Abstract: Provided herein are novel p62 compositions for the prophylaxis and treatment of cancer and related methods. The invention also provides modified p62 compositions that increase the anti-cancer activity of p62.

Abstract: An apparatus for substantially horizontally oscillating one or more vessels containing a liquid, a solid, or a mixture thereof that operates to thoroughly disrupt and mix solid and liquid substances in vessels, like test tubes. The apparatus provides superior mixing through oscillation of the vessels both horizontal and vertical directions through the use of one or more springs and rotating mechanical components. The apparatus includes a circular rotating ring having a toothed circumference that rotates horizontally, at least one vessel support having a compartment configured to hold the one or more vessel vessels and a spring attached to the housing and in constant contact with each of the one or more vessel supports.

Abstract: A hand operated device for storing, measuring, and dispensing powder or granular materials, with a simplified structure and reduced number of parts. The housing integrates a material storage container with a dispenser, comprising: special compartments and sound damper, made of elastic porous material that makes use of the device quiet; a one touch assembly and disassembly of an inner space of the device where the dispenser is located; structural elements for dispensing a predetermined volume of the material or its fraction, including a way to reduce the length of the working stroke of the dispensing mechanism; wall extensions to prevent bridges of sticky particles forming; separating walls to allow delivery a more than one material stored in one device including more than one material transporting mechanisms inside the dispenser; and structural elements providing exact measuring, and sifting or pouting of the materials.

Abstract: An apparatus for substantially horizontally oscillating one or more vessels containing a liquid, a solid, or a mixture thereof that operates to thoroughly disrupt and mix solid and liquid substances in vessels, like test tubes. The apparatus provides superior mixing through oscillation of the vessels both horizontal and vertical directions through the use of one or more springs and rotating mechanical components. The apparatus includes a circular rotating ring having a toothed circumference that rotates horizontally, at least one vessel support having a compartment configured to hold the one or more vessel vessels and a spring attached to the housing and in constant contact with each of the one or more vessel supports.

Abstract: Provided herein are novel p62 compositions for the prophylaxis and treatment of cancer and related methods. The invention also provides modified p62 compositions that increase the anti-cancer activity of p62.

Abstract: Systems, devices, and methods for linking orders to develop a consolidated audit trail (CAT) are configured to receive event data for one or more orders based on one or more order characteristics; determine linkages between the one or more orders based on parent relationships of the one or more orders; verify the linkages between the one or more orders based on the event data; and determine order lifecycles based on the linkages between the one or more orders.

Abstract: A device for generating a scented mist of an atomized liquid fragrance oil includes an atomizer complex, a reservoir assembly, a drainage tube, and a vacuum tube. The atomizer complex can atomize the liquid fragrance oil into a scented mist and deliver the scented mist to air outside of the atomizer complex, where the liquid fragrance oil the fragrance oil that is not atomized into the scented mist delivered to the air outside of the atomizer complex includes collected oil that is collected and drained to a reservoir assembly. A drainage tube extends from a bottom area of the atomizer complex into the liquid fragrance oil. The device can filter the liquid fragrance oil in the reservoir assembly and the collected oil from the atomizer complex that drained down the drainage tube. The vacuum tube can suction the filtered liquid fragrance oil and the collected oil into the atomizer complex for atomization.

Abstract: The invention is directed to a hand operated device for storing, measuring and dispensing of powder or granular materials, with effectively simplified structure and reduced number of parts, having a solid housing integrating material storage container with stationer parts of a dispenser, comprising: special compartments and sound damper, made of elastic porous material that makes work of the device quite and thus acceptable for users; a means for one touch assembly and disassembly of an inner space of the device where a dispenser is located; structural elements for dispensing a predetermined volume of the material or its fraction, including stopping means for reduction of length of working stroke of the dispensing mechanism; a means making the device reliable when it is used with materials including sticky particles; a means providing the device configured to delivery more then one material stored in one device, including more then one material transporting mechanisms inside the dispenser; and structural elem

Abstract: Provided herein are novel p62 compositions for the modulation of expression of a proinflammatory cytokines, osteogenic transcription factors, a bone resorptive factors and endogenous p62. Consequently, such p62 compositions are useful for prophylaxis and treatment of inflammatory diseases and related methods. In certain embodiments the inflammatory diseases are not cancer-related. In various embodiments, the inflammatory diseases include, but are not limited to osteoporosis, obesity, metabolic syndrome, type 2 diabetes, fat liver, inflammatory bowel disease, chronic pancreatitis, asthma, chronic obstructive pulmonary disease (COPD), rheumatoid arthritis (RA), osteoarthritis, multiple sclerosis (MS), psoriasis, congestive heart failure (CHF), atherosclerosis, neurodegenerative diseases (ALS, Parkinson, Alzheimer's, Huntington disease), depression, schizophrenia, gout, asbestosis and silicosis.

Abstract: A device for generating a scented mist of an atomized liquid fragrance oil includes an atomizer complex, a reservoir assembly, a drainage tube, and a vacuum tube. The atomizer complex can atomize the liquid fragrance oil into a scented mist and deliver the scented mist to air outside of the atomizer complex, where the liquid fragrance oil the fragrance oil that is not atomized into the scented mist delivered to the air outside of the atomizer complex includes collected oil that is collected and drained to a reservoir assembly. A drainage tube extends from a bottom area of the atomizer complex into the liquid fragrance oil. The device can filter the liquid fragrance oil in the reservoir assembly and the collected oil from the atomizer complex that drained down the drainage tube. The vacuum tube can suction the filtered liquid fragrance oil and the collected oil into the atomizer complex for atomization.

Abstract: A paint tray includes a body having a base portion and sidewalls forming a paint well. Each sidewall has an upper top portion. The upper top portions collectively define an upper rim of a mouth of the well. A barred shaped member is hingedly connected to the upper top portion of a first sidewall such that the barred shaped member pivots relative to the body between first and second positions. In the first position, the barred shaped member is disposed within and surrounded by an inner perimeter of the upper rim of the mouth of the paint well. In the second position, the barred shaped member extends away from the upper rim and neither extends over nor within the mouth of the paint well. The paint tray is fabricated out of a molded material, and preferably comprises molded plastic.

Abstract: A method and system for optimizing and keeping operational a wireless link layered network in which a system control and modifying message (SCMM) is elicited from nodes receiving information packets and based upon whether the node originating the SCMM is from a link layer level which is equal to or less than the link layer level eliciting the SCMM, rerouting or adjusting future transmissions can be effected or items like a less current time at a receiving node and a most recent utilization rate of a receiving node can be adjusted, recorded or set.

Abstract: A method and system for optimizing and keeping operational a wireless link layered network in which a system control and modifying message (SCMM) is elicited from nodes receiving information packets and based upon whether the node originating the SCMM is from a link layer level which is equal to or less than the link layer level eliciting the SCMM, rerouting or adjusting future transmissions can be effected or items like a less current time at a receiving node and a most recent utilization rate of a receiving node can be adjusted, recorded or set.

Abstract: A method of mixing together liquids or liquid/solid combinations, and mixing apparatus/universal combine utilizing a vertical spinning container or vessel having a rib, or a cross rib in its bottom wall. The container is spun about a vertical axis with no wobbling component to the motion. Meshed elements are used for high shear mixing. Start/stop routines, and variable acceleration/speed values are used, to facilitate complete mixing. Use of ‘impeller’ blade stirrers is completely eliminated.

Abstract: A device for generating a scented mist of an atomized liquid fragrance oil includes an atomizer complex, a reservoir assembly, a drainage tube, and a vacuum tube. The atomizer complex can atomize the liquid fragrance oil into a scented mist and deliver the scented mist to air outside of the atomizer complex, where the liquid fragrance oil the fragrance oil that is not atomized into the scented mist delivered to the air outside of the atomizer complex includes collected oil that is collected and drained to a reservoir assembly. A drainage tube extends from a bottom area of the atomizer complex into the liquid fragrance oil. The device can filter the liquid fragrance oil in the reservoir assembly and the collected oil from the atomizer complex that drained down the drainage tube. The vacuum tube can suction the filtered liquid fragrance oil and the collected oil into the atomizer complex for atomization.

Abstract: A paint tray includes a body having a base portion and sidewalls forming a paint well. Each sidewall has an upper top portion. The upper top portions collectively define an upper rim of a mouth of the well. A barred shaped member is hingedly connected to the upper top portion of a first sidewall such that the barred shaped member pivots relative to the body between first and second positions. In the first position, the barred shaped member is disposed within and surrounded by an inner perimeter of the upper rim of the mouth of the paint well. In the second position, the barred shaped member extends away from the upper rim and neither extends over nor within the mouth of the paint well. The paint tray is fabricated out of a molded material, and preferably comprises molded plastic.

Abstract: In various embodiments, the present invention relates generally to analysis of complex mixtures and, more specifically, to detection and quantitative determination of multiple proteins, protein modifications, and protein-nucleic acid interactions in those complex mixtures.

Abstract: In various embodiments, the present invention relates generally to analysis of complex mixtures and, more specifically, to detection and quantitative determination of multiple proteins, protein modifications, and protein-nucleic acid interactions in those complex mixtures.

Abstract: The present invention relates to a brace installation instrument placement that is mounted to anchors secured in an animal subject. The installation instrument includes anchor extensions coupled to the anchors. The instrument is movable with respect to the anchors to position a brace in a position more proximate the anchors. The brace can be indexed for insertion at a predetermined orientation with respect to the installation instrument. Methods and techniques for using the installation instrument are also provided.

Abstract: A device for generating a scented mist of an atomized liquid fragrance oil includes an atomizer complex, a reservoir assembly, a drainage tube, and a vacuum tube. The atomizer complex can atomize the liquid fragrance oil into a scented mist and deliver the scented mist to air outside of the atomizer complex, where the liquid fragrance oil the fragrance oil that is not atomized into the scented mist delivered to the air outside of the atomizer complex includes collected oil that is collected and drained to a reservoir assembly. A drainage tube extends from a bottom area of the atomizer complex into the liquid fragrance oil. The device can filter the liquid fragrance oil in the reservoir assembly and the collected oil from the atomizer complex that drained down the drainage tube. The vacuum tube can suction the filtered liquid fragrance oil and the collected oil into the atomizer complex for atomization.