Patents by Inventor Michael McLoughlin
Michael McLoughlin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240115157Abstract: Methods and devices for analyzing non-volatile organics in exhaled breath and other aerosols using various diagnostic tools that enable rapid, low-cost point of care assays for several diseases including respiratory tract diseases such as COVID-19. The disclosed methods and systems selectively capture non-volatile organics in exhaled breath and other aerosols in a packed bed column. The non-volatile organics are eluted and samples are analysis using diagnostic devices including MALDI-TOFMS. The disclosed systems and methods provide for a diagnostic test result in less than about 20 minutes and provides for autonomous operation with minimal human intervention.Type: ApplicationFiled: December 7, 2023Publication date: April 11, 2024Applicant: Zeteo Tech, Inc.Inventors: Dapeng CHEN, Wayne A. BRYDEN, Michael McLOUGHLIN
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Publication number: 20240074673Abstract: Methods and devices to capture and analyze aerosolized particles in exhaled air including protein biomarkers and their truncated proteoforms characteristic of tuberculosis to enable rapid detection of diseases. Methods and systems to selectively capture aerosolized particles using a packed bed column. The captured particles are eluted using one or more solvents and analyzed using devices including MALDI-TOFMS.Type: ApplicationFiled: October 27, 2023Publication date: March 7, 2024Applicant: Zeteo Tech, Inc.Inventors: Dapeng Chen, Wayne A. Bryden, Michael McLoughlin, Kiana M. Kiser, Emily R. Caton, Caroline R. Haddaway
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Patent number: 11839463Abstract: Disclosed are methods and devices for analyzing non-volatile organics in exhaled breath and other aerosols using various diagnostic tools that enable rapid, low cost point of care assays for several diseases including respiratory tract diseases such as COVID-19. The disclosed methods and systems selectively capture non-volatile organics in exhaled breath and other aerosols in a packed bed column. The non-volatile organics are eluted and samples are analysis using diagnostic devices including MALDI-TOFMS. The disclosed systems and methods provide for a diagnostic test result in less than about 20 minutes and provides for autonomous operation with minimal human intervention.Type: GrantFiled: August 26, 2020Date of Patent: December 12, 2023Assignee: Zeteo Tech, Inc.Inventors: Dapeng Chen, Wayne A. Bryden, Michael McLoughlin
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Publication number: 20230245876Abstract: Systems and methods to provide rapid and autonomous detection of biological and chemical analyte particles in gas and liquid samples. Systems and methods for capturing and identifying biological and chemical aerosol analyte particles using matrix assisted laser desorption mass spectrometry (MALDI-MS) and using time-of-flight mass spectrometry (TOFMS) are disclosed. High specificity for capture and detection of aerosolized fentanyl was demonstrated using a portable sample capture and analysis system.Type: ApplicationFiled: April 11, 2023Publication date: August 3, 2023Applicant: Zeteo Tech, Inc.Inventors: Wayne A. BRYDEN, Charles J. CALL, Michael MCLOUGHLIN, Dapeng CHEN, Scott ECELBERGER, Nathaniel K. JONES, Steven STROHL
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Publication number: 20230157573Abstract: Disclosed are methods and devices for analyzing non-volatile organics in exhaled breath and other aerosols using various diagnostic tools that enable rapid, low cost point of care assays for several diseases including respiratory tract diseases such as COVID-19. The disclosed methods and systems selectively capture non-volatile organics in exhaled breath and other aerosols in a packed bed column. The non-volatile organics are eluted and samples are analysis using diagnostic devices including MALDI-TOFMS. The disclosed systems and methods provide for a diagnostic test result in less than about 20 minutes and provides for autonomous operation with minimal human intervention.Type: ApplicationFiled: August 26, 2020Publication date: May 25, 2023Applicant: Zeteo Tech, Inc.Inventors: Dapeng CHEN, Wayne A. BRYDEN, Michael McLOUGHLIN
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Patent number: 11658021Abstract: Disclosed are systems and methods to provide rapid and autonomous detection of analyte particles in gas and liquid samples. Disclosed are methods and devices for identifying biological aerosol analytes using MALDI-MS and chemical aerosol analytes using LDI and MALDI-MS using time-of-flight mass spectrometry (TOFMS).Type: GrantFiled: August 26, 2020Date of Patent: May 23, 2023Assignee: Zeteo Tech, Inc.Inventors: Wayne A. Bryden, Charles J. Call, Michael McLoughlin, Dapeng Chen, Scott Ecelberger, Nathaniel K. Jones, Steven Strohl, Gary Anderson
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Publication number: 20230039261Abstract: Disclosed are systems and methods to provide rapid and autonomous detection of analyte particles in gas and liquid samples. Disclosed are methods and devices for identifying biological aerosol analytes using MALDI-MS and chemical aerosol analytes using LDI and MALDI-MS using time-of-flight mass spectrometry (TOFMS).Type: ApplicationFiled: August 26, 2020Publication date: February 9, 2023Applicant: Zeteo Tech, Inc.Inventors: WAYNE A. BRYDEN, Charles J. CALL, Michael MCLOUGHLIN, Dapeng CHEN, Scott ECELBERGER, Nathaniel K. JONES, Steven STROHL, Gary ANDERSON
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Publication number: 20220386893Abstract: Methods and devices to capture and analyze aerosolized particles such as protein biomarkers and their truncated proteoforms characteristic of a disease, including a respiratory disease, in exhaled breath to enable rapid detection of diseases are disclosed. The disclosed methods and systems selectively capture aerosolized particles using a packed bed column. The captured particles are then eluted using one or more solvents and analyzed using devices including mass spectrometry.Type: ApplicationFiled: August 11, 2022Publication date: December 8, 2022Applicant: Zeteo Tech Inc.Inventors: Dapeng Chen, Wayne A. Bryden, Michael McLoughlin
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Publication number: 20220323045Abstract: Methods and devices to capture and analyze aerosolized particles such as protein biomarkers and their truncated proteoforms characteristic of a disease, including a respiratory disease, in exhaled breath to enable rapid detection of diseases are disclosed. The disclosed methods and systems selectively capture aerosolized particles using a packed bed column. The captured particles are then eluted using one or more solvents and analyzed using devices including mass spectrometry.Type: ApplicationFiled: May 29, 2022Publication date: October 13, 2022Applicant: Zeteo Tech, Inc.Inventors: Dapeng Chen, Wayne A. Bryden, Michael McLoughlin
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Publication number: 20220252545Abstract: Disclosed are systems are methods for identifying the composition of single aerosol particles, particularly that of bioaerosol particles, without pre-treatment using complex organic MALDI matrices. A continuous timing laser may be used to index aerosol particles, measure particle properties, and trigger a pulse ionization laser. Ionized fragments and optionally photons associated with each particle producing by the ionization laser may be analyzed using one or more detectors including a TOF-MS detector and an optical detector. The laser pulse may comprise a simultaneous IR and UV laser pulse when fragments comprise predominantly of UV chromophores. Unique spectral data associated with each indexed particle from each detector may be compiled using data fusion to generate compiled spectral data. Machine learning methods may be used to improve the prediction of composition over time.Type: ApplicationFiled: June 27, 2020Publication date: August 11, 2022Applicant: Zeteo Tech, Inc.Inventors: MICHAEL MCLOUGHLIN, Wayne A. Bryden, CHARLES J. CALL, Dapeng Chen
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Publication number: 20220044921Abstract: Disclosed are systems are methods for identifying the composition of single aerosol particles, particularly that of bioaerosol particles. A continuous timing laser tightly coupled with a pulse ionization laser is used to index aerosol particles, measure particle properties, and trigger the ionization laser to fire when each particle enters the beam of the trigger laser. Ionized fragments and optionally photons produced when each particle is struck by the ionization laser are analyzed using one or more detectors including a TOF-MS detector and an optical detector. Individual single particle spectra are aligned and denoised prior to averaging.Type: ApplicationFiled: October 21, 2021Publication date: February 10, 2022Applicant: Zeteo Tech, Inc.Inventors: Michael McLoughlin, Ross Kliegman, Tim Cornish, Vadym Berkout, Scott Ecelberger, Gonzalo Arce, Kyle Regan
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Publication number: 20220039353Abstract: Devices and methods for enhanced hearing protection for animals are disclosed. Passive noise reduction components provide reduction of at least 20 dB to 30 dB in dogs using flexible soft muffs that are housed in a hearing protection sleeve. Active noise cancellation (ANC) features may also be used to increase noise reduction to about 40 dB over a large frequency range. The devices may employ passive noise reduction electronic bypass to measure and playback sounds at safe levels bypassing at least one of ANC and passive noise reduction. Communication components may be employed to provide for communication between the handler and the animal. The systems and methods may be used to protect the hearing and utility of military working dogs and hunting dogs.Type: ApplicationFiled: September 15, 2019Publication date: February 10, 2022Applicant: Zeteo Tech, Inc.Inventors: Thomas McCreery, Michael McLoughlin, Evelyn McCreery, Noella A. Bryden, Stuart Collymore, Thomas Sager, Rebecca Baxter
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Publication number: 20220034854Abstract: Disclosed are methods and devices for analyzing aerosol particles in exhaled breath using diagnostic tools that enable rapid, low cost and autonomous point of care assays for several diseases including respiratory tract diseases. Disclosed are methods and devices for capturing exhaled breath aerosols in a packed bed column and analyzing exhaled captured breath aerosols for tuberculosis diagnosis.Type: ApplicationFiled: October 12, 2021Publication date: February 3, 2022Applicant: Zeteo Tech, Inc.Inventors: Dapeng Chen, Wayne A. Bryden, Michael McLoughlin
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Publication number: 20210233508Abstract: Systems and methods for enhanced hearing protection and data recording are disclosed. Recorded data is analyzed to determine user compliance with standard operating procedures. Additionally, hearing loss is monitored using neurological response of the auditory system to environmental noise. Optional sensors such as temperature sensors, accelerometers, GPS sensors are used to correlate noise data with external events. An optional acoustic source may be used to identify unusual conditions such as ear drum perforations and capture information related to health of the tympanic membrane and external auditory meatus. The systems and methods may also be used to protect the hearing and utility of military working dogs.Type: ApplicationFiled: June 3, 2019Publication date: July 29, 2021Applicant: Zeteo Tech, Inc.Inventor: Michael McLoughlin
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Patent number: 10663686Abstract: A device is disclosed for managing at least one flexible cable including a rigid portion. In at least one embodiment the device includes a first axial end and a second axial end distanced from one another along an axis of the device; at least a first winding surface at the first axial end and at least a second winding surface at the second axial for receiving at least first coil and a second coil of the flexible cable, the first and second winding surfaces being transversal with respect to the axis; and a constraint in the form of a clip or a cylindrical surface for supporting the rigid portion of the flexible cable between the first and the second axial end.Type: GrantFiled: October 28, 2016Date of Patent: May 26, 2020Assignee: SIEMENS AKTIENGESELLSCHAFTInventors: Michael McLoughlin, Jens Holt Spanggaard, Kelly Turner
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Publication number: 20190025448Abstract: A hose assembly for use underwater or in a wet or severe environment which includes a hose having an interior space and extending in a longitudinal direction. A first termination assembly terminates the hose at a first end and a second termination assembly terminates the hose at a second end. A signal carrier is disposed in the interior space of the hose and extends between the first and second termination assemblies. A strength member is disposed in the interior space of the hose.Type: ApplicationFiled: January 5, 2017Publication date: January 24, 2019Applicant: Siemens AktiengesellschaftInventors: Michael McLoughlin, David Michael Tucker
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Publication number: 20190004270Abstract: A device is disclosed for managing at least one flexible cable including a rigid portion. In at least one embodiment the device includes a first axial end and a second axial end distanced from one another along an axis of the device; at least a first winding surface at the first axial end and at least a second winding surface at the second axial for receiving at least first coil and a second coil of the flexible cable, the first and second winding surfaces being transversal with respect to the axis; and a constraint in the form of a clip or a cylindrical surface for supporting the rigid portion of the flexible cable between the first and the second axial end.Type: ApplicationFiled: October 28, 2016Publication date: January 3, 2019Applicant: Siemens AktiengesellschaftInventors: Michael MCLOUGHLIN, Jens Holt SPANGGAARD, Kelly TURNER
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Patent number: 6971043Abstract: An apparatus and method for accessing a first local mass storage device or a second local mass storage device in a fault-tolerant server. In one embodiment, the fault-tolerant server establishes communication between a first computing element and a first local mass storage device. The fault-tolerant server also establishes communications between a second computing element and a second local mass storage device. In one embodiment, the first computing element and the second computing element issue substantially similar instruction streams to one of the local mass storage devices.Type: GrantFiled: April 11, 2001Date of Patent: November 29, 2005Assignee: Stratus Technologies Bermuda LTDInventors: Michael McLoughlin, Gerry Griffin
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Publication number: 20050255456Abstract: A method and apparatus for evaluating a bioaerosol sample is provided which includes detecting frequency and/or time resolution factors that allow discriminate between a plurality of signals emitted by the bioaerosol to selectively detect biological materials contained in the bioaerosol sample from materials of non-biological origin and potentially associated with a pathogenic bioaenosol.Type: ApplicationFiled: April 16, 2003Publication date: November 17, 2005Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: George Murray, Cheryl Schein, David Kohler, Jennifer Sample, Jennifer Nix, Protagoras Cutchis, Adam Arabian, Harvey Ko, Micah Carlson, Michael McLoughlin
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Publication number: 20050211606Abstract: A system and method (FIG. 1) for automated handling and identification of parcels sorted by an automated high-speed mail sorting apparatus that identifies parcels that contain hoax or biological threat material comprising an opener (120) and a particle sampler (170) wherein said sampler analyzes air flow created as the parcels are compressed by pinch rollers (140).Type: ApplicationFiled: April 16, 2003Publication date: September 29, 2005Inventors: Stuart Harshbarger, Adam Arabian, Michael McLoughlin, Micah Carlson