Abstract: The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

Abstract: Disclosed are exemplary embodiments of systems and methods for routing return products from prior purchasers to subsequent purchasers. In an exemplary embodiment, a method generally includes receiving a search request for a target product, identifying a return product associated with the target product, in response to the search request, the return product designated for return from a prior purchaser to a seller of the return product, but not yet received by the seller, receiving a purchase request for the return product, the purchase request indicating a subsequent purchaser, and issuing an instruction, to a courier in possession of the return product and/or the prior purchaser of the return product, to route the return product to the subsequent purchaser.

Abstract: The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

Abstract: A medical appliance for the treatment of one or more sleep disorders such as obstructive sleep apnea in a patient, the appliance comprising: a biasing member for inserting behind and exerting a force upon the patient's soft palate or tongue, wherein the biasing member is inserted in a reduced or minimized form and then expanded or firms once in place to exert the force. The appliance may be nasally inserted or be placed through the mouth. In a particular configuration, both the soft palate and tongue are biased to prevent obstruction of the flow of air in the nasopharyngeal airway.

Abstract: Example apparatus and methods concern automated testing of a capacitive touch interface (e.g., touch screen). One example apparatus includes probes that extend and retract from the apparatus under programmatic control. The probes produce a capacitive touch response on a capacitive touch interface. The example apparatus includes logics configured to control touch testing of the interface using the probes. A first logic may provide a closed loop vision system for controlling the position of the interface relative to the apparatus. A second logic may calibrate a co-ordinate system associated with the apparatus and a co-ordinate system associated with the interface so that the apparatus may function in the pixel space of the interface being tested. A third logic may control the probes to test the interface by producing a series of touches, multi-touches, or gestures on the interface.

Abstract: A method and system for detecting potentially manipulative order patterns and assisting compliance professionals with analyzing and determining whether remedial actions are required with respect to such patterns to comply with governing regulations.

Abstract: Systems and methods for cooling a heat-treated metallic part include a plurality of atomization nozzles disposed on a stage and radially disposed about the part to be cooled; and a fluid in fluid communication with the atomization nozzles. The fluid may gas, liquid, or a combination thereof, e.g., water and gas. During use, the atomization nozzles are generally configured to rapidly cool the thicker sections of the part relative to the thinner section since the thicker sections are generally slower to cool. In some embodiments, the stage can be configured to rotate about the part during cooling. Methods are also disclosed.

Abstract: Provided are methods, systems and apparatuses for producing delivery devices, for example, for oral intake of an agent. In the broadest aspect, the method can include assembling one or more layers including one or more materials with an agent or an agent-releasing formulation to form an integrated, for example a laminated, device; folding the integrated delivery device to form a folded integrated delivery device; and at least partially enclosing the fold delivery device to a form suitable for oral delivery. The integrated device can include a first external layer of a first material; a frame of a second material mounted on the first external layer; an agent-releasing formulation housed within the frame; and a second external layer of the first material mounted on the frame.

Abstract: The invention provides a compound of Formula (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ii), (Ij), (Ik), or (Il) as defined herein, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

Abstract: The present invention discloses a liquid precursor composition adapted for application on a on a desired surface, this composition comprising: a. at least one therapeutic agent suitable for the treatment or prevention of a disorder or pathological condition, wherein said disorder or pathological condition excludes oral disorders, b. at least one acidic-pH sensitive polymer, c. at least one hydrophobic polymer, and d. a pharmaceutically acceptable volatile solvent, wherein a weight ratio between the at least one hydrophobic polymer and the at least one acidic-pH sensitive polymer is larger than 1.

Abstract: A secret (e.g. a password, key, certificate) is automatically generated by a system. For example, at the time of deployment of a computing machine, a password may be generated and securely stored by the system with other secrets. The password may be used by the system to perform various operations (e.g. configuring the machine, . . . ). When a secret is requested by a user to access a resource, a secret is provided to the user. Once the secret has been utilized by the user, the secret is reset and replaced with a newly generated secret. All/portion of the secrets may also be automatically regenerated. For example, when a breach occurs and/or is suspected, each of the secrets may be replaced with newly generated secrets and securely stored. Auditing and reporting may also be provided (e.g. each request/access to a secret is logged).

Abstract: Example apparatus and methods concern automated testing of a capacitive touch interface (e.g., touch screen). One example apparatus includes probes that extend and retract from the apparatus under programmatic control. The probes produce a capacitive touch response on a capacitive touch interface. The example apparatus includes logics configured to control touch testing of the interface using the probes. A first logic may provide a closed loop vision system for controlling the position of the interface relative to the apparatus. A second logic may calibrate a co-ordinate system associated with the apparatus and a co-ordinate system associated with the interface so that the apparatus may function in the pixel space of the interface being tested. A third logic may control the probes to test the interface by producing a series of touches, multi-touches, or gestures on the interface.

Abstract: The present disclosure relates to methods for predicting time-to-delivery in pregnant women. The methods include predicting that a pregnant woman will deliver within a predetermined time frame if PAMG-1 is determined to be present at a level above a predetermined detection threshold in a vaginal fluid sample obtained from the pregnant woman. Also provided are methods for determining a patient's risk of preterm labor and/or spontaneous rupture of the chorioamniotic membrane.

Abstract: The invention provides a compound of Formula (Ie), pharmaceutically acceptable salts, or stereoisomers thereof wherein the variables are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

Abstract: The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

Abstract: The present invention is directed to novel aminopyrrolidines of formula I pharmaceutically acceptable salts thereof, metabolites thereof, isomers thereof, stereoisomers thereof or pro-drugs thereof, wherein the variables are as defined herein. The compounds of formula (I) are useful as chemokine receptor antagonists and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.

Abstract: Provided are methods, systems and apparatuses for producing delivery devices, for example, for oral intake of an agent. The method can include assembling one or more layers including one or more materials with an agent or an agent-releasing formulation to form an intergraded device; folding the intergrated delivery device to form a folded integrated delivery device; and at least partially enclosing the folded delivery device to a form suitable for oral delivery.

Abstract: A secret (e.g. a password, key, certificate) is automatically generated by a system. For example, at the time of deployment of a computing machine, a password may be generated and securely stored by the system with other secrets. The password may be used by the system to perform various operations (e.g. configuring the machine, . . . ). When a secret is requested by a user to access a resource, a secret is provided to the user. Once the secret has been utilized by the user, the secret is reset and replaced with a newly generated secret. All/portion of the secrets may also be automatically regenerated. For example, when a breach occurs and/or is suspected, each of the secrets may be replaced with newly generated secrets and securely stored. Auditing and reporting may also be provided (e.g. each request/access to a secret is logged).

Abstract: The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

Abstract: A method and system for detecting potentially manipulative order patterns and assisting compliance professionals with analyzing and determining whether remedial actions are required with respect to such patterns to comply with governing regulations.