Abstract: The compounds of the present invention are represented by the following compounds having Formula (I) and Formula (I?): where the substituents R, R1, R3 R4, R?, W, X, Y, Z, k, and m are as defined herein and where the substituents R, R1, R2, R3, R4, X, Y, Z, and m are as defined herein. These compounds are used in the treatment of bacterial infections, parasite infections, fungal infections, cancer, immunologic disorders, autoimmune disorders, neurodegenerative diseases and disorders, inflammatory disorders, or muscular dystrophy or for providing immunosuppression for transplanted organs or tissues.

Abstract: The present disclosure relates to polypeptides (also referred to herein as CXCR4 binding molecules or polypeptides) that are directed against the G-coupled protein receptor CXCR4, also known as Fusin or CD184. The invention also relates to nucleic acids encoding such polypeptides; to methods for preparing such polypeptide; to compositions, and in particular to pharmaceutical compositions that comprise such polypeptides and to uses of such polypeptides for therapeutic or diagnostic purposes.

Abstract: Compounds of formula: are useful as antitumor agents. In these compounds, R10 is (a) (C1-C10) hydrocarbyl, (C1-C10)halohydrocarbyl, (C1-C6)hydroxyalkyl, or or R10 is (b) in which Q and A are linkers and Ar is optionally substituted monocyclic or bicyclic aryl or heteroaryl.

Abstract: The present disclosure relates to polypeptides (also referred to herein as CXCR4 binding molecules or polypeptides) that are directed against the G-coupled protein receptor CXCR4, also known as Fusin or CD184. The invention also relates to nucleic acids encoding such polypeptides; to methods for preparing such polypeptide; to compositions, and in particular to pharmaceutical compositions that comprise such polypeptides and to uses of such polypeptides for therapeutic or diagnostic purposes.

Abstract: This disclosure relates to an amyloid beta peptide (A?)-oligomer-specific antigen binding molecule and the use thereof as a diagnostic agent or as a therapeutic agent for the treatment or prevention of Alzheimer's Disease, Down's syndrome, mild cognitive impairment, cerebral amyloid angiopathy, vascular dementia, multi-infarct dementia, Parkinson's disease, Dementia with Lewy Bodies, Huntington's disease, Creutzfeldt-Jakob disease, cystic fibrosis, or Gaucher's disease.

Abstract: Disclosed are AMA-1 immunogenic peptides and epitopes, nucleotide sequences encoding the peptides and epitopes, compositions, and vaccines including the peptides and/or epitopes. Antibodies that specifically bind to AMA-1 and the AMA-1 epitopes and immunogenic peptides disclosed herein are also provided. The disclosure provides for expression vectors, host cells, and methods for making the polypeptides and antibodies. Also provided are methods of treatment, prevention, vaccination, and/or immunization of a subject against malaria and the clinical indications associated with malaria.

Abstract: A technology is described for embedding a semantic annotation in operation code. An example method may include creating an executable package file that includes operation code obtained from a source executable package file. The operation code may be analyzed to identify a program element included in the operation code that is associated with a semantic annotation. The semantic annotation may then be inserted into the operation code relative to the program element associated with the semantic annotation. The executable package file may be executed, launching a program, and the semantic annotation may be evaluated during execution of the program to retrieve semantic context obtained from the ontological data referenced by the semantic annotation. The semantic context may be processed, causing execution behavior of the program to be analyzed in relation to the program element included in the operation code.

Abstract: The present disclosure relates to polypeptides (also referred to herein as CXCR4 binding molecules or polypeptides) that are directed against the G-coupled protein receptor CXCR4, also known as Fusin or CD184. The invention also relates to nucleic acids encoding such polypeptides; to methods for preparing such polypeptide; to compositions, and in particular to pharmaceutical compositions that comprise such polypeptides and to uses of such polypeptides for therapeutic or diagnostic purposes.

Abstract: An unmanned aerial vehicle (UAV), a stand for launching, landing, testing, refueling and recharging a UAV, and methods for testing, landing and launching the UAV are disclosed. Further, embodiments may include transferring a payload onto or off of the UAV, and loading flight planning and diagnostic maintenance information to the UAV.

Abstract: A method comprising syncing, by a platform implemented by one or more processors, a plurality of computer files within an existing client data repository on a server to a specified geolocated polygons on a digital mapping interface, wherein the plurality of computer files are at least one of standalone computer files or computer files in a plurality of file directories; utilizing, by the platform, a geolocated polygon and attribute recommendation tool such that multiple embedded engines including (i) file directory and computer file property parsing to generate address or building name query strings to be processed through a machine learning gazetteer system; and (ii) optical character recognition to locate the address or building name query strings, to be processed through the machine learning gazetteer system, and keywords, processed into n-gram data structures to be cross-referenced against multiple internal or external keyword databases; and recommending, by the platform, geolocated polygons and geofile a

Abstract: An unmanned aerial vehicle (UAV), a stand for launching, landing, testing, refueling and recharging a UAV, and methods for testing, landing and launching the UAV are disclosed. Further, embodiments may include transferring a payload onto or off of the UAV, and loading flight planning and diagnostic maintenance information to the UAV.

Abstract: An unmanned aerial vehicle (UAV), a stand for launching, landing, testing, refueling and recharging a UAV, and methods for testing, landing and launching the UAV are disclosed. Further, embodiments may include transferring a payload onto or off of the UAV, and loading flight planning and diagnostic maintenance information to the UAV.

Abstract: Disclosed are AMA-1 immunogenic peptides and epitopes, nucleotide sequences encoding the peptides and epitopes, compositions, and vaccines including the peptides and/or epitopes. Antibodies that specifically bind to AMA-1 and the AMA-1 epitopes and immunogenic peptides disclosed herein are also provided. The disclosure provides for expression vectors, host cells, and methods for making the polypeptides and antibodies. Also provided are methods of treatment, prevention, vaccination, and/or immunization of a subject against malaria and the clinical indications associated with malaria.

Abstract: The present invention is directed to a conveyor belt cleaning apparatus comprising a frame having a front side, a rear side, two lateral sides and one or more openings located between the front side, the rear side and the lateral sides; a first scraping blade and a second scraping blade, wherein each of the scraping blades is positioned between the lateral sides of the frame, and wherein the second scraping blade is rearward of the first scraping blade; and means for securing the frame to the underside of a conveyor belt assembly such that the first scraping blade and the second scraping blade make contact with the conveyor belt of the conveyor belt assembly.

Abstract: The present invention is directed to a conveyor belt cleaning apparatus comprising a frame having a front side, a rear side, two lateral sides and one or more openings located between the front side, the rear side and the lateral sides; a first scraping blade and a second scraping blade, wherein each of the scraping blades is positioned between the lateral sides of the frame, and wherein the second scraping blade is rearward of the first scraping blade; and means for securing the frame to the underside of a conveyor belt assembly such that the first scraping blade and the second scraping blade make contact with the conveyor belt of the conveyor belt assembly.

Abstract: The invention relates to a compound of Formula I or a pharmaceutically acceptable ester, salt, prodrug or metabolite thereof;

Abstract: A method performed by a computing device and having one or more processors and memory storing one or more programs for execution by the one or more processors, comprising information including a representation of at least one compliance issue is received. The information is analyzed to determine at least one entity to which the at least one compliance issue is pertinent. The information is forwarded to the at least one entity in response to a determination that the legal change is pertinent to the at least one entity. A response is received from the at least one entity a response including a representation as to how the at least one entity intends to address the compliance issue.

Abstract: A first machine (e.g., server VM) authenticates an untrusted second machine (e.g., new client VM) as a condition to performing or allowing a protected operation. An authentication identifier is written to a file of a file system using one mechanism, and then read from the file using another mechanism. One of the mechanisms is an untrusted mechanism employing the untrusted second machine, while the other is a trusted mechanism performed by the first machine either alone or in combination with a trusted management component that has privileged access to the file system. If the written and read values match, it can be inferred that the second machine is authentic, because the trusted management component has identified and accessed an existing file system that is also separately accessed by the second machine.