Patents by Inventor Michael S. Strano

Michael S. Strano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10215752
    Abstract: A composition can include a nanostructure, and a linker associated with the nanostructure, wherein the linker is configured to interact with a capture protein. The nanostructure can include a single-walled carbon nanotube. A plurality of the compositions can be configured in an array.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: February 26, 2019
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Michael S. Strano, Jin-Ho Ahn, Jong-Ho Kim, Paul W. Barone, Nigel F. Reuel
  • Publication number: 20180356404
    Abstract: A living plant can function as self-powered auto-samplers and preconcentrators of an analyte within ambient groundwater, detectors of the analyte contained therein. For example, a pair of near infrared (IR) fluorescent sensors embedded within the mesophyll of the plant leaf can be used as detectors of the nitroaromatic molecules, with the first IR channel engineered through CoPhMoRe to recognize analyte via an IR fluorescent emission and the second IR channel including a functionalized nanostructure that acts as an invariant reference signal.
    Type: Application
    Filed: December 2, 2016
    Publication date: December 13, 2018
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Michael S. STRANO, Juan Pablo GIRALDO GOMEZ, Seongyeon KWAK, Min Hao WONG
  • Publication number: 20180356414
    Abstract: Corona Phase Molecular Recognition (CoPhMoRe) utilizing a heteropolymer adsorbed onto and templated by a nanoparticle surface to recognize a specific target analyte can be used for macromolecular analytes, including proteins. A variant of a CoPhMoRe screening procedure of single walled carbon nanotubes (SWCNT) can be used against a panel of human blood proteins, revealing a specific corona phase that recognizes fibrinogen and insulin, respectively, with high selectivity.
    Type: Application
    Filed: November 22, 2016
    Publication date: December 13, 2018
    Applicant: Massachusetts Institute of Technology
    Inventors: Michael S. Strano, Gili H. Bisker Raviv
  • Publication number: 20180317415
    Abstract: A plant nanobionic approach can utilize a system of four nanoparticle types, including luciferase conjugated silica, luciferin releasing poly(lactic-co-glycolic acid), coenzyme A functionalized chitosan, and semiconductor nanocrystal phosphors for wavelength modulation.
    Type: Application
    Filed: November 4, 2016
    Publication date: November 8, 2018
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Michael S. STRANO, Seongyeon KWAK, Juan Pablo Giraldo GOMEZ, Min Hao WONG
  • Patent number: 10041951
    Abstract: An imaging probe can include a photoluminescent carbon nanostructure configured to emit a wavelength of light detectable through living tissue, and a targeting moiety including a first binding partner configured to interact with a second binding partner.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: August 7, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Hyunjung Yi, Debadyuti Ghosh, Jifa Qi, Angela M. Belcher, Michael S. Strano, Neelkanth M. Bardhan
  • Patent number: 10012657
    Abstract: Systems and methods related to optical nanosensors comprising photoluminescent nanostructures are generally described. Generally, the nanosensors comprise a photoluminescent nanostructure and a polymer that interacts with the photoluminescent nanostructure. In some cases, the interaction between the polymer and the nanostructure can be non-covalent (e.g., via van der Waals interactions). The nanosensors comprising a polymer and a photoluminescent nanostructure may be particularly useful in determining the presence and/or concentration of relatively small molecules, in some embodiments. In addition, in some instances the nanosensors may be capable of determining relatively low concentrations of analytes, in some cases determining as little as a single molecule. In some embodiments, the interaction between the analyte and the nanosensor (e.g.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: July 3, 2018
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Michael S. Strano, Jong-Ho Kim, Jinqing Zhang, Daniel A. Heller
  • Patent number: 9980668
    Abstract: A composition for sensing an analyte can include a photoluminescent nanostructure complexed to a sensing polymer, where the sensing polymer includes an organic polymer non-covalently bound to the photoluminescent nanostructure and an analyte-binding protein covalently bound to the organic polymer, and where the analyte-binding protein is capable of selectively binding the analyte, and the analyte-binding protein undergoes a substantial conformational change when binding the analyte. Separately, a composition for sensing an analyte, can include a complex, where the complex includes a photoluminescent nanostructure in an aqueous surfactant dispersion and a boronic acid capable of selectively reacting with an analyte. The compositions can be used in devices and methods for sensing an analyte.
    Type: Grant
    Filed: July 31, 2012
    Date of Patent: May 29, 2018
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Michael S. Strano, Paul W. Barone, Jin-Ho Ahn, Kyungsuk Yum, Thomas P. McNicholas
  • Patent number: 9901295
    Abstract: A nanosensor for detecting an analyte can include a substrate, a photoluminescent nanostructure, and a polymer interacting with the photoluminescent nanostructure. The nanosensor can be used in in vivo for biomedical applications.
    Type: Grant
    Filed: September 16, 2014
    Date of Patent: February 27, 2018
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Nicole M. Iverson, Michael S. Strano, Nigel F. Reuel, Thomas P. McNicholas
  • Publication number: 20180011072
    Abstract: Systems and methods related to optical nanosensors comprising photoluminescent nanostructures are generally described.
    Type: Application
    Filed: June 6, 2017
    Publication date: January 11, 2018
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Michael S. Strano, Daniel A. Heller, George W. Pratt, Jingqing Zhang
  • Publication number: 20170328890
    Abstract: A composition can include a complex, where the complex includes a photoluminescent nanostructure and a polymer free from selective binding to an analyte, the polymer adsorbed on the photoluminescent nanostructure, and a selective binding site associated with the complex.
    Type: Application
    Filed: May 26, 2017
    Publication date: November 16, 2017
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Michael S. Strano, Jingqing Zhang, Paul Walter Barone, Daniel A. Heller, Jong-Ho Kim
  • Publication number: 20170299601
    Abstract: A single chirality single walled carbon nanotubes (SWNT), and combinations thereof, can be used to detect trace levels of chemical compounds in vivo with high selectivity.
    Type: Application
    Filed: September 18, 2015
    Publication date: October 19, 2017
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Juan Pablo Giraldo Gomez, Markita Patricia Landry, Michael S. Strano
  • Patent number: 9664677
    Abstract: A composition can include a complex, where the complex includes a photoluminescent nanostructure and a polymer free from selective binding to an analyte, the polymer adsorbed on the photoluminescent nanostructure, and a selective binding site associated with the complex.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: May 30, 2017
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Michael S. Strano, Jingqing Zhang, Paul Walter Barone, Daniel A. Heller, Jong-Ho Kim
  • Publication number: 20170131287
    Abstract: A composition for sensing an analyte can include a photoluminescent nanostructure (e.g. a carbon nanotube) complexed to a sensing polymer, where the sensing polymer includes a phenylboronic acid based polymer non-covalently bound to the photoluminescent nanostructure where the composition is capable of selectively binding the analyte, and the composition undergoes a substantial conformational change when binding the analyte. Separately, a composition for sensing an analyte can include a complex, where the complex include a photoluminescent nanostructure in an aqueous surfactant dispersion and a phenylboronic acid capable of selectively reacting with an analyte. The compositions can be used in devices and methods for sensing an analyte.
    Type: Application
    Filed: June 5, 2015
    Publication date: May 11, 2017
    Applicant: Massachusetts Institute of Technology
    Inventors: Thomas P. McNicholas, Jiyoung Ahn, Michael S. Strano
  • Patent number: 9403684
    Abstract: The present invention generally relates to compositions, methods, and systems for separating carbon-based nanostructures.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: August 2, 2016
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Michael S. Strano, Thomas P. McNicholas, Andrew J. Hilmer, Rishabh M. Jain, Kevin C. Tvrdy
  • Publication number: 20160178597
    Abstract: Systems and methods related to optical nanosensors comprising photoluminescent nanostructures are generally described.
    Type: Application
    Filed: June 10, 2013
    Publication date: June 23, 2016
    Applicant: Massachusetts Institute of Technology
    Inventors: Michael S. Strano, Daniel A. Heller, George W. Pratt, Jingqing Zhang
  • Publication number: 20150133752
    Abstract: A nanosensor for detecting an analyte can include a substrate, a photoluminescent nanostructure, and a polymer interacting with the photoluminescent nanostructure. The nanosensor can be used in in vivo for biomedical applications.
    Type: Application
    Filed: September 16, 2014
    Publication date: May 14, 2015
    Inventors: Nicole M. Iverson, Michael S. Strano, Nigel F. Reuel, Thomas P. McNicholas
  • Publication number: 20150050208
    Abstract: Select embodiments of the present invention employ biological means to direct assemble CNT-based nanostructures, allowing for scaling to macrostructures for manufacture. In select embodiments of the present invention, a method is provided for assembling DNA-functionalized SWNTs by phosphodiester bonding catalyzed by ssDNA-ligase to form macroscopic CNT aggregates.
    Type: Application
    Filed: October 6, 2011
    Publication date: February 19, 2015
    Inventors: Thomas A. Carlson, Charles P. Marsh, Jae Hee Han, Michael S. Strano, Charles R. Welch, Clint M. Arnett
  • Publication number: 20150047074
    Abstract: In one aspect, a composition can include an organelle, and a nanoparticle having a zeta potential of less than ?10 mV or greater than 10 mV contained within the organelle. In a preferred embodiment, the organelle can be a chloroplast and the nanoparticle can be a single-walled carbon nanotube associated with a strongly anionic or strongly cationic polymer.
    Type: Application
    Filed: August 7, 2014
    Publication date: February 12, 2015
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Michael S. Strano, Juan Pablo Giraldo Gomez, Sean Mitchell Faltermeier, Markita P. Landry
  • Patent number: 8941285
    Abstract: In one aspect, the present invention provides nanosized systems for generating electrical energy based on the use of a chemically reactive composition to generate a thermoelectric wave. For example, the system can include at least one nanostructure (e.g., a carbon nanotube) extending along an axial direction between a proximal end and a distal end. A chemically reactive composition is dispersed along at least a portion of the nanostructure, e.g., along its axial direction, so as to provide thermal coupling with the nanostructure. The chemical composition can undergo an exothermic chemical reaction to generate heat. The system can further include an ignition mechanism adapted to activate the chemical composition so as to generate a thermal wave that propagates along the axial direction of the nanostructure, where the thermal wave is accompanied by an electrical energy wave propagating along the axial direction.
    Type: Grant
    Filed: April 23, 2012
    Date of Patent: January 27, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Michael S. Strano, Won Joon Choi, Joel T. Abrahamson, Jae-Hee Han
  • Publication number: 20140308681
    Abstract: Sensing compositions, sensing element, sensing systems and sensing devices for the detection and/or quantitation of one or more analytes. Compositions comprising carbon nanotubes in which the carbon nanotubes retain their ability to luminesce and in which that luminescence is rendered selectively sensitive to the presence of an analyte. Compositions comprising individually dispersed carbon nanotubes, which are electronically isolated from other carbon nanotubes, yet which are associated with chemical selective species, such as polymers, particularly biological polymers, for example proteins, which can interact selectively with, or more specifically selectivity bind to, an analyte of interest. Chemically selective species bind, preferably non-covalently, to the carbon nanotube and function to provide for analyte selectivity. Chemically selective species include polymers to which one or more chemically selective groups are covalently attached.
    Type: Application
    Filed: June 30, 2014
    Publication date: October 16, 2014
    Inventors: Michael S. Strano, Seunghyun Baik, Paul Barone