Abstract: Devices and methods for fluid enhanced ablation therapy using microwave antennas are described herein that provide improved heat transfer into a target volume of tissue and improved antenna cooling compared to prior art designs. In one embodiment, fluid can be introduced into a target volume of tissue along with the delivery of therapeutic energy from a microwave antenna positioned within the target volume of tissue. The fluid can become heated by cooling the microwave antenna and, if additional heating of the fluid is desired, a heating element disposed within the microwave antenna can supplementally heat the fluid prior to introduction into the target volume of tissue.

Abstract: Devices and methods for fluid enhanced ablation therapy using microwave antennas are described herein that provide improved heat transfer into a target volume of tissue and improved antenna cooling compared to prior art designs. In one embodiment, fluid can be introduced into a target volume of tissue along with the delivery of therapeutic energy from a microwave antenna positioned within the target volume of tissue. The fluid can become heated by cooling the microwave antenna and, if additional heating of the fluid is desired, a heating element disposed within the microwave antenna can supplementally heat the fluid prior to introduction into the target volume of tissue.

Abstract: Devices, systems, and methods for degassing fluid prior to applying fluid to a treatment site during ablation therapy are provided. In one embodiment, an ablation system can include an elongate body, an ablation element, a heating assembly, and a fluid source. Fluid in the fluid source can be at least partially degassed prior to being provided as part of the system, or, in some embodiments, a degassing apparatus can be provided that can be configured to degas fluid within the system prior to applying the fluid to the treatment site. The degassing apparatus can include one or more gas-permeable and fluid-impermeable tubes disposed therein, which can allow gas to be removed from fluid passing through the apparatus. Other exemplary devices, systems, and methods are also provided.

Abstract: Devices, systems, and methods for degassing fluid prior to applying fluid to a treatment site during ablation therapy are provided. In one embodiment, an ablation system can include an elongate body, an ablation element, a heating assembly, and a fluid source. Fluid in the fluid source can be at least partially degassed prior to being provided as part of the system, or, in some embodiments, a degassing apparatus can be provided that can be configured to degas fluid within the system prior to applying the fluid to the treatment site. The degassing apparatus can include one or more gas-permeable and fluid-impermeable tubes disposed therein, which can allow gas to be removed from fluid passing through the apparatus. Other exemplary devices, systems, and methods are also provided.

Abstract: Devices, systems, and methods for degassing fluid prior to applying fluid to a treatment site during ablation therapy are provided. In one embodiment, an ablation system can include an elongate body, an ablation element, a heating assembly, and a fluid source. Fluid in the fluid source can be at least partially degassed prior to being provided as part of the system, or, in some embodiments, a degassing apparatus can be provided that can be configured to degas fluid within the system prior to applying the fluid to the treatment site. The degassing apparatus can include one or more gas-permeable and fluid-impermeable tubes disposed therein, which can allow gas to be removed from fluid passing through the apparatus. Other exemplary devices, systems, and methods are also provided.

Abstract: Systems and methods for visualizing fluid enhanced ablation therapy are described herein. In one embodiment, a method for ablating tissue is provided that includes inserting an elongate body into a tissue volume, heating an imageable fluid within the elongate body to transform the imageable fluid into an imageable therapeutic fluid, delivering the imageable therapeutic fluid into the tissue volume to deliver a therapeutic dose of thermal energy to the tissue volume, and imaging the tissue volume to determine the extent of the tissue volume containing the imageable therapeutic fluid. The imageable therapeutic fluid can indicate the extent of the tissue volume that has received the therapeutic dose of thermal energy.

Abstract: Devices and methods for fluid enhanced ablation therapy using microwave antennas are described herein that provide improved heat transfer into a target volume of tissue and improved antenna cooling compared to prior art designs. In one embodiment, fluid can be introduced into a target volume of tissue along with the delivery of therapeutic energy from a microwave antenna positioned within the target volume of tissue. The fluid can become heated by cooling the microwave antenna and, if additional heating of the fluid is desired, a heating element disposed within the microwave antenna can supplementally heat the fluid prior to introduction into the target volume of tissue.

Abstract: Devices and methods for shaping an ablation treatment volume formed in fluid enhanced ablation therapy are provided. The devices and methods disclosed herein utilize the interaction of fluids to create ablation treatment volumes having a variety of shapes. In one embodiment, a method for forming an ablation treatment volume having a desired shape includes delivering therapeutic energy to tissue to form an ablation treatment volume and simultaneously delivering a first fluid and a second fluid to the tissue. The first and second fluids can convect the therapeutic energy in a desired direction such that the ablation treatment volume has a desired shape.

Abstract: Devices and methods for shaping an ablation treatment volume formed in fluid enhanced ablation therapy are provided. The devices and methods disclosed herein utilize the interaction of fluids to create ablation treatment volumes having a variety of shapes. In one embodiment, a method for forming an ablation treatment volume having a desired shape includes delivering therapeutic energy to tissue to form an ablation treatment volume and simultaneously delivering a first fluid and a second fluid to the tissue. The first and second fluids can convect the therapeutic energy in a desired direction such that the ablation treatment volume has a desired shape.

Abstract: Low profile devices and methods for delivering fluid enhanced ablation therapy are provided herein. In one embodiment, an ablation device is provided that includes an elongate body having proximal and distal ends, an inner lumen extending therethrough and at least one outlet port formed therein and configured to deliver fluid to surrounding tissue. The device can also include at least one ablation element disposed along a length of the body adjacent to the at least one outlet port and configured to deliver energy to surrounding tissue, as well as at least one heating element disposed within the inner lumen of the elongate body. The device further includes a handle having proximal and distal ends, the distal end of the handle being coupled to the proximal end of the elongate body. Further, a longitudinal axis of the elongate body extends at an angle to a longitudinal axis of the handle.

Abstract: Devices and methods for monitoring the temperature of tissue at various locations in a treatment volume during fluid enhanced ablation therapy are provided. In one embodiment, an ablation device is provided having an elongate body, at least one ablation element, and at least one temperature sensor. The elongate body includes a proximal and distal end, an inner lumen, and at least one outlet port to allow fluid to be delivered to tissue surrounding the elongate body. The at least one ablation element is configured to heat tissue surrounding the at least one ablation element. The at least one temperature sensor can be positioned a distance away from the at least one ablation element and can be effective to output a measured temperature of tissue spaced a distance apart from the at least one ablation element such that the measured temperature indicates whether tissue is being heating to a therapeutic level.

Abstract: Devices, systems, and methods for degassing fluid prior to applying fluid to a treatment site during ablation therapy are provided. In one embodiment, an ablation system can include an elongate body, an ablation element, a heating assembly, and a fluid source. Fluid in the fluid source can be at least partially degassed prior to being provided as part of the system, or, in some embodiments, a degassing apparatus can be provided that can be configured to degas fluid within the system prior to applying the fluid to the treatment site. The degassing apparatus can include one or more gas-permeable and fluid-impermeable tubes disposed therein, which can allow gas to be removed from fluid passing through the apparatus. Other exemplary devices, systems, and methods are also provided.

Abstract: Devices and methods for shaping an ablation treatment volume formed in fluid enhanced ablation therapy are provided. The devices and methods disclosed herein utilize the interaction of fluids to create ablation treatment volumes having a variety of shapes. In one embodiment, a method for forming an ablation treatment volume having a desired shape includes delivering therapeutic energy to tissue to form an ablation treatment volume and simultaneously delivering a first fluid and a second fluid to the tissue. The first and second fluids can convect the therapeutic energy in a desired direction such that the ablation treatment volume has a desired shape.

Abstract: Devices and methods for efficiently and reproducibly heating fluid for use in fluid enhanced ablation are disclosed herein. In one embodiment, an ablation device is provided having an elongate body, at least one wire extending through an inner lumen of the elongate body, and at least one spacer disposed within the inner lumen. The at least one wire extends through the at least one spacer such that the at least one spacer is effective to maintain an adjacent portion of the at least one wire in a substantially fixed geometric relationship with the inner lumen, thereby preventing electrical shorts and providing for the consistent and uniform heating of fluid flowing through the inner lumen of the elongate body.

Abstract: Devices and methods for controlling ablation therapy are provided herein. In one embodiment, an ablation device is provided that includes an elongate body having proximal and distal ends, and an inner lumen extending therethrough. The inner lumen can be configured to receive fluid therein and to deliver fluid to the distal end of the elongate body. The device can also include an ablation element positioned at a distal end of the elongate body that is configured to heat surrounding tissue, and a heater element disposed within the inner lumen adjacent to a distal end of thereof, the heater element being configured to heat fluid flowing through the inner lumen.

Abstract: A catheter and method for determining a position of the catheter within the cardiovascular system is provided. Local bending and twisting is measured at multiple locations along the catheter. By integrating the measurements, the position and orientation of the catheter is determined. Based on the catheter position information, the location and orientation of an ultrasound transducer array connected with the catheter is known. The imaging array position and orientation information may be used to assist a physician in determining the tissue structure or fluid being scanned and/or assist in the accurate generation of three-dimensional representations.

Abstract: A method and system for mapping surface data onto a geometrical representation of a structure for 3D imaging is provided. A boundary of a structure is determined from one type of data, such as Doppler energy data. Another type of data, such as B-mode data, representing the boundary or an area adjacent the boundary is extracted or identified. The B-mode data is then rendered as a function of the boundary, such as by texture mapping the B-mode data onto or adjacent the boundary. As the user examines the structure representation, the texture mapped data may provide texture details based on an optimally determined representation. The boundary may alternatively be used to select data for volume rendering.

Abstract: A method and system for therapeutically treating a selected volume of tissue with a heated liquid. A therapeutic device, such as a catheter, is coupled to a source of liquid is heated to therapeutic temperatures by a heating mechanism. The device imparts thermal energy into the tissue while simultaneously injecting the heated liquid into the tissue. In a preferred embodiment, the device includes at least one electrode for conducting a radio-frequency current through the tissue in conjunction with the infusion of heated saline solution to selectively destroy the tissue.

Abstract: The preferred embodiments include a method for manufacturing an end portion surrounding a catheter-mounted phased-array ultrasound transducer. The material used for the end portion can be altered to give the end portion focusing, defocusing, or non-focusing characteristics. In one preferred embodiment, a thermoplastic material is injection molded or insert molded around a phased-array ultrasound transducer carried at a distal end of a catheter. In another preferred embodiment, a thermoset material is used to form the end portion using a casting or transfer molding technique. In yet another preferred embodiment, the phased-array ultrasound transducer is placed into a pre-formed end portion. The pre-formed end portion can be adhesively-attached to the phased-array transducer and catheter. If the pre-formed end portion is made from a thermoplastic material, the end portion can be thermally melted to attach the end portion to the phased-array transducer and catheter.

Abstract: A skin-mounted physiological recording electrode assembly has a foam pad having a front surface having a central recess and mounted to the skin, and a rear surface. A pad passage extends from the central recess to the rear surface. An electrode in the pad passage has a sensing end in the central recess and a connector end to which a clip attaches. The clip attaches to a lead wire connecting to a monitoring device. At least one deformation gauge is coupled to the rear surface of the foam pad, and may be a strain gauge, a bending sensor, or a combination of both. The electrode assembly may be used in a patient monitoring system having an electrode signal processor, sensor signal processors, a multiplexer, an A-to-D convertor, and a microprocessor programmed with an adaptive noise canceling algorithm.