Patents by Inventor Michael J. Malin
Michael J. Malin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7670798Abstract: The present invention describes semi- and fully-automated methods and reagents therefor for the assay and analysis of body fluid samples, particularly non-blood samples. The methods and reagents are especially useful for the assay and analysis of cerebrospinal fluid (CSF) samples. The reagent compositions sphere and fix all cells in the sample in suspension. Reported results can include red blood cell (RBC) and white blood cell (WBC) counts, WBC differential values, cell-by-cell volumes and dry-mass concentrations.Type: GrantFiled: May 20, 2003Date of Patent: March 2, 2010Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Leonard Ornstein, Gena Fischer, David Zelmanovic, Pamela Elsins, Jolanta Kunicka, Michael J. Malin
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Publication number: 20030215890Abstract: The present invention describes semi- and fully-automated methods and reagents therefor for the assay and analysis of body fluid samples, particularly non-blood samples. The methods and reagents are especially useful for the assay and analysis of cerebrospinal fluid (CSF) samples. The reagent compositions sphere and fix all cells in the sample in suspension. Reported results can include red blood cell (RBC) and white blood cell (WBC) counts, WBC differential values, cell-by-cell volumes and dry-mass concentrations.Type: ApplicationFiled: May 20, 2003Publication date: November 20, 2003Inventors: Leonard Ornstein, Gena Fischer, David Zelmanovic, Pamela Elsins, Jolanta Kunicka, Michael J. Malin
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Patent number: 6623972Abstract: The invention provides a new method and system for detecting and monitoring extracellular or exogenously added hemoglobin, i.e., a cell-free hemoglobin substitute or derivative, in a blood, plasma, or serum sample of an individual, particularly a whole blood sample. The invention further describes the use of automated hematology analyzers to determine and quantify at the same time the concentration of total, cellular and exogenous hemoglobin in a blood, plasma, or serum sample, and is particularly advantageous for medical use during or after patient trauma or surgery, as well as for monitoring hemoglobin levels during patient recovery.Type: GrantFiled: May 18, 2001Date of Patent: September 23, 2003Assignee: Bayer CorporationInventors: Michael J. Malin, Phyllis Shapiro
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Patent number: 6468732Abstract: The invention provides a bicarbonate-containing, crosslinker-free reagent composition which reverses and/or reduces sample handling effects, such as aeration-induced shrinkage and storage-induced swelling of cells in a whole blood sample, particularly for a blood sample requiring repeated sampling and/or subjected to long-term storage. The reagent composition serves as a diluent medium for a blood sample, or an aliquot or portion thereof. The pH of the reagent is in the range of about 7.2 to about 7.5, preferably 7.3. The stability of the pH 7.2-7.5 bicarbonate-containing reagent over time is maintained by storing the reagent in a flexible collapsible container which is impermeable to carbon dioxide and is comprised of a multilayered flexible material, preferably plastic, and attachable to a hematology analyzer.Type: GrantFiled: March 28, 2001Date of Patent: October 22, 2002Assignee: Bayer CorporationInventors: Michael J. Malin, Leonard Ornstein
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Publication number: 20020012904Abstract: The invention provides a new method and system for detecting and monitoring extracellular or exogenously added hemoglobin, i.e., a cell-free hemoglobin substitute or derivative, in a blood, plasma, or serum sample of an individual, particularly a whole blood sample. The invention further describes the use of automated hematology analyzers to determine and quantify at the same time the concentration of total, cellular and exogenous hemoglobin in a blood, plasma, or serum sample, and is particularly advantageous for medical use during or after patient trauma or surgery, as well as for monitoring hemoglobin levels during patient recovery.Type: ApplicationFiled: May 18, 2001Publication date: January 31, 2002Inventors: Michael J. Malin, Phyllis Shapiro
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Patent number: 5888752Abstract: The present invention provides a heretofore unknown use for a aqueous reagent composition that serves as a universal rinse for performing and/or improving a variety of hematological analyses on automated analyzers. The universal rinse reagent comprises a phosphate buffer to maintain the rinse solution pH at from about 7.0 to about 7.6; a nonhemolytic nonionic surfactant, such as a Pluronic.RTM. an alkali metal salt, such as NaCi; antimicrobial and anti-oxidant compounds; and has an osmolality of about 285 to 305 mOsmol/kg. The universal rinse reagent composition is highly suitable for use in the rinse phases or cycles of all types of blood cell analysis methods and processes performed on semi- and fully-automated systems. The invention allows the replacement of mutiple and specific rinse solutions with the disclosed universal rinse to obtain accurate and acceptable results, independent of the types of blood cell analyses that are performed.Type: GrantFiled: May 16, 1995Date of Patent: March 30, 1999Assignee: Bayer CorporationInventors: Michael J. Malin, Phyllis Shapiro
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Patent number: 5858794Abstract: The invention describes an improved stable reagent composition and method for the determination of hemoglobin (Hb) using whole blood samples and automated hematology analyzers. The Hb reagent contains an inorganic cyanide salt, at least one surfactant and a base and has a final pH of about 10.0 to about 11.2, preferably about 10.4 to about 11.2 or less and more preferably about 10.8 to about 11.2 or less. This reagent is intended for use as a universal Hb determination reagent for all of the instruments in the aforementioned series and will provide accurate and precise results without accompanying interference from elevated numbers of white blood cells, especially as found in abnormal blood specimens, and without system-to-system variation in the results obtained.Type: GrantFiled: May 13, 1997Date of Patent: January 12, 1999Assignee: Bayer CorporationInventor: Michael J. Malin
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Patent number: 5639630Abstract: The present invention provides an improved reagent composition and method to perform white blood cell differential counting and subpopulation analysis using both fresh and aged blood samples with accuracy and precision. The invention is particularly applicable for the analysis of aged blood samples that have been stored at room temperature for over a day, thereby allowing accurate and useful information to be obtained from samples that are normally considered to be suboptimal. The improved reagent composition and method are particularly related to the peroxidase method of white blood cell differential determinations. One aspect of the invention includes an improved aqueous reagent composition for carrying out the peroxidase method of differential counting.Type: GrantFiled: May 16, 1995Date of Patent: June 17, 1997Assignee: Bayer CorporationInventors: Michael J. Malin, Phyllis Shapiro, John F. Cremins
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Patent number: 5468640Abstract: A novel method and reagent useful therein are cyanide-free and capable of providing a rapid indication, e.g., less than 30 seconds, of total hemoglobin in a blood sample, so as to find particular application in automated hematological instrumentation. The novel reagent comprises an ionic surfactant, a pH of at least about 11.3 and is free of ionic cyanide. The ionic surfactant itself can impart the required pH or a strong base independent of such surfactant may be included.Type: GrantFiled: February 7, 1994Date of Patent: November 21, 1995Assignee: Bayer CorporationInventors: Jeffrey Benezra, Michael J. Malin
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Patent number: 4978624Abstract: This invention relates to a method for the rapid determination of a differential white blood cell count in a sample, which method comprises:(a) preparing a reagent solution comprisingformaldehyde or paraformaldehyde;a surfactant;a sugar or sugar alcohol; anda buffer; and(b) rapidly mixing the reagent solution with the sample to be analyzed to form a reaction mixture, wherein both the reagent solution and the sample are initially at room temperature; and(c) rapidly heating the reaction mixture to a temperature of from about 62.degree. C. to about 72.degree. C. in order to lyse the red blood cells in the sample and fix the white blood cells in said sample. The invention also relates to the reagent solution of part (a) of the method.Type: GrantFiled: September 14, 1988Date of Patent: December 18, 1990Assignee: Technicon Instruments CorporationInventors: John F. Cremins, Young R. Kim, Michael J. Malin, Louis D. Sclafani
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Patent number: 4853338Abstract: A method and reagent useful therein are cyanide-free and capable of providing a rapid indication, e.g., less than 30 seconds, of total hemoglobin in a blood sample, so as to fine particular application in automated hematological instrumentation. The novel reagent comprises an ionic surfactant, a pH of at least about 11.3 and is free of ionic cyanide. The ionic surfactant itself can impart the required pH or a strong base independent of such surfactant may be included.Type: GrantFiled: December 13, 1988Date of Patent: August 1, 1989Assignee: Technicon Instruments CorporationInventors: Jeffrey Benezra, Michael J. Malin
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Patent number: 4801549Abstract: This invention relates to a method for the rapid determination of a differential white blood cell count in a sample, which method comprises:(a) preparing a reagent solution comprising;formaldehyde or paraformaldehyde;a surfactant;a sugar or sugar alcohol; anda buffer; and(b) rapidly mixing the reagent solution with the sample to be analyzed to form a reaction mixture, wherein both the reagent solution and the sample are initially at room temperature; and(c) rapidly heating the reaction mixture to a temperature of from about 62.degree. C. to about 72.degree. C. in order to lyse the red blood cells in the sample and fix the white blood cells in the sample.Type: GrantFiled: February 2, 1987Date of Patent: January 31, 1989Assignee: Technicon Instruments CorporationInventors: John F. Cremins, Young R. Kim, Michael J. Malin, Louis D. Sclafani
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Patent number: 4744968Abstract: This invention relates to a novel stabilized aqueous hydrogen peroxide solution which comprises hydrogen peroxide in admixture with an aromatic polysulfonic acid, or a salt thereof.Type: GrantFiled: September 3, 1985Date of Patent: May 17, 1988Assignee: Technicon Instruments CorporationInventors: Michael J. Malin, Louis D. Sclafani
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Patent number: 4565688Abstract: New phthalocyanin derivatives which can be used to differentiate basophils from other blood cells are disclosed. The compounds to which the present invention are quaternary salts of a substituted phthalocyanin structure wherein the substitutions are each independently hydrogen, sulfonate, or a C.sub.1 -C.sub.7 hydrocarbon, optionally containing at least one heteroatom, with the proviso that at least one of them is ##STR1## in which R.sub.1 -R.sub.3 are each independently lower alkyls, cycloalkyls or olefins of which at least one is C.sub.2 -C.sub.4 and two may join to form a ring; R.sub.4 is hydrogen or a C.sub.1 -C.sub.3 alkyl; n is an integer from 1 to 6; M is a polyvalent metal ion. It is preferred that at least two and especially at least three substitutions have the structure so set forth.Type: GrantFiled: November 14, 1983Date of Patent: January 21, 1986Assignee: Technicon Instruments CorporationInventors: Michael J. Malin, Bernard Loev, Deng R. Hwang
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Patent number: 4463117Abstract: A heat-stable, polymer-forming composition of a polymerizable material, a transition metal compound, a polymer chain terminator, and, optionally, a preventive antioxidant is disclosed as well as particular uses of such composition.Type: GrantFiled: April 19, 1982Date of Patent: July 31, 1984Assignee: Technicon Instruments CorporationInventor: Michael J. Malin
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Patent number: 4250257Abstract: Method and apparatus for analyzing whole blood samples which feature impregnating a gel medium used for the analysis of the whole blood sample with an inert substance. When the whole blood sample is placed on the gel medium, the inert substance diffuses from the gel as the plasma solutes of the blood diffuse into the gel. The amount of the inert substance diffusing from the gel medium is inversely proportional to the hematocrit of the blood sample. In one embodiment, plasma solutes are caused to react with one or more reagents in the gel medium to assay various specific analytes. Also, the hematocrit, indicated by the diffusion rate of the inert substance from the gel, is determined and used to correct such assay.Type: GrantFiled: August 24, 1978Date of Patent: February 10, 1981Assignee: Technicon Instruments CorporationInventors: Martin J. Lee, Michael J. Malin