Patents by Inventor Michael J. Coghlan

Michael J. Coghlan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prostaglandin endoperoxide H synthase biosynthesis inhibitors
    Publication number: 20090042888
    Abstract: The present invention describes pyridazinone compounds of formula I which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important “housekeeping” enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectivity of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with currently marketed non-steroidal anti-inflammatory drugs (NSAIDs).
    Type: Application
    Filed: June 23, 2006
    Publication date: February 12, 2009
    Inventors: Lawrence A. Black, Anwer Basha, Teodozyj Kolasa, Michael E. Kort, Huaqing Liu, Catherine M. McCarty, Meena Patel, Jeffrey J. Rohde, Michael J. Coghlan, Andrew O. Stewart
  • Prostaglandin endoperoxide H synthase biosynthesis inhibitors
    Patent number: 7115591
    Abstract: The present invention describes pyridazinone compounds of formula I which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2), COX-2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important “housekeeping” enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectivity of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with currently markered non-steroidal anti-inflammatory drugs (NSAIDs).
    Type: Grant
    Filed: June 19, 2003
    Date of Patent: October 3, 2006
    Assignee: Abbott Laboratories
    Inventors: Lawrence A. Black, Anwer Basha, Teodozyj Kolasa, Michael E. Kort, Huaqing Liu, Catherine M. McCarty, Meena Patel, Jeffrey J. Rohde, Michael J. Coghlan, Andrew O. Stewart
  • Prostaglandin endoperoxide H synthase biosynthesis inhibitors
    Patent number: 7001895
    Abstract: The present invention describes pyridazinone compounds of formula I which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important “housekeeping” enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectivity of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with currently marketed non-steroidal anti-inflammatory drugs (NSAIDs).
    Type: Grant
    Filed: April 17, 2003
    Date of Patent: February 21, 2006
    Assignee: Abbott Laboratories
    Inventors: Lawrence A. Black, Anwer Basha, Teodozyj Kolasa, Michael E. Kort, Huaqing Liu, Catherine M. McCarty, Meena Patel, Jeffrey J. Rohde, Michael J. Coghlan, Andrew O. Stewart
  • Glucocorticoid-selective anti-inflammatory agents
    Patent number: 6951942
    Abstract: Compounds having Formula I are useful for partially or fully antagonizing, repressing, agonizing, or modulating the glucocorticoid receptor and treating immune, autoimmune and inflammatory diseases in a mammal. Also disclosed are pharmaceutical compositions comprising compounds of Formula I and methods of inhibiting immune or autoimmune diseases in a mammal.
    Type: Grant
    Filed: July 23, 2002
    Date of Patent: October 4, 2005
    Assignees: Abbott Laboratories, Ligand Pharmaceuticals Incorporated
    Inventors: Michael J. Coghlan, James P. Edwards, Steven W. Elmore, Todd K. Jones, Michael E. Kort, Philip R. Kym, Jimmie L. Moore, John K. Pratt, Alan X. Wang
  • Prostaglandin endoperoxide H synthase biosynthesis inhibitors
    Publication number: 20040158064
    Abstract: The present invention describes pyridazinone compounds of formula I 1
    Type: Application
    Filed: June 19, 2003
    Publication date: August 12, 2004
    Inventors: Lawrence A. Black, Anwer Basha, Teodozyj Kolasa, Michael E. Kort, Huaqing Liu, Catherine M. McCarty, Meena Patel, Jeffrey J. Rohde, Michael J. Coghlan, Andrew O. Stewart
  • Prostaglandin endoperoxide H synthase biosynthesis inhibitors
    Publication number: 20030225276
    Abstract: The present invention describes pyridazinone compounds of formula I 1
    Type: Application
    Filed: April 17, 2003
    Publication date: December 4, 2003
    Inventors: Lawrence A. Black, Anwer Basha, Teodozyj Kolasa, Michael E. Kort, Huaqing Liu, Catherine M. McCarty, Meena Patel, Jeffrey J. Rohde, Michael J. Coghlan, Andrew O. Stewart
  • Glucocortiocoid-selective antinflammatory agents
    Publication number: 20030073703
    Abstract: Compounds having Formula I 1
    Type: Application
    Filed: July 23, 2002
    Publication date: April 17, 2003
    Applicant: Abbott Laboratories and Ligand Pharmaceuticals Incorporated
    Inventors: Michael J. Coghlan, James P. Edwards, Steven W. Elmore, Todd K. Jones, Michael E. Kort, Philip R. Kym, Jimmie L. Moore, John K. Pratt, Alan X. Wang
  • Glucocortiocoid-selective antinflammatory agents
    Patent number: 6506766
    Abstract: Compounds having Formula I are useful for partially or fully antagonizing, repressing, agonizing, or modulating the glucocorticoid receptor and treating immune, autoimmune and inflammatory diseases in a mammal. Also disclosed are pharmaceutical compositions comprising compounds of Formula I and methods of inhibiting immune or autoimmune diseases in a mammal.
    Type: Grant
    Filed: July 5, 2000
    Date of Patent: January 14, 2003
    Assignees: Abbott Laboratories, Ligand Pharmaceuticals Incorporated
    Inventors: Michael J. Coghlan, James P. Edwards, Steven W. Elmore, Todd K. Jones, Michael E. Kort, Philip R. Kym, Jimmie L. Moore, John K. Pratt, Alan X. Wang
  • Glucocortiocoid-selective antiinflammatory agents
    Patent number: 6380207
    Abstract: Compounds having Formula I are useful for partially or fully antagonizing, repressing, agonizing, or modulating the glucocorticoid receptor in a mammal and treating immune, autoimmune and inflammatory diseases in a mammal. Also disclosed are pharmaceutical compositions comprising compounds of Formula I and methods of inhibiting immune or autoimmune diseases in a mammal.
    Type: Grant
    Filed: February 13, 1998
    Date of Patent: April 30, 2002
    Assignees: Abbott Laboratories, Ligand Pharmaceuticals, Inc.
    Inventors: Michael J. Coghlan, James P. Edwards, Todd K. Jones, Michael E. Kort
  • Prostaglandin endoperoxide H synthase biosynthesis inhibitors
    Publication number: 20020028938
    Abstract: The present invention describes pyridazinone compounds of formula I 1
    Type: Application
    Filed: May 31, 2001
    Publication date: March 7, 2002
    Inventors: Lawrence A. Black, Anwer Basha, Teodozyj Kolasa, Michael E. Kort, Huaqing Liu, Catherine M. McCarty, Meena Patel, Jeffrey J. Rohde, Michael J. Coghlan, Andrew O. Stewart
  • Prostaglandin endoperoxide H synthase biosynthesis inhibitors
    Publication number: 20020013318
    Abstract: The present invention describes pyridazinone compounds of formula I 1
    Type: Application
    Filed: May 31, 2001
    Publication date: January 31, 2002
    Inventors: Lawrence A. Black, Anwer Basha, Teodozyj Kolasa, Michael E. Kort, Huaqing Liu, Catherine M. McCarty, Meena Patel, Jeffrey J. Rohde, Michael J. Coghlan, Andrew O. Stewart
  • GLUCOCORTIOCOID-SELECTIVE ANTIINFLAMMATORY AGENTS
    Publication number: 20010049377
    Abstract: Compounds having Formula I 1
    Type: Application
    Filed: February 13, 1998
    Publication date: December 6, 2001
    Inventors: MICHAEL J. COGHLAN, JAMES P. EDWARDS, TODD K. JONES, MICHAEL E. KORT
  • Prostaglandin endoperoxide H synthase biosynthesis inhibitors
    Patent number: 6307047
    Abstract: The present invention describes pyridazinone compounds of formula I which are cyclooxygenase (COX) inhibitors, and in particular, are selective inhibitors of cyclooxygenase-2 (COX-2). COX-2 is the inducible isoform associated with inflammation, as opposed to the constitutive isoform, cyclooxygenase-1 (COX-1) which is an important “housekeeping” enzyme in many tissues, including the gastrointestinal (GI) tract and the kidneys. The selectivity of these compounds for COX-2 minimizes the unwanted GI and renal side-effects seen with currently marketed non-steroidal anti-inflammatory drugs (NSAIDs).
    Type: Grant
    Filed: October 27, 1999
    Date of Patent: October 23, 2001
    Assignee: Abbott Laboratories
    Inventors: Lawrence A. Black, Anwer Basha, Teodozyj Kolasa, Michael E. Kort, Huaqing Liu, Catherine M. McCarty, Meena Patel, Jeffrey J. Rohde, Michael J. Coghlan, Andrew O. Stewart
  • Glucocortiocoid-selective agents
    Patent number: 6166013
    Abstract: Compounds having Formula I ##STR1## are useful for modulating the glucocorticoid receptor in a mammal. Also disclosed are pharmaceutical compositions comprising compounds of Formula I and methods of treating immune, autoimmune, inflammatory, adrenal imbalance, cognitive and behavioral diseases in a mammal.
    Type: Grant
    Filed: July 30, 1999
    Date of Patent: December 26, 2000
    Assignee: Abbott Laboratories
    Inventors: Michael J. Coghlan, Jay R. Luly, Jeffrey M. Schkeryantz, Alan X. Wang
  • Quinoline derivatives
    Patent number: 5296484
    Abstract: The compounds of the formula: ##STR1## wherein the substituents are herein below defined; are plant fungicides, insecticides, and miticides.
    Type: Grant
    Filed: March 20, 1989
    Date of Patent: March 22, 1994
    Assignee: DowElanco
    Inventors: Michael J. Coghlan, Barry A. Dreikorn, Glen P. Jourdan, Robert G. Suhr
  • Naphthyridine derivatives
    Patent number: 5240916
    Abstract: Substituted naphthyridines of the formula (1): ##STR1## wherein one of A, B, C, or D is N, and the others are CR.sup.1 ;R.sup.1 and R.sup.2 are independently H or halo.X, Y and Z are defined in the specification.
    Type: Grant
    Filed: March 4, 1992
    Date of Patent: August 31, 1993
    Assignee: DowElanco
    Inventors: Blake A. Caley, Michael J. Coghlan, Leon N. Davis, Barry A. Dreikorn
  • Quinoline and cinnoline fungicide compositions
    Patent number: 5240940
    Abstract: Fungicidal compositions comprise a combination of two fungicides, one of which is a quinoline or cinnoline compound of the formula (1) ##STR1## the substituents being as described in the specification.
    Type: Grant
    Filed: May 12, 1992
    Date of Patent: August 31, 1993
    Assignee: DowElanco
    Inventors: Wendell R. Arnold, Michael J. Coghlan, Glen P. Jourdan, Eriks V. Krumkalns, Robert G. Suhr
  • Quinoline and cinnoline fungicides
    Patent number: 5145843
    Abstract: Compounds of the formula (1) ##STR1## the substituents are described in the specification. The compouns of formula (I) are plant fungicides.
    Type: Grant
    Filed: April 7, 1989
    Date of Patent: September 8, 1992
    Assignee: DowElanco
    Inventors: Wendell R. Arnold, Michael J. Coghlan, Glen P. Jourdan, Eriks V. Krumkalns, Robert G. Suhr