Patents by Inventor Michael Zengerle

Michael Zengerle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11179373
    Abstract: There is provided novel small molecule E3 ubiquitin ligase protein binding ligand compounds, having utility in PROteolysis Targeted Chimeras (PROTACs), as well as processes for the preparation thereof, and use in medicine. There is particularly provided PROTACs which bind to a protein within the bromo- and Extra-terminal (BET) family of proteins, and especially to PROTACs including novel small molecule E3 ubiquitin ligase protein binding ligand compounds which selectively induce degradation of the BRD4 protein within the bromodomain of the BET family of proteins.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: November 23, 2021
    Assignee: University of Dundee
    Inventors: Alessio Ciulli, Michael Zengerle, Kwok-Ho Chan
  • Publication number: 20180050021
    Abstract: There is provided novel small molecule E3 ubiquitin ligase protein binding ligand compounds, having utility in PROteolysis Targeted Chimeras (PROTACs), as well as processes for the preparation thereof, and use in medicine. There is particularly provided PROTACs which bind to a protein within the bromo- and Extra-terminal (BET) family of proteins, and especially to PROTACs including novel small molecule E3 ubiquitin ligase protein binding ligand compounds which selectively induce degradation of the BRD4 protein within the bromodomain of the BET family of proteins.
    Type: Application
    Filed: March 14, 2016
    Publication date: February 22, 2018
    Inventors: Alessio CIULLI, Michael ZENGERLE, Kwok-Ho CHAN
  • Publication number: 20170122958
    Abstract: A method of selectively inhibiting a bromodomain in the presence of other bromodomains comprising introducing a functionally silent mutation into the bromodomain in the presence of other wild type bromodomains and selectively inhibiting the mutated bromodomain.
    Type: Application
    Filed: November 28, 2014
    Publication date: May 4, 2017
    Inventors: Enrique Lin Shiao, Matthias Gerard Jacky Baud, Alessio Ciulli, Kwok-Ho Chan, Michael Zengerle