Patents by Inventor Michael J. Sailor

Michael J. Sailor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10702474
    Abstract: The disclosure describes a fusogenic liposome-coated porous silicon nanoparticles for high loading efficiency of anionic payloads (small molecules, dyes, nucleic acids), and for non-endocytic delivery of hydrophilic and lipophilic payloads by membrane fusion. The liposome coating can be further modified with targeting peptides or antibodies via covalent binding chemistry between the ligands and functionalized poly(ethylene glycol). The surface moieties can be transferred to the cellular membrane surface by fusogenic uptake. The composition of the disclosure can be applied in the treatment of diseases by delivering entrapped/encapsulated payloads.
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: July 7, 2020
    Assignee: The Regents of the University of California
    Inventors: Michael J. Sailor, Byungji Kim, Jinyoung Kang
  • Publication number: 20200009053
    Abstract: This invention relates to devices, systems and methods for delivering preprogrammed quantities of an active ingredient to a biological system over time without the need for external power or electronics.
    Type: Application
    Filed: February 7, 2019
    Publication date: January 9, 2020
    Inventors: William R. Freeman, Michael J. Sailor, Lingyun Cheng
  • Publication number: 20180193268
    Abstract: The disclosure describes a fusogenic liposome-coated porous silicon nanoparticles for high loading efficiency of anionic payloads (small molecules, dyes, nucleic acids), and for non-endocytic delivery of hydrophilic and lipophilic payloads by membrane fusion. The liposome coating can be further modified with targeting peptides or antibodies via covalent binding chemistry between the ligands and functionalized poly(ethylene glycol). The surface moieties can be transferred to the cellular membrane surface by fusogenic uptake. The composition of the disclosure can be applied in the treatment of diseases by delivering entrapped/encapsulated payloads.
    Type: Application
    Filed: July 8, 2016
    Publication date: July 12, 2018
    Inventors: Michael J. SAILOR, Byungji KIM, Jinyoung KANG
  • Patent number: 9937129
    Abstract: This invention relates to devices, systems and methods for delivering preprogrammed quantities of an active ingredient to a biological system over time without the need for external power or electronics.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: April 10, 2018
    Assignee: The Regents of the University of California
    Inventors: William R. Freeman, Michael J. Sailor, Lingyun Cheng
  • Patent number: 9909985
    Abstract: A preferred embodiment biosensor is a multi-layer micro-porous thin film structure. Pores in a top layer of the micro-porous thin film structure are sized to accept a first molecule of interest. Pores in a second layer of the micro-porous thin film structure are smaller than the pores in the top layer and are sized to accept a second molecule of interest that is smaller than the first molecule of interest. The pores in the second layer are too small to accept the first molecule of interest. The pores in the top layer and the pores in the second layer are sized and arranged such that light reflected from the multi-layer micro-porous thin film structure produces multiple superimposed interference patterns that can be resolved. In preferred embodiments, the multi-layer micro-porous thin film structure is a porous silicon thin film multi-layer structure formed on a silicon substrate, such as a silicon wafer. Specific and nonspecific binding can be detected with biosensors of the invention.
    Type: Grant
    Filed: January 7, 2010
    Date of Patent: March 6, 2018
    Assignee: The Regents of the University of California
    Inventors: Claudia Pacholski, Gordon M. Miskelly, Michael J. Sailor
  • Publication number: 20180055765
    Abstract: A minimally invasive controlled drug delivery system for delivering a particular drug or drugs to a particular location of the eye, the system including a porous film template having pores configured and dimensioned to at least partially receive at least one drug therein, and wherein the template is dimensioned to be delivered into or onto the eye.
    Type: Application
    Filed: November 6, 2017
    Publication date: March 1, 2018
    Inventors: William Freeman, Michael J. Sailor, Lingyun Cheng, Frederique Cunin, Emily Anglin, Yang Yang Li
  • Patent number: 9694074
    Abstract: Disclosed are nanovectors of formula (I) that can be used simultaneously for the targeting, imaging and treatment, by photodynamic therapy, of cancer cells, and to biodegradable silicon nanoparticles containing a variety of photosensitizing molecules, in particular porphyrins, capable of targeting diseased cells and inducing cell death by excitation in the near-infrared region (>600 nm) in monophotonic and biphotonic modes. In formula (I), (AA) is a porous silicon nanoparticle.
    Type: Grant
    Filed: March 26, 2013
    Date of Patent: July 4, 2017
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER
    Inventors: Frederique Cunin, Jean-Olivier Durand, Michael J. Sailor, Marcel Garcia, Emilie Secret, Magali Gary-Bobo, Marie Maynadier, Alain Morere
  • Patent number: 9555114
    Abstract: A method of controlled in vivo drug delivery is provided. A porous silicon matrix having pores sized and configured to admit to trap and then release a predetermined molecular complex with a predetermined dose-time profile is selected. The matrix contains the predetermined molecular complex so that the predetermined molecular complex is disposed within the pores of the porous silicon matrix. The matrix is introduced into a human body. The drug releases according the dose-time profile. The introduction can be via transdermal introduction, intramuscular injection, intravenous introduction, surgical implantation, inhalation, and oral ingestion.
    Type: Grant
    Filed: September 19, 2014
    Date of Patent: January 31, 2017
    Assignee: The Regents of the University of California
    Inventors: Michael J. Sailor, Guarav Abbi, Boyce E. Collins, Keiki-Pua S. Dancil
  • Publication number: 20160338960
    Abstract: This invention relates to devices, systems and methods for delivering preprogrammed quantities of an active ingredient to a biological system over time without the need for external power or electronics.
    Type: Application
    Filed: January 22, 2016
    Publication date: November 24, 2016
    Inventors: William R. Freeman, Michael J. Sailor, Lingyun Cheng
  • Patent number: 9499407
    Abstract: The invention provides nanostructure composite porous silicon and carbon materials, and also provides carbon nanofiber arrays having a photonic response in the form of films or particles. Composite materials or carbon nanofiber arrays of the invention are produced by a templating method of the invention, and the resultant nanomaterials have a predetermined photonic response determined by the pattern in the porous silicon template, which is determined by etching conditions for forming the porous silicon. Example nanostructures include rugate filters, single layer structures and double layer structures. In a preferred method of the invention, a carbon precursor is introduced into the pores of a porous silicon film. Carbon is then formed from the carbon precursor.
    Type: Grant
    Filed: September 29, 2011
    Date of Patent: November 22, 2016
    Assignee: The Regents of the University of California
    Inventors: Michael J. Sailor, Timothy Kelly
  • Patent number: 9394369
    Abstract: The disclosure relates to immunizing agents and devices.
    Type: Grant
    Filed: January 3, 2012
    Date of Patent: July 19, 2016
    Assignee: The Regents of the University of California
    Inventors: Michael J. Sailor, Stephen M. Hedrick, Lou Gu, Laura Ruff, Zhengtao Qin
  • Patent number: 9241906
    Abstract: This invention relates to devices, systems and methods for delivering preprogrammed quantities of an active ingredient to a biological system over time without the need for external power or electronics.
    Type: Grant
    Filed: May 3, 2013
    Date of Patent: January 26, 2016
    Assignee: The Regents of the University of California
    Inventors: William R. Freeman, Michael J. Sailor, Lingyun Cheng
  • Publication number: 20160002272
    Abstract: The present invention relates generally to a surface functionalized porous containing material and method of making thereof.
    Type: Application
    Filed: February 25, 2014
    Publication date: January 7, 2016
    Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, SPINNAKER BIOSCIENCES, INC.
    Inventors: Chia-Chen WU, Michael J. SAILOR, Michelle Y. CHEN
  • Publication number: 20150367149
    Abstract: This disclosure concerns materials for detecting and removing gaseous chemical agents (e.g., cyanide, cyanogen, sulfide, nitrite, nitric oxide, and combinations thereof), devices including the materials, and methods of making and using the disclosed materials. Embodiments of the disclosed materials include a support material impregnated with cobinamide and/or a cobinamide derivative.
    Type: Application
    Filed: June 23, 2015
    Publication date: December 24, 2015
    Inventors: Lee A. Greenawald, Gerry R. Boss, Nicole Fry, Michael J. Sailor, Matthew Brenner, Sari B. Mahon
  • Patent number: 9181634
    Abstract: The invention concerns a particle having a code from a library of codes embedded in its physical structure by refractive index changes between different regions of the particle. In preferred embodiments, a thin film possesses porosity that varies in a manner to produce a code detectable in the reflectivity spectrum. An assay detection method uses such a particle and detects a spectral shift in the presence of an analyte. Additional embodiments are disclosed including additional features.
    Type: Grant
    Filed: December 21, 2004
    Date of Patent: November 10, 2015
    Assignee: The Regents of the University of California
    Inventors: Michael J. Sailor, Shawn O. Meade
  • Patent number: 9007593
    Abstract: Methods and systems of the invention can determine the identity and quantity of analytes in a vapor. In preferred methods, a porous optical film is exposed to vapor which contains analyte. The porous optical film is heated and its optical response is monitored during heating. An optical response observed via heating can determine the identity and/or quantity of the analyte. In preferred embodiments, optical response during a thermal pulse is compared to a database of sensor responses that are characteristic of various analytes. Preferred methods are conducted a relatively low temperatures, for example below about 200° C. In preferred methods, a heating and cooling cycle produces a hysteresis curve in the optical response that is indicative of analytes. In preferred embodiments, a thermal reset pulse resets the porous optical film for later use and also provides an optical response that can be used for sensing.
    Type: Grant
    Filed: July 19, 2011
    Date of Patent: April 14, 2015
    Assignee: The Regents of the University of California
    Inventors: Michael J. Sailor, Brian H King, Sadafumi Noda
  • Publication number: 20150087050
    Abstract: Disclosed are nanovectors of formula (I) that can be used simultaneously for the targeting, imaging and treatment, by photodynamic therapy, of cancer cells, and to biodegradable silicon nanoparticles containing a variety of photosensitizing molecules, in particular porphyrins, capable of targeting diseased cells and inducing cell death by excitation in the near-infrared region (>600 nm) in monophotonic and biphotonic modes. In formula (I), (AA) is a porous silicon nanoparticle.
    Type: Application
    Filed: March 26, 2013
    Publication date: March 26, 2015
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, ECOLE NATIONAL SUPERIEURE DE CHIMIE DE MONTPELLIER
    Inventors: Frederique Cunin, Jean-Olivier Durand, Michael J. Sailor, Marcel Garcia, Emilie Secret, Magali Gary-Bobo, Marie Maynadier, Alain Morere
  • Publication number: 20150076412
    Abstract: The invention concerns an article of manufacture that is a manufactured product marked with a microparticle and a method of marking manufactured produces. The microparticle tag includes a predetermined code embedded in its physical structure by refractive index changes between different regions of the particle. The particle has a diameter of a few hundred microns or less and has a plurality of layers.
    Type: Application
    Filed: May 30, 2014
    Publication date: March 19, 2015
    Applicant: The Regents of the University of California
    Inventors: Michael J. Sailor, Thomas Schmedake, Frederique Cunin, Jamie Link
  • Patent number: 8945602
    Abstract: A minimally invasive controlled drug delivery system for delivering a particular drug or drugs to a particular location of the eye, the system including a porous film template having pores configured and dimensioned to at least partially receive at least one drug therein, and wherein the template is dimensioned to be delivered into or onto the eye.
    Type: Grant
    Filed: March 29, 2013
    Date of Patent: February 3, 2015
    Assignee: The Regents of the University of California
    Inventors: William Freeman, Michael J. Sailor, Lingyun Cheng, Frederique Cunin, Emily Anglin, Yang Yang Li
  • Publication number: 20150011521
    Abstract: A method of controlled in vivo drug delivery is provided. A porous silicon matrix having pores sized and configured to admit to trap and then release a predetermined molecular complex with a predetermined dose-time profile is selected. The matrix contains the predetermined molecular complex so that the predetermined molecular complex is disposed within the pores of the porous silicon matrix. The matrix is introduced into a human body. The drug releases according the dose-time profile. The introduction can be via transdermal introduction, intramuscular injection, intravenous introduction, surgical implantation, inhalation, and oral ingestion.
    Type: Application
    Filed: September 19, 2014
    Publication date: January 8, 2015
    Inventors: Michael J. Sailor, Guarav Abbi, Boycee E. Collins, Keiki-Pua S. Dancil