Abstract: Provided herein are methods for site-specific conjugation of glycan intact antibodies by a transglutaminase. According to particular embodiments, the reaction conditions are maintained or reduced to a low-ionic strength condition, which allows for efficient and fast conjugation without the need for antibody deglycosylation. Also described are pharmaceutical compositions and uses related to the conjugation method.

Abstract: Provided herein are methods for site-specific conjugation of glycan intact antibodies by a transglutaminase. According to particular embodiments, the reaction conditions are maintained or reduced to a low-ionic strength condition, which allows for efficient and fast conjugation without the need for antibody deglycosylation. Also described are pharmaceutical compositions and uses related to the conjugation method.

Abstract: Engineered antibodies useful for site-specific conjugation by a transglutaminase are described. Also described are methods of site-specific conjugation of the antibodies, the site-specifically conjugated antibodies, and pharmaceutical compositions and uses related to the site-specifically conjugated antibodies.

Abstract: Provided herein are methods for site-specific conjugation of glycan intact antibodies by a transglutaminase. According to particular embodiments, the reaction conditions are maintained or reduced to a low-ionic strength condition, which allows for efficient and fast conjugation without the need for antibody deglycosylation. Also described are pharmaceutical compositions and uses related to the conjugation method.

Abstract: A storage module assembly for a refrigerator door having an outer shell and an inner liner, including a rear wall and side walls forming a recess in the liner. Each side walls has a series of vertically spaced apart ribs aligned with corresponding ribs on the facing side wall. The ribs extend outwardly from the liner bottom wall and each rib has a horizontal top wall with an upwardly projecting tab adjacent its distal end. The bottom wall of each rib has a short horizontal portion adjacent the liner rear wall and an upwardly inclined portion adjacent its distal end. The module includes side walls positionable adjacent the liner side walls. A pair of vertically spaced apart, generally horizontally extending rails project outwardly of each module side wall and each rail defines a downwardly opening recess.

Abstract: A refrigerator cabinet has a valve controlling the amount of cooled air flowing from a cooling chamber having an evaporator to a fresh food compartment to control the ratio of the air flow from the cooling chamber to a freezer compartment and the fresh food compartment. The valve is retained in a predetermined position at the time of assembly by a duct cover, which is forward of an evaporator cover in the freezer compartment, having a frangible key on its front wall extend through an opening in a disc of the valve. If a user deems the freezer compartment too hot or too cold, a service person breaks the frangible key with pliers, for example, after removing the duct cover and rotates the valve to one of a plurality of selected positions to change the air flow. The dics has a plurality of notches in its periphery for cooperation with a second key on the front wall of the duct cover to hold the valve in its selected position.

Abstract: The present invention relates to a room air conditioning unit and is more specifically directed to the airflow control mechanism for adjusting the airflow through a vent generally associated with such units for permitting a flow of air between the air conditioned space and the outdoor air.