Patents by Inventor Michael Heffernan
Michael Heffernan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11958849Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.Type: GrantFiled: April 25, 2022Date of Patent: April 16, 2024Assignee: Board of Regents, The University of Texas SystemInventors: Maria Emilia Di Francesco, Philip Jones, Timothy Heffernan, Matthew M. Hamilton, Zhijun Kang, Michael J. Soth, Jason P. Burke, Kang Le, Christopher Lawrence Carroll, Wylie S. Palmer, Richard Lewis, Timothy McAfoos, Barbara Czako, Gang Liu, Jay Theroff, Zachary Herrera, Anne Yau
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Patent number: 10136955Abstract: Provided herein are actuation transmission lines used for robotic systems, for example, MRI guided robots, for image-guided robot-assisted surgical and medical intervention procedures. This actuation transmission lines may include any of the following: one or more sections of a flexible channel; one or more sections of a rigid channel in a connecting relationship with the one or more sections of a flexible channel; solid media disposed inside the channel; one or more mechanical links in contact with the solid media inside the channel electronically or mechanically linked to a power source; a fine-tuning module disposed in the flexible channel; and one or more media motion sensors.Type: GrantFiled: January 9, 2017Date of Patent: November 27, 2018Assignee: University of Houston SystemInventors: Nikolaos V. Tsekos, Michael Heffernan
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Publication number: 20180101659Abstract: The presently disclosed subject matter is directed to systems, devices, and methods that provide measurement and monitoring of mental health well-being of a patient for a healthcare provider. In some embodiments the method includes; receiving contact information for the patient from a remote computing device; transmitting a plurality of questions for the patient to the remote computing device, wherein the remote computing device is configured to display the plurality of questions and receive a plurality of responses to the questions from the patient; receiving the plurality of responses to the questions from the remote computing device indicating a mental health status of the patient; determining trends indicative of the mental health well-being of the patient based on the plurality of responses to the questions; transmitting at least a first portion of the trends to the remote computing device; and transmitting at least a second portion of the trends to a healthcare provider's computing device.Type: ApplicationFiled: October 2, 2017Publication date: April 12, 2018Inventors: Philip T. Ninan, Michael Heffernan
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Publication number: 20170135772Abstract: Provided herein are actuation transmission lines used for robotic systems, for example, MRI guided robots, for image-guided robot-assisted surgical and medical intervention procedures. This actuation transmission lines may include any of the following: one or more sections of a flexible channel; one or more sections of a rigid channel in a connecting relationship with the one or more sections of a flexible channel; solid media disposed inside the channel; one or more mechanical links in contact with the solid media inside the channel electronically or mechanically linked to a power source; a fine-tuning module disposed in the flexible channel; and one or more media motion sensors.Type: ApplicationFiled: January 9, 2017Publication date: May 18, 2017Inventors: Nikolaos V. Tsekos, Michael Heffernan
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Patent number: 9203909Abstract: A technique for enabling a plurality of software components to communicate in a software component matrix environment is disclosed. In one particular exemplary embodiment, the technique may be realized by a method for enabling a plurality of software components to communicate in a software component matrix environment comprising the steps of encoding a request at a client side; communicating the request to a server at a server side via a communication interface; comparing the request to a plurality of operations supported at the server side; determining whether a function match exists at the server side; and returning a response comprising the function match to the client side in response to the request via the communication interface wherein the response is mapped to a data model of a client.Type: GrantFiled: April 21, 2014Date of Patent: December 1, 2015Assignee: RPX Clearinghouse, LLCInventors: Martin J. Soukup, Gregory Hughes, Michael Heffernan
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Publication number: 20150098994Abstract: Pharmaceutical compositions are provided for the pharmacological treatment of breathing disorders and, more specifically, to compositions containing agents having serotonin receptor modulating activity for the alleviation of sleep apnea (central and obstructive) and other sleep-related breathing disorders wherein the active ingredients are released such as to extend effective blood plasma concentrations across the period of sleep.Type: ApplicationFiled: June 17, 2014Publication date: April 9, 2015Applicant: COLLEGIUM PHARMACEUTICAL, INC.Inventors: Roman V. Rariy, Michael Heffernan
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Patent number: 8828214Abstract: A method includes removing a casting shell and core from a cast component, which may be a gas turbine blade. The method further includes utilizing a focused removal technique, such as a water jet or laser drill, to remove a portion of a virtual pattern cast (VPC) shell from the cast component. The cast component is then exposed to a leaching solution and high pressure water wash to remove an internal core material and a portion of the VPC shell remainder from the cast component. The method further includes exposing the cast component to a high agitation leaching solution and to the high pressure water wash for a minimal time. An electroless nickel-boron coating is then applied to the cast component, and an electrolytic palladium coating is further applied to the cast component. The cast component is further exposed to a high agitation leaching solution for an extended period.Type: GrantFiled: December 28, 2011Date of Patent: September 9, 2014Assignees: Rolls-Royce Corporation, Rolls-Royce North American Technologies, Inc.Inventors: Michel Shawn Smallwood, Tab Michael Heffernan, Mark Steven McCormick, Randolph Clifford Helmink, Matthew Kush
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Publication number: 20140229536Abstract: A technique for enabling a plurality of software components to communicate in a software component matrix environment is disclosed. In one particular exemplary embodiment, the technique may be realized by a method for enabling a plurality of software components to communicate in a software component matrix environment comprising the steps of encoding a request at a client side; communicating the request to a server at a server side via a communication interface; comparing the request to a plurality of operations supported at the server side; determining whether a function match exists at the server side; and returning a response comprising the function match to the client side in response to the request via the communication interface wherein the response is mapped to a data model of a client.Type: ApplicationFiled: April 21, 2014Publication date: August 14, 2014Applicant: Rockstar Consortium US LPInventors: Martin J. Soukup, Gregory Hughes, Michael Heffernan
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Patent number: 8706806Abstract: A technique for enabling a plurality of software components to communicate in a software component matrix environment is disclosed. In one particular exemplary embodiment, the technique may be realized by a method for enabling a plurality of software components to communicate in a software component matrix environment comprising the steps of encoding a request at a client side; communicating the request to a server at a server side via a communication interface; comparing the request to a plurality of operations supported at the server side; determining whether a function match exists at the server side; and returning a response comprising the function match to the client side in response to the request via the communication interface wherein the response is mapped to a data model of a client.Type: GrantFiled: December 21, 2012Date of Patent: April 22, 2014Assignee: Rockstar Consortium US LPInventors: Martin Jan Soukup, Gregory Hughes, Michael Heffernan
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Publication number: 20130337061Abstract: Pharmaceutical compositions are provided for the pharmacological treatment of breathing disorders and, more specifically, to compositions containing agents having serotonin receptor modulating activity for the alleviation of sleep apnea (central and obstructive) and other sleep-related breathing disorders wherein the active ingredients are released such as to extend effective blood plasma concentrations across the period of sleep.Type: ApplicationFiled: August 19, 2013Publication date: December 19, 2013Applicant: Collegium Pharmaceutical, Inc.Inventors: Roman V. Rariy, Michael Heffernan
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Patent number: 8512751Abstract: Pharmaceutical compositions are provided for the pharmacological treatment of breathing disorders and, more specifically, to compositions containing agents having serotonin receptor modulating activity for the alleviation of sleep apnea (central and obstructive) and other sleep-related breathing disorders wherein the active ingredients are released such as to extend effective blood plasma concentrations across the period of sleep.Type: GrantFiled: December 20, 2005Date of Patent: August 20, 2013Assignee: Collegium Pharmaceutical, Inc.Inventors: Roman V. Rariy, Michael Heffernan
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Patent number: 8341218Abstract: A technique for enabling a plurality of software components to communicate in a software component matrix environment is disclosed. In one particular exemplary embodiment, the technique may be realized by a method for enabling a plurality of software components to communicate in a software component matrix environment comprising the steps of encoding a request at a client side; communicating the request to a server at a server side via a communication interface; comparing the request to a plurality of operations supported at the server side; determining whether a function match exists at the server side; and returning a response comprising the function match to the client side in response to the request via the communication interface wherein the response is mapped to a data model of a client.Type: GrantFiled: December 22, 2011Date of Patent: December 25, 2012Assignee: Rockstar Consortium US LPInventors: Martin Jan Soukup, Gregory Hughes, Michael Heffernan
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Publication number: 20120222961Abstract: A method includes removing a casting shell and core from a cast component, which may be a gas turbine blade. The method further includes utilizing a focused removal technique, such as a water jet or laser drill, to remove a portion of a virtual pattern cast (VPC) shell from the cast component. The cast component is then exposed to a leaching solution and high pressure water wash to remove an internal core material and a portion of the VPC shell remainder from the cast component. The method further includes exposing the cast component to a high agitation leaching solution and to the high pressure water wash for a minimal time. An electroless nickel-boron coating is then applied to the cast component, and an electrolytic palladium coating is further applied to the cast component. The cast component is further exposed to a high agitation leaching solution for an extended period.Type: ApplicationFiled: December 28, 2011Publication date: September 6, 2012Inventors: Michel Shawn Smallwood, Tab Michael Heffernan, Mark Steven McCormick, Randolph Clifford Helmink, Matthew Kush
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Publication number: 20120102100Abstract: A technique for enabling a plurality of software components to communicate in a software component matrix environment is disclosed. In one particular exemplary embodiment, the technique may be realized by a method for enabling a plurality of software components to communicate in a software component matrix environment comprising the steps of encoding a request at a client side; communicating the request to a server at a server side via a communication interface; comparing the request to a plurality of operations supported at the server side; determining whether a function match exists at the server side; and returning a response comprising the function match to the client side in response to the request via the communication interface wherein the response is mapped to a data model of a client.Type: ApplicationFiled: December 22, 2011Publication date: April 26, 2012Applicant: ROCKSTAR BIDCO, LPInventors: Martin Soukup, Gregory Hughes, Michael Heffernan
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Patent number: 8086665Abstract: A technique for enabling a plurality of software components to communicate in a software component matrix environment is disclosed. In one particular exemplary embodiment, the technique may be realized by a method for enabling a plurality of software components to communicate in a software component matrix environment comprising the steps of encoding a request at a client side; communicating the request to a server at a server side via a communication interface; comparing the request to a plurality of operations supported at the server side; determining whether a function match exists at the server side; and returning a response comprising the function match to the client side in response to the request via the communication interface wherein the response is mapped to a data model of a client.Type: GrantFiled: August 21, 2002Date of Patent: December 27, 2011Assignee: Rockstar Bidco, LPInventors: Martin Soukup, Gregory Hughes, Michael Heffernan
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Patent number: 7789621Abstract: A gas turbine engine airfoil including at least one outer tile coupled to a supporting member. The outer tile is coupled to the supporting member by a pin passing though the supporting member and the outer tile.Type: GrantFiled: June 27, 2006Date of Patent: September 7, 2010Assignee: Rolls-Royce North American Technologies, Inc.Inventors: Douglas David Dierksmeier, Jeffrey F. Rhodes, Tab Michael Heffernan
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Publication number: 20100074759Abstract: A gas turbine engine airfoil including at least one outer tile coupled to a supporting member. The outer tile is coupled to the supporting member by a pin passing though the supporting member and the outer tile.Type: ApplicationFiled: June 27, 2006Publication date: March 25, 2010Inventors: Douglas David Dierksmeier, Jeffrey F. Rhodes, Tab Michael Heffernan
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Patent number: 7575409Abstract: An active blade clearance control system for a gas turbine engine. The clearance between the tip of a rotatable blade and an inner surface of a blade track is adjusted by moving the blade track relative to the tip of the blades. A split control ring is manipulated to adjust tension therein and a resulting force is transmitted to an inner member. The plurality of blade tracks are coupled to the inner member and move in response to the force transmitted from the split control ring.Type: GrantFiled: July 1, 2005Date of Patent: August 18, 2009Assignee: Allison Advanced Development CompanyInventors: Douglas David Dierksmeier, Tab Michael Heffernan
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Publication number: 20080207593Abstract: A once daily formulation containing the combination of a non-sedating or selective antihistamine (Loratadine) with a sedating or non-selective antihistamine (Chlorpheniramine) administered at bed-time has demonstrated greater efficacy in relieving allergic symptoms than Loratadine alone.Type: ApplicationFiled: August 20, 2007Publication date: August 28, 2008Inventors: Michael Heffernan, Jane C. Hirsh, Roman V. Rariy
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Publication number: 20080200508Abstract: Pharmaceutical compositions are provided for the pharmacological treatment of breathing disorders and, more specifically, to compositions containing agents having serotonin receptor modulating activity for the alleviation of sleep apnea (central and obstructive) and other sleep-related breathing disorders wherein the active ingredients are released such as to extend effective blood plasma concentrations across the period of sleep.Type: ApplicationFiled: December 20, 2005Publication date: August 21, 2008Applicant: COLLEGIUM PHARMACEUTICAL, INC.Inventors: Roman V. Rariy, Michael Heffernan