privileges associated with a container-internal user; determine an association between the container-internal user and a host user associated with an operating system external to the container, wherein the determining is based on a cache that maintains a mapping between container-internal users and host users; and grant privileges to the containerized application based on the host user.

Abstract: The invention is a system and a device for use in open or minimally invasive surgical procedures, such as a bone implant fixation procedure. The device is configured to perform various functions during a bone implant fixation procedure, including performing at least one of: penetration of a bone to form a hole or opening for receipt of a screw; neuromonitoring, in cooperation with a neuromonitoring device, of the hole during, or post-, formation of the hole so as to sense any nearby nerves adjacent to the hole that may be in the path of a screw, or otherwise affected, when a screw is placed within the hole; neurostimulation, in cooperation with a neuromonitoring device, of nerves adjacent to the hole during, or post-, formation of the hole; and measuring of a depth of the hole and providing a digital measurement of the depth to assist the surgeon in selecting the appropriate length of screw.

Abstract: A system to calibrate a camera of a mobile device includes a fixture configured to hold the mobile device with the camera and a display of the mobile device exposed to an outside of the fixture; and a moving mechanism to move the fixture.

Abstract: A non-crosslinked polymeric heat shrink tubing including poly(ether-block-amide) (PEBA) and methods for making such non-crosslinked polymeric heat shrink tubing is provided. The non-crosslinked PEBA heat shrink tubing disclosed herein finds application, e.g., as a processing aid and final component in the manufacture of catheters and other medical devices.

Abstract: Disclosed are various embodiments providing user authentication through registered device communications. An authentication request is received from a client device. A user is authenticated for access to a user account based at least in part on the client device providing the authentication token. The authentication token is generated by the client device or by one or more other computing devices and sent to the client device. The client device encrypts the authentication token based at least in part on a user authenticating factor and stores the encrypted authentication token on the client device.

Abstract: A single space parking meter assembly for retrofitting onto an existing coin vault assembly includes a number of parking meter components enclosed within a protective outer covering that is rotatably or slidably engageable with the coin vault assembly when a bottom surface of the protective outer covering is positioned against or adjacent to an upper surface of the coin vault assembly. A locking mechanism secures the protective outer covering to the coin vault assembly when the protective outer covering is engaged with the coin vault assembly.

Abstract: An entity may want to capture personal data associated with one or more individuals. Personal data can include, for example, phone number(s), physical address(es), job titles, email address(es), or any other item of personal identifying information. The entity may be able to find such personal data via a variety of different data sources. For example, the entity may be able to find such personal data via tens, hundreds, thousands, or millions of different websites, documents, files, etc. The entity may also want to categorize the captured personal data by individual.