Patents by Inventor Michael T. Trentalange

Michael T. Trentalange has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR MANIPULATING THE LEVEL OF GLYCAN CONTENT OF A GLYCOPROTEIN
    Publication number: 20230159974
    Abstract: The present invention provides a method for manipulating the fucosylated glycan content on a recombinant protein.
    Type: Application
    Filed: January 18, 2023
    Publication date: May 25, 2023
    Applicant: AMGEN INC.
    Inventors: Daniel R. LEISKE, Michael T. TRENTALANGE
  • PROCESS FOR MANIPULATING THE LEVEL OF GLYCAN CONTENT OF A GLYCOPROTEIN
    Publication number: 20210017565
    Abstract: The present invention provides a method for manipulating the fucosylated glycan content on a recombinant protein.
    Type: Application
    Filed: October 2, 2020
    Publication date: January 21, 2021
    Applicant: AMGEN INC.
    Inventors: Daniel R. LEISKE, Michael T. TRENTALANGE
  • Process for manipulating the level of glycan content of a glycoprotein
    Patent number: 10822630
    Abstract: The present invention provides a method for manipulating the fucosylated glycan content on a recombinant protein.
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: November 3, 2020
    Assignee: Amgen Inc.
    Inventors: Daniel R. Leiske, Michael T. Trentalange
  • PROCESS FOR MANIPULATING THE LEVEL OF GLYCAN CONTENT OF A GLYCOPROTEIN
    Publication number: 20200172947
    Abstract: The present invention provides a method for manipulating the fucosylated glycan content on a recombinant protein.
    Type: Application
    Filed: February 5, 2020
    Publication date: June 4, 2020
    Applicant: AMGEN INC.
    Inventors: Daniel R. LEISKE, Michael T. TRENTALANGE
  • PROCESS FOR MANIPULATING THE LEVEL OF GLYCAN CONTENT OF A GLYCOPROTEIN
    Publication number: 20190085370
    Abstract: The present invention provides a method for manipulating the fucosylated glycan content on a recombinant protein.
    Type: Application
    Filed: November 14, 2018
    Publication date: March 21, 2019
    Applicant: AMGEN INC.
    Inventors: Daniel R. LEISKE, Michael T. TRENTALANGE
  • Process for manipulating the level of glycan content of a glycoprotein
    Patent number: 10167492
    Abstract: The present invention provides a method for manipulating the fucosylated glycan content on a recombinant protein.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: January 1, 2019
    Assignee: AMGEN INC.
    Inventors: Daniel R. Leiske, Michael T. Trentalange
  • PROCESS FOR MANIPULATING THE LEVEL OF GLYCAN CONTENT OF A GLYCOPROTEIN
    Publication number: 20170362625
    Abstract: The present invention provides a method for manipulating the fucosylated glycan content on a recombinant protein.
    Type: Application
    Filed: December 1, 2015
    Publication date: December 21, 2017
    Applicant: AMGEN INC.
    Inventors: Daniel R. LEISKE, Michael T. TRENTALANGE
  • Methods for increasing polypeptide production
    Patent number: 7452695
    Abstract: The invention provides methods of increasing the production of polypeptides, optionally recombinant polypeptides, from mammalian cells using xanthine derivatives or hybrid polar compounds and cultures containing the same. Combinations of inducers including a hybrid polar compound and/or a xanthine derivative and/or an alkanoic acid can also be used, optionally at temperatures less than 37° C.
    Type: Grant
    Filed: February 4, 2005
    Date of Patent: November 18, 2008
    Assignee: Immunex Corporation
    Inventors: Kirk P Van Ness, Michael T Trentalange, Bradley D Dell, Jeffrey T McGrew
  • Methods for increasing polypeptide production
    Patent number: 6872549
    Abstract: The invention provides methods of increasing the production of polypeptides, optionally recombinant polypeptides, from mammalian cells using xanthine derivatives or hybrid polar compounds and cultures containing the same. Combinations of inducers including a hybrid polar compound and/or a xanthine derivative and/or an alkanoic acid can also be used, optionally at temperatures less than 37° C.
    Type: Grant
    Filed: March 27, 2003
    Date of Patent: March 29, 2005
    Assignee: Immunex Corporation
    Inventors: Kirk P. Van Ness, Michael T. Trentalange, Bradley D. Dell, Jeffrey T. McGrew
  • Methods for increasing polypeptide production
    Publication number: 20030211579
    Abstract: The invention provides methods of increasing the production of polypeptides, optionally recombinant polypeptides, from mammalian cells using xanthine derivatives or hybrid polar compounds and cultures containing the same. Combinations of inducers including a hybrid polar compound and/or a xanthine derivative and/or an alkanoic acid can also be used, optionally at temperatures less than 37° C.
    Type: Application
    Filed: March 27, 2003
    Publication date: November 13, 2003
    Inventors: Kirk P. Van Ness, Michael T. Trentalange, Bradley D. Dell, Jeffrey T. McGrew