Patents by Inventor Michael S. Goligorsky

Michael S. Goligorsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for restoring endothelial glycocalyx
    Patent number: 10849924
    Abstract: The present disclosure relates to compositions and methods for restoring endothelial glycocalyx. Exemplary compositions include nanoparticle compositions of preassembled glycocalyx.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: December 1, 2020
    Assignee: NEW YORK MEDICAL COLLEGE
    Inventors: Michael S. Goligorsky, Dong Sun
  • COMPOSITIONS AND METHODS FOR RESTORING ENDOTHELIAL GLYCOCALYX
    Publication number: 20190091257
    Abstract: The present disclosure relates to compositions and methods for restoring endothelial glycocalyx. Exemplary compositions include nanoparticle compositions of preassembled glycocalyx.
    Type: Application
    Filed: September 21, 2018
    Publication date: March 28, 2019
    Inventors: Michael S. GOLIGORSKY, Dong SUN
  • Reversing or preventing premature vascular senescence
    Patent number: 6967219
    Abstract: Premature vascular senescence is reversed or prevented in tissue or cells by contacting the tissue or cells with a hydroxyguanidine. This finds application in treatment of patients with a disorder associated with elevated levels of advanced glycation end products in blood or tissue, e.g., patients with end stage renal disease or poorly controlled diabetes, and in contacting vascular tissue or cells ex vivo to prevent occurrence of premature senescence.
    Type: Grant
    Filed: October 10, 2002
    Date of Patent: November 22, 2005
    Assignees: Cornell Research Foundation, Inc., The Research Foundation of the State University of New York
    Inventors: Steven S. Gross, Michael S. Goligorsky
  • Use of peroxynitrite scavengers or peroxynitrite formation inhibitors that do not diminish nitric oxide synthesis or activity to reverse or prevent premature vascular senescence
    Publication number: 20030086916
    Abstract: Premature vascular senescence is reversed or prevented in tissue or cells by contacting the tissue or cells with a peroxynitrite scavenger or peroxynitrite formation inhibitor that does not diminish nitric oxide synthesis. This finds application in treatment of patients with a disorder associated with elevated levels of advanced glycation end products in blood or tissue, e.g., patients with end stage renal disease or poorly controlled diabetes, and in contacting vascular tissue or cells ex vivo to prevent occurrence of premature senescence.
    Type: Application
    Filed: October 11, 2002
    Publication date: May 8, 2003
    Inventors: Michael S. Goligorsky, Jun Chen
  • Reversing or preventing premature vascular senescence
    Publication number: 20030073747
    Abstract: Premature vascular senescence is reversed or prevented in tissue or cells by contacting the tissue or cells with a hydroxyguanidine. This finds application in treatment of patients with a disorder associated with elevated levels of advanced glycation end products in blood or tissue, e.g., patients with end stage renal disease or poorly controlled diabetes, and in contacting vascular tissue or cells ex vivo to prevent occurrence of premature senescence.
    Type: Application
    Filed: October 10, 2002
    Publication date: April 17, 2003
    Inventors: Steven S. Gross, Michael S. Goligorsky