Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of protein and/or checkpoint kinases, methods of preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of preparing pharmaceutical formulations including one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the protein or checkpoint kinases using such compounds or pharmaceutical compositions. The invention also relates to the inhibition of hepatitis C virus (HCV) replication. In particular, embodiments of the invention provide compounds and methods for inhibiting HCV RNA-dependent RNA polymerase enzymatic activity. The invention also provides compositions and methods for the prophylaxis and treatment of HCV infection.

Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

Abstract: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

Abstract: In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyridine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

Abstract: According to some embodiments, a conditional Single Instruction, Multiple Data instruction is provided. For example, a first conditional instruction may be received at an n-channel SIMD execution engine. The first conditional instruction may be evaluated based on multiple channels of associated data, and the result of the evaluation may be stored in an n-bit conditional mask register. A second conditional instruction may then be received at the execution engine and the result may be copied from the conditional mask register to an n-bit wide, m-entry deep conditional stack.

Abstract: Thread to thread communication is provided. A first thread registers with a gateway for receiving communication. Registration includes identifying a location for receiving messages. The gateway maps message payloads received from second threads to the location of the first thread. The first thread detects a payload in the location and consumes it for processing.

Abstract: The present invention relates to four distinct crystalline polymorphs of a monohydrate of Compound A having the following chemical structure: These four polymorphic forms, herein referred to as Forms I, II, III and IV are active as a CXC-chemokine receptor ligands. The invention is further directed to formulations, methods of treatment, and processes of synthesis of these polymorphic forms.

Abstract: In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

Abstract: Disclosed are compounds of the formula (I) or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

Abstract: Disclosed are compounds of the formula (I) or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

Abstract: Disclosed are compounds of the formula: 1

Abstract: There are disclosed compounds of the formula 1

Abstract: There are disclosed compounds of the formula 1

Abstract: There are disclosed compounds of the formula 1

Abstract: Disclosed compounds of the formula (I) 1

Abstract: Disclosed are compounds of the formula (I) 1

Abstract: Disclosed are compounds of the formula: 1

Abstract: There are disclosed compounds of the formula 1

Abstract: A restructurable enclosure having a plurality of mounting blocks which are secured to the body of the enclosure at various spaced locations around and adjacent the outer peripheral portions of the door and wall panel openings therein. Each of the mounting blocks includes a plurality of threaded bores in the bottom surface thereof which communicate with openings in the enclosure body to facilitate permanent mounting of such blocks to the enclosure, and to facilitate attachment of sub-panels and other assemblies within the interior thereof, without obstructing the same. Each block also includes a pair of threaded or open bores extending inward from its outer mounting surface to facilitate mounting of the enclosure door or various wall panels to the enclosure solely from the exterior of the enclosure, without the need for accessing the interior thereof.